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Cyclamen Aldehyde

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23 views3 pages

Cyclamen Aldehyde

Uploaded by

Arfianda Bachtiar
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Amendment 49 IFRA STANDARD

Cyclamen aldehyde

CAS-No.: 103-95-7
The scope of this Standard includes, but is not limited to the CAS number(s) indicated
above; any other CAS number(s) used to identify this fragrance ingredient should be
considered in scope as well.

Synonyms: Benzenepropanal, α-methyl-4-(1-methylethyl)-


Benzenepropanol, .α.-methyl-4-(1-methylethyl)-
3-p-Cumenyl-2-methylpropionaldehyde
p-Isopropyl-α-methylhydrocinnamaldehyde
3-(4-Isopropylphenyl)-2-methylpropanal
2-Methyl-3-(p-isopropylphenyl)propionaldehyde
α-Methyl-p-isopropylphenylpropylaldehyde
α-Methyl-4-(1-methylethyl)benzenepropanal
Cyclamal (commercial name)
Cyclaviol (commercial name)
Cyclosal (commercial name)

History: Publication date: 2020 (Amendment 49) Previous 2013


Publications: 2015

Implementation For new creation*: February 10, 2021


dates: For existing creation*: February 10, 2022
*These dates apply to the supply of fragrance mixtures (formulas) only, not to the
finished consumer products in the marketplace.

RECOMMENDATION: RESTRICTION / SPECIFICATION

MAXIMUM ACCEPTABLE CONCENTRATIONS IN THE FINISHED PRODUCT (%):

Category 1 0.11 % Category 7A 0.076 %

Category 2 0.14 % Category 7B 0.076 %

Category 3 0.038 % Category 8 0.025 %

Category 4 0.95 % Category 9 0.23 %

Category 5A 0.45 % Category 10A 0.23 %

Category 5B 0.076 % Category 10B 0.72 %

Category 5C 0.076 % Category 11A 0.025 %

2020 (Amendment 49) 1/3


Amendment 49 IFRA STANDARD

Cyclamen aldehyde

Category 5D 0.025 % Category 11B 0.025 %

Category 6 0.076 % Category 12 16 %

FRAGRANCE INGREDIENT SPECIFICATION: Cyclamen aldehyde should not contain more than
1.5% of Cyclamen alcohol.

FLAVOR REQUIREMENTS: Due to the possible ingestion of small amounts of


fragrance ingredients from their use in products in
Categories 1 and 6, materials must not only comply
with IFRA Standards but must also be recognized
as safe as a flavoring ingredient as defined by the
IOFI Code of Practice (www.iofi.org). For more
details see chapter 1 of the Guidance for the use of
IFRA Standards.

CONTRIBUTIONS FROM OTHER SOURCES: NONE TO CONSIDER BEYOND TRACES (SEE


ALSO THE SECTION ON CONTRIBUTIONS
FROM OTHER SOURCES IN CHAPTER 1 OF
THE GUIDANCE FOR THE USE OF IFRA
STANDARDS)

Cyclamen aldehyde has been found in natural extracts but only at trace levels.

INTRINSIC PROPERTY DRIVING RISK DERMAL SENSITIZATION AND SYSTEMIC


MANAGEMENT: TOXICITY

RIFM SUMMARIES:

Maximum acceptable concentrations are based on a comprehensive safety assessment, considering


various endpoints. Depending on the outcome of the safety assessment, it might be one or more
endpoint(s) that will drive the derivation of the concentration levels. If more than one endpoint is of
relevance, the maximum acceptable concentrations for each product category are derived from comparing
maximum permitted level per endpoint consideration (e.g. dermal sensitization and/or systemic toxicity).
Such maximum acceptable concentrations correspond to the lowest level obtained per category.

Additional information is available in the RIFM safety assessment for Cyclamen aldehyde, which can be
downloaded from the RIFM Fragrance Material Safety Assessment Center:
http://fragrancematerialsafetyresource.elsevier.com/.

EXPERT PANEL FOR FRAGRANCE SAFETY RATIONALE / CONCLUSION:

The Expert Panel for Fragrance Safety reviewed all the available data for Cyclamen aldehyde and
recommends the concentrations for the 12 different product categories, which are the maximum acceptable
concentrations of Cyclamen aldehyde in the various product categories.
In addition, they recommend to use Cyclamen aldehyde according to the specification above mentioned.

REFERENCES:

2020 (Amendment 49) 2/3


Amendment 49 IFRA STANDARD

Cyclamen aldehyde

The IFRA Standard on Cyclamen aldehyde is based on at least one of the following publications:

• The RIFM Safety Assessment on Cyclamen aldehyde if available at the RIFM Fragrance Material Safety
Assessment Center: http://fragrancematerialsafetyresource.elsevier.com

• Api A.M., Belsito D., Bruze M., Cadby P., Calow P., Dagli M. L., Dekant W., Dent M., Ellis G., Fryer A. D.,
Fukayama M., Griem P., Hickey C., Kromidas L., Lalko J., Liebler D.C., Miyachi Y., Politano V.T., Renskers
K., Ritacco G., Salvito D., Schultz T.W., Sipes I. G., Smith B., Vitale D., Wilcox D.K. (2015). Criteria for the
Research Institute for Fragrance Materials, Inc. (RIFM) safety evaluation process for fragrance ingredients.
Food Chem Toxicol. 2015 Aug;82 Suppl:S1-S19
(http://fragrancematerialsafetyresource.elsevier.com/sites/default/files/Criteria_Document_Final.pdf).

• Salvito D.T., Senna R. J., Federle T.W. (2002). A framework for prioritizing fragrance materials for
aquatic risk assessment. Environ Toxicol Chem. 2002;21:1301-1308
(https://www.ncbi.nlm.nih.gov/pubmed/12069318).

Additional information on the application of IFRA Standards is available in the Guidance for the use of IFRA
Standards, publicly available at www.ifrafragrance.org.

2020 (Amendment 49) 3/3

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