Published Article IMF
Published Article IMF
Published Article IMF
e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 23, Issue 7 Ser. 7 (July. 2024), PP 55-63
www.iosrjournals.org
Abstract
Over the past two decades, dentistry has witnessed a significant shift towards metal-free restorative materials,
driven by the need to improve the aesthetic value of dental restorations. Eliminating metal allows for restorations
that more closely mimic the natural dentition, free from traditional materials' dark, opaque substructures. Beyond
aesthetics, metal-free restorations offer numerous benefits, including conserving tooth structure, wear
compatibility, strength, durability, and improved bonding capabilities. These advancements align with patient
preferences for minimally invasive procedures and the preservation of natural tooth structure. Dental
restorations are categorized into direct and indirect types. Direct restorations involve placing a malleable
material into the tooth that is prepared and allowing it to set, typically in a single visit. Indirect restorations,
including inlays, crowns, onlays bridges, and veneers, which are fabricated outside the mouth using dental
impressions and are usually bonded in a subsequent visit. Innovations such as the CEREC chairside CAD/CAM
system allow for the precise fabrication of ceramic restorations, further enhancing the quality and efficiency of
dental restorative procedures. This review explores the evolution, benefits, and clinical considerations of indirect
metal-free restorations, highlighting the advancements that have made them a preferred choice in modern
dentistry
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Date of Submission: 08-07-2024 Date of Acceptance: 18-07-2024
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I. Introduction
In the last 20 years, dentistry has increasingly adopted metal-free restorative materials to improve the
aesthetics of dental work. These options eliminate the dark, opaque substructures found in traditional materials,
providing a more natural look. Besides aesthetics, metal-free materials offer benefits such as conserving tooth
structure, wear compatibility, strength, durability, and better bonding capabilities, catering to patient preferences
for minimally invasive treatments.1
The introduction of new materials has expanded available options, emphasizing the importance of factors
like mechanical properties, bond durability, and marginal integrity for long-term success. The strength and
bonding requirements of these materials depend on the functional stresses they will endure and their location in
the mouth, with additional aesthetic considerations for anterior teeth. 2-3
The ongoing development of restorative materials simplifies the selection process for dentists, ensuring
durable and aesthetically pleasing outcomes. An ideal restorative material should closely mimic natural teeth in
physical, material, and optical properties, and withstand masticatory forces and wear.4
Dental restorations are classified into direct and indirect types. Direct restorations involve placing and
setting a malleable material into the tooth in one visit. Indirect restorations, including inlays, crowns, inlays,
bridges, and veneers, which are fabricated outside the mouth using dental impressions and bonded in a later visit.
The CEREC chairside CAD/CAM system enables precise ceramic restorations, improving the quality and
efficiency of dental procedures. This review explores the advancements and advantages of indirect metal-free
restorations, highlighting their significance in modern dentistry.5,6
Aesthetics: Indirect tooth-colored restorations are recommended for Class II restorations placed in
patient-important aesthetic regions.
Major flaws or prior restorations: When restoring major Class II defects or replacing large compromised
pre-existing restorations, especially those that are wide facio lingually and necessitate cusp coverage, indirect
tooth-colored restorations should be taken into consideration. The optimum restoration for large preparations is
an adhesive restoration that fortifies the remaining tooth structure. Using indirect approaches makes it easier to
develop the contours of massive restorations.7
When it comes to maintaining occlusal surfaces and occlusal contacts, indirect tooth-colored restorative
materials outlast direct composites in larger occlusal posterior restorations. Large posterior restorations involving
most or all of the occlusal contacts require the wear resistance that indirect materials give. However, a large
indirect ceramic or composite restoration may fracture under occlusal pressure if it lacks sufficient bulk, especially
in the molar region.8
Economic factors: Regardless of price, some patients want the greatest dental care possible. Indirect
tooth-colored restorations may be recommended for these patients for both large and moderately sized restorations
that would normally require direct restorative material (often composite).9
Contraindications
Excessive occlusal stress or insufficient mass can cause ceramic restorations to crack, as in the case of
individuals with clenching or bruxing habits. Severe wear facets or a deficiency of occlusal enamel serve as
reliable markers of habits related to biting and grinding.
