Gpat at Your Fingertip Objective

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OBJECTIVE GPAT AT YOUR FINGERTIPS : PHARMACEUTICS
PHARMACEUTICS
F
PD
E
PL
M
PHYSICAL PHARMACY
SA
PS
TI
ER
1. The Gibb’s Phase rule [GPAT-2016]
(a) Holds only for systems with more than components
G
(b) Predicts that a maximum of three phase can exits in one components system
(c) Does not count phase compositions as intensive variables
N
FI
(d) Does not count pressure and temperature as intensive variables
R
2. Identify the molecule which will not exhibit Dipole moment [GPAT-2019]
U
(a) Carbon dioxide (b) Carbon monoxide (c) Chloroform (d) Ammonia
YO
3. Choose the wrong statement from the following with regard to Amorphous solids [GPAT-2020]
(a) Usually they are anisotropic
AT
(b) They tend to flow when subjected to sufficient pressure

(c) Considered as super cooled fluids
T
PA
(d) They do not have definite melting point

4. The Crystal form of Sulphacetamide is [GPAT-2020]
G
(a) Rhombohedral (b) Orthorhombic (c) Monoclinic (d) Triclinic

VE
5. Which of the following is most appropriate to crystalline solid [GPAT–2022]
(a) Give diffraction bands (b) Characteristics geometrical shapes

TI
(c) Sharp melting point (d) All of these

EC
6. Molecules in the smectic liquid crystals are characterized by which one of the following
BJ
[GPAT-2011]
(a) Mobility in three directions and rotation in one axis

O
(b) Mobility in two directions and rotation in one axis

C
(c) Mobility in two directions and no rotation

D
(d) Mobility in three directions and no rotation

G

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1
GPAT DISCUSSION CENTER : MAKES STUDY EASY
50. Read the following statements [GPAT-2012]
[P] The surface area measurement using BET approach utilizes argon gas for adsorption
[Q] Full form of BET is Brunauer, Emmett and Teller
F
Choose the correct answer
PD
(a) P & Q both are correct (b) P is correct but Q is incorrect
(c) Q is correct but P is incorrect (d) Both P & Q are incorrect
E
51. Which of the following is the correct choice of particle size measurement technique in
PL
scoring order of size [GPAT-2023 SHIFT-II]
M
[P] Sieve [Q] Anderson Pipette
SA
[R] Coulter counter [S] Light scattering
(a) P, Q, R, S (b) Q, S, R, P (c) P, R, Q, S (d) S, P, R, Q
PS
52. Kozeny Carman equation is used to determine the [GPAT-2023 SHIFT-I]
(a) Surface area of the powder (b) Viscosity of a liquid
TI
(c) Surface tension of a liquid (d) Density of a liquid
ER
53. If S is the solubility of small particles of radius r, is the normal solubility (i.e., of a solid
G
consisting of fairly large particles), is the interfacial energy, M is the molecular weight of the
N
solid, ρ is the density of the bulk solid, R is the gas constant and T is the thermodynamic
FI
temperature, then which of the following equation indicates the changes in interfacial free
energy that accompany the dissolution of particles of varying sizes causing the solubility of
R
U
substance to increase with decreasing particle size [GPAT-2023 SHIFT-II]

YO
(a) Log (S0/S)=2yMr/2.303RT (b) Log(S/S0)=2yMr/2.303RT

(c) Log(S0/S)=2yMr/2.303RTr (d) Log (S/S0)=2yM/2.303RTr
AT
54. What are the specific surface per unit volume Sv of spherical particles with density of
3 gm/cm3 and volume surface diameter, dvs of 2.57 m [GPAT-2018]
T
(a) 7.78 x103 cm2/cm3 (b) 2.33 x103 cm2/cm3

PA
(c) 1.55 x103 cm2/cm3 (d) 1.00 x103 cm2/cm3

55. Determine the correctness or otherwise of the following Assertion [A] and the Reason [R]
G
[GPAT-2011]
VE
Assertion[A]: For a pharmaceutical powder true density is greater than the granule density.
TI
Reason[R]: Mercury displacement used for determining granule density, allows penetration
EC
of liquid into internal pores of the particles

(a) [A] is true but [R] is false
BJ
(b) Both [A] and [R] are false

O
(c) Both [A] and [R] are true and [R] is the correct reason for [A]
(d) Both [A] and [R] are true but [R] is NOT the correct reason for [A]
C
56. Hausner Ratio is [GDC PRACTICE MCQ]

D
G
(a) Bulk volume / Void volume (b) Bulk density / Tapped density
(c) Tapped density / Bulk density (d) Void volume / Bulk volume

6 Gpat Discussion Center Pvt. Ltd. |  www.gdclive.com, www.gdconlinetest.in |  gdcgpat037@gmail.com | 8602227444, 9770765680
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171. An amphoteric surfactant used in pharmaceutical disperse systems is [GATE-2004]
PD
(a) Bile salts (b) Lecithin
(c) Sorbitan monolaurate (d) Sorbitan monostearate
E
172. An electrochemical method that enhances the transport of some solute molecules by
PL
creating a potential gradient through skin tissue with an applied electrical current or
voltage is called [GATE-2004]
M
(a) Electrophoresis (b) Iontophoresis (c) Osmosis (d) Implants
SA
173. Which statement is FALSE for Association Colloids [GPAT-2011]
(a) They are also called amphiphiles (b) They contain aggregated molecules
PS
(c) They show partial solvation (d) They are also called micelles
174. Read the following statements [GPAT-2012]
TI
[P] At temperature below Krafft point, micelles will, not form
ER
[Q] At Krafft point, solubility of surfactant equals CMC
[R] Krafft point increases with increasing chain length of hydrocarbon
G
[S] Krafft point is normally exhibited by non-ionic surfactants
Choose the correct combination of answers
N
FI
(a) P is correct but Q, R & S are wrong (b) R & S are correct but P & Q are wrong
R
(c) P, Q & R are correct but S is wrong (d) All are correct
U
175. Identify the wrong match pattern of DLVO theory [GPAT-2014]

YO
(a) Primary minimum - High attraction - Irreversible coagulation

(b) Primary maximum - High repulsion - Prevents coagulation
AT
(c) Secondary minimum - Weak interaction - Flocculation

(d) None of these
T
176. Schulze-Hardy rule is for [GPAT-2015]

PA
(a) Lyophilic colloid (b) Hydrophilic colloid

(c) Association colloid (d) Both (b) and (c)
G
177. DLVO theory is [GPAT-2016]

VE
[P] Derjaguin Landou Vervey Overbeek theory

[Q] Used to explain double electric layer theory
TI
[R] Used to explain stability ointments

EC
[S] Used to explain Brownian movement of colloids

(a) [P], [Q] (b) [Q], [R] (c) [R], [S] (d) [Q], [S]
BJ
178. Colligative properties depend on [GPAT-2016]

O
(a) Structural arrangement of atoms within the molecules of solute and solvent
(b) The number of solute particles in solution
C
(c) The physical properties of the solute particles dissolved in solution

D
(d) Sum of the corresponding properties of individual atoms or functional group within
G
the molecules

303. Given below are the equipment used in manufacturing powder and their purpose [P] to [T]
F
PD
Match them correctly [GATE-1988]
1. Coulter counter [P] To determine the total surface
E
2. Sorptometer [Q] To determine particle size
PL
3. Andreasen apparatus [R] To determine the flow rate
4. Shear box [S] To determine sedimentation rate
M
[T] To determine the cohesiveness
SA
(a) 1-[P], 2-[Q], 3-[S], 4-[R] (b) 1-[P], 2-[Q], 3-[T], 4-[R]
(c) 1-[T], 2-[Q], 3-[S], 4-[R] (d) 1-[Q], 2-[P], 3-[S], 4-[T]
PS
304. Match the following Group I with Group II [GATE-2008]
TI
Group I Group II
Name of equation Equation
ER
dc DS
1. Noyes & Whitney equation [P] = (CS - C)
G
dt h
N
FI P 1 b -1  P 
2. B.E.T equation [Q] = +  
Y(P0 - P) Ym b Ym  P0 
R
d2(PS - PO )g
U
3. Stokes equation [R] V

18η0
YO
1
4. Higuchi equation [S] Q =[D(2A - C )C × t]2
S S
AT
(a) 1-[S], 2-[Q], 3-[R], 4-[P] (b) 1-[Q], 2-[S], 3-[P], 4-[R]
(c) 1-[R], 2-[P], 3-[Q], 4-[S] (d) 1-[P], 2-[Q], 3-[R], 4-[S]
T
305. Given below in [P] to [T] are the names of instruments used for the determination of the
PA
following. Match them correctly [GATE-1989]

1. Particle volume [P] Clarity apparatus
G
2. Presence of Foreign particle [Q] Du Nouy ring

VE
3. Surface tension [R] Coulter counter

TI
4. Presence of polymorph [S] Compactor

[T] Differential thermal calorimeter
EC
(a) 1-[R], 2-[P], 3-[Q], 4-[T] (b) 1-[S], 2-[R], 3-[Q], 4-[P]
BJ
(c) 1-[Q], 2-[R], 3-[P], 4-[S] (d) 1-[R], 2-[Q], 3-[S], 4-[P]
306. Match the following Equipment and their determination [GATE-2009]
O
Group I Group II
C
Equipment To determine
D
1. Cascade Impactor [P] Flash point

G
2. Tag Open Cup apparatus [Q] Sedimentation rate

3. Pycnometer [R] Particle size
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3. Hanson-paddle equipment [R] For consistency and hardness of
relatively rigid semisolids
4. Glass electrode [S] Dissolution of granules and tablets
F
[T] pH indicating electrode
PD
(a) 1-[Q], 2-[P], 3-[S], 4-[R] (b) 1-[P], 2-[R], 3-[S], 4-[T]
(c) 1-[T], 2-[Q], 3-[R], 4-[P] (d) 1-[R], 2-[T], 3-[Q], 4-[S]
E
PL
M
DISPENSING PHARMACY
SA
PS
TI
ER
1. Prescription price consists of [GPAT–2022]
G
(a) Cost of ingredients only
N
(b) Cost of professional fee only FI
(c) Cost of ingredients and cost of dispensing only
R
(d) Cost of ingredients and professional fee only
U
2. Match List I with List II [GPAT-2021]

YO
List - I (Term or Phrase) List - II (Meaning)

1. Gutturi [P] Into the left ear
AT
2. In oculum sinistram [Q] Into the right eye

3. In aurem sinistram [R] For the left eye
T
4. In oculum dextrum [S] To the throat

PA
Choose the correct answer from the options given below

G
(a) 1 - [S], 2 - [R], 3 - [P], 4 - [Q] (b) 1 - [Q], 2 - [P], 3 - [S], 4 - [R]
VE
(c) 1 - [R], 2 - [S], 3 - [P], 4 - [Q] (d) 1 - [P], 2 - [R], 3 - [Q], 4 - [S]
3. The part of prescription that means ‘take thou’ is [GPAT-2021]
TI
(a) Subscription (b) Inscription (c) Superscription (d) Signatura

EC
4. In absence of instruction by the prescriber, unless otherwise directed, the dose given for
the mixture preparation should be stated on the label as [GPAT–2023 SHIFT-I]
BJ
(a) One five ml spoonful to be taken three times a day in water

O
(b) Two five ml spoonful to be taken three times a day in water

C
(c) Two five ml spoonful to be taken two times a day in water

D
(d) One five ml spoonful to be taken two times a day in water

G
5. Auristillae is the latin term for [GPAT-2016]

(a) Eye drop (b) Ear drop (c) Nasal drop (d) Spray solution
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33
(a) Idiosyncrasy (b) Incompatibility (c) Accumulation (d) Antagonism
98. Causes for therapeutic incompatibility are [GDC PRACTICE MCQ]
(a) Error dose (b) Wrong dose
F
(c) Contraindicated drugs (d) All of these
PD
99. Which type of incompatibility is observed in the following prescription R x Codeine
phosphate-0.5 gm powder [GDC PRACTICE MCQ]
E
(a) Physical incompatibility (b) Chemical incompatibility
PL
(c) Therapeutic incompatibility (d) None of these
M
100. The combination of penicillin and Probenecid shows [GDC PRACTICE MCQ]
SA
(a) Additive effect (b) Antagonism (c) Synergism (d) All of these
101. Which type of incompatibility observed in the following prescription R x [GDC PRACTICE MCQ]
PS
Acetophenatidin Acetyl salicylic acid Caffeine
TI
(c) Therapeutic incompatibility (d) None of these
ER
102. Reasons for physical incompatibility [GDC PRACTICE MCQ]
G
(a) Immiscibility (b) Insolubility (c) Liquefaction (d) All of these
N
103. Physical incompatibility can be corrected by [GDC PRACTICE MCQ]
FI
(a) Order of mixing (b) Addition of suspending agent
(c) Change in the form of ingredient (d) All of these
R
U
104. Which type of incompatibility is observed in the following prescription R x [GDC PRACTICE MCQ]
YO
Menthol Camphor
Ammonium chloride Light magnesium carbonate
AT

(c) Therapeutic incompatibility (d) All of these
T
105. The incompatibility observed between strychnine and soluble iodides are [GDC PRACTICE MCQ]
PA

G
(c) Therapeutic incompatibility (d) All of these

VE
TI
HOSPITAL PHARMACY
EC
1. Hospital formulary consists of [GPAT-2021]

BJ
(a) List of hospital staff (b) List of drugs present in the hospital
O
(c) List of equipments (d) List of patients

C
2. Hospital Formulary contains information on the following parameters EXCEPT [GPAT–2022]

D
(a) Composition (b) Indication

G
(c) Pricing (d) Dosage and administration

41
COSMETIC TECHNOLOGY
F
PD
E
PL
1. Titanium dioxide is used in sun screen products as a topical protective. The topical
M
protective effect of titanium dioxide is arising due to one of the following properties.
SA
Identify that[GPAT-2012]
(a) It has a high bulk density (b) It has a high LTV absorptivity
PS
(c) It has a low water solubility (d) It has a high refractive index
2. Which one of the followings is NOT used in preparation of baby powders [GPAT-2012]
TI
(a) Stearic acid (b) Boric acid
ER
(c) Kaolin (d) Calcium carbonate
3. Determine the correctness or otherwise of the following Assertion [A] and the Reasons
G
N
[R & S][GPAT-2012] FI
Assertion [A]: Butylated hydroxytoluene is added as one of the ingredients in the
lipstick formulation
R
Reason [R]: It is a good solvent for the wax - oil mixtures and coloring pigments in the
U
lipstick
YO
Reason [S] : It is an antioxidant and prevents rancidity on storage

(a) [A] is true, and [R] and [S] are true and correct reasons for [A]
AT
(b) [A], [R] and [S] are all false

(c) [A] is true, [S] is false, and [R] is the correct reason for [A]
T
PA
(d) [A] is true, [R] is false, and [S] is the correct reason for [A]
4. The healing agent used in hand creams is [GPAT-2010]
G
(a) Soft paraffin (b) Urea (c) Bees wax (d) Stearyl alcohol
VE
5. The role of borax in cold creams is [GPAT-2010]

(a) Anti-microbial agent
TI
(b) To provide fine particles to polish skin

EC
(c) In-situ emulsifier

(d) Antioxidant
BJ
6. Titanium dioxide is commonly present in [GATE-1990]

O
(a) Vanishing cream (b) Sunscreen cream

(c) Aqueous calamine cream (d) Ophthalmic cream
C
7. Vanishing cream is an ointment that may be classified as [GPAT-2023 SHIFT-II]

D
(a) Water soluble base (b) Oleaginous base (c) Absorption base(d) Emulsion base
G
8. A typical skin cream consisting of stearic acid, potassium hydroxide, glycerin, water,
preservative and perfume, would be commonly known as [GPAT-2022]

41. Size reduction of a material with the addition of another material is called as [GPAT-2016]
F
PD
(a) Mixing (b) Trituration (c) Levigation (d) Pulverization
42. Rittinger’s hypothesis relates [GPAT-2023 SHIFT-II]
E
[P] Energy used in size reduction [Q] New surface area produced
PL
[R] Equivalent shape [S] Reynold’s number
(a) P and Q (b) Q and S (c) P and R (d) P and S
M
43. When adhesive attractions between molecules of different species exceeds cohesive attrac
SA
tion between like molecules, the deviation according to Raoult’s law is said to be [GPAT-2020]
(a) Partial (b) Positive (c) Neutral (d) Negative
PS
44. A pharmaceutical API is prone to environmental oxidation. To achieve a Better therapeutic
TI
action, its size needs to be reduced method of choice for pulverization is [GPAT-2015]
(a) Ball milling (b) Hammer mill
ER
(c) Colloid mill (d) Rotary cutter mill
G
45. Hardinge mill is a variant of [GPAT-2019]
N
(a) Fluid energy mill (b) Ball mill FI
(c) Hammer mill (d) Rotary cutter mill
46. One of the following mills works on both the principles of attrition and impact [GATE-2002]
R
(a) Cutter mill (b) Hammer mill (c) Roller mill (d) Fluid energy mill
U
47. How much can be the working revolution per minute (RPM) of the Ball mill [GPAT-2013]
YO
(a) 23-28 “D where D means the diameter of jar

(b) Two times more than the critical revolution per minute
AT
(c) 42.3 “D (D=diameter of the jar)

(d) The average of critical RPM and the optional RPM
T
48. Choose the correct combination [GPAT-2012]

PA
(I) Rod mill (P) Dried plant drug

G
(II) Hammer mill (Q) Thermolabile drug

(III) Fluid energy mill (R) Paint
VE
(a) (I) & (Q), (II) & (P), (III) & (R) (b) (I) & (R), (II) & (P), (III) & (Q)
TI
(c) (I) & (Q), (II) & (R), (III) & (P) (d) (I) & (P), (II) & (Q), (III) & (R)
EC
49. In communition, certain type of materials listed in [P] to [T] are not suitable for the mills
mentioned below. Match them [GATE-1992]
BJ
1. Cutter mill [P] Soft material

2. Hammer mill [Q] Adhesive material
O
3. Revolving mill [R] Friable material

C
4. Fluid energy mill [S] Liquifiable material

D
[T] Abrasive material

G
(a) 1-[R], 2-[P], 3-[S], 4-[Q] (b) 1-[Q], 2-[S], 3-[R], 4-[P]
(c) 1-[T], 2-[R], 3-[S], 4-[Q] (d) 1-[R], 2-[T], 3-[P], 4-[Q]

