Scribd
Upload
38 views3 pages

Practical 8

prctl

Uploaded by

paruldamor666
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
38 views3 pages

Practical 8

prctl

Uploaded by

paruldamor666
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
You are on page 1/ 3

PRACTICAL 8

AIM: Formulation and evalution of sustained release matrix tablets.

REFERENCE:

REQUIREMENT: Beaker, UV Spectrophotometer, Dissolution apparatus, Filter paper, Water bath


shaker

PROCEDURE:

[SUSTAINED RELEASE TABLET]

 Sustained release tablets of Paracetamol were prepared by direct compression using


different polymers at various concentrations (50, 100, 150 mg) will be accurately weighed
and passed through sieve no. 45.
 The content was mixed thoroughly in a mixer for 10 minutes.
 Add lubricant and glidants to the above mixture and again mixed for 5 minutes.
 Then the mixture was directly compressed on a Rotary Tablet Machine.

USING BINDER 1- [HPMC]

FORMULA

Paracetamol
Lactose
HPMC
PVP K40
Magnesium Stearate
SSG

EVALUTION STUDIES:

1.WEIGHT VARIATION: Twenty tablets were randomly selected from each batch individually
weigh, the average weight and standard deviation of 20 tablet calculated.

2.CAR’S INDEX: Carr's index (CI) is a measurement of a powder's flowability and is


calculated using the formula: CI=100[ρT−ρB/ρB]

3.Bulk density: To calculate the bulk density of tablet, you can use the following
formula:
ρ = m/V

formula: 𝑚/𝑉f
4.TAPPED DENSITY: To calculate the tapped density of tablet, you can use the following
5.THICKNESS: The thickness of the tablet was measured by using digital vernier caliper,
twenty tablets from each batch were randomly selected and thickness was measured.

6.HARDNESS: Hardness was measured using hardness tester, for each batch three tablet
were tested.

7.% FRIABILITY: Twenty tablets were weighed and placed in the Roche Friabilator and
apparatus was rotated at 25 rpm for 4 min.
After revolution the tablets were dusted weight.
% loss= (initial wt. of tablets – final wt. of tablets /initial wt. of tablet) x 100

8.DISINTEGRATION TEST:
 The disintegration time is determined by using disintegration apparatus.
 Randomly select 6 tablets and Place them in the disintegration basket containing
900ml of phosphate buffer pH 7.8, maintaining the temperature at 37±20C as this is
the required temperature per monograph to run disintegration test.
 Note the time taken for complete disintegrate in to small particles.
 Perform the test in triplicate and note down the average time taken by the tablets
for disintegration

9.DISSOLUTION TEST:

 The dissolution medium was 900 ml of 0.1 N HCl.


 The dissolution vessel was maintained at 37±0.500C with 750ml , being stirred at 50
rpm during the first 2 hours, then 242 ml of 0.2 M Na3PO4(tri-sodium phosphate)
was added, and adjusted to pH 7.4 by 6 N NaOH.
 Samples were filtered through filter paper (0.70 μm), and collected at
predetermined time intervals for 12 h dissolution studies.
 Filtered solutions were centrifuged at 3000 rpm for 10 minutes, supernatants were
filtered again through 0.45 μm membrane and measure paracetamol absorbance at
257 nm.
 Dissolution drug concentrations were determined via standard curves.

OBSERVATION TABLE:

Sr WT. CAR’S Bulk TAPPED HARDNESS % DISINTEGRATION DISSOLUTION


no. VARIATIO INDEX density DENSIT FRIABILITY
N Y
1.
2.
3.
4.
5.
6.
USING BINDER 2-[TALC]

FORMULA

Paracetamol
Talc
Lactose
Magnesium Stearate
PVP K40
SSG

OBSERVATION TABLE FOR BINDER 2 [TALC]

Sr WT. CAR’S Bulk TAPPED HARDNESS % DISINTEGRATION DISSOLUTION


no. VARIATIO INDEX density DENSIT FRIABILITY
N Y
1.
2.
3.
4.
5.
6.

RESULT:

You might also like

pFad - Phonifier reborn

Pfad - The Proxy pFad of © 2024 Garber Painting. All rights reserved.

Note: This service is not intended for secure transactions such as banking, social media, email, or purchasing. Use at your own risk. We assume no liability whatsoever for broken pages.


Alternative Proxies:

Alternative Proxy

pFad Proxy

pFad v3 Proxy

pFad v4 Proxy