Inability to maintain a dry field— Despite some evidence claiming that current dental adhesives can
combat certain types of contamination. For adhesive procedures to produce excellent long-term clinical results,
moisture control must be almost flawless.
Deep subgingival preparations: Preparements with deep subgingival margins should be avoided, albeit
this is not a strict contraindication. These margins are challenging to complete and challenging to record with an
impression. Furthermore, bonding to the enamel borders is highly recommended, particularly on the gingival
margins of the proximal boxes.8,9
8. Difficult Try-In and Delivery: Polishing and delivering ceramics can be challenging due to hard surfaces and
potential marginal gaps.10-12
The following are the primary indications for creating a ceramic or composite inlay or onlay:
1. In patients who require exceptionally beautiful outcomes.
2. Individuals who practise good dental hygiene.
3. Individuals with allergic reaction to amalgam.
4. In the back teeth where there has been a noticeable loss of firm dental tissue.
When teeth are prepared in a way that provides the necessary support or enough enamel for a successful
bonding, it is possible to construct an onlay when there has been a significant loss of tooth tissue. Enamel is
significant because it provides a highly predictable and long-lasting adhesive contact.14-16
Contraindications
I. Individuals with extreme deterioration.
II. Individuals with inadequate oral hygiene and periodontal disease.
III. Individuals who have tooth erosion.
IV. Individuals whose teeth have lost too much tissue, leaving them unsuitable for bonding.
V. In teeth where there is a lot of discoloured tissue left, which has a bad cosmetic effect.
VI. Individuals have behaviours that are not functional. 16
Advantages
Ceramic inlays and onlays have the following benefits:
a. High biocompatibility.
b. They don't promote tooth plaque buildup on their surfaces. When paired with cutting-edge bonding methods,
ceramic inlays and onlays seem to have exceptional mechanical endurance resistance to wear and don't transfer
the forces inside the tooth under functional loads.
c. They fit the tooth properly, and when combined with their superior bonding to the enamel, we see a significant
reduction in dentine sensitivity and microleakage.
d. We are able to obtain a high-quality replica of the tooth's anatomy and great contact points because they are
built in a lab.
e. Perfect consistency of colour.
f. The bonding between the ceramic and composite cement is adequate. By using silica-based ceramic, we can
apply a chemical agent to etch the ceramic, which will increase our connection.
g. Because onlays correctly seal the tooth and stop subsequent deterioration that may typically occur with ordinary
fillings, they frequently avoid the need for root canal therapy.
h. Even when margins are placed on, long-term research has shown no correlation with an increase in caries.
i. Over time, they preserve the anatomic form.
j. The thin cement layer reduces the negative effects of polymerization shrinkage. Therefore, it may be that the
binding to the dentin is significantly more protected than it would be if direct composite were used. 17,18
Disadvantages
One of the drawbacks of ceramic onlays or inlays is
1. They are expensive
2. The dentist needs to be knowledgeable about contemporary bonding methods.
3. Difficulties in repairing the ceramic inlay if it breaks in the mouth, but this is achievable with the new composite
systems (Adovo-Ivoclar).18
To prepare the tooth for an inlay or Onlay, we must have in mind some principles
In order to get the tooth ready for an onlay or inlay, there are a few things to consider.
a. Even out the tooth's internal line angles.
b. Beveled chamfer within the preparation's boundaries is prohibited.
c. A 90-degree angle on the shoulder or a bevelled chamfer is recommended.
d. simple0, smooth preparations having cervical and pulpal walls that are flat.
e. Concave-walled preparations directed towards the masticatory surface.
f. To guarantee optimal adaptation, do not remove healthy tooth tissue for retention.
g. When the dentin is not supporting the cusps, the inlay is changed to an onlay.
h. Even if the dentin supports a cusp that has a crevice in it, onlay preparation is done in these cases.
i. The repair should have a minimum thickness of 1.5 to 2 mm.
j.
Use block-out resin to remove undercuts.
k.
The tooth's existing buccal or lingual walls should be at least 1 mm thick.
We are prepared to take impressions after the preparations are complete. 19,20
Clinical Significance:
• Posterior Teeth: When posterior teeth are weakened by wide cavity preparations, direct resin-based composites
may fail. Ceramic inlays/onlays provide durable, esthetic and biologically compatible restorations in such cases.