96. The relation between emissive power of the surface and its absorptivity is given by [GPAT-2019]
F
PD
(a) Stefan - Boltzmann Law (b) Darcy’s Law
(c) Fourier’s Law (d) Kirchhoff’s Law
E
COMMON DATA FOR QUESTION (97-99)
PL
In a pharmaceutical industry, batch filtration of liquids where the proportion of solids to
liquids is high is to be carried out. The complete recovery of solids is required. After
M
filtration, the filtrate, which is corrosive, gives a crystalline product on evaporation. The
SA
liquid tends to deposit scales or crystals on the heating surface during evaporation [GATE-2005]
97. The suitable filtration equipment’s is
PS
(a) Plate and frame filter press (b) Leaf filters
TI
(c) Meta filters (d) Membrane filters
98. The filter aid used in the above filtration is
ER
(a) Sand (b) Nylon fiber cloth
G
(c) Activated carbon (d) Filter paper
N
99. A suitable evaporator is FI
(a) Falling film evaporator (b) Forced circulation evaporator
(c) Vertical evaporator (d) Horizontal evaporator
R
U
100. The fluid flows through the filter medium by virtue of [GPAT-2023 SHIFT-II]
YO
(a) Pressure difference across the filter

(b) Temperature difference across the filter
AT
(c) Volume difference across the filter

(d) Potential difference across the filter
T
101. Viscosity of the fluid is _____ proportional to the filtrate [GDC PRACTICE MCQ]
PA
(a) Directly (b) Inversely (c) Equal (d) None of these

102. Prefilter and membrane filter is in [GDC PRACTICE MCQ]
G
(a) Cartridge Filter (b) Rota Filter (c) Double Filter (d) Ring Filter
VE
103. The process of separating the solids whose concentration is less than 1% w/v in the solvent
[GDC PRACTICE MCQ]
TI
(a) Filtration (b) Ultra Filtration

EC
(c) Surface Filtration (d) Clarification

BJ
104. Filters are used to obtain sterile air [GDC PRACTICE MCQ]
(a) Cellulose fibre (b) Sterile (c) Anti-microbial (d) HEPA

O
105. Filter aid should be [GDC PRACTICE MCQ]

C
(a) Low Specific Gravity (b) Less Viscous

D
(c) High Boiling Point (d) Low Boiling Point

G
106. Talc, Kieselguhr and Asbestos are [GDC PRACTICE MCQ]
(a) Diluents (b) Glidants (c) Lubricants (d) Filter Aids


61
PHARMACEUTICAL TECHNOLOGY
F
PD
E
PL
1. Which polymorphic form of a drug candidate has highest melting point [GPAT-2019]
M
(a) Unstable (b) Metastable (c) Hydrates (d) Stable
SA
2. In Preformulation study polymorphs can be detected by [GPAT-2019]
(a) Counter - current chromatography (b) Refractometry
PS
(c) High performance liquid chromatography (d) Differential scanning
3. Phase solubility analysis curve is not a good tool for [GPAT-2019]
TI
(a) Complex formation (b) Bioavailability determination
ER
(c) Polymorph detection (d) Impurity detection
G
4. Dynamic Vapour Sorption (DVS) isotherm is a plot of A versus B [GPAT-2021]
N
(a) A - Crystallization Peak Energy (J/g), B - Percentage Relative Humidity FI
(b) A - Percentage Change in Mass, B - Percentage Relative Humidity
(c) A - Crystallization Peak Energy (J/g), B - Percentage Change in Mass
R
(d) A - Crystallization Peak Energy (J/g), B - Amorphous Content

U
5. Which of the following techniques is not useful to detect polymorphs [GPAT-2017]

YO
(a) DSC (b) HPLC

(c) PXRD (d) Melting point determination
AT
6. Hot stage microscopy is an important tool in Preformulation studies for the study of
[GPAT-2013, 2017]
T
(a) Pseudo polymorphism (b) Particle size measurement

PA
(c) Microbial contamination (d) Compaction behaviour

G
7. The polymorphs exhibit the following different properties EXCEPT [GPAT-2020]

(a) X-ray crystal and diffraction patterns (b) Melting points
VE
(c) Solubilities (d) Chemical structures

TI
8. While studying solid state physicochemical properties, the packing property of drug
EC
include [GPAT-2020]
(a) Heat capacity (b) Solubility (c) Refractive index (d) Entropy
BJ
9. Which of the following molecular properties can be determined by Thermogravimetric

Analysis [GPAT-2023 SHIFT-I]
O
(a) Solubility (b) Hygroscopicity (c) Colour stability (d) Hydrolysis

C
10. As per European Pharmacopoeia technical guide, substance stored at 25°C for 24 hours at
D
80% RH, called very hygroscopic when increase in weight is [GPAT-2020]

G
(a) 0.2% w/w and <15% w/w (b) > 0.2% w/w and < 20% w/w
(c) > 15% w/w (d) 0.2% w/w and < 2% w/w

69
244. For disguising the astringent and metallic taste of iron salts in children’s mixture, the
following flavoring agent in used [GPAT–2023 SHIFT-I]
(a) Orange syrup and compound orange syrup
F
(b) Lemon syrup
PD
(c) Liquorice liquid extract
(d) Aromatic water
E
245. Which of the following formulations are “Pharmaceutically equivalent” Match List I with
PL
List II
M
INGREDIENT FUNCTION TABLET A TABLET B TABLET C TABLET D
SA
P Acetaminophen I Drug 300mg -- 300mg 300mg
Q Aspirin II Drug -- 300mg -- --
R Lactose III Filler 100mg 100mg -- 100mg
PS
S Avicel IV Filler -- -- 100mg --
Starch Disintegrant 50mg 50mg -- 50mg
TI
Avicel Disintegrant -- -- 50mg --
Mag stearate Lubricant 2mg 2mg 2mg 2mg
ER
Gelatin Binder 10mg 10mg 10mg 10mg
Choose the correct answer from the options given below [GPAT–2023 SHIFT-I]
G
N
(a) P and Q (b) Q and R (c) P and R (d) Q and S
FI
246. Statement I: The problem of declining potency in an unstable preparation can be
ameliorated by the addition of an excess or overage of the active ingredient
R
Statement II: Overages, are added to pharmaceutical formulations to keep the content of
U
YO
the active ingredient well above the limit, compatible with therapeutic requirements, for
a predetermined period of time [GPAT–2022]
(a) Both Statement I and Statement II are correct
AT
(b) Both Statement I and Statement II are incorrect

T
(c) Statement I is correct but Statement II is incorrect

PA
(d) Statement I is incorrect but Statement II is correct

247. Which of the following statement is false [GPAT–2022]
G
[DROPPED QUESTION]
VE
(a) Reducing agents often cause fading of dyes

(b) Anionic dyes are the most stable at acid pH
TI
(c) Basic dyes are not sensitive to alkalies

EC
(d) Cationic dyes may be precipitated by soaps and clays

BJ
248. Taste sensation of some liquid oral formulation are given. Match the compatible flavour
used in the formulation [GATE-2000]
O
1. Salt [P] Wild cherry

C
2. Sour [Q] Vanilla

D
[R] Citrus
G
[S] Chocolate
(a) 1-[Q], 2-[R] (b) 1-[R], 2-[S] (c) 1-[R], 2-[P] (d) 1-[P], 2-[S]

91
332. Some substances used in tablet coating process are given. Match them with their correct
use mentioned in [P] to [S] [GATE–1999]
1. Shellac [P] Polishing
F
2. Hydroxy propyl methyl cellulose [Q] Seal coating
PD
[R] Film former
[S] Sub-coating
E
(a) 1-[Q], 2-[R] (b) 1-[P], 2-[Q] (c) 1-[R], 2-[P] (d) 1-[P], 2-[S]
PL
333. Given below are the type of excipients. Match them with the examples [GATE-2000]
M
1. Disintegrant [P] Talc
SA
2. Glidant [Q] P.V.P
[R] Lactose
PS
[S] Acacia
(a) 1-[S], 2-[Q] (b) 1-[R], 2-[S] (c) 1-[R], 2-[P] (d) 1-[S], 2-[P]
TI
334. The ingredients mentioned in [P] to [T] are used in various stages of sugar coating of tablets.
ER
Match them [GATE-1993]
1. Seal coating [P] Gelatin
G
2. Sub coating [Q] Carnauba wax
N
3. Syrup coating [R] Methanol
FI
4. Polishing [S] PEG 4000
R
[T] Cane sugar

U
(a) 1-[S], 2-[P], 3-[T], 4-[Q] (b) 1-[P], 2-[R], 3-[T], 4-[S]
YO
(c) 1-[P], 2-[Q], 3-[T], 4-[R] (d) 1-[S], 2-[R], 3-[T], 4-[P]
335. Match the coatings given below with their corresponding techniques listed [P] to [T]
AT
[GATE–1994]
T
1. Compression coating [P] Air in the coating pan is replaced with

PA
nitrogen
2. Dip Coating [Q] Application of coating to conductive
G
substrates
VE
3. Electrostatic Coating [R] Acid insoluble coating

4. Vacuum Film coating [S] A tablet within a tablet
TI
[T] Repeated coating and drying

EC
(a) 1-[S], 2-[T], 3-[Q], 4-[P] (b) 1-[P], 2-[Q], 3-[S], 4-[R]
BJ
(c) 1-[T], 2-[P], 3-[Q], 4-[R] (d) 1-[Q], 2-[R], 3-[T], 4-[P]
336. Match the given ingredients from [P] to [T] with the purpose for which it is incorporated in
O
the formulation of tablets [GATE-1988]

C
1. Glidant [P] Pre – gelatinzed starch

D
2. Diluent [Q] Pyramine

G
3. Adherents [R] Colloidal silica

4. Disintegrant [S] Calcium sulphate

101
518. Applying relatively thin coating to small particles of solid and droplets of liquids called as
[GDC PRACTICE MCQ]
(a) Coating (b) Dip coating
F
(c) Microencapsulation (d) All of these
PD
519. High bloom strength gelatin is used in the manufacturing of [GDC PRACTICE MCQ]
(a) Soft gelatin capsules (b) Hard gelatin caules
E
(c) More physically stable (d) Both (a) and (b)
PL
520. Which component of a capsule shell is responsible for its dissolution or disintegration in
M
the gastrointestinal tract[GDC PRACTICE MCQ]
SA
(a) Gelatin (b) Plasticizer (c) Colorant (d) Opacifier
521. Concerning hard gelatin capsules, which of the following statements are true [GDC PRACTICE MCQ]
PS
(a) Gelatin is a polysaccharide that is derived from animal sources
(b) There are two types of gelatins, each exhibiting same isoelectric points
TI
(c) The grade of gelatin is defined by the bloom strength
ER
(d) Gelatin is freely soluble in water at room temperature
522. Given below are two statements, one is labelled as Assertion [A] and the other is labelled as
G
Reason [R][GDC PRACTICE MCQ]
N
Assertion[A]: Soft gelatin capsules are often preferred for containing liquid formulations
FI
Reason [R]: Soft gelatin capsules have a more flexible shell that can accommodate liquid
R
fillings more effectively

U
In light of the above statements, choose the correct answer from the options given below
YO
(a) Both [A] and [R] are true and [R] is the correct explanation of [A]
(b) Both [A] and [R] are true but [R] is NOT the correct explanation of [A]
AT
(c) [A] is true but [R] is false

(d) [A] is false but [R] is true
T
PA
523. Solid fills for hard gelatin capsules frequently contain which of the following excipients for
the designated purpose except[GDC PRACTICE MCQ]
G
(a) Glidants – to improve powder flow (b) Magnesium stearate – as a lubricant

VE
(c) Starch – as a disintegrant (d) None of these

524. Which of the following type of dissolution test apparatus is used for capsule [GDC PRACTICE MCQ]
TI
(a) Paddle type (b) Basket type

EC
(c) Both (a) and (b) (d) None of these

525. Identify the correct steps for preparation of empty gelatin shell [GDC PRACTICE MCQ]
BJ
(a) DippingSpinningDryingStrippingTrimmingJoiningPolishing
O
(b) DippingSpinningStrippingDryingTrimmingJoiningPolishing
C
(c) DippingSpinningDryingStrippingJoiningTrimmingPolishing
D
(d) SpinningDippingDryingStrippingTrimmingJoiningPolishing
G
526. Which of the following is used to increase the acid solubility and reduce the aldehyde
tanning of gelatin[GDC PRACTICE MCQ]

F
41. Concentration of drug in blood is 40mg/ml. dose of the drug is 200mg. assuming minute
PD
elimination Vd will be [GPAT-2015]
(a) 5 litre (b) 0.5 litre (c) 2.5 litre (d) 3 litre
E
42. The Volume of distribution of a drug administered at a dose of 300 mg and exhibiting 30
PL
microgram/ mL instantaneous concentration in plasma shall be [GPAT-2010]
(a) 10 L (b) 100 L (c) 1.0 L (d) 0.10 L
M
43. In a pharmacokinetic model depicted in the following scheme, what is the half-life of the
SA
drug if the apparent volume of distribution of the drug is 25 L [GPAT-2012]
PS
250 mg i.v.
TI
ER
0.173 /hr
G
(a) 1.7 hrs (b) 2 hrs (c) 4 hrs
N
(d) 3hrs
FI
44. Which marker is used for measuring the volume of plasma [GPAT-2013]
R
(a) Deuterium oxide (b) Mannitol (c) Evan blue (d) Inulin
U
45. Which is used as a marker to determine total body water volume [GPAT-2014]
YO
(a) Antipyrine (b) Mannitol (c) Evans blue (d) Raffinose

46. The initial distribution of a drug into the tissue is determined chiefly by [GATE–1999]
AT
(a) Rate of blood flow to the tissue (b) Plasma protein binding of the drug
(c) Affinity for the tissue (d) Stomach emptying time
T
47. The intracellular fluid volume including those of blood cells is approximately [GPAT–2022]
PA
(a) 7L (b) 17 L (c) 27 L (d) 37 L

G
48. Match the following concept in List I with parameters in List II [GPAT–2023 SHIFT-I]
LIST I (Concept) LIST II (Parameters)
VE
1. Volume of distribution [P] Measure volume of real

TI
physiological plasma
EC
2. Evans blue [Q] Human serum albumin

3. 3.5 - 5% [R] Volume of blood
BJ
4. Metallothionein [S] Ratio of body drug content to plasma

O
concentration
[T] Protein present in kidney to bind metal
C

D
(a) 1-[P], 2-[Q], 3-[R], 4-[S] (b) 1-[T], 2-[S], 3-[R], 4-[Q]
G
(c) 1-[S], 2-[P], 3-[Q], 4-[T] (d) 1-[R], 2-[Q], 3-[S], 4-[T]

151
F
196. Chapter IV of which law states that experiments on animals are avoided wherever it is
PD
possible to do so, as for example; in medical schools, hospitals, colleges and the like, if other
teaching devices such as books, models, films and the like, may equally suffice. Also, that
E
experiments on larger animals are avoided when it is possible to achieve the same results by
PL
experiments upon small laboratory animals like guinea- pigs, rabbits, frogs and rats [GPAT-2017]
(a) The Prevention of Cruelty to Animal Act, 1960
M
(b) The Pharmacy Act, 1948
SA
(c) Drugs and Cosmetics Act, 1940
(d) Medicinal and Toilet Preparations Act, 1955
PS
197. In which year was the Prevention of Cruelty to Animals Act enacted in India [GDC PRACTICE MCQ]
TI
(a) 1956 (b) 1960 (c) 1972 (d) 1980
198. Animal Welfare Board of India constituted under the Prevention of Cruelty to Animal Act
ER
situated in [GDC PRACTICE MCQ]
G
(a) New Delhi (b) Mumbai (c) Kolkata (d) Chennai
N
199. Animal Welfare Board is established by [GDC PRACTICE MCQ] FI
(a) State Government (b) State Council
(c) Central Council (d) Central Government
R
U
200. According to The Prevention of Cruelty to Animals Act, 1960________ member/s who is/are
YO
actively engaged in the promotion animal welfare is nominated by Central Government

[GDC PRACTICE MCQ]
(a) Five (b) Six (c) Two (d) One

AT
201. According to the Prevention of Cruelty to Animals Act, 1960 experimentation on animals is
T
carried out for the following purposes except [GDC PRACTICE MCQ]
PA
(a) Development of new drug (b) Production of vaccines and sera

(c) Development in medical field (d) To have the practice
G
202. Under the Prevention of Cruelty to Animals Act, what is the role of the Animal Welfare Board
VE
of India [GDC PRACTICE MCQ]

(a) Promoting the use of animals in entertainment
TI
(b) Regulating the export of exotic animals

EC
(c) Advising the government on animal welfare issues

(d) Conducting wildlife census
BJ
203. Which body is responsible for formulating and updating the rules under the Prevention of
O
Cruelty to Animals Act [GDC PRACTICE MCQ]

C
(a) Central Zoo Authority (b) Animal Welfare Board of India

D
(c) National Institute of Animal Welfare (d) Indian Veterinary Research Institute
G
204. Under CPCSEA guidelines, what is the primary responsibility of the Institutional Animal
Ethics Committees (IAECs) at research establishments [GDC PRACTICE MCQ]

