Rajiv

RajivGandhi
GandhiUniversity
Universityofof
Health Sciences,
Health Karnataka
Sciences, Karnataka
Second Semester B.Pharm Degree Examination – JAN-2019
Time: Three Hours Max. Marks: 75 Marks
Pharmaceutical Organic Chemistry-I
Q.P. CODE: 5006
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary

LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks

1. What happens when propene is treated with hydrogen bromide? Discuss the mechanism
involved in the presence and absence of peroxide.
2. Discuss the mechanism, stereochemistry and kinetics involved in unimolecular nucleophilic
substitution reaction by selecting an appropriate example.
3. Explain the mechanism of Benzoin condensation and crossed Cannizzaro reaction.

SHORT ESSAYS (Answer any Seven) 7 x 5 = 35 Marks

4. Give the structure of (a) 2,2-dimethyl propane (b) 3-chloro pentane-2-one (c)1,3-
butadiene (d) Ethyl methyl ketone (e) 2-bromo-3-methyl hexane.
5. Enlist the different types of hybridization in carbon compounds and explain any one type.
6. Explain the orientation and mechanism of E2 reaction.
7. Enlight the concept of rearrangement reaction of carbocation with suitable examples.
8. Give any four qualitative tests for alcohol.
9. Explain the mechanism of Aldol condensation.
10. What are carbonyl compounds? Describe any two methods of preparation for aldehydes
and ketones.
11. Explain the effect of substituents on acidity of carboxylic acids.
12. What are aliphatic amines? Explain any three chemical reactions of aliphatic amines.

SHORT ANSWERS (Answer All) 10 x 2 = 20 Marks

13. Define functional isomerism with example.
14. Write the structure of a) 2-bromo 3-methyl hexane b) Methanol.
15. What are paraffins? Give two examples.
16. Explain the stability of alkene with examples.
17. Give the structure and use of Iodoform and chloroform.
18. Write the structure and uses of vanillin and benzaldehyde.
19. Write any one qualitative test for cinnamaldehyde and paraldehyde.
20. Write any two qualitative test for esters.
21. Write the structure and uses of succinic acid and oxalic acid.
22. Write the structure and uses of ethylenediamine an amphetamine.

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Rajiv
RajivGandhi
GandhiUniversity
Universityofof
Health Sciences,
Health Karnataka
Sciences, Karnataka
Second Semester B.Pharm Degree Examination – JUNE-2019
Time: Three Hours Max. Marks: 75 Marks

Pharmaceutical Organic Chemistry-I

Q.P. CODE: 5006
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary

LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks

1. Explain the factors affecting SN1 and SN2 reactions.

2. a) Carboxylic acids are acidic in nature, Why? Chloro acetic acid more acidic than acetic
acid. Give reason.
b) Explain the SP3 hybridization in alkanes.

3. Outline the mechanism of Perkin’s condensation and Aldol condensation.

SHORT ESSAYS (Answer any Seven) 7 x 5 = 35 Marks

4. Explain in detail Free radical substitution reaction mechanism.
5. Explain the kinetics, mechanism and order of reactivity of E 1 reaction.
6. Explain the basicity of amines with suitable examples.
7. Explain Cannizzaro condensation with mechanism.
8. Write the structure and IUPAC name of a) Formic acid b) Neopentane c) Isopropyl alcohol
d) Ethyl acetoacetate e) Formamide.

9. What are Cycloaddition reactions? Explain Diel’s alder reaction with mechanism.,
10. Define and classify attacking reagents with examples.
11. Write the mechanism of Benzoin condensation reaction.
12. What is peroxide effect Write its mechanism.

SHORT ANSWERS (Answer All) 10 x 2 = 20 Marks

13. Define structural isomerism with example.
14. What are paraffins? Give two examples.
15. Write any one qualitative test for Benzyl alcohol and Benzoic acid.
16. Write structure and uses of Amphetamine and Chlorobutanol.
17. Write the structure and uses of Ethanolamine and Trichloroethylene.
18. Define free radical and nucleophile.
19. What is Inductive effect? Give example.
20. What is Cross Cannizzaro reaction?
21. What is markownikoff’s reaction?
22. What is ozonolysis? Give example.

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Rajiv
RajivGandhi
GandhiUniversity
Universityofof
Health Sciences,
Health Karnataka
Sciences, Karnataka
Second Semester B.Pharm Degree Examination – 07-Jan-2020
Time: Three Hours Max. Marks: 75 Marks
Pharmaceutical Organic Chemistry-I
Q.P. CODE: 