• Material Developments: Since 1985, dental ceramics with enhanced mechanical properties have been
developed for posterior teeth, allowing metal-free restorations.
Fabrication Techniques:
• Innovative Methods: New processing methods include centrifugal casting (castable glass-ceramic), lost wax
technique, pressure injection of ceramic ingots (pressable ceramics), and CAD/CAM systems.
• Popularity: These innovations have increased the popularity of ceramic inlays/onlays due to their esthetic
appeal and advancements in materials, fabrication, adhesives, and luting agents. 21
Ceramic Materials:
• Types: Hot-pressed ceramics, machinable ceramics and Feldspathic porcelain, designed for CAD/CAM
systems.
• Properties: Ceramics have mechanical and physical properties similar to enamel than composites, with excellent
wear resistance and a coefficient of thermal expansion similar to tooth structure.
• Fabrication: Using distilled water or a unique liquid combined with finely ground ceramic powders, the material
is formed, burned, and left translucent to resemble the structure of teeth. In dental laboratories, some are created
by burning dental porcelains on refractory dies.22-24
- Requirements: Must resist dissolution, provide strong bonds through mechanical adhesion and interlocking,
have high tensile strength, is biologically compatible and have good handling properties.
VII. Overlays
Minimally invasive dentistry is a growing field in modern restorative dentistry, driven by advancements
in adhesive materials and techniques. This shift focuses on biological, adhesive, and biomimetic approaches rather
than conventional mechanical retention. Lithium disilicate stands out among these new materials for its high
mechanical strength, satisfactory medium and long-term survival, and excellent optical properties. This versatility
makes it the gold standard for indirect restorations in the posterior sector, including use in the esthetic anterior
sector and as monolithic inlays in posterior teeth. Its biomechanical characteristics allow working in minimum
thickness values of 0.7 mm in the posterior sector without compromising strength. 29,30
Despite these advances, full-coverage crowns remain the most common fixed prosthodontic treatment
in the posterior sector. However, they come with significant drawbacks, including substantial tooth structure loss
and potential post-prosthetic complications such as the need for endodontic therapy, tooth weakening, root
fracture, and possible extraction. These restorations, including overlays, provide cuspid protection while
preserving healthier tooth structure. Overlays cover all posterior tooth cusps with direct or indirect restorative
material and are especially recommended for cusps thinner than 2 mm in vital teeth or 3 mm in non-vital posterior
teeth.31
Overlays are effective for various clinical situations, such as cuspid coverage of endodontically treated
teeth, managing teeth prone to fracture due to significant tooth structure loss, restoring large occlusal surfaces
compromised by wear or erosion, and treating cracked tooth syndrome. Studies indicate that overlay restorations
can eliminate cracked tooth syndrome symptoms without requiring endodontic treatment in most cases. 29,31,32
The success of overlay restorations relies on bonding and luting agents, materials like dental ceramics
and resin-based composites, and preparation designs that maximize tooth structure preservation and minimize
stress. Adhesive indirect restorations, including overlays, have demonstrated success rates comparable to full
crowns, often exceeding 90% survival rates. The primary failure modes include ceramic and tooth fractures,
decementation, and caries leakage. However, their survival rate and overall performance, especially when bonded
correctly and using modern adhesive technologies, provide a compelling case for their use in posterior
restorations.33-35
Biomimetic Considerations
Biomimetic dentistry aims to preserve the tooth's natural structures, particularly those biologically
supporting the tooth under stress. This approach aligns with the natural biomechanics of the tooth, enhancing the
longevity of both the restoration and the tooth. Overlays, as biomimetic restorations, offer advantages such as
working in harmony with natural tooth biomechanics, extending the tooth's restorative life cycle, and maximizing
ceramic materials' fracture resistance.39
Inlay
- Size: Small, covering only the central point of the treated tooth.
- Function: Suitable for severe caries with large cavities.
- Production: Impressions sent to a lab; includes design, milling, contouring, and staining.
- Durability: High durability due to porcelain material.
- Cost: Similar to one complete tooth.
Onlay
- Size: Larger than inlays, covering the central point and part of the cusps.
- Function: Suitable for severe caries spreading to the cusp or slightly chipped teeth.
- Durability: Similar to inlays.
Overlay
- Size: Almost the same as a complete denture, often compared to crowns.