PHARMACEUTICAL TECHNOLOGY
1-d 2-d 3-c 4-b 5-b 6-a 7-d 8-c 9-b 10-c
11-d 12-c 13-d 14-b 15-c 16-d 17-d 18-a 19-c 20-b
F
21-a 22-d 23-a 24-a 25-c 26-d 27-d 28-a 29-a 30-a
PD
31-c 32-d 33-c 34-b 35-d 36-d 37-a 38-d 39-d 40-c
41-d 42-c 43-b 44-d 45-d 46-b 47-a 48- b 49-c 50- a
51-a 52-d 53-b 54- a 55-b 56-a 57-b 58-d 59-b 60-c
E
PL
61-a 62-a 63-b 64-a 65-b 66-c 67- d 68-c 69-c 70-c
71-d 72-d 73-c 74-b 75-c 76-d 77-c 78-a 79-c 80-d
M
81-b 82-a 83-c 84-d 85-a 86-c 87-b 88-d 89-a 90-d
91-d 92-d 93-b 94-a 95-d 96-a 97-a 98-d 99-b 100-b
SA
101-c 102-b 103-d 104-d 105-a 106-b 107-c 108-a 109-b 110-b
111-b 112-a 113-a 114-a 115-c 116-c 117-a 118-b 119-a 120- c
PS
121-b 122-a 123-a 124-a 125-a 126-b 127-a 128-b 129-b 130-b
131-b 132-a 133-b 134-a 135-c 136-d 137-c 138-b 139-b 140-b
TI
141-b 142-c 143-c 144-b 145-c 146-c 147-d 148-a 149-b 150-d
ER
151-c 152-a 153-d 154-c 155-b 156-a 157-a 158-c 159-d 160-d
161-c 162-b 163-c 164-d 165-d 166-b 167-a 168-b 169-c 170-d
G
171-a 172-c 173-d 174-b 175-b 176-c 177-b 178-c 179-c 180-c
N
181-d 182-c 183-a 184-b 185-b 186-d 187-b 188-a 189-b 190-a
191-d 192-c 193-b 194-b 195-b 196-d 197-a 198-b 199-c 200- c
FI
201- d 202-c 203-c 204-b 205-b 206-a 207-c 208-c 209-a 210-d
R
211-c 212-b 213-a 214-a 215- a 216-b 217- a 218- a 219- c 220-d
U
221- d 222-b 223- b 224-c 225-c 226-c 227-a 228-a 229-d 230-c
YO
231- d 232-a 233-b 234-a 235-d 236- b 237-a 238-a 239-d 240-b
241- c 242-d 243- b 244-a 245-c 246-c 247-* 248-a 249-c 250-d
251-d 252-b 253-c 254-b 255-c 256-d 257-b 258-c 259-b 260-a
AT
261-d 262- b 263-a 264-a 265-d 266-b 267-a 268-a 269-a 270-c
271-d 272-a 273-a 274-a 275-b 276-d 277-b 278-a 279-c 280-d
T
281-a 282- b 283- c 284-d 285- c 286-b 287-a 288-b 289- a 290-b
PA
291-c 292-a 293-c 294-d 295- a 296-b 297-d 298-a 299-a 300-c
301-b 302-a 303-c 304-b 305-a 306-c 307-a 308-a 309-d 310- b
G
311-c 312-a 313-b 314-a 315-b 316-d 317-b 318-a 319-a 320-a
321-d 322-a 323-b 324-a 325-b 326-c 327-a 328-d 329-d 330-a
VE
331-a 332-a 333-d 334-a 335-a 336-a 337-a 338-b 339-d 340-a
341-a 342-b 343-c 344-c 345-a 346- d 347-d 348- d 349-c 350-b
TI
351-c 352-b 353- c 354- d 355- d 356-d 357-b 358- b 359- b 360- c
EC
361-a 362- c 363-c 364- a 365-b 366-b 367-a 368-c 369-d 370-a
371-c 372-c 373-d 374- a 375-a 376-a 377-b 378- d 379-c 380-c
BJ
381-d 382-a 383- d 384-d 385-c 386-c 387-c 388-c 389-c 390-b
391-c 392- d 393- d 394- a 395- a 396- b 397-a 398- b 399- c 400- b
O
401-d 402-b 403-d 404-d 405-a 406-c 407-b 408-b 409-b 410-a
C
411-c 412-a 413-b 414-b 415-b 416-d 417-d 418-b 419-b 420-c
D
421-a 422-a 423-c 424-d 425-b 426-c 427-a 428-b 429-d 430-d
431-b 432-c 433-d 434-c 435-c 436-a 437-c 438-b 439-b 440-d
G
441-d 442-c 443-a 444-b 445-b 446-a 447-d 448-b 449-b 450-d
451-c 452-a 453-c 454-b 455-c 456-a 457-a 458-c 459-d 460-c

OBJECTIVE GPAT AT YOUR FINGERTIPS : HUMAN ANATOMYAND PHYSIOLOGY
HUMAN ANATOMY
F
AND PHYSIOLOGY
PD
E
PL
M
SA
1. RNA molecules having intrinsic catalytic activity are called as [GPAT-2019]
(a) mRNAs (b) Ribozymes (c) snRNAs (d) rRNAs
PS
2. Which of the following statement is NOT TRUE about prokaryotes [GPAT-2018]
TI
(a) Nucleus is not bounded by nuclear membrane
ER
(b) Cell wall contains peptidoglycan
(c) 80S ribosomes are distributed in cytoplasm
G
(d) It is Haploid in nature
3. Which of the following cell organelles does not contain DNA [GDC PRACTICE MCQ]
N
FI
(a) Nucleus (b) Lysosomes (c) Chloroplast (d) Mitochondria
R
4. This site serves as the synthesis and assembly of ribosomes [GDC PRACTICE MCQ]
U
(a) Peroxisome (b) Plasma membrane (c) Chromatin (d) Nucleolus

YO
5. Plasmodesmata are located in narrow areas of [GDC PRACTICE MCQ]

(a) Cell walls (b) Protoplasm (c) Cellulose (d) Nuclei
AT
T
PA
6. Conversion of pseudostratified columnar epithelium in chronic bronchitis and

G
bronchiectasis to columnar type epithelium is an example of which type of metaplasia

VE
[GPAT-2021]
(a) Squamous metaplasia (b) Columnar metaplasia

TI
(c) Osseous metaplasia (d) Cartilaginous metaplasia

EC
7. Inflammation of soft tissue due to hyaluronidase is called as [GPAT-2015]

BJ
(a) Tendinitis (b) Bursitis

(c) Cellulitis (d) Cumulative Injury Disorder (CID)
O
8. What is the name of the tissues which helps in protection and support of the body
C
[GPAT-2013]
D
(a) Muscular tissue (b) Nervous tissue

G
(c) Connective tissue (d) Epithelial tissue

215
46. Lacrimal glands are concerned with secretion of [GDC PRACTICE MCQ]
(a) Hormones (b) Digestive juices
(c) Enzymes (d) Tears
F
47. Astigmatism is corrected by the use of [GDC PRACTICE MCQ]
PD
(a) Convex lens (b) Concave lens (c) Cylindrical lens (d) Surgery
48. The waxy substance which coats the surface of auditory canal is produced by [GDC PRACTICE MCQ]
E
(a) Tympanum (b) Ceruminous glands
PL
(c) Sebaceous glands (d) Meibomian glands
49. Vascular coat of eye ball is made up of [GDC PRACTICE MCQ]
M
(a) Sclerotic, choroid and retina (b) Optic, ciliary and iridial
SA
(c) Sclerotic, cornea and conjunctiva (d) Choroid, ciliary body and iris
50. Color perception in man is due to [GDC PRACTICE MCQ]
PS
(a) Rhodopsin present in rod cells (b) Iodopsin present in cone cells
(c) Rhodopsin present in cone cells (d) Iodopsin present in rod cells
TI
ER
G
51. Which of the following is true for bone tissue cell differentiation and maturation
N
FI
[GPAT–2023 SHIFT-I]
R
(a) Osteogenic  Osteoblasts  Osteocytes (b) Osteogenic  Osteoblasts  Osteoclasts

U
(c) Osteocytes  Osteogenic  Osteoblasts (d) Osteoclasts  Osteoblasts  Osteocytes

YO
52. Match List I with List II [GPAT-2023 SHIFT-II]

List - 1 List - 2
AT
1. Vibrations in skeletal muscles of larynx [P] Facial contractions

2. Involuntary contraction of skeletal muscles [Q] Regulate voice
T
PA
that is regulated by the brain

3. Contraction of skeletal muscles in the legs [R] Shivering
G
4. Pull of skeletal muscles on attachments [S] Assists return of blood to the heart
VE
to skin of face
[T] Causes facial expressions
TI

EC
(a) 1-[Q], 2-[R], 3-[S], 4-[P] (b) 1-[R], 2-[S], 3-[P], 4-[T]
(c) 1-[Q], 2-[R], 3-[S], 4-[T] (d) 1-[R], 2-[S], 3-[T], 4-[P]
BJ
53. Which of the following statement is true for the periosteum of bone [GPAT–2022]
O
(a) Protects the bone by assisting in fracture repair

C
(b) Has osteogenic cells which enable bone to grow in thickness, but not in length
D
(c) It is composed of an outer fibrous layer of dense irregular connective tissue and
G
an inner osteogenic layer that consists of cells

(d) All of these

OBJECTIVE GPAT AT YOUR FINGERTIPS : PATHOPHYSIOLOGY
PATHOPHYSIOLOGY
F
PD
E
PL
1. Put the events of acute inflammation in proper sequence [GPAT–2023 SHIFT-I]
M
(a) Accumulation of fluid and plasma at the affected site  intravascular activation of
platelets  polymorphonuclear neutrophils  followed by healing
SA
(b) Polymorphonuclear neutrophils  accumulation of fluid and plasma at the affected
PS
site  intravascular activation of platelets  followed by healing
(c) Accumulation of fluid and plasma at the affected site  polymorphonuclear
TI
neutrophils  intravascular activation of platelets  followed by healing
ER
(d) Intravascular activation of platelets  polymorphonuclear neutrophils 
accumulation of fluid and plasma at the affected site  followed by healing
G
2. Which one of the following is an autosomal dominant syndrome in its inheritance
N
[GPAT-2023 SHIFT-II] FI
(a) Gilbert’s syndrome (b) Crigler-Najjar syndrome Type-I
R
(c) Dubin- Johnson syndrome (d) Rotor syndrome

U
3. Which is a protein marker which can be detected within three hours of acute ischemic
YO
kidney injury from patient’s urine [GPAT-2023 SHIFT-II]

(a) N-acetyl- b-D-glucose aminidase (b) Glutathione-S-transferase
AT
(c) Neutrophil gelatinase associated lipocalin (d) g-glutamyl transpeptidase

4. Laboratory findings of which one of the following disease include markedly elevated serum
T
amylase levels during the first 24 hours followed by rising serum lipase levels within 72-96
PA
hours [GPAT-2023 SHIFT-II]

G
(a) Acute pancreatitis (b) Cirrhosis of liver

(c) Jaundice (d) Cystic fibrosis of lungs
VE
5. Which one of the following types of hepatitis can lead to fulminant hepatitis causing
TI
massive hepatic cell death more frequently among infected pregnant women, showing third
EC
trimester mortality as high as 30% [GPAT-2023 SHIFT-II]

(a) Hepatitis A (b) Hepatitis B (c) Hepatitis C (d) Hepatitis E
BJ
6. Which of the following is a specific enzyme marker of cell death in acute myocardial
infarction [GPAT–2022]
O
(a) Creatine Kinase-MB (b) Aspartate aminotransferase

C
(c) Lactate dehydrogenase (d) Cardiac troponin

D
7. Viable cells (viability assay) are assayed by all of the following methods EXCEPT [GPAT–2022]
G
(a) MTT/MTS/Resazurin assay (b) Apoptosis assay

(c) ATP assay (d) Protease marker assay

227
OBJECTIVE GPAT AT YOUR FINGERTIPS : PATHOPHYSIOLOGY
34. Match the following group I with group II
Group-I Group-II [GATE-2005]
Patho immunological condition Drugs used in the treatment
F
1.Urticaria [P] Cyclosporin
PD
2. Autoimmune thrombocytopenia [Q] Antihistamines
3. Rheumatoid arthritis [R] Intravenous immunoglobulin
E
4. Organ transplant rejection [S] Glucocorticoids
PL
(a) 1-[P], 2-[Q], 3-[S], 4-[R] (b) 1-[S], 2-[P], 3-[R], 4-[Q]
M
(c) 1-[R], 2-[P], 3-[Q], 4-[S] (d) 1-[Q], 2-[R], 3-[S], 4-[P]
SA
35. Identify the non-pathogenic organism [GATE-2004]
(a) Mycobacterium bovis (b) Mycobacterium smegmatis
PS
(c) Mycobacterium avium (d) Mycobacterium intracellulare
36. Which of these is true about the discovery of HB antigen in the blood of people infected
TI
with Hepatitis-B [GATE-2004]
ER
(a) It provided a basis for vaccine design
G
(b) It indicated that specific vaccines cannot be designed for Hepatitis-B
N
(c) It has not been of much significance FI
(d) It indicated that Hepatitis-B is a viral disease
37. Decreased risk of Atherosclerosis is associated with increase in [GATE-2003]
R
U
(a) Very-low-density lipoproteins (b) Low-density lipoproteins

YO
(c) Cholesterol (d) High-density lipoproteins

38. Measurement of which of the following two of the constituents of human plasma is of great
AT
value in the differential diagnosis of rheumatoid diseases [GATE-2002]

(a) Rheumatoid factor and immunoglobulin G
T
(b) Rheumatoid factor and C - reactive protein

PA
(c) HL-A antigen and C-reactive protein

(d) Immunoglobulin and bradykinin
G
39. Infected blood products may produce serum hepatitis due to the presence of [GATE-1992]
VE
(a) Hepatitis A virus (b) Hepatitis B virus

TI
(c) Hepatitis C virus (d) None of these

EC
40. Which of the following is an example of hypertrophy [GDC PRACTICE MCQ]

(a) Increased liver size after partial hepatectomy
BJ
(b) Increased size of the female breast at puberty

O
(c) Increased respiratory epithelium seen in vitamin A deficiency

(d) Increased size of the uterus in pregnancy
C
41. Zellweger’s syndrome is associated with abnormality of [GDC PRACTICE MCQ]

D
G
(a) Nonessential fatty acid metabolism (b) Essential fatty acid metabolism
(c) Cholesterol metabolism (d) Lipoprotein metabolism

231
OBJECTIVE GPAT AT YOUR FINGERTIPS : PHARMACOLOGY
PHARMACOLOGY
F
PD
E
PL
M
GENERAL PHARMACOLOGY
SA
PS
TI
1. What do you mean by Orphan drug [GPAT–2023 SHIFT-I]
ER
(a) A drug meant to be distributed among orphans who cannot afford the cost of drug
(b) A drug for a disease which is not having any other treatment options at all
G
(c) A drug which is useful for rare disease
N
(d) A drug that is available in abundance
FI
2. Which of the statement is TRUE in geriatrics practice [GPAT–2022]
R
(a) The incidence of adverse drug reactions diminishes with advancement of age
U
(b) Dose reduction is inevitable for each and every drug used in geriatric patients
YO
(c) Patient compliance is highest in geriatric patients

(d) Polypharmacy is often a problem in elderly
AT
3. Which of the following is considered as differentiated product [GPAT-2019]

(a) Ranitidine (b) Zantac (c) Isoniazid (d) Paracetamol
T
PA
4. In relation to buccal and sublingual route of administration which of the following

statement is INCORRECT [GPAT-2017]
G
(a) Absorption through epithelium is not affected by partition coefficient of the drug
VE
(b) Drug absorption by these routes by pass first pass metabolism

(c) There is an optimum log P for sublingual absorption
TI
(d) These are preferred routes for anti-anginal drug

EC
5. Which of the following routes of administration of drugs is associated with Phlebitis

[GPAT-2011]
BJ
(a) Subcutaneous (b) Intravenous (c) Intraspinal (d) Intradural

O
6. The pKa of lidocaine is 7.9. if the pH of the infected is 8.9, the fraction of the drug in the
ionized form will be [GATE-2002]
C
D
(a) 1% (b) 10% (c) 90% (d) 99%

G
[GDC PRACTICE MCQ]

7. Which of the following is not an essential drug
(a) Octreotide (b) Atropine (c) Paracetamol (d) Calamine lotion

237
122. To understand the drug receptor interaction is necessary to quantify the relation
between [GATE-1988]
(a) Drug and its toxicity (b) Drug and its absorption
F
(c) Drug and its biological effect (d) Drug and intermediate product
PD
123. The osmotic activity of mannitol is an example of [GDC PRACTICE MCQ]
(a) Physical action (b) Chemical action
E
(c) Enzymatic action (d) Receptor action
PL
[GDC PRACTICE MCQ]
124. Which one of the following is an example of competitive enzyme inhibition
(a) Acetazolamide  Carbonic anhydrase (b) Digoxin  Na+K+ ATPase enzyme
M
(c) Sulphonamides  Folate synthase (d) Theophylline  Phosphodiesterase
SA
125. A drug that activates a receptor to produce an effect in the opposite direction to that of
[GDC PRACTICE MCQ]
recognized agonist is
PS
(a) Agonist (b) Antagonist (c) Partial agonist (d) Inverse agonist
TI
[GDC PRACTICE MCQ]
126. Following receptors are membrane proteins, EXCEPT
ER
(a) Receptors for fast neurotransmitters, coupled directly to an ion channel
(b) Receptors for many hormones and slow transmitters, coupled to effectors system
G
(c) Receptors for insulin and various growth factors, which are directly linked tyrosine
kinase
N
FI
(d) Receptors for steroid hormone
R
[GDC PRACTICE MCQ]
127. Which of the following is TRUE
U
(a) As the concentration of the drug increases over the therapeutic range, only the
YO
bound form of the drug increases

(b) The bound form is not available for metabolism but is available for excretion
AT
(c) Acidic drugs binds to beta globulin and basic drugs bind to albumin
(d) Binding sites are non-specific and one drug can displace the other
T
[GDC PRACTICE MCQ]

128. Partial agonist are drugs which
PA
(a) Have affinity but low intrinsic activity (b) Have only affinity
G
(c) Have only intrinsic affinity (IA) (d) Have low affinity but high (IA)
[GDC PRACTICE MCQ]
129. Which of the following acts by inhibiting enzyme in the body
VE
(a) Atropine (b) Allopurinol (c) Levodopa (d) Metoclopramide

TI
[GDC PRACTICE MCQ]

130. Receptor which has 7 helical membrane structure is
EC
(a) Tyrosine kinase receptor (b) Gene expression regulating receptor

(c) Intrinsic ionic channel containing receptor (d) G protein coupled receptor
BJ
131. All are intracellularly secondary messengers in receptor mediated signal transduction
[GDC PRACTICE MCQ]
except
O
(a) Cyclic AMP (b) Inositol triphosphate (IP 3)

C
(c) Diacylglycerol (DAG) (d) G protein

D
[GDC PRACTICE MCQ]

132. Following statement is TRUE about receptors linked directly to ion channels
G
(a) These receptors are involved mainly in fast synaptic transmission

