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BFE Past Paper 2013

Uob Bioscience for Grads recent year paper

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Shreyas Kolwankar
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18 views6 pages

BFE Past Paper 2013

Uob Bioscience for Grads recent year paper

Uploaded by

Shreyas Kolwankar
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 6

Calculators may be used in this examination but must not be used to store

text. Calculators with the ability to store text should have their memories
deleted prior to the start of the examination.

School of Chemical Engineering

MSc Advanced Chemical Engineering


MSc Biochemical Engineering
MSc Mathematics and Computation in Biology and Medicine
EngD Formulation Engineering
PhD with Integrated Studies Physical Sciences of Imaging in the Biomedical
Sciences
UG Aff School of Chemical Engineering

04 17142, 04 18520, 04 19767

Bioscience for Engineers


Bioscience for graduates of other scientific disciplines

January 2013

Time Allowed: 2 hours

Answer THREE questions from five.

All questions carry equal marks.

The distribution of marks within each question is given as a percentage of the


total marks for the question.

ANSWER EACH QUESTION IN A SEPARATE ANSWER BOOK.

PLEASE TURN OVER

Page 1 of 6
1. Answer ALL parts (a)-(d).

a) Proteins are a class of polymeric macromolecule present in cells. What


are the monomer units that comprise proteins, and how are they joined
together? Illustrate your answer with chemical structures.

[10% of the marks]

b) Describe the four levels of protein structure. How does each level of
protein structure affect the function of the protein?

[20% of the marks]

c) Proteins are synthesised in a process called translation. Describe this


process, making sure to include:

 The molecules and enzyme(s) involved in translation; and


 The stages that are involved in translation.
[50% of the marks]

d) Many proteins are enzymes. What are the general properties of


enzymes?
[20% of the marks]

PLEASE TURN OVER

Page 2 of 6
2. Answer ALL parts (a)-(c).

Control of cellular function is mediated on a number of levels, both


within a single cell and between different cells.

a) Compare and contrast cell signalling via Type 1 (Direct ligand-gated


ion channel) and Type 3 (Tyrosine-kinase lined) receptors. Describe
the events that occur in each type of receptor upon ligand binding, and
the timescale over which these events occur. What sort of cellular
functions does each type of receptor mediate?
[25% of the marks]

b) In eukaryotic cells, mRNA generated during transcription is processed


before being translated to protein. Describe each step of this process,
and ensure that you explain the function of each modification step.
Where does this process occur?
[25% of the marks]

c) Describe the process of mitosis in somatic cells.


[50% of the marks]

PLEASE TURN OVER

Page 3 of 6
3. Answer ALL parts (a)-(e)
Many cellular functions occur at the membrane or cell wall.

a) Describe the structure and properties of an animal (eukaryotic) cell


membrane.
[15% of the marks]

b) Describe the differences in the structure of Gram-positive and Gram-


negative bacterial cell walls.
[25% of the marks]

c) Other than energy generation, describe the function of three classes of


proteins that can be found in the bacterial membrane.
[15% of the marks]

d) Describe how the electron transport chain is used to generate energy


in the form of ATP. Where does this process occur in eukaryotic cells?
[35% of the marks]

e) What properties of ATP make it an ideal energy transfer molecule?


[10% of the marks]

PLEASE TURN OVER

Page 4 of 6
4. Answers ALL parts (a)-(d)

a) The cardiovascular system comprises the heart, blood vessels and the
lungs. Describe, with the aid of a diagram, the oxygenation of the blood
in the heart-lung circuit. Make sure to include the direction of blood flow
in your description.
[35% of the marks]

b) In general, oxygenated blood is carried in arteries to the capillary beds


of the tissues where gas exchange occurs whereas deoxygenated
blood is carried in veins. State the structural differences between
arteries and veins and explain the functional importance of these
structural differences.
[15% of the marks]

c) The walls of the heart are made of a specialised type of muscle known
as cardiac muscle. Compare and contrast this muscle type with
skeletal muscle, giving information about the cell type, nervous control
and function.
[20% of the marks]

d) Give an account of the contraction of skeletal muscle from the fibre


level to the whole muscle level and make reference to how this action
controls movement of the body.
[30% of the marks]

PLEASE TURN OVER

Page 5 of 6
5. Answer all parts (a-c)

Proteins, in the form of enzymes and growth factors, are produced industrially
using prokaryotic and eukaryotic cell cultures.

a) Enzymes are highly sensitive to process conditions.

i) What is it that causes this sensitivity?


[10% of the marks]

ii) List which process conditions influence enzyme activity?


[15% of the marks]

b) Proteins designed for therapeutic use are more likely to be functional if formed
in a eukaryotic cell. Explain why this is the case giving attention to:

i) How the protein may be modified and by which organelles?


[20% of the marks]

ii) What is the result of incorrect modification in prokaryotic cells?


[10% of the marks]

c) Cells can be induced to form a particular protein using the process of


transfection. Transfection, however, is usually of low efficiency. Describe,
using a flow diagram, one method that can be used to select for cells that
have been successfully transfected.
[45% of the marks]

END

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