- Function: Replaces severely damaged teeth while retaining good working roots.
- Durability: High durability due to comprehensive coverage.
Overall, overlays are a highly effective, conservative treatment option for posterior restorations,
preserving significant amounts of natural tooth structure while providing necessary protection and support. Their
design and application align with the principles of biomimetic dentistry, ensuring a long-lasting and
biomechanically compatible restoration.
VIII. Veneers
Veneers are tooth-colored materials applied to teeth to restore defects and intrinsic discolorations. They
can be made from composite, porcelain, or pressed ceramic materials.
Types of Veneers
1. Based on Tooth Preparation:
Case Selection
- Indications:
1. Correcting tooth position or shape alterations.
2. Changes in tooth morphology.
3. Diastemas closure
4. Repairing incisal fractures.
5. anterior restorations which are extensive
6. Non-Carious Lesions (attrition, abrasion, abfraction).
7. Changing color of the tooth
8. rehabilitation for developing anterior guide
9. Repairing crowns and bridges.
- Contraindications:
- Inadequate enamel or tooth structure (e.g., amelogenesis, dentinogenesis imperfecta).
- root canal-treated teeth or Large existing restorations with minimal tooth structure.
- Oral habits causing excessive interdental spacing or excessive stress
Procedure for shade selection
- Key tips for shade selection:
- Perform shade matching early in the appointment to avoid color fatigue.
- Use neutral-colored drapes, remove patient makeup, and clean teeth.
- Match shades at 5-second intervals to prevent eye fatigue.
- Use canines as reference points.
- Grind off the shade tabs with darker neck.
- When in doubt, select a shade with lower chroma and higher value.
Tooth Preparation
- Need for Preparation:
- finish line needs to be definite
- should Provide space for veneer.
- Expose fluoride rich layer .
- for better retention Create a rough surface
- Recommended Preparation:
- Conservative intra-enamel preparation with 0.3-0.5 mm facial enamel reduction.
- Finish line close or at the gingival margin.
- Avoid sharp internal angles, especially at the incisal edge.
- Ensure a path of insertion free from undercuts. 40-43
IX. Conclusion
Importance of Esthetics in Dentistry
- Esthetics is now a respected term in dentistry, previously overshadowed by function, structure, and biology.
- Successful treatment planning must prioritize esthetic impact to avoid poor outcomes.
- Interdisciplinary treatment planning should start with clear esthetic objectives and consider function, structure,
and biology for optimal dental care.
- Increased patient awareness highlights the need for responsible esthetics, emphasizing minimal intervention and
treating disease before resorting to surgery.
- Maintaining healthy tooth structure through minimal intervention improves overall oral health.
Reference
[1] Roulet Jf. Marginal Integrity: Clinical Significance. Journal Of Dentistry. 1994 Jan 1;22:S9-12.
[2] Fondriest J, Raigrodski Aj. Incisal Morphology And Mechanical Wear Patterns Of Anterior Teeth: Reproducing Natural Wear
Patterns In Ceramic Restorations. Am J Esthet Dent. 2012;2(2):98-114.
[3] Hornbrook D. Metal-Free Restorative Dentistry “It’s More Than Just About Aesthetics “. Oral Health Journal. 2014;4:E10-24.
[4] Mathew C, Mathew S, Karthik Ks. A Review On Ceramic Laminate Veneers. J Indian Acad Dent Spec. 2010 Oct;1(4):33-7.
[5] Wildgoose Dg, Johnson A, Winstanley Rb. Glass/Ceramic/Refractory Techniques, Their Development And Introduction Into
Dentistry: A Historical Literature Review. The Journal Of Prosthetic Dentistry. 2004 Feb 1;91(2):136-43.
[6] Pitel Ml. Low-Shrink Composite Resins: A Review Of Their History, Strategies For Managing Shrinkage, And Clinical
Significance. Compend Contin Educ Dent. 2013 Sep 1;34(8):578-90.
[7] Conrad Hj, Seong Wj, Pesun Ij. Current Ceramic Materials And Systems With Clinical Recommendations: A Systematic Review.
The Journal Of Prosthetic Dentistry. 2007 Nov 1;98(5):389 404.
[8] Van Meerbeek B, Vargas M, Inoue S, Yoshida Y, Peumans M, Lambrechts P, Vanherle G. Adhesives And Cements To Promote
Preservation Dentistry. Operative Dentistry. 2001 Aug 1;26:119-44.