(b) These are monomeric proteins containing one transmembrane segment

F
PD
144. A patient with pheochromocytoma is undergoing surgery and has not been adminis
tered with alpha receptor blocker. If he is administered with intravenous Propranolol,
E
then which of the following effects will be evident [GPAT–2022]
PL
(a) There will be a rise in the blood pressure
(b) There will be a fall in the blood pressure
M
(c) The blood pressure will remain unchanged
SA
(d) The patient may suffer severe bronchoconstriction
145. Except one of the following pairs represent drugs used in the treatment of glaucoma
PS
and their primary mechanism. Select the wrong pair from the following [GPAT-2020]
TI
(a) Topical prostaglandin analogues : Increase aqueous outflow
ER
(b) Topical beta-adrenergic blockers : Decrease aqueous outflow
(c) Topical miotics : Increase aqueous outflow
G
(d) Topical carbonic anhydrase inhibitors : Decrease aqueous formation
N
146. Which of the following pair of drugs is considered as selective -Blockers [GPAT-2019]
FI
(a) Timolol and Metoprolol (b) Prazosin and Terazosin
R
(c) Formoterol and Levalbuterol (d) Yohimbine and Corynanthine
U
147. Which of the following is NOT a cardio selective -blocker [GPAT-2019]

YO
(a) Bisoprolol (b) Nebivolol (c) Acebutolol (d) Pindolol

148. Topical application of Timolol to the eye would be expected to induce which of the
AT
following [GPAT-2017]
(a) Decreased formation of aqueous humor (b) Miosis
T
(c) Mydriasis (d) Increased outflow of aqueous humor

PA
149. Characteristics of carvedilol includes [GPAT-2016]
[P] It is a  -selective antagonist

G
[Q] It has both -selective and -blocking effects

VE
[R] It inhibits vascular smooth muscle mitogenesis

(a) [P] true, [Q] & [R] false (b) [P], [Q] & [R] true
TI
(c) [Q] true, [P] & [R] false (d) [P], [Q] & [R] false
EC
150. Which of the following is true for -Blocker, EXCEPT [GPAT-2015]

BJ
(a) Blockade of vasoconstriction

(b) Cause Nasal stuffiness and miosis
O
(c) Increased intestinal motility

C
(d) Tone of smooth muscle in bladder trigone and sphincter is increased

D
151. Which of the following is selective 2-selective antagonists [GPAT-2013]

G
(a) Clonidine (b) Prazosin (c) Phentolamine (d) Yohimbine

F
PD
E
PL
M
1. “Wheal and Flare” reaction is characteristic reaction associated with identification of
SA
[GPAT-2021]
(a) Type - 1 hypersensitivity reaction (b) Type - 2 hypersensitivity reaction
PS
(c) Type - 3 hypersensitivity reaction (d) Type - 4 hypersensitivity reaction
TI
2. Histamine concentration is highest in [GPAT-2018]
ER
(a) Beta cells (b) Mast cells (c) Lymphocytes (d) Adipocytes
3. Following is an example of preformed and not lipid derived mast cell mediator of
G
inflammatory process [GPAT-2015]
N
(a) LTC4 (b) PGD2 (c) PAF (d) Kallidin
FI
4. Following is an example of preformed and not lipid-derived mast cell mediator of
R
inflammatory process [GPAT-2014]
U
(a) LTC4 (b) PGD2 (c) PAF (d) Histamine

YO
5. The histamine is formed from histidine by [GPAT-2014]
(a) Methylation (b) Decarboxylation (c) Acetylation (d) Esterification

AT
6. Which one of the following drug is withdrawn from the market due to torsade de pointes
[GPAT-2010]
T
(a) Chlorpromazine (b) Astemizole (c) Haloperidol (d) Domperidone

PA
7. The following receptor are associated with drug mentioned. Match them [GATE-2000]
G
1. H receptor [P] Ketanserin

1
2. 5HT receptor [Q] Cimetidine
VE
3
[R] Diphenhydramine
TI
[S] Ondansetron
(a) 1-[Q], 2-[S] (b) 1-[R], 2-[S] (c) 1-[R], 2-[P] (d) 1-[P], 2-[Q]
EC
8. Match the following [GDC PRACTICE MCQ]

BJ
RECEPTOR PATHWAY
1. H1 receptor [P] Increase cAMP
O
2. H2 receptor [Q] Increase cGMP

C
3. H3 receptor [R] Decrease cAMP

D
(a) 1 - [P] 2-[Q], 3-[R] (b) 1-[R], 2-[Q], 3-[P]

G
(c) 1 - [Q] 2-[R], 3-[P] (d) 1-[Q], 2-[P] 3-[R]

277
F
PD
E
PL
1. Prominent biochemical features of Graves’ disease are [GPAT-2023 SHIFT-II]
M
(a) Decreased ionized calcium in body fluids
SA
(b) Decreased T4 and T3 in circulation
(c) Increased ionized calcium in body fluids
PS
(d) Increased T4 and T3 in circulation
2. Conversion of T4 to T3 inhibition is associated with [GPAT-2021]
TI
(a) Propylthiouracil (b) Radioactive iodine
ER
(c) Lugol’s iodine (d) Carbimazole
3. Identify the hormone that stimulates sperm production in testes and ovulation in females
G
[GPAT-2018]
(a) Prolactin (b) Luteinizing hormone

N
FI
(c) Follicle stimulating hormone (d) Adrenocorticotropic hormone
R
4. Which one of the following is a organ specific localized autoimmune disease [GPAT-2020]
U
(a) Grave’s disease (b) Scleroderma

YO
(c) Polyarteritis nodosa (d) Rheumatoid arthritis

5. The thymus secretes several hormones related to the immunity. These hormones promote
AT
the maturation of T lymphocyte cells. These hormones are [GPAT-2017]

1. Thymosin 2. Thymic humoral factor
T
3. Thymic factor 4. Interleukins

PA
(a) Only 1, 2 (b) 1, 2 and 3 (c) Only 3 (d) Only 4

G
6. Insulin and Thyroxine arrive at an organ / tissue / cell at the same time. Thyroxine
causes an effect on the organ but insulin does NOT because [GPAT-2017]
VE
(a) The organ cell have receptors for thyroxine but no receptor for insulin
TI
(b) Thyroxine is a lipid -soluble hormone and insulin is water soluble

EC
(c) The target cell in the organ have up-regulated for thyroxine
(d) Thyroxine is local hormone and insulin is a circulating hormone
BJ
123
7. Indicate which one of the following drugs may interfere with the uptake of I in thyroid
O
gland [GPAT-2016]
(a) Beta-blockers (b) Alpha-blockers
C
(c) Calcium channel blockers (d) Amiodarone

D
8. Wolff-chaikoff effect is
G
[GPAT-2013]
(a) Reduced Thyroxine synthesis by radiotherapy

(b) Reduced Thyroxine synthesis by Propylthiouracil

F
PD
57. Normal value of HbA1c falls in the range of [GPAT–2023 SHIFT-I]
(a) 0.1% to 0.8% (b) 6.5% to 7.5% (c) 21.5% to 24.5% (d) 51.5% to 53.5%
E
58. Exenatide is a [GPAT-2023 SHIFT-II]
PL
(a) Glucagon like peptide 1 (GLP1) receptor agonist
(b) Diphenyl Peptidase-4 (DPP4) inhibitors
M
(c) Facilitator of glucose transport across the cell
SA
(d) Inhibitor of glucose absorption in the GIT
59. Which among the following statement is CORRECT with respect to their mechanism of
PS
antidiabetic action [GPAT-2023 SHIFT-II]
TI
(a) Dapagliflozin/Canagliflozin - Sodium glucose cotransporter-2 inhibitors
(b) Glipizide/Gliclazide - Dipeptidyl peptidase-4 inhibitors
ER
(c) Linagliptin/Alogliptin - AMPK activators
(d) Acarbose / Voglibose - K+ATP channel blockers
G
N
60. Match List I with List II Match the following with their mechanism of action [GPAT–2022]
FI
LIST I LIST II
Mechanism of action Drugs
R
1. DPP4 inhibitors [P] Metformin

U
2. KATP Channel blocker [Q] Pioglitazone

YO
3. PPAR activator [R] Glimepiride

4. AMPK Activator [S] Teneligliptin
AT
[T]  glucosidase inhibitors

T
(a) 1 - [Q], 2 - [T], 3 - [R], 4 - [S] (b) 1 - [Q], 2 - [R], 3 - [S], 4 - [P]
PA
(c) 1 - [S], 2 - [R], 3 - [Q], 4 - [P] (d) 1 - [S], 2 - [P], 3 - [T], 4 - [R]
G
61. Which of the following clinical feature is not responsible for insulin resistance in type 2
diabetes [GPAT–2022]
VE
(a) Increased LDL (b) Increased HDL

TI
(c) Reduced HDL (d) Increased triglycerides

EC
62. Which among the following statement is CORRECT with respect to their mechanism of
action [GPAT-2021]
BJ
(a) Sitagliptin/Vildagliptin : Dipeptidyl peptidase-4 inhibitors

(b) Dapagliflozin/Canagliflozine : AMPk activators
O
(c) Glibenclamide/ Glimepiride : -Glucosidase inhibitors

C
(d) Acarose/Metformin : KATP channel blockers

D
63. The oral oligosaccharide hypoglycemic agent, which is administered at the start of the
G
meal is [GPAT-2018]
(a) Pioglitazone (b) Miglitol (c) Acarbose (d) Glimepiride

299
F
PD
E
PL
M
1. Two pore domain K+ ions channels are opened by which one of the following categories
SA
of anaesthetic [GPAT-2020]
(a) Barbiturates (b) Benzodiazepines
PS
(c) Opioid analgesics (d) Halogenated inhalation anaesthetic
2. Accepted measure of anaesthetic potency [GPAT-2015]
TI
(a) Lipid solubility
(b) Speed of induction
ER
(c) Presence of a “second gas effect”
(d) Minimum alveolar concentration (MAC value)
G
3. GABA, an important transmitter in the brain [GATE-2006]
[P] Is an inhibitory transmitter [Q] Is an excitatory transmitter
N
FI
[R] Increases chloride conductance [S] Is antagonized by Naloxone
R
Identify the correct statements
U
(a) [P], [Q] (b) [Q], [R] (c) [P], [R] (d) [R], [S]
YO
4. Ketamine is useful as an anesthetic agent in [GDC PRACTICE MCQ]
(a) Ischemic heart disease (b) Intracranial hemorrhage

(c) Hyperactive airways (d) Glaucoma
AT
5. Pharmacological effects of ketamine are [GDC PRACTICE MCQ]
(a) Disagreeable dreams during induction and after recovery

T
(b) Bronchospasm
PA
(c) Production of excellent skeletal muscle relaxation

(d) Cardiovascular and respiratory depression
G
6. Intravenous general anaesthetic of choice in bronchial asthma is [GDC PRACTICE MCQ]

VE
(a) Thiopentone (b) Propofol (c) Etomidate (d) Ketamine

7. Which of the following state regarding isoflurane is INCORRECT [GDC PRACTICE MCQ]
TI
(a) It is an isomer of enflurane

EC
(b) It produces a rapid induction anaesthesia

(c) It produces marked respiratory depression
BJ
(d) It decreases secretions

8. The following statement about nitric oxide is TRUE [GDC PRACTICE MCQ]
O
(a) It produces analgesia only in very anaesthetic concentration

C
(b) It can be safely combined with skeletal muscle relaxants during anaesthesia
D
(c) It is a potent anaesthetic

(d) It causes slow induction and recovery from anaesthesia
G
9. Which of the following causes dissotive anaesthesia [GDC PRACTICE MCQ]

(a) Ketamine (b) Fentanyl (c) Propofol (d) Halothane

F
50. A drug ‘X’ is more selective for the  subunit of BZD receptors. It lacks effect on slow-wave
PD
sleep. Minimum residual daytime sedation, no rebound insomnia on discontinuation, low abuse
potential. Which of the following can be ‘X’ [GPAT–2023 SHIFT-I]
E
(a) Flurazepam (b) Flumazenil (c) Melatonin (d) Zolpidem
PL
51. Which one of the following is a competitive antagonist at benzodiazepine site of
M
GABA-receptor gated chloride channel [GPAT-2021]
SA
(a) Muscimol (b) Flumazenil
(c) Picrotoxin (d) Beta-carboline (DMCM)
PS
52. Which among the following is a structural variant of GABA and is used as a muscle
relaxant [GPAT-2017]
TI
(a) Metocurine (b) Tybamate (c) Baclofen (d) Cyclobenzaprine
ER
53. The ultra-short acting barbiturates have brief duration of action due to [GATE-2002]
(a) High degree of binding to plasma protein
G
(b) Low lipid solubility resulting in a minimal concentration in the brain
N
(c) Metabolism is slow in the liver
FI
(d) Rapid rate of redistribution from the brain due to its high liposolubility
R
54. Benzodiazepines potentiate [GATE–1994]

U
(a) The binding of protein to nervous tissue (b) The binding of GABA to liver
YO
(c) The binding of GABA to receptors (d) The binding of GABA to carbohydrates
55. All the statement mentioned below about chloral hydrate is true EXCEPT that it [GATE-1990]
AT
(a) Produces hypnosis (b) Produces analgesia

(c) Produce dependence (d) Irritate gastric mucosa
T
PA
56. Following is a barbiturate [GDC PRACTICE MCQ]
(a) Thiopentone (c) Clobazam

G
(b) Chlordiazepoxide (d) Lorazepam

VE
57. All are non-benzodiazepine hypnotics EXCEPT [GDC PRACTICE MCQ]

(a) Zopiclone (b) Zolpidem (c) Zaleplone (d) Ziprasidone
TI
58. Which of the following is a benzodiazepine antagonist [GDC PRACTICE MCQ]

EC
(a) Bicuculin (b) Clorazepam (c) Flumazenil (d) Beta-carboline

59. Respiratory depression produced by following agent is reversed by Flumazenil [GDC PRACTICE MCQ]
BJ
(a) Fentanyl (b) Midazolam (c) Pentobarbitone (d) Halothane

O
60. Correct statement about diazepam is [GDC PRACTICE MCQ]

(a) It acts by directly stimulating GABA receptors in the brain
C
D
(b) It is a phenothiazine derivative

G
(c) It has anxiolytic and muscle relaxant properties

(d) It is a powerful inducer of hepatic microsomal enzymes

300. Rivastigmine and Donepezil are drugs used predominantly in the management of [GDC PRACTICE MCQ]
(a) Depression (b) Dissociation (c) Delusions (d) Dementia
F
PD
E
PL
M
SA
1. A hypertensive patient receiving a drug ‘Y’ for managing BP was prescribed a tricyclic
antidepressant. As a result, there was an abolition of the antihypertensive action of ‘Y’.
PS
Which of the following drug could be ‘Y’ [GPAT–2023 SHIFT-I]
(a) Atenolol (b) Captopril (c) Clonidine (d) Diltiazem
TI
2. Following statement is CORRECT with respect to voltage sensitive calcium channels
ER
[GPAT-2023 SHIFT-II]
(a) L-type Blocker : Nifedipine (b) T-type Blocker : Verapamil
G
(c) N-type Blocker : Mibefradil (d) R-type Blocker : Diltiazem
3. Which of the following is not an ACE inhibitor [GPAT-2023 SHIFT-II]
N
FI
(a) Captopril (b) Trandolapril (c) Verapamil (d) Lisinopril
R
4. A hypertensive patient Mr. Zee already receiving a drug ‘X’ to control his blood pressure
U
was prescribed a tricyclic antidepressant. This resulted in the abolition of the

YO
antihypertensive action of ‘X’. Which of the following drug could be X [GPAT-2021]

(a) Enalapril (b) Clonidine (c) Atenolol (d) Diltiazem
AT
5. Long - term use of thiazide diuretics in hypertension can produce all of the following
EXCEPT [GPAT-2021]
T
(a) Hyperkalemia (b) Hyperuricemia

PA
(c) Hyperlipidemia (d) Hyperglycemia

G
6. L-type calcium channel located in [GPAT-2016]
(a) Cardiac muscle (b) Smooth muscle

VE
(c) Skeletal muscle (d) All of these

TI
7. Match the following [GPAT-2016]

EC
Action Description
1. Chronotropic [P] Force of contraction
BJ
2. Inotropic [Q] Frequency of heartbeat or heart rate

3. Dromotropic [R] Excitability of cardiac muscle
O
4. Bathmotropic [S] Conduction of impulse through heart

C
(a) 1-[P], 2-[Q], 3-[R], 4-[S] (b) 1-[Q], 2-[P], 3-[R], 4-[S]
D
(c) 1-[P], 2-[Q], 3-[S], 4-[R] (d) 1-[Q], 2-[P], 3-[S], 4-[R]
G
8. Which of the following Calcium channel blocker is Phenyl alkyl derivative [GPAT-2015]
(a) Bepridil (b) Nifedipine (c) Diltiazem (d) Verapamil

F
PD
152. Statement I: In vasospastic angina, the imbalance occurs when the myocardial oxygen
requirement increases, as during exercise, and coronary blood flow does not increase
E
proportionately.
PL
Statement II: In Prinz metal’s angina, oxygen delivery decreases as a result of reversible
coronary vasospasm
M
In light of the above statements, choose the most appropriate answer from the options
SA
given below [GPAT–2023 SHIFT-I]
(a) Both Statement I and Statement II are correct
PS
(b) Both Statement I and Statement II are incorrect
TI
(c) Statement I is correct but Statement II is incorrect
ER
(d) Statement I is incorrect but Statement II is correct
153. Nitric oxide synthase exists in [GPAT–2022]
G
(a) Two isoforms (b) Three isoforms (c) Four isoforms (d) Five isoforms
N
154. Which one of the following calcium channel blockers used as anti - anginal agents has the
FI
highest possibility to produce a negative inotropic effect, AV nodal block, bradycardia, decreased
R
cardiac output, constipation, edema and is contraindicated in sick sinus syndrome [GPAT-2021]
U
(a) Nifedipine (b) Amlodipine (c) Diltiazem (d) Verapamil

YO
155. Which one of the following is NOT the role of Nitric oxide [GPAT-2019]
(a) Reliving vascular smooth muscle (b) Mediating microbicidal action of macrophages
AT
(c) Serving as neurotransmitter in CNS (d) Inducing platelet aggregation

156. Which of the following side effect of ACE inhibitors result from inhibition of bradykinin
T
breakdown [GPAT-2018]
PA
(a) Analgesia (b) Hyperglycaemia

