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Paracetmol Polymorphs

Importance of Paracetmol Polymorphs

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7 views

Paracetmol Polymorphs

Importance of Paracetmol Polymorphs

Uploaded by

pripexams
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd
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Exp. No.

: Preparation & Evaluation of Paracetmol Polymorphic Forms

Principle: Polymorphism refers to the ability of a substance to exist in multiple crystalline


forms. Paracetamol exhibits polymorphism, meaning it can exist in more than one crystalline
form. Different polymorphs of the same compound exhibit different physical properties such
as solubility, melting point etc. although their chemical properties remain unchanged. By
crystallizing paracetamol under different conditions e.g. temperature, solvent etc. we can
prepare its different polymorphic forms. In this experiment, Paracetamol will be subjected to
controlled crystallization from different solvents, leading to the formation of distinct
polymorphic forms.

Dissolution testing is an important study conducted during formulation development to


determine the rate of drug release from the dosage form. It provides insight into the in vitro
drug release behavior and bioavailability parameters.

Dissolution profile of a drug varies with the polymorphic form present in the formulation.
Polymorphs exhibit differences in aqueous solubility due to variations in crystal lattice
structures and free energies. The less stable, high energy polymorph shows higher solubility
and intrinsic dissolution rate compared to the more thermodynamically stable form.

In order to evaluate the effect of polymorphism on drug release, dissolution studies of


different polymorphic forms of paracetamol will be carried out. Paracetamol samples will be
filled in capsules and subjected to dissolution.

Dissolution profiles of two or more polymorphic forms will be compared to determine rapid
and slow dissolving forms. The relative bioavailability of paracetamol polymorphs can be
predicted based on the dissolution data. Thus suitable polymorphs with ideal dissolution can
be selected during formulation development.

Procedure:

1. Preparation of Paracetamol Solution: a. Weigh 5 gm of Paracetamol using an


analytical balance. b. Dissolve the Paracetamol in a suitable solvent (e.g., ethanol,
methanol, acetone, chloroform) to form a saturated solution. Stir the solution until
complete dissolution is achieved.
2. Crystallization: Induce crystallization by cooling the solution in an ice bath or by
placing it in a refrigerator.
3. Filtration: Filter the formed crystals to separate them from the mother liquor.
4. Washing: a. Wash the collected crystals with a small amount of cold solvent to
remove any impurities adhering to the surface. b. Allow the crystals to air-dry or use a
drying oven.
5. Characterization: a. Examine the crystalline forms under a microscope to observe
differences in crystal morphology. b. Measure the melting points of the different
forms using a melting point apparatus.

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