[9] Worschech Cc. Case Report: Ceramic Microlaminates For Esthetic Restoration/Claudia Cia Worschech. Micro: The International
Journal Of Microdentistry Inaugural. 2009;1(1):48-55.
[10] Worschech Cc. Ceramic Microlaminates For Esthetic Restoration. Micro: The International Journal Of Microdentistry. 2009 Aug
1;1.
[11] Gary M. Radz. Composite Resins In 2013: An Update On Their Progress. Compend 2013; 34(1):48-51.
[12] Alhekeir Df, Al-Sarhan Ra, Al Mashaan Af. Porcelain Laminate Veneers: Clinical Survey For Evaluation Of Failure. The Saudi
Dental Journal. 2014 Apr 1;26(2):63-7.
[13] Cramer Nb, Stansbury Jw, Bowman Cn. Recent Advances And Developments In Composite Dental Restorative Materials. Journal
Of Dental Research. 2011 Apr;90(4):402-16.
[14] Feigal Rj, Hitt J, Splieth C. Retaining Sealant On Salivary Contaminated Enamel. Journal Of The American Dental Association
(1939). 1993 Mar 1;124(3):88-97.
[15] Ferrari M, Mason Pn, Fabianelli A, Cagidiaco Mc, Kugel G, Davidson Cl. Influence Of Tissue Characteristics At Margins On
Leakage Of Class Ii Indirect Porcelain Restorations. American Journal Of Dentistry. 1999 Jun 1;12(3):134-42.
[16] Thompson Jy, Bayne Sc, Heymann Ho. Mechanical Properties Of A New Mica-Based Machinable Glass-Ceramic For Cad/Cam
Restorations. The Journal Of Prosthetic Dentistry. 1996 Dec 1;76(6):619-23.
[17] Taylor Df, Bayne Sc, Leinfelder Kf, Davis S, Koch Gg. Pooling Of Long-Term Clinical Wear Data For Posterior Composites.
American Journal Of Dentistry. 1994 Jun 1;7(3):167-74.
[18] Wendt Jr Sl, Leinfelder Kf. The Clinical Evaluation Of Heat-Treated Composite Resin Inlays. The Journal Of The American
Dental Association. 1990 Feb 1;120(2):177-81.
[19] Feilzer Aj, De Gee Aj, Davidson Cl. Increased Wall-To-Wall Curing Contraction In Thin Bonded Resin Layers. Journal Of Dental
Research. 1989 Jan;68(1):48-50.
[20] Kj A. Phillips’ Science Of Dental Materials. St. Louis: Wb Saunders. 2003;596:41-3.
[21] Skorulska A, Piszko P, Rybak Z, Szymonowicz M, Dobrzyński M. Review On Polymer, Ceramic And Composite Materials For
Cad/Cam Indirect Restorations In Dentistry—Application, Mechanical Characteristics And Comparison. Materials. 2021 Mar
24;14(7):1592.
[22] Astekar D, Vagarali H, Pujar M, Uppin V, Kittur M. Indirect Restorations-A Review. Al Ameen J Med Sci; Volume 13, No.2,
2020 (2)
[23] Zvezdin Vv, Hisamutdinov Rm, Rakhimov Rr, Israfilov Ih, Saubanov Rr. Technology Of Overlay Laser Welding Of Durable
Powdery Into Blade Edge Of Miller. Iniop Conference Series: Materials Science And Engineering 2018 Sep 1 (Vol. 412, No. 1,
P. 012083). Iop Publishing.
[24] Burns Dr, Beck Da, Nelson Sk. A Review Of Selected Dental Literature On Contemporary Provisional Fixed Prosthodontic
Treatment: Report Of The Committee On Research In Fixed Prosthodontics Of The Academy Of Fixed Prosthodontics. The
Journal Of Prosthetic Dentistry. 2003;90(5):474-97.
[25] Marchesi G, Camurri Piloni A, Nicolin V, Turco G, Di Lenarda R. Chairside Cad/Cam Materials: Current Trends Of Clinical Uses.
Biology. 2021 Nov 12;10(11):1170.