(c) Productive cough (d) Dry cough
G
157. Bosentan is [GPAT-2014]

VE
(a) Serotonin uptake inhibitor (b) Endothelin receptor antagonist

(c) Leukotriene modifier (d) Calcium sensitizer
TI
158. Which one of the following drugs produces significant relaxation of both venules and
EC
arterioles [GPAT-2012]
BJ
(a) Hydralazine (b) Minoxidil

(c) Diazoxide (d) Sodium nitroprusside
O
159. All of the given four drugs cause vasodilation

C
[P] Bradykinin [Q] Minoxidil [R] Acetylcholine [S] Hydralazine

D
Choose the correct statement about them [GPAT-2011]

G
(a) P & Q cause release of nitric oxide (b) Q & R do not cause release of nitric oxide
(c) R & S cause release of nitric oxide (d) P & S do not cause release of nitric oxide

361
F
PD
E
PL
M
1. Most common type of megaloblastic anemia caused by malabsorption of vitamin B 12
SA
and characterized by decreased production of hydrochloric acid in the stomach and a
deficiency of intrinsic factor is [GPAT-2023 SHIFT-II]
PS
(a) Iron deficiency anemia (b) Sideroblastic anemia
(c) Pernicious anemia (d) Aplastic anemia
TI
2. Compounds that have both TXA 2 synthase inhibition as well as TXA 2 receptor-blocking
ER
activity [GPAT-2014]
(a) Dazoxiben (b) Ridogrel (c) Moxonidine (d) Aspirin
G
3. An iron compound used as heamatinic agent must meet two requirements i.e. it should
N
be biologically available and be non-irritating. Which one of the following compounds
FI
meet the above two requirements most closely [GPAT-2011]
R
(a) Ferric chloride (b) Ferric ammonium sulphate

U
(c) Ferric ammonium citrate (d) Ferrous thioglycolate

YO
4. An example of hemopoietic growth factor is [GATE-2004]

(a) Platelet derived growth factor (b) Epidermal growth factor
AT
(c) Iron dextran (d) Erythropoietin

5. Methyl malonyl CoA mutase which catalyzes the conversion of propionyl CoA to
T
succinyl utilizes the prosthetic group derived from [GATE-2002]

PA
(a) Cyanocobalamine (b) Pyridoxine

G
(c) Thiamine (d) Nicotinamide

6. Which of the following factor facilitate iron absorption from intestine [GDC PRACTICE MCQ]
VE
(a) Antacid (b) Phosphate (c) Vitamin C (d) Tetracycline

TI
7. Which of the following is not a valid indication for parenteral iron therapy [GDC PRACTICE MCQ]
(a) Inability to tolerate oral iron
EC
(b) Anaemia during pregnancy

BJ
(c) Depletion of iron stores associated with chronic bleeding

(d) Inflammatory bowel disorder
O
8. Parenteral iron preparations include the following EXCEPT [GDC PRACTICE MCQ]
C
(a) Iron sorbitol citric acid (b) Iron sucrose

D
(c) Iron dextran (d) Iron ammonium citrate

G
9. Iron binding globulin in blood is [GDC PRACTICE MCQ]
(a) Transferrin (b) Ferritin (c) Apoferritin (d) Haemosiderin


371
F
PD
36. Tendon rupture or tendonitis of Achilles tendon is an adverse reaction of [GPAT–2022]
(a) Fluoroquinolones (b) Tetracycline’s
E
(c) Cephalosporins (d) Aminoglycosides
PL
37. Cotrimoxazole is combination of trimethoprim with sulfamethoxazole. Which of the
M
following statement is CORRECT about Cotrimoxazole [GPAT-2020]
SA
(a) Cotrimoxazole is contraindicated during pregnancy
(b) Most effective ratio of trimethoprim: Sulfamethoxazole in plasma is 20:1
PS
(c) Trimethoprim: sulfamethoxazole are administered in a dose ratio of 5:1 to achieve
optimal synergistic effect
TI
(d) Cotrimoxazole is ineffective in treating respiratory tract infections
ER
38. The mechanism of action of Ciprofloxacin is [GPAT-2018]
(a) Inhibition of protein synthesis by interacting with 30S ribosome
G
(b) Inhibition of protein synthesis by interacting with 50S ribosomes
(c) Inhibition of DNA synthesis by interacting with topoisomerase
N
FI
(d) Inhibition of cell wall synthesis
R
39. Most accepted mechanism for developing bacterial resistance to Sulphonamide is [GPAT-2017]
U
(a) An alternative metabolic pathway for synthesis of essential

YO
(b) An increasing capacity to metabolize the drug

(c) Increased antagonism of drug
AT
(d) An alteration in enzyme that utilizes PABA

40. Because Trimethoprim enters many tissue, has a larger V d than Sulfamethoxazole,
T
therefore for obtaining optional synergistic, which will be the CORRECT dose ratio [GPAT-2014]
PA
(a) Sulfamethoxazole 5: Trimethoprim 1

G
(b) Trimethoprim 5: Sulfamethoxazole 1

(c) Sulfamethoxazole 5: Trimethoprim 1/5
VE
(d) Trimethoprim 5: Sulfamethoxazole 1/5

TI
41. Which one of the following statements is FALSE for fluoroquinolones [GPAT-2012]
EC
(a) These are highly effective by oral and parenteral routes

(b) These are relatively more susceptible to development of resistance
BJ
(c) These are effective against those bacteria that are resistant to -lactam and
O
aminoglycoside antibiotics
(d) These are bactericidal with broad spectrum of activity
C
42. Stevens Johnson syndrome is the most common adverse effect associated with one of
D
the following categories of drugs [GPAT-2010]

G
(a) Sulphonamides (b) Macrolides (c) Penicillins (d) Tetracyclines

223. One of the drugs when coadministered with Terfenadine may lead to life threatening
Cardiac arrhythmia [GATE-2001]
(a) Lomefloxacin (b) Clofazimine (c) Itraconazole (d) Neomycin
F
224. Which of the following is a polyene antifungal agent [GDC PRACTICE MCQ]
PD
(a) Amphotericin B (b) Miconazole
(c) Griseofulvin (d) Fluconazole
E
225. Mechanism of action of Rifampin [GDC PRACTICE MCQ]
PL
(a) PABA competitor
(b) Mycolic acid synthesis
M
(c) Inhibits RNA synthesis by binding to DNA dependent RNA polymerase
SA
(d) Protein synthesis inhibitors
226. Azole used by systemic route [GDC PRACTICE MCQ]
PS
(a) Econazole (b) Clotrimazole (c) Ketoconazole (d) Miconazole
TI
227. The antifungal agent given orally for systemic fungal infection is [GDC PRACTICE MCQ]
ER
(a) Amphotericin B (b) Clotrimazole (c) Griseofulvin (d) Fluconazole
228. Antifungal drug binding to ergosterol and forming micropores is [GDC PRACTICE MCQ]
G
(a) Amphotericin B (b) Clotrimazole (c) Griseofulvin (d) Fluconazole
229. Antifungal drug inhibiting 14 alpha demethylase enzyme is
N
[GDC PRACTICE MCQ]
FI
(a) Amphotericin B (b) Voriconazole (c) Griseofulvin (d) Terbinafine
R
230. Antifungal drug inhibiting squalene epoxidase enzyme is [GDC PRACTICE MCQ]
U
(a) Amphotericin B (b) Voriconazole (c) Griseofulvin (d) Terbinafine

YO
231. Azole with widest antifungal spectrum is [GDC PRACTICE MCQ]
(a) Clotrimazole (b) Ketoconazole (c) Fluconazole (d) Voriconazole

AT
232. Following statement about griseofulvin is TRUE [GDC PRACTICE MCQ]
(a) It is effective topically as well as systemically

T
(b) It can induce hepatic microsomal enzyme

PA
(c) It is used in systemic candidiasis

G
(d) It has no action on growing fungal cells

233. Which of the following adverse effect does not belong to Ketoconazole [GDC PRACTICE MCQ]
VE
(a) Antiandrogenic (b) Decreased steroid synthesis

TI
(c) Drug interaction (d) Elevation of hepatic enzymes

EC
234. Which of the following is the treatment of choice for cryptococcal meningitis [GDC PRACTICE MCQ]
(a) Fluconazole (b) Itraconazole (c) Flucytosine (d) Amphotericin B
BJ
235. Which of the following antibiotics can be used in the treatment of fungal keratomycotic
[GDC PRACTICE MCQ]
O
(a) Linezolid (b) Vancomycin

C
(c) Silver sulphadiazine (d) Doxycycline

D
236. Topical antifungal of choice for aspergillus infection of eye is [GDC PRACTICE MCQ]
G
(a) Miconazole (b) Clotrimazole (c) Econazole (d) Fluconazole

F
PD
1. Which of the following metabolite is used to inactivate the vasicotoxic metabolites leading to
hemorrhagic cystitis by alkylating agents used in the treatment of cancer [GPAT–2023 SHIFT-I]
E
(a) Acroline (b) Aldophosphamide
PL
(c) Cyclophosphamide (d) Mesna
M
2. Trastuzumab is a/an [GPAT–2023 SHIFT-I]
SA
(a) EGFR/HER2 inhibitor (b) Angiogenesis inhibitor
(c) EGF receptor (HER1) inhibitor (d) BCR-ABL tyrosine kinase inhibitor
PS
3. Which of the following drug used in the chemotherapy of some types of leukemia,
satisfies the statements
TI
Statement I: It is effective orally
ER
Statement II: It has near 100% oral bioavailability
In light of the above statements, choose the CORRECT answer from the options given
G
below [GPAT–2023 SHIFT-I]
N
(a) Asparaginase (b) Doxorubicin (c) Mitomycin (d) Hydroxyurea
FI
4. One of the following is CORRECT match or mechanisms. Select it [GPAT-2023 SHIFT-II]
(a) Methotrexate – Inhibition of microtubules, Vinca alkaloids – Inhibition of Purine
R
synthesis, Bleomycin – Inhibition of RNA, 5-Fluoro Uracil – DNA damage

U
(b) Methotrexate – Inhibition of Purine synthesis, Vinca alkaloids – Inhibition of Micro

YO
tubules, Bleomycin – DNA damage, 5-Fluoro Uracil – Inhibition of 2-deoxythymidylate

(c) Methotrexate – DNA damage, Vinca alkaloids – Inhibition of micro tubules, Bleomycin
AT
– Inhibition of 2-deoxythymidylate, 5-Fluoro Uracil – RNA damage

(d) Methotrexate – DNA damage, Vinca alkaloids – RNA damage, Bleomycin – Inhibition
T
of Purine synthesis, 5-Fluoro Uracil – Inhibition of 2-deoxythymidylate

PA
5. Which phase of cell cycle is the shortest phase in terms of time [GPAT-2023 SHIFT-II]
(a) G1 (b) S (c) M (d) G2
G
6. Which of the following is a malignant type of tumor [GPAT–2022]

VE
(a) Lipoma (b) Adenoma (c) Melanoma (d) Osteoma

7. Which of the following statement/s are CORRECT regarding the alkylating agents as
TI
anticancer agents
EC
[A] They get converted into highly nucleophilic anions and bind to the nitrogen atom
of guanine intercalating the DNA strands
BJ
[B] Cyclophosphamide and Busulfan belong to this class

O
[C] They inhibit the DNA synthesis by inhibiting the DNA polymerase enzyme
[D] They inhibit the DNA supercoiling by irreversibly inhibiting the DNA topoisomerase
C
enzyme
D
Choose the CORRECT answer from the options given below [GPAT–2022]
G
(a) A, B and D only are correct (b) Only B is correct

(c) Only A and B are correct (d) All A, B, C and D are correct

423
F
PD
1. Match the following List I with List II [GPAT–2022]
E
LIST I (Poisoning) LIST II (Treatment)
PL
1. Warfarin [P] Pralidoxime
2. Carbon monoxide [Q] Oxygen
M
3. Cyanide [R] Vitamin K
SA
4. Nitrites [S] Dicobalt edetate
5. Organophosphates [T] Methylene blue
PS
Choose the CORRECT answer from the options given below
(a) 1-[R], 2-[Q], 3-[S], 4-[T], 5-[P] (b) 1-[P], 2-[Q], 3-[T], 4-[S], 5-[R]
TI
(c) 1-[Q], 2-[S], 3-[P], 4-[R], 5-[T] (d) 1-[T], 2-[Q], 3-[R], 4-[P], 5-[S]
ER
2. Match the following drugs with alteration they produces in structure and functions of
G
kidney [GPAT-2017]
N
LIST I (Class of drug) LIST II (Structure and function of kidney)
FI
1. Aminoglycoside antibiotics [P] Glomerular abnormality
2. ACE inhibitors [Q] Tubular epithelial cell damage
R
3. Methotrexate [R] Hemodynamic mediated kidney injury

U
4. NSAIDs [S] Obstructive nephropathy

YO
(a) 1-[Q], 2-[R], 3-[S], 4-[P] (b) 1-[P], 2-[Q], 3-[R], 4-[S]
(c) 1-[R], 2-[S], 3-[P], 4-[Q] (d) 1-[S], 2-[P], 3-[Q], 4-[R]
AT
3. Select the CORRECT option regarding screening models and their activity [GPAT-2016]
LIST I (Screening model) LIST II (Activities)
T
1. Actophotometer [P] Locomotor

PA
2. Rota road and Chimney [Q] Muscle relaxant

G
3. Tail flick and Hot plate [R] Analgesics

4. Elevated plus maze and Mirror chamber [S] Antianxiety
VE
(a) 1-[P], 2-[Q], 3-[R], 4-[S] (b) 1-[P], 2-[S], 3-[R], 4-[Q]
TI
(c) 1-[Q], 2-[P], 3-[R], 4-[S] (d) 1-[S], 2-[Q], 3-[R], 4-[P]
4. Given below are the drug and their antagonist [P] to [T]. Match them CORRECTLY [GATE 1988]
EC
LIST I (Drug) LIST II (Antagonist)

BJ
1. 5-HT [P] Bemegride

2. Codeine [Q] Atropine
O
3. Phenobarbitone [R] Cyproheptadine

C
4. Muscarine [S] Naloxone

D
[T] Pyridoxine
G
(a) 1-[P], 2-[Q], 3-[S], 4-[R] (b) 1-[P], 2-[Q], 3-[T], 4-[R]
(c) 1-[T], 2-[Q], 3-[S], 4-[R] (d) 1-[R], 2-[S], 3-[P], 4-[Q]

42. Given below the drug and their enzyme [P] to [T] inhibited by them. Match the
following [GATE-1988]
Group I (Drug) Group II (Enzyme)
1. Physostigmine [P] COMT inhibitors
F
PD
2. Imipramine [Q] Acetaldehyde dehydrogenase
3. Pyrogallol [R] Carbonic anhydrase
E
4. Disulfiram [S] Cholinesterase
PL
[T] MAO inhibitors
(a) 1-[S], 2-[T], 3-[R], 4-[P] (b) 1-[S], 2-[P], 3-[R], 4-[Q]
M
(c) 1-[S], 2-[Q], 3-[P], 4-[R] (d) 1-[P], 2-[R], 3-[Q], 4-[S]
SA
43. Given below the antibacterial agent and mode of action [P] to [T]. Match the CORRECTLY
[GATE-1988]
PS
Group I (Antibacterial agent) Group II (Mechanism of action)
1. Gentamicin [P] Inhibit the mycolic acid synthesis
TI
2. Isoniazid [Q] Prevent the bacterial cell wall synthesis
ER
3. Polymyxin B [R] Bind with 30S ribosomal subunit (take
false amino acid)
G
4. Penicillin [S] Get accumulated at cell wall membrane
N
and counteract with cell phospholipids
FI
[T] Destroys the nucleic acid counteract with
R
cell phospholipids
U
(a) 1-[R], 2-[P], 3-[S], 4-[Q] (b) 1-[P], 2-[Q], 3-[T], 4-[R]
YO
(c) 1-[T], 2-[Q], 3-[S], 4-[R] (d) 1-[P], 2-[T], 3-[Q], 4-[S]
44. Given below are the aliments and the drugs used [P] to [T]. Match them correctly [GATE-1988]
AT
Group I (Disease) Group II (Drug)

1. Parkinson’s disease [P] Probenecid
T
2. Glaucoma [Q] Ampicillin

PA
3. Gout [R] Nitroglycerin

4. Angina [S] Pilocarpine
G
[T] Levodopa
VE
(a) 1-[P], 2-[Q], 3-[S], 4-[R] (b) 1-[P], 2-[Q], 3-[T], 4-[R]
(c) 1-[T], 2-[S], 3-[P], 4-[R] (d) 1-[P], 2-[T], 3-[Q], 4-[S]
TI
45. Given below are the hypertensive agents. Match their mode of action [P] to [T] [GATE-1988]
EC
Group I (Antihypertensive Drug) Group II (Mechanism of action)

1. Minoxidil [P] Alpha adrenoreceptor antagonist
BJ
2. Prazosin [Q] Beta adrenoreceptor antagonist

O
3. Alpha methyldopa [R] From alpha methyl norepinephrine

4. Clonidine [S] Direct action on blood vessel (vasodilation)
C
[T] Decrease sympathetic activity through

D
brain
G
(a) 1-[P], 2-[Q], 3-[S], 4-[R] (b) 1-[S], 2-[P], 3-[R], 4-[T]
(c) 1-[T], 2-[Q], 3-[S], 4-[R] (d) 1-[P], 2-[T], 3-[Q], 4-[S]

OBJECTIVE GPAT AT YOUR FINGERTIPS : PHARMACOGNOSY
PHARMACOGNOSY
F
PD
E
PL
M
SA
General Introduction
PS
1. Charaka, a physician belonged to which system of medicine [GPAT-2018]
TI
(a) Ayurveda (b) Unani (c) Siddha (d) Homeopathy
ER
2. Choose that scientist who classified the plants and introduced the system of naming
the plants known as the binomial system [GDC PRACTICE MCQ]
G
(a) Seydler (b) Berg
N
(c) Swede Linnaeus (d) Bentham and Hooker FI
3. Which of the following scientist describes _________ 365 drugs, one for each day of the year and
R
titled as[GDC PRACTICE MCQ]
U
(a) Charaka Samhita, Ayurveda (b) Papyrus Ebers, Pen-t’sao

YO
(c) Shen Nung, Pen-t’sao (d) Dioscorides, Materia medica

4. Who is consider as a father of surgery[GDC PRACTICE MCQ]
AT
(a) Dioscorides (b) Galen (c) Aristotle (d) Sushruth

5. Match the following drugs isolated in which year[GDC PRACTICE MCQ]
T
Plant constituent Year

PA
1. Strychnine - [P] 1819

G
2. Quinine - [Q] 1817

VE
3. Cocaine - [R] 1820

4. Piperine - [S] 1860
TI
(a) 1 – [Q] , 2 – [R] , 3 – [P] , 4- [S] (b) 1 – [Q] , 2 – [S] , 3 – [R] , 4 -[P]
EC
(c) 1 – [Q] , 2 – [R] , 3 – [S] , 4- [P] (d) 1 – [R] , 2 – [Q] , 3 – [S] , 4- [P]
6. In which year Morphine from Opium was extracted[GDC PRACTICE MCQ]
BJ
(a) 1803 (b) 1820 (c) 1806 (d) 1860

O
7. Who is regarded as “Father of Natural History” [GDC PRACTICE MCQ]

C
(a) Edward bach (b) Hippocrates (c) Dioscorides (d) Aristotle

D
G

459
92. In plant tissue culture the leaf surface can be sterilized by [GDC PRACTICE MCQ]
(a) 0.1% w/v Mercuric chloride (b) 2% Potassium Hypochloride
(c) 10% Calcium hypochloride (d) All of these
F
93. Plant cell devoid of cell wall is called [GDC PRACTICE MCQ]
PD
(a) Protoplast (b) Cytoplasts (c) Cybrids (d) Hybrids
94. The cytoplasmic hybrids where the nucleus is derived from only one parent and the
E
cytoplasm is derived from both the parents are called as [GDC PRACTICE MCQ]
PL
(a) Hybrids (b) Cybrids (c) Heterokaryon (d) None of these
M
95. The macronutrient found in culture media [GDC PRACTICE MCQ]
SA
(a) Potassium (b) Molybdenum (c) Zinc (d) All of these
96. The most effective method for producing virus free plants is [GDC PRACTICE MCQ]
PS
(a) Root culture (b) Meristem culture
(c) Somatic embryogenesis (d) Floriculture
TI
97. ABA is involved in[GDC PRACTICE MCQ]
ER
(a) Dormancy of seeds (b) Root elongation
(c) Shoot elongation (d) Increased cell division
G
98. Stress hormone is[GDC PRACTICE MCQ]
(a) Auxin (b) Gibberellin (c) Abscisic acid
N
(b) Cytokinin
FI
99. Plant hormone causing abscission of leaves, senescence and inhibition of cell division
R
is[GDC PRACTICE MCQ]

U
(a) IAA (b) Ethylene (c) Cytokinin (d) ABA

YO
100. The hormone responsible for stimulation of closing of stomata is due to [GDC PRACTICE MCQ]
(a) Abscisic acid (b) Cytokinin (c) Ethylene (d) All of these
AT
101. The hormone responsible for stimulation of opening of stomata is due to [GDC PRACTICE MCQ]
(a) Abscisic (b) Cytokinin (c) Ethylene (d) All of these
T
102. The phytohormone shows triple response growth is [GDC PRACTICE MCQ]
PA
(a) Ethylene (b) Abscisic acid (c) Cytokinin (d) Auxins

G
103. Choose correct option for the following statement [GDC PRACTICE MCQ]
[I] Auxins (cell elongation)

VE
[II] Gibberellins (cell elongation + cell division - translated into growth)

TI
[III]Cytokinins (cell division + inhibits senescence)

EC
[IV] Abscisic acid (promotes senescence, epinasty, and fruit ripening)

[V] Ethylene (abscission of leaves and fruits)
BJ
(a) I, II, III (b) I, III, IV (c) I, III, IV, V (d) I, II, III, IV, V
O
Biogenetic Pathway
C
D
104. Sesquiterpenes are biosynthesized from _____ in plants [GPAT-2023 SHIIFT-II]

G
(a) Farnesyl-pyrophosphate (b) Geranyl farnesyl pyrophosphate

(c) Terpenes (d) Degraded products of terpenes

469
33. Which of the following alkaloids is derived from tyrosine [GPAT-2011]
(a) Quinine (b) Morphine (c) Atropine (d) Ephedrine
34. A glycoalkaloid [GPAT-2011]
F
[P] Contains sulphur in addition to nitrogen in its molecule
PD
[Q] Is glycosidic in nature
[R] Can be hydrolysed to an alkaloid
E
[S] Always contains endocyclic nitrogen in its molecule
PL
(a) P & R (b) Q & S (c) Q & R (d) P & Q
35. Alkaloids are NOT precipitated by [GPAT-2010]
M
(a) Mayer’s reagent (b) Dragendorff reagent (c) Picric acid (d) Millon’s reagent
SA
36. The chemical behaviour of morphine alkaloid is [GPAT-2010]
(a) Acidic (b) Basic (c) Neutral (d) Amphoteric
PS
37. Tropane alkaloids are NOT present in [GPAT-2010]
(a) Datura stramonium (b) Erythroxylum coca
TI
(c) Duboisia myoporoides (d) Lobelia inflata
ER
38. Choose the right combination [GPAT-2010]
(a) Quinine, antimalarial, isoquinoline alkaloid
G
(b) Reserpine, antihypertensive, indole alkaloid
(c) Quantitative microscopy, stomatal number, myrrh
N
FI
(d) Palmitic acid, salicylic acid, fatty acids
R
39. Genetically modified species of Papaver namely Papaver bracteatum and Papaver
U
orientale contain the predominant alkaloid [GATE-2009]

YO
(a) Morphine (b) Codeine (c) Thebaine (d) Narcotine

40. Different species of Ephedra can be identified by observing the nature of [GATE-2009]
AT
(a) Inner surface (b) Outer surface (c) Trichomes (d) Scaly leaves
STATEMENT FOR QUESTION NO. 41 & 42
T
PA
Extract of Chondrodendron tomentosum, family manispermaceae contains several alkaloids

41. One of the important alkaloid is [GATE-2008]
G
(a) (-) Phyllandrene (b) (+) Hollarhenine

(c) (+) Tubocurarine (d) () Colchicine
VE
42. This alkaloid has [GATE-2008]

TI
(a) Bis benzyl tetrahydro isoquinoline ring (b) Quinoline ring

EC
(c) Phenanthrene ring (d) Pyrido pyrimidine ring

43. Two tests for ephedrine are [GATE-2008]
BJ
[P] A solution in dilute HCI, treated with copper sulphate and sodium hydroxide gives
a violet color
O
[Q] An alcoholic solution gives a red color with FeCl3

C
[R] On shaking with solvent ether, the organic layer shows purple while the aqueous
D
layer becomes blue in color

G
[S] A solution of vanillin gives a violet-red color

(a) [Q], [S] (b) [P], [S] (c) [P], [R] (d) [Q], [R]

481
191. Non-lignified hypodermal fibre is the characteristic microscopy of [GDC PRACTICE MCQ]
(a) Kurchi (b) Ephedra (c) Datura (d) Mentha
192. Purine alkaloids are identified by [GDC PRACTICE MCQ]
F
(a) Benedict test (b) Dragendorff’s rest
PD
(c) Virali morin rest (d) Murexide test
193. Colour of the leaves changes during fermentation is due to the presence of an enzyme
E
[GDC PRACTICE MCQ]
PL
(a) Thease (b) Diastase (c) Oxidase (d) Amylase
194. Theophylline on oxidation with KCIO/HCl gives [GDC PRACTICE MCQ]
M
(a) Trimethyl alloxan and urea (b) Methyl alloxan and dimethyl urea
SA
(c) Dimethyl alloxan and methyl urea (d) None of these
PS
Quinazoline and Diterpene alkaloids
TI
195. Cystoliths present in[GDC PRACTICE MCQ]
ER
(a) Datura leaves (b) Digitalis leaves (c) Vasaka leaves (d) Vinca leaves
196. Vasicine is an alkaloid obtained from the plant Adhatoda vasica, which belongs to the
G
family[GDC PRACTICE MCQ]
(a) Apocynaceae (b) Acanthaceae
N
(c) Scrophulariacea (d) Rutaceae
FI
197. The Aconite plant is propagated from [GDC PRACTICE MCQ]
R
(P) Stem and Seeds (Q) Tubers (R) Root

U
(a) P Only (b) Q Only (c) R Only (d) P, Q & R

YO
198. The highly poisonous drug which use in treatment of neuralgia [GDC PRACTICE MCQ]
(a) Monkshood (b) Ephedra (c) Belladonna (d) Nux vomica
AT
199. Which alkaloid contains diterpene moiety is[GDC PRACTICE MCQ]

(a) Cocaine (b) Aconitine (c) Reserpine (d) Pilocarpine
T
PA
200. Hydrolysis of Aconitine gives[GDC PRACTICE MCQ]

(a) Aconine + Benzoic acid (b) Aconine + Benzoyl Aconine
G
(c) Benzoyl Aconine + Acetic acid (d) Benzoyl Aconine + Benzoic acid
VE
TI
EC
1. Modified borntrager’s test is used to detect the presence of which type of glycosides
BJ
[GPAT-2023 SHIFT-II]
(a) O-type of glycosides (b) C-type of glycosides

O
(c) S-type of glycosides (d) N-type of glycosides

C
2. Unicellular conical, warty trichomes, paracytic stomata, xylem vessels with annular
D
thickening are important microscopical features of which plant [GPAT-2023 SHIFT-II]

G
(a) Datura metel (b) Cassia angustifolia

(c) Digitalis purpurea (d) Atropa belladonna

73. What is true about Chenopodium oil [GDC PRACTICE MCQ]
1. It contain not less than 65% of ascaridiole
2. It is used as anthelmintic
F
3. It is contraindicated in pregnancy
PD
4. It has no action on large tapeworms
(a) 1,2 and 3 are true (b) 2,3 and 4 are true
E
(c) 2 and 3 are true (d) All of these
PL
74. Eucalyptus oil is obtained from the eucalyptus leaves by ____ method [GDC PRACTICE MCQ]
M
(a) Eucelle method (b) Enfleurage method
SA
(c) Soxhlet evaporation (d) Steam distillation
75. 1, 8-Cineol is an active constituent of [GDC PRACTICE MCQ]
PS
(a) Eucalyptus oil (b) Peppermint oil (c) Lemon oil (d) Turpentine oil
76. Diacytic stomata is microscopic feature of which alcoholic volatile oil drug [GDC PRACTICE MCQ]
TI
(a) Fennel (b) Dill (c) Anise (d) Peppermint oil
ER
77. Choose the right constituents given below is considered by U.S.F.D.A as generally
regarded as safe (GRAS) to use as nasal decongestant [GDC PRACTICE MCQ]
G
(a) Anethol (b) Menthol (c) Carvone (d) Phellandrene
N
FI
78. The anti-inflammatory and antiulcer activity of peppermint oil is due to [GDC PRACTICE MCQ]
(a) Azulene (b) Menthol (c) Pulegone (d) Menthol
R
79. The bitter substance which is present in bitter orange peel is [GDC PRACTICE MCQ]
U
(a) Aurantimarin (b) Hesperidin (c) Limonene (d) Pectin

YO
80. Volatile oil from Lemon peels contains d-limonene which is [GDC PRACTICE MCQ]
(a) Phenyl propane derivative (b) Bicyclic monoterpene derivative

AT
(c) Monocyclic monoterpene derivative (d) Acyclic sesquiterpene

81. Which volatile oil containing drug is used for extraction of citral [GDC PRACTICE MCQ]
T
PA
(a) Mentha oil (b) Palmarosha oil (c) Orange peel (d) Indian Melissa oil
82. Name of the active constituent that is obtained by steam distillation from the leaves
G
and aerial parts of the plants Cymbopogon flexuousus is [GDC PRACTICE MCQ]
VE
(a) Camphor (b) Carvone (c) Linalool (d) Citral

83. Which of the following chemical constituents is used as mosquito repellant [GDC PRACTICE MCQ]
TI
(a) Citral (b) Geraniol (c) Citronellal (d) Eugenol

EC
84. On enzymatic hydrolysis of Gaultherin it produces [GDC PRACTICE MCQ]

(a) Methyl cinnamate and Primeverose (b) Primeverose and Methyl salicylate
BJ
(c) Digitoxose and Methyl salicylate (d) Digitoxose and Methyl cinnamate
O
85. Camphor is obtained from Cinnamomum comphora belonging to the family [GDC PRACTICE MCQ]
C
(a) Rubiaceae (b) Lauraceae (c) Myristicaceae (d) Myrtaceae

D
86. A drop of Vanillin and Sulphuric acid added to X powder, then produce finally blue
G
color, here X powder drug is [GDC PRACTICE MCQ]

(a) Chenopodium (b) Camphor (c) Eucalyptus (d) All of these

523
3. Choose the right combination from the following Microscopic features Crude drugs [GPAT-2017]
Type of stomata Drugs
1. Diacytic stomata and sessile, glandular trichomes [P] Datura
2. Paracytic stomata and unicellular warty trichomes [Q] Vasaka
F
PD
3. Anomocytic Stomata, and glandular, multicellular [R] Senna
covering trichomes
4. Anisocytic stomata and multicellular covering [S] Digitalis
E
trichomes
PL
(a) 1-[Q], 2-[R], 3-[S], 4-[P] (b) 1-[R], 2-[S], 3-[P], 4-[Q]
M
(c) 1-[P], 2-[S], 3-[Q], 4-[R] (d) 1-[S], 2-[Q], 3-[P], 4-[R]
SA
4. Given below are some microscopical diagnostic of the drug listed in A to E. Choose the
appropriate one [GATE-1989]
PS
Microscopical characters Plant drugs
1. Unlignified septate fiber [P] Rhubarb
TI
2. Raphides of calcium oxalate embedded in mucilage [Q] Liquorice
ER
3. Anisocytic type of stomata [R] Ginger
4. Star spots [S] Squill
G
[T] Solanaceous plants
N
(a) 1-[P], 2-[Q], 3-[R], 4-[S] (b) 1-[S], 2-[R], 3-[Q], 4-[P]
FI
(c) 1-[Q], 2-[R], 3-[P], 4-[S] (d) 1-[R], 2-[S], 3-[T], 4-[P]
5. The diagnostic features of crude drugs are given in 1-4. Their descriptions are given in
R
[P] to [U]. Match them. [GATE–1997]

U
Diagnostic features Description

YO
1. Trichome [P] Two similar cells placed with their long axis parallel and
having smaller intercellular space.
AT
2. Cicatrix [Q] Epidermal cells which do not have any definite function
3. Stomata [R] An elongated tubular outgrowth of an epidermal cell
T
4. Mesophyll [S] Trichomes having fallen or been rubbed leaving a scar

PA
[T] The whole of the parenchymatous ground tissue between two

epidermises
G
[U] Flat and has one or more rows of Palisade cells.

VE
(a) 1-[R], 2-[S], 3-[P], 4-[T] (b) 1-[P], 2-[R], 3-[S], 4-[T]
(c) 1-[P], 2-[R], 3-[T], 4-[S] (d) 1-[P], 2-[Q], 3-[R], 4-[U]
TI
6. Match the following under chemical compounds under Column I with their respective
EC
chemical tests under Column II [GPAT-2021]

COLUMN - I (COMPOUNDS) COLUMN - II (CHEMICAL TESTS)
BJ
1. Quinine [P] Borntrager’s

O
2. Digitoxin [Q] Thalleoquin

3. Atropine [R] Vitali Morin
C
4. Sennosides [S] Keller kiliani

D

G
(a) 1 - [Q], 2 - [S], 3 - [R], 4 - [P] (b) 1 - [R], 2 - [S], 3 - [Q], 4 - [P]
(c) 1 - [P], 2 - [Q], 3 - [R], 4 - [S] (d) 1 - [S], 2 - [R], 3 - [Q], 4 - [P]

PHARMACEUTICAL
F
CHEMISTRY
PD
E
PL
M
SA
PHYSICAL CHEMISTRY
PS
TI
ER
1. The value of R in energy of activation is [GPAT-2021]
G
(a) 1.98 cal/deg.molecule (b) 1.89 cal/deg.molecule
N
(c) 8.91 cal/deg.molecule (d) 9.18 cal/deg.molecule
FI
2. One of the units used for expressing pressure is ‘torr’ and is equal to [GATE-2004]
R
(a) Cm of Hg (b) Mm of mercury (c) Psi (d) Gause
U
3. The interaction of one dipole liquid to another induced dipole liquid molecule is known
YO
as [GDC PRACTICE MCQ]

(a) Polar forces (b) London forces
AT
(c) French forces (d) Van der wall forces

4. The temperature at which vapour pressure of a liquid can be measured is [GDC PRACTICE MCQ]
T
(a) Freezing point (b) Boiling point

PA
(c) Critical temperature (d) Inversion temperature

G
5. Which one of the following is the correct order of interactions [GDC PRACTICE MCQ]
(a) Covalent < Hydrogen bonding < Van der Waals < Dipole-dipole
VE
(b) Van der Waals < Hydrogen bonding < Dipole < Covalent
TI
(c) Van der Waals < Dipole-dipole < Hydrogen bonding < Covalent
EC
(d) Dipole-dipole < Van der Waals < Hydrogen bonding < Covalent
6. Van der Waals’ real gas, acts as an ideal gas, at which conditions [GDC PRACTICE MCQ]
BJ
(a) High temperature, low pressure (b) Low temperature, high pressure
O
(c) High temperature, high pressure (d) Low temperature, low pressure
7. The total pressure exerted by a number of non-reacting gases is equal to the sum of the
C
D
partial pressures of the gases under the same conditions is known as [GDC PRACTICE MCQ]
G
(a) Boyle’s law (b) Charle’s law (c) Avogadro’s law (d) Dalton’s law