[26] Yun Z, Jing B, Jing Zx. The Survival Rate Of Ceramic Inlay And Onlay Restorations In Posterior Teeth With One-Surface Or
Multi-Surface After A 10-Year Follow-Up: A Systematic Review And Meta-Analysis. Vojnosanitetski Pregled. 2021 Jun 11;78(5).
[27] Sorrentino R, Ruggiero G, Toska E, Leone R, Zarone F. Clinical Evaluation Of Cement Retained Implant-Supported Cad/Cam
Monolithic Zirconia Single Crowns In Posterior Areas: Results Of A 6-Year Prospective Clinical Study. Prosthesis. 2022 Jul
27;4(3):383-93.
[28] Falahchai M, Babaee Hemmati Y, Neshandar Asli H, Neshandar Asli M. Marginal Adaptation Of Zirconia‐Reinforced Lithium
Silicate Overlays With Different Preparation Designs. Journal Of Esthetic And Restorative Dentistry. 2020 Dec;32(8):823-30.
[29] Baader K, Hiller Ka, Buchalla W, Schmalz G, Federlin M. Self-Adhesive Luting Of Partial Ceramic Crowns: Selective Enamel
Etching Leads To Higher Survival After 6.5 Years In Vivo. J Adhes Dent. 2016 Jan 1;18(1):69-79.
[30] Hegde Vr, Joshi Sr, Hattarki Sa, Jain A. Morphology-Driven Preparation Technique For Posterior Indirect Bonded Restorations.
Journal Of Conservative Dentistry: Jcd. 2021 Jan;24(1):100.
[31] Vagropoulou Gi, Klifopoulou Gl, Vlahou Sg, Hirayama H, Michalakis K. Complications And Survival Rates Of Inlays And Onlays
Vs Complete Coverage Restorations: A Systematic Review And Analysis Of Studies. Journal Of Oral Rehabilitation. 2018
Nov;45(11):903-20.
[32] Luciano M, Francesca Z, Michela S, Tommaso M, Massimo A. Lithium Disilicate Posterior Overlays: Clinical And Biomechanical
Features. Clinical Oral Investigations. 2020 Feb;24:841-8.
[33] Lu T, Peng L, Xiong F, Lin Xy, Zhang P, Lin Zt, Wu Bl. A 3-Year Clinical Evaluation Of Endodontically Treated Posterior Teeth
Restored With Two Different Materials Using The Cerec Ac Chair-Side System. The Journal Of Prosthetic Dentistry. 2018 Mar
1;119(3):363-8.
[34] Burgoyne Ar, Nicholls Ji, Brudvik Js. In Vitro Two-Body Wear Of Inlay-Onlay Composite Resin Restoratives. The Journal Of
Prosthetic Dentistry. 1991 Feb 1;65(2):206-14.
[35] Alhekeir Df, Al-Sarhan Ra, Al Mashaan Af. Porcelain Laminate Veneers: Clinical Survey For Evaluation Of Failure. The Saudi
Dental Journal. 2014 Apr 1;26(2):63-7
[36] Worschech Cc. Case Report: Ceramic Microlaminates For Esthetic Restoration/Claudia Cia Worschech. Micro: The International
Journal Of Microdentistry Inaugural. 2009;1(1):48-55.
[37] Worschech Cc. Ceramic Microlaminates For Esthetic Restoration. Micro: The International Journal Of Microdentistry. 2009 Aug
1;1.
[38] Gary M. Radz. Composite Resins In 2013: An Update On Their Progress. Compend 2013; 34(1):48-51.
[39] Kaur P, Luthra R. Nanocomposites-A Step Towards Improved Restorative Dentistry. Indian Journal Of Dental Sciences. 2011 Oct
1;3(4). .
[40] Isgro G, Van Noort R, Cannavina G. Development Of Dental Laboratory Composites. Qdt. 2001.
[41] Ravi Rk, Alla Rk, Shammas M, Devarhubli A. Dental Composites-A Versatile Restorative Material: An Overview. Indian Journal
Of Dental Sciences. 2013 Dec 1;5(5)..
[42] Nandini S. Indirect Resin Composites. Journal Of Conservative Dentistry: Jcd. 2010 Oct;13(4):184..
[43] Radz Gm. Minimum Thickness Anterior Porcelain Restorations. Dental Clinics Of North America. 2011 Apr 1;55(2):353-70