40. Which is NOT the colligative property [GPAT-2021]
F
PD
[P] Depression of freezing point [Q] Elevation of boiling point
[R] Elevation of vapour pressure [S] Osmotic pressure
E
Choose the correct one of the following
PL
(a) (P), (Q) and (S) (b) (P) and (Q)
(c) (P) and (S) (d) (R) only
M
41. Cottrell’s method is used for the measurement of [GPAT–2022]
SA
(a) Depression of freezing-point (b) Elevation of boiling-point
(c) Lowering of vapour pressure (d) Osmotic pressure
PS
42. Which of the following method is used for the determination of osmotic pressure [GPAT-2021]
(a) Beckmann’s method (b) Berkeley and Hartley’s method
TI
(c) Cottrell’s method (d) Landsberger’s method
ER
43. Calculate the accurate osmotic pressure at 0°C of a blood serum sample using Lewis
equation having freezing point - 0.53°C [GPAT-2019]
G
(a) 0.636 ATM (b) 6.39 ATM (c) 574.28 ATM (d) 0.0441 ATM
N
FI
44. Parachor and Molar refraction can be categorized under one of the following properties.
Identify that [GPAT-2012]
R
(a) Additive properties (b) Constitutive properties

U
(c) Colligative properties (d) Additive and constitutive property

YO
45. Rast’s camphor method is used for determination of molecular weight of solutes which are
soluble in molten camphor. The basic principle of the method is dependent on one of the
AT
following properties. Identify that [GPAT-2012]

(a) Elevation of freezing point of camphor by the solute
T
(b) Lowering of vapour pressure of camphor by the solute

PA
(c) Lowering of freezing point of camphor by the solute

(d) Elevation of boiling point of camphor by the solute
G
46. The statement “The mass of a gas dissolved in a given mass of a solvent at any temperature
VE
is proportional to the pressure of the gas above the solvent” is [GDC PRACTICE MCQ]
(a) Dalton’s Law of Partial Pressures (b) Law of Mass Action
TI
(c) Henry’s Law (d) None of these

EC
47. Determination of correct molecular mass from Raoult’s law is applicable to [GDC PRACTICE MCQ]
BJ
(a) An electrolyte in solution (b) A non-electrolyte in a dilute solution

(c) A non-electrolyte in a concentrated solution(d) An electrolyte in a liquid solvent
O
48. An ideal solution is that which[GDC PRACTICE MCQ]

C
(a) Shows positive deviation from Raoult’s law

D
(b) Shows negative deviation from Raoult’s law

G
(c) Has no connection with Raoult’s law

(d) Obeys Raoult’s law

(a) I < II < III (b) III < I < II (c) II < I < III (d) II < III < I
4. Most acidic compound will be [GDC PRACTICE MCQ]
(a) Cl3C–COOH (b) F3C–COOH (c) H3C–COOH (d) CHC–COOH
F
5. Most basic compound will be [GDC PRACTICE MCQ]
PD
(a) CH3–NH–CH3 (b) Cl2CH–NH–CH3
(c) ClCH2 – NH – CH3 (d) Cl3C–NH–CH3
E
PL
6. The correct order of decreasing basic character of the three amines are [GDC PRACTICE MCQ]
CH3NH 2 CH 3NHCH3 C2H5NHC2H5
M
I II III
SA
(a) II > III > I (b) I > III> II (c) I > II > III (d) III > II > I
7. Which of compound will be most acidic [GDC PRACTICE MCQ]
PS
(a) CH3OH (b) C2H5OH (c) C3H7OH (d) CH3-CH(Cl)-OH
TI
8. Most acidic compound will be [GDC PRACTICE MCQ]
ER
(a) HCOOH (b) CH3COOH (c) C2H5COOH (d) None of these
9. Amongst the amines C6H4NH2 (I), CH3NH2 (II), (CH3)2NH (III) and (CH3)3N (IV) the order of
G
basicity (in aqueous medium) is [GDC PRACTICE MCQ]
(a) I < IV < II < III (b) IV < III < II < I (c) I < II < III < IV
N (d) II < III < IV < I
FI
10. Value of pKa will be minimum for [GDC PRACTICE MCQ]
R
OH OH OH OH
U
YO
(a) (b) (c) (d)

AT
CH3 OCH3 CHO NO2

T
11. The order of reactivity of the compounds [GDC PRACTICE MCQ]

PA
O
CH 3
G
O C CH3 NH C CH3 CH
VE
O O CH 3
TI
(I) (II) (III) (IV)

EC
Towards substitution with a given electrophile is

BJ
(a) IV > III > II > I (b) I > II > III > IV (c) III > II > I > IV (d) I > III > II > IV
12. Which of the following is least acidic [GDC PRACTICE MCQ]
O
COOH SO3 H OH
C
D
G
(a) (b) (c) (d)

OBJECTIVE GPAT AT YOUR FINGERTIPS : PHARMACEUTICAL CHEMISTRY
89. Identify which statement among the following is true in case of E 2 and SN2 [GPAT–2022]
(a) Secondary substitution undergoes slow elimination and fast substitution
(b) Primary substitution undergoes slow elimination and fast substitution
F
(c) Tertiary substitution undergoes slow elimination and fast substitution
PD
(d) Primary substitution does not undergo elimination and substitution reactions
90. The set of specific reagents used in the below-mentioned synthesis of m-(n-Butyl) toluene
E
from n-propyl m-tolyl ketone is [GPAT–2022]
PL
O
M
?
SA
(a) Zn(Hg), HCl (b) NaBH4, CH3OH
PS
(c) NH2NH2, NaOH (d) SnCl2, CH3OH
TI
91. Identify the functional groups from the below mentioned options that lead to weakening of
ER
benzoic acid [GPAT–2022]
[A] –OH [B] –Cl [C] –NH2 [D] –NO2
G
(a) A and B (b) A and C (c) B and C (d) A and D
N
92. The dehydration of aldol product of two acetaldehyde molecules through E1cb mechanism
FI
affords formation of [GPAT-2021]
R
(a) 1-Butenal (b) 2-Butenal (c) 3-Butenal (d) 4-Butenal
U
93. Which of the following groups stabilizes carbocation in electrophilic aromatic substitution
YO
[GPAT-2020]
(a) -CN, -SO3H (b) -COOH, -CHO (c) -NH2, -OH (d) –N(CH3)3+, -NO2
AT
94. Walden inversion or complete reversal of stereochemistry occurs in one of the following
substitution reaction [GPAT-2020]
T
(a) SNAr reactions (b) SNi reaction (c) SN2 reactions (d) SN1 reactions
PA
95. What is the product of the following reaction [GPAT-2020]

G
O
NaCN, HCN
VE
80C-100C
TI
N
O
EC
C NC CN HO CN
(a) (b) (c) (d)
CN
BJ
96. The chief product obtained by the reaction of neo-pentyl bromide under E 1 reaction
O
conditions [GPAT-2019]
C
(a) Neopentyl alcohol (b) 2-methyl-2-butane

D
(c) 2-methyl-1, 3-butadiene (d) 2-methyl butane

G

595
31. The dehydrohalogenation of 2-bromobutane with alcoholic KOH gives mainly [GDC PRACTICE MCQ]
(a) 2-Butene (b) 2-Butyne (c) 1-Butene (d) 1-Butyne
32. The major product of acid-catalyzed dehydration of 3 - pentanol is [GDC PRACTICE MCQ]
F
(a) 1-Pentene (b) 2-Methyl-1-butene (c) 2-Pentene (d) 3-Methyl-1-butene
PD
33. In a reaction [GDC PRACTICE MCQ]
CH2OH
Hypochlorus acid R
E
H2C CH2 M
PL
CH2OH
Where M = molecule; R = reagent; M and R are
M
(a)CH3CH2Cl and NaOH (b) CH3Cl – CH2OH and aq. NaHCO3
SA
(c) CH3CH2OH and HCl (d) CH2 = CH2 and heat
34. 2-Methylpropene reacts with HBr to give [GDC PRACTICE MCQ]
PS
(a) Tert-Butyl bromide (b) Isobutane
TI
(c) N-Butyl bromide (d) None of these
35. Which of the following compounds is the major product when 1-hexyne is treated with
ER
excess HBr [GDC PRACTICE MCQ]
G
(a) 1,1-dibromohexane (b) 1,1-dibromohexene
N
(c) 1,2-dibromohexene (d) 2,2-dibromohexane FI
36. Acetylene reacts with water in the presence of sulfuric acid and mercuric sulfate to give
[GDC PRACTICE MCQ]
R
(a) Acetone (b) Acetic acid (c) Formaldehyde (d) Acetaldehyde

U
37. 1 - Chlorobutane, on reaction with alcoholic potash (KOH), gives [GDC PRACTICE MCQ]
YO
(a) 1-Butene (b) 1-Butanol (c) 2-Butene (d) 2-Butanol

38. 3 - Hexyne reacts with Na/liq. NH3 to produce [GDC PRACTICE MCQ]
AT
(a) cis-3-Hexene (b) trans-3-Hexene (c) 3-Hexylamine (d) 2-Hexylamine

39. When 2-pentyne is treated with dil. H2SO4 and HgSO4, the product formed is [GDC PRACTICE MCQ]
T
PA
(a) 1-pentanol (b) 2-pentanol (c) 2-pentanone (d) 3-pentanone

40. Propyne and propene can be distinguished by [GDC PRACTICE MCQ]
G
(a) Conc. H2SO4 (b) Br2 in CCl4

(c) Dil. KMnO4 (d) AgNO3 in ammonia
VE
41. Identify the reagent from the following list which can easily distinguish between 1-butyne
TI
and 2-butyne [GDC PRACTICE MCQ]

EC
(a) Bromine, CCl4 (b) H2, Lindlar catalyst

(c) Dilute H2SO4, HgSO4 (d) Ammonical Cu2Cl2 solution
BJ
42. Butene-1 may be converted to butane by reaction with [GDC PRACTICE MCQ]
(a) Sn/HCl (b) Zn/Hg (c) Pd/H2 (d) Zn/HCl
O
43. The decreasing order of boiling points is [GDC PRACTICE MCQ]

C
(a) n-Pentane > iso-Pentane > neo-Pentane

D
(b) iso-Pentane > n-Pentane > neo-Pentane

G
(c) neo-Pentane > iso-Pentane > n-Pentane

(d) n-Pentane > neo-Pentane > iso-Pentane

613
211. Reactants in skraup synthesis for quinoline are [GPAT-2014]
(a) Aniline, nitrobenzene, glycerol (b) Aniline and glycerol
(c) Nitrobenzene and glycerol (d) None of these
F
212. Product of the following reaction [GPAT-2020]
PD
O
E
NH2NH2
PL
Base
NH2 OH NH NH2
M
SA
(a) (b) (c) (d)
PS
213. The protons ortho to the nitro group in p-nitrotoluene are examples of which one of the
Following types [GPAT-2011]
TI
(a) Chemically equivalent but magnetically non-equivalent protons
ER
(b) Chemically and magnetically equivalent protons
(c) Chemically and magnetically nonequivalent protons
G
(d) Chemically nonequivalent but magnetically equivalent protons
N
214. Choose the correct statement regarding the synthesis of phenyl n-propyl ether [GPAT-2012]
FI
(a) Phenyl n-propyl ether is prepared from n-propyl bromide and sodium phenoxide
R
(b) Phenyl n-propyl ether is prepared from bromobenzene and sodium n-propoxide
U
(c) Phenyl n-propyl ether can be prepared by either of the two methods
YO
(d) Both (a) and (b) are not the correct methods for the synthesis of phenyl n-propyl ether
215. Phenol, an antiseptic when treated as follows [GATE-2009]
AT
OH OCOC2H 5 OH OH
COC2H5
T
C2H 5COCl AlCl3,CS2

+
PA
G
COC2H 5
VE
Gave the above two phenolic ketones. The Reaction is

(a) Hofmann Rearrangement (b) Fries Rearrangement
TI
(c) Kolbe’s Reaction (d) Reimer-Tiemann Reaction

EC
216. What is/are the parameters of aromatic compounds [GDC PRACTICE MCQ]
(a) It must have coplanar structure (b) Must follow (4n+2)p rule
BJ
(c) Must have p bond dislocation (d) All of these

O
217. What is the general structure of a diazonium salt[GDC PRACTICE MCQ]

(a) R-NH2 (b) R-N2+ (c) R-OH (d) R-CHO
C
218. The diazonium salts are the reaction products of the reaction of nitrous acid with
D
G
[GDC PRACTICE MCQ]
(a) Primary aliphatic amines (b) Primary aromatic amines

(c) Secondary aliphatic amines (d) Secondary aromatic amines

143. Enantiomerism is the phenomenon of existence of enantiomers in a single structural

formula, in configuration[GDC PRACTICE MCQ]
(a) Same (b) Opposite
F
(c) Same as well as opposite (d) Initially opposite and then same
PD
144. Which of the following statements are true regarding racemic mixture [GDC PRACTICE MCQ]
i. A racemic mixture is optically active
E
ii. It is a mixture of two equal proportions mixture
PL
iii. It is a mixture of two optically active compounds
M
(a) Statement (i) and (ii) are true (b) Statement (i) and (iii) are true
SA
(c) Statement (ii) and (iii) are true (d) All are true
145. Which one of the following compound is optically active[GDC PRACTICE MCQ]
PS
(a) 1-Butanol (b) 2-Chlorobutane (c) 4-Heptanol (d) 3-Chloropentane
146. Which of the following statements are correct about the following compounds [GDC PRACTICE MCQ]
TI
CH3 CH3
ER
H OH OH H
G
H OH OH H
N
C2H 5
FI C 2H5
1. Pair of Enantiomers 2. Both are threo form
R
3. Pair of Diastereomers 4. Both are d, l pair

U
YO
(a) 1, 4 (b) 1, 2, 4 (c) 2, 3, 4 (d) 3, 4

147. What is the configuration of following compounds respectively [GDC PRACTICE MCQ]
AT
H OH
CH3 H CH=CH 2
T
Cl CF3 C CH
PA
(a) R and R (b) R and S (c) S and R

(d) S and S
G
148. Which of the following compounds will be optically active [GDC PRACTICE MCQ]
VE
(a) Succinic acid (b) Meso-tartaric acid

(c) Lactic acid (d) Chloroacetic acid
TI
149. 2-Butanol is optically active because it contains [GDC PRACTICE MCQ]

EC
(a) An asymmetric carbon (b) A plane of symmetry

(c) A hydroxyl group (d) A centre of symmetry
BJ
150. Which of the following represents a racemic mixture[GDC PRACTICE MCQ]

O
(a) 75% (R)-2-butanol, 25% (S)-2-butanol (b) 25% (R)-2-butanol, 75% (S)-2-butanol
C
(c) 50% (R)-2-butanol, 50% (S)-2-butanol (d) None of these

D
151. How many asymmetric centers are present in a molecule of 2,4,6- trimethyl heptane
G
[GDC PRACTICE MCQ]
(a) 0 (b) 1 (c) 2 (d) 3


655
33. N, N-dimethyl-(diphenylmethoxy)ethylamine is [GDC PRACTICE MCQ]
(a) Diphenhydramine (b) Dimenhydrinate (c) Clemastine (d) None of these
34. PGs are rapidly metabolized and inactivated by ____________pathways [GDC PRACTICE MCQ]
F
(a) Hydroxylation (b) Oxidative and reductive
PD
(c) Acetylation and conjugation (d) None of these
35. The initial step of PGs involves rapid oxidation of the 15 -OH group to [GDC PRACTICE MCQ]
E
(a) Aldehyde (b) Ketone (c) Carboxylic acid (d) Alcohol
PL
36. In the given structure X will be [GDC PRACTICE MCQ]
M
COOH NH 2
SA
CH 3
Cl
+ Condensation
x
PS
CH3
TI
(a) Piroxicam (b) Parecoxib
ER
(c) Oxyphenbutazone (d) Mephenamic acid
37. Product form during xenobiotic metabolism of paracetamol is [GDC PRACTICE MCQ]
G
(a) N-acetyl-p-benzpyrrole imine (b) N-acetyl-p-benzoquinone imine
N
(c) N-ethyl-p-benzoquinone amine (d) None of these FI
38. Identify the given structure [GDC PRACTICE MCQ]
R
O
U
YO
O
AT
OH HO O
(a) Diflunisal (b) Nimesulide (c) Piroxicam (d) Salsalate
T
39. N-aryl anthranilic acid are structural analogue of [GDC PRACTICE MCQ]
PA
(a) Ibuprofen (b) Indomethacin (c) Naproxen (d) Diclofenac

G
40. Allopurinol undergoes metabolism, where it transforms into [GDC PRACTICE MCQ]
(a) Hydropurinol (b) Oxypurinol (c) Carbopurinol (d) Allyl benzene

VE
41. Febuxostat generally contains__________ ring [GDC PRACTICE MCQ]

TI
(a) Thiazole (b) Imidazole (c) Pyrazole (d) Pyridazine

EC
42. Sulindac is generally__________ derivative [GDC PRACTICE MCQ]
(a) Indole acetic acid (b) Indene acetic acid

BJ
(c) Xanthene (d) Xanthine

43. Drug which is used to increase metabolism of uric acid [GDC PRACTICE MCQ]
O
(a) Pegloticase (b) Allopurinol (c) Colchicine (d) Sulfinpyrazone

C
44. Substitution of 2-phenyl thioethyl group at the 4 position of pyrazolidinedione produces

th
D
[GDC PRACTICE MCQ]

G
(a) Antiemetic effect (b) Anti-influenza effect

(c) Antigout effect (d) Antileprotic effect

689
4. Pheniramine [S] Pyrazine
[T] Pyridazine
(a) 1-[R], 2-[P], 3-[S], 4-[Q] (b) 1-[Q], 2-[S], 3-[R], 4-[P]
F
(c) 1-[P], 2-[Q], 3-[S], 4-[R] (d) 1-[Q], 2-[T], 3-[R], 4-[P]
PD
19. Match the each pair with the type of a structural relationship they exhibit [GATE-1992]
1. (R) and (S) Naproxen [P] Tautomer’s of one another
E
2. Dilactim and Monolactim form of [Q] Diastereomers of one another
PL
Barbituric acid
3. Quinine and Quinidine [R] Non-superimposable mirror images of
M
SA
each other
4. Eclipsed and staggered form of [S] Superimposable mirror images of each
PS
other phenothiazine
[T] Conformational isomers of one another
TI
(a) 1-[R], 2-[P], 3-[Q], 4-[T] (b) 1-[Q], 2-[S], 3-[R], 4-[P]
ER
(c) 1-[P], 2-[Q], 3-[S], 4-[R] (d) 1-[Q], 2-[T], 3-[R], 4-[P]
20. Following are some naturally occurring substances. They are classified under different
G
categories which are listed in [P] to [T]. match them correctly [GATE-1992]
N
1. Prostaglandins [P] Opioids
FI
2. Codeine [Q] Eicosanoids
R
3. Angiotensin II [R] Corticoids

U
4. Strophanthidin [S] Peptide

YO
[T] Cardenolide
(a) 1-[R], 2-[P], 3-[S], 4-[Q] (b) 1-[Q], 2-[P], 3-[S], 4-[T]
AT
(c) 1-[P], 2-[Q], 3-[S], 4-[R] (d) 1-[Q], 2-[T], 3-[R], 4-[P]
T
21. The side chain structure for the following drugs are given from [P] to [T]. Match them
PA
[GATE-1993]
(a) 1-[Q], 2-[P], 3-[S], 4-[R] (b) 1-[R], 2-[Q], 3-[P], 4-[S]
G
(c) 1-[T], 2-[Q], 3-[P], 4-[S] (d) 1-[R], 2-[S], 3-[P], 4-[Q]
VE
22. The starting material for the synthesis of drug 1 to 4 are mentioned from [P] to [T]. Match
them correctly [GATE-1993]
TI
1. L-tyrosine [P] 3-chloroacetyl phenol

EC
2. Phenylephrine [Q] 4-chloroacetyl catechol

BJ
3. Isoprenaline [R] Catechol

4. Adrenaline [S] Thyroxine
O
[T] Resorcinol
C
(a) 1-[Q], 2-[P], 3-[S], 4-[R] (b) 1-[P], 2-[Q], 3-[R], 4-[S]
D
(c) 1-[P], 2-[R], 3-[Q], 4-[T] (d) 1-[S], 2-[P], 3-[Q], 4-[R]
G

735
(a) Coupling constant rarely exceeds 20 cps while chemical shifts are over 1000 cps
(b) Spin - Spin interactions are dependent of strength of the applied field
(c) Coupling constants increase with distance
F
(d) Equivalent nuclei interact with each other to show interaction
PD
123. On scale the position of TMS signal is taken as [GPAT-2013]
(a) 0.0 ppm (b) 0.2 ppm (c) 2.0 ppm (d) 10.0 ppm
E
124. What will be type of proton NMR spectrum of 2,2,-dimethylpropane [GPAT-2021]
PL
(a) Quartet (b) Doublet (c) Triplet (d) Singlet
M
125. According to the n + 1 rule, what would be the multiplicities of the signals in the proton
SA
NMR spectrum of 1, 1- dibromoethane [GPAT–2022]
(a) Triplet and doublet (b) Quartet and doublet
PS
(c) Triplet and quartet (d) Triplet and triplet
126. Which list below gives only spin active nuclei [GPAT-2016]
TI
1 2 12 1 12 19 1 13 19 2 12 19
(a) H, H, C (b) H, C, F (c) H, C, F (d) H, C, F
ER
127. In NMR, the aromatic proton resonate in a characteristic narrow range at [GPAT-2018]
(a)  6.5 –  8.0 (b)  11.0 –  12.0 (c)  2.0 –  4.0 (d)  0.7 –  1.3
G
128. In NMR spectrum of a substance the environment of absorbing proton with respect to the
environment of neighboring proton tells about [GPAT-2016]
N
FI
(a) Position of signals (b) Intensity of different signals
R
(c) Number of signals (d) Splitting of signals

U
129. o, m, p- isomers can be differentiated on the basis of [GPAT-2014]

YO
(a) Chemical shift (b) Coupling constant

(c) Extinction coefficient (d) Dipole moment
AT
130. Rotation of electrons about the proton generates a secondary magnetic field which may
oppose the applied magnetic field. The proton is then said to be [GATE-2003]
T
(a) Shielded (b) Shifted (c) Hydrogen (d) Deshielded

PA
131. Karplus curve is associated with which spectroscopy [GPAT-2013]

G
(a) UV (b) Mass (c) FTIR (d) NMR

132. Conformation of drugs is commonly determined by [GATE-1992]
VE
(a) NMR (b) NMI

TI
(c) Mass spectrometry (d) pH determination

EC
133. Both of the CMR and PMR spectra of an unknown compound show four absorption peaks
each. Identify the unknown compound [GPAT-2012]
BJ
CH3
CH3 CH
O
3
H 3C CH 3
CH 3
C
D
(a) (b) (c) (d)

G
CH 3
CH3

779
OTHER SUBJECTS
F
PD
E
PL
M
BIOCHEMISTRY
SA
PS
TI
1. Carbohydrates have hydrogen oxygen atom ratio of [GPAT-2023 SHIFT-II]
ER
(a) 1 : 2 (b) 3 : 1 (c) 1 : 3 (d) 2: 1
G
2. An aldopentose can be converted into aldohexose by [GPAT-2020]
N
(a) Ruffs degradation method (b) Wohl’s method FI
(c) Kiliani-Fischer synthesis (d) Hoffmann degradation method
3. Glucose upon treatment with nitric acid yields [GPAT-2021]
R
U
(a) Gluconic acid (b) Glucaric acid (c) Glucitol (d) Heptanoic acid
YO
4. Glucose is the only source of energy for one of the following. Identify that [GPAT-2012]
(a) Cardiac cells (b) Nephrons (c) RBCs (d) Thrombocytes
AT
5. A compound with an –OH group and –OR group bonded to the same carbon atom is [GPAT-2013]
(a) An acetal (b) A hemiacetal (c) A simple ether (d) An aldol
T
6. D-Fructose on simple reduction gives [GATE-1992]

PA
(a) L-Fructose (b) Only Sorbitol

(c) Only mannitol (d) Mixture of Mannitol and Sorbitol
G
7. Read the following statements

VE
[P] Caramelization occurs in acidic conditions

[Q] Caramel is optically inactive glucose
TI
[R] Caramel is obtained by burning of glucose

EC
[S] Caramel is obtained by degradation of fructose

Choose the right combination of statements [GPAT-2012]
BJ
(a) P & Q are true but R & S are false (b) P & S are true but Q & R are false
O
(c) Q & R are true but P & S are false (d) R & S are true but P & Q are false
C
8. Identify pair of C-4 epimers [GPAT-2023 SHIIFT-II]

D
(a) D-glucose and D-galactose (b) D-glucose and D-fructose

G
(c) D-glucose and D-mannose (d) D-glucose and D-xylulose

OBJECTIVE GPAT AT YOUR FINGERTIPS : OTHER SUBJECTS
112. Which of the following reagent used for Ninhydrin test [GDC PRACTICE MCQ]
(a) HNO3 (b) 1-Fluoro 2,4 dinitro benzene
(c) 2, 2 dihydroxy indane 1, 3-dione (d) 10 % -naphthol + ethanol
F
113. Arrange the correct sequence of urea formation in our body [GDC PRACTICE MCQ]
PD
(P) Ammonia + CO2 (Q) Argininosuccinate
(R) Ornithine (S) Citrulline
E
(T) Arginine
PL
(a) P  R  Q  S  T (b) P  Q  R  S  T
(c) P  S  Q  T  R (d) P  T  R  Q  S
M
114. Match the following base on the biologically important compounds formed by amino acid
SA
[GDC PRACTICE MCQ]
Amino acid Biological important
PS
(1) Cysteine (P) For adrenaline, Nor adrenaline
TI
(2) Serine (Q) Formation of Heme
ER
(3) Glycine (R) Form Choline
(4) Phenylalanine (S) Constituent of bile acid
G
(a) 1-S, 2-R, 3-P, 4-Q (b) 1-Q, 2-S, 3-P, 4-R
(c) 1-S, 2-R, 3-Q, 4-P (d) 1-P, 2-Q, 3-S, 4-R
N
FI
115. Match the following base on the Metabolic defect of amino acid [GDC PRACTICE MCQ]
R
Disorder Metabolic defect

U
(1) Phenylketonuria (P) Defect in renal reabsorption

YO
(2) Alkaptonuria (Q) Defect in phenylalanine hydroxylase

(3) Glycinuria (R) Defect in homogentisate oxidase
AT
(4) Albinism (S) Defect in tyrosinase

(a) 1-R, 2-P, 3-Q, 4-S (b) 1-Q, 2-R, 3-P, 4-S
T
(c) 1-S, 2-R, 3-Q, 4-P (d) 1-P, 2-Q, 3-S, 4-R
PA
116. The amino acids that cannot be synthesized in the body and must be supplied in the diet
G
are known as [GDC PRACTICE MCQ]

VE
(a) Alicyclic compounds (b) Aliphatic compounds

(c) Essential Amino acids (d) Aromatic amino acids
TI
117. Which group of amino acid is CORRECT in relation to essential amino acids [GDC PRACTICE MCQ]
EC
(a) Isoleucine, methionine, valine, lysine

(b) Isoleucine, arginine, valine, phenylalanine, lysine
BJ
(c) Phenylalanine, alanine, valine, lysine

O
(d) Alanine, arginine, leucine, glutamine

118. Which among the following is an amide containing amino acid [GDC PRACTICE MCQ]
C
D
(a) Leucine (b) Serine (c) Asparagine (d) Cysteine

G
119. The specific test for identifying imidazole ring in amino acids is [GDC PRACTICE MCQ]
(a) Pauly’s test (b) Biuret test (c) Millon’s test (d) Folin’s test

813
BIOTECHNOLOGY
F
PD
E
PL
1. Micropropagation of the plants is carried out through [GATE-2004]
M
(a) Cross fertilization (b) Seed germination
SA
(c) Plant tissue culture (d) Grafting
2. The most effective method for producing virus-free plants is [GATE-2005]
P S
(a) Root culture (b) Meristem culture
TI
(c) Somatic embryogenesis (d) Floriculture
ER
3. Which statements are not true about the grafts [GPAT–2022]
[A] Isografts are grafts in which the donor and recipient is the same individual
G
[B] Autografts are grafts between the donor and recipient of the same genotype
N
[C] Allografts are those in which the donor is of the same species but of a different genotype
FI
[D] Xenografts are those in which the donor is of a different species from that of the recipient
R
U
(a) A, B and D only (b) A and B (c) B and C (d) C and D

YO
4. The artificial or synthetic seeds are prepared by the following process [GPAT-2021]
(a) Somatic hybridization and culture
AT
(b) Somatic embryogenesis and immobilization

(c) Microprojectile and transformation
T
(d) Artificial pollination and embryogenesis

PA
5. A technique of using very small metal particles coated with desired DNA in the gene transfer
is called [GPAT-2018]
G
(a) Microinjection (b) Biolistic

VE
(c) Liposome mediated (d) Electroporation

6. Some of the organic reactions are catalyzed by a product obtained from starch on treatment
TI
with amylase from Bacillus macerans. It is [GATE-2009]

EC
(a) Amylopectin (b) Amylose (c) Cellulose (d) Cyclodextrin

BJ
7. Tryptophan is involved in the formation of [GDC PRACTICE MCQ]
(a) Heme (b) Vitamin Niacin and Indole Acetic Acid

O
(c) Hormones (d) Urea formation in liver

C
8. Abscisic acid controls [GDC PRACTICE MCQ]

D
(a) Stem elongation (b) Cell expansion and cell wall plasticity
G
(c) Cell division (d) Leaf fall and dormancy

9. Protoplast fusion can be achieved by [GDC PRACTICE MCQ]

829
PHARMACEUTICAL MANAGEMENT
F
PD
1. Which of the following product life cycle phases, it is indicative of market saturation in the
sense that all the potential customers have bought the product EXCEPT those who have
E
PL
decided not to have it [GPAT-2021]
(a) Growth phase (b) Introductory phase
M
(c) Decline Phase (d) Maturity phase
SA
2. Which of the following represents a complete list of products that are offered by a company
for sale [GPAT–2023 SHIFT-I]
PS
(a) Product Variety (b) Product Mix (c) Product Item (d) Product Line
TI
3. The process of establishing a product in the minds of target customer is called as [GPAT–2022]
ER
(a) Product positioning (b) Product differentiation
(c) Product targeting (d) Market segmentation
G
4. Boston Consulting Group (BCG) Matrix is used for [GPAT–2022]
N
(a) Product life cycle management (b) SWOT analysis FI
(c) Product portfolio management (d) Gap analysis
R
5. Product,_________and Promotion are four ‘P’s of marketing [GPAT-2017]
U
(a) Price, Place (b) Place

YO
(c) Process (d) Production, Process, Price, Production

6. High lightening differences among brands within the same product category is [GPAT-2017]
AT
(a) Product brand (b) Brand launch

(c) Product differentiation (d) Branding
T
7. Henri Fayol’s principle “Espirit de corps” means [GPAT-2018]

PA
(a) Corporate objective (b) Group objective

G
(c) Team activity (d) Team spirit

VE
8. How customer’s bias about the product will influence the marketing communication
[GPAT-2018]
TI
(a) Positive effect (b) Negative effect

EC
(c) No effect (d) Both (a) and (b)

9. Consumer who are loyal to two-three brands are considered as [GPAT-2019]
BJ
(a) Split loyals (b) Switcher loyals (c) Semi-core loyals (d) Shifting loyals
O
10. Which of the following statement is the correct description of product positioning [GPAT-2021]
C
(a) Selecting one or more segment to enter

D
(b) Occupying distinctive position in the mind of customer

G
(c) Identifying group of buyers with common need

(d) Distinguishes company’s product from competitor’s product

861
MODEL PAPER
F
PD
E
PL
CHEMISTRY
M
1. HVZ Reactions is possible when
SA
(a) Carboxylic acids with - hydrogen (b) Aldehydes with - hydrogen
(c) Carboxylic acids without - hydrogen (d) Aldehydes without - hydrogen
PS
2. The following statements are true regarding Oppenauer oxidation reaction except
(a) Reagent is Isopropoxide (b) Secondary alcohol are oxidized to ketone
TI
(c) Primary alcohols are oxidized to ketone (d) It is a reversible reaction or MPV reaction
ER
3. Which of the following is correct
G
(a) In stereospecific reaction, different substrates give different products
N
(b) In stereoselective reaction unequal amounts of stereo isomers are produced
FI
(c) In stereo specific reaction are stereoselective reaction but reversal is not true
(d) All of these
R
4. In a small bridged ring system one cannot have double bond at the bridge head position. This
U
is known as
YO
(a) Pfeiffers rule (b) Bredt’s rule (c) Baldwin rule (d) Barton rule
5. The solvent which facilitates the SN reaction is
1
AT
(a) Aprotic Polar (b) Protic Polar (c) Non polar (d) All kind of solvents
6. The nomenclature of the given compound is
T
PA
G
(a) Bicyclo [2.2.1] Octane (b) Bicyclo [1.1.1] Octane

VE
(c) 1,4 bismethylene cyclohexane (d) Bicyclo [2.2.2] Octane

7. Which of the following conformation of cyclohexane has the most energy
TI
(a) Chair (b) Half- chair (c) Boat (d) Twist Boat
EC
8. Which of the following conditions will always lead to a nonspontaneous change

(a) Positive H and positive S (b) Negative H and negative S
BJ
(c) Positive H and negative S (d) Negative H and positive S

O
9. Upon nitration, pyrrole gives which of the following as major product

C
NO2 NO2
D
G
(a) NO2 (b) (c) (d) N

N NO2
H N N NO2
H H


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G

(b) They tend to flow when subjected to sufficient pressure

(d) They do not have definite melting point

(a) Rhombohedral (b) Orthorhombic (c) Monoclinic (d) Triclinic

5. Which of the following is most appropriate to crystalline solid [GPAT–2022]

(a) Give diffraction bands (b) Characteristics geometrical shapes

(c) Sharp melting point (d) All of these

(a) Mobility in three directions and rotation in one axis

(b) Mobility in two directions and rotation in one axis

(c) Mobility in two directions and no rotation

(d) Mobility in three directions and no rotation

substance to increase with decreasing particle size [GPAT-2023 SHIFT-II]

(a) Log (S0/S)=2yMr/2.303RT (b) Log(S/S0)=2yMr/2.303RT

(a) 7.78 x103 cm2/cm3 (b) 2.33 x103 cm2/cm3

(c) 1.55 x103 cm2/cm3 (d) 1.00 x103 cm2/cm3

of liquid into internal pores of the particles

(b) Both [A] and [R] are false

56. Hausner Ratio is [GDC PRACTICE MCQ]

175. Identify the wrong match pattern of DLVO theory [GPAT-2014]

(a) Primary minimum - High attraction - Irreversible coagulation

(c) Secondary minimum - Weak interaction - Flocculation

176. Schulze-Hardy rule is for [GPAT-2015]

(a) Lyophilic colloid (b) Hydrophilic colloid

177. DLVO theory is [GPAT-2016]

[P] Derjaguin Landou Vervey Overbeek theory

[R] Used to explain stability ointments

[S] Used to explain Brownian movement of colloids

178. Colligative properties depend on [GPAT-2016]

(c) The physical properties of the solute particles dissolved in solution

3. Stokes equation [R] V

following. Match them correctly [GATE-1989]

2. Presence of Foreign particle [Q] Du Nouy ring

3. Surface tension [R] Coulter counter

4. Presence of polymorph [S] Compactor

1. Cascade Impactor [P] Flash point

2. Tag Open Cup apparatus [Q] Sedimentation rate

2. Match List I with List II [GPAT-2021]

List - I (Term or Phrase) List - II (Meaning)

2. In oculum sinistram [Q] Into the right eye

4. In oculum dextrum [S] To the throat

Choose the correct answer from the options given below

(a) Subscription (b) Inscription (c) Superscription (d) Signatura

(a) One five ml spoonful to be taken three times a day in water

(b) Two five ml spoonful to be taken three times a day in water

(c) Two five ml spoonful to be taken two times a day in water

(d) One five ml spoonful to be taken two times a day in water

5. Auristillae is the latin term for [GPAT-2016]

(a) Error dose (b) Wrong dose

(a) Physical incompatibility (b) Chemical incompatibility

(a) Physical incompatibility (b) Chemical incompatibility

(c) Therapeutic incompatibility (d) All of these

1. Hospital formulary consists of [GPAT-2021]

(c) List of equipments (d) List of patients

2. Hospital Formulary contains information on the following parameters EXCEPT [GPAT–2022]

(a) Composition (b) Indication

(c) Pricing (d) Dosage and administration

Reason [S] : It is an antioxidant and prevents rancidity on storage

(b) [A], [R] and [S] are all false

5. The role of borax in cold creams is [GPAT-2010]

(b) To provide fine particles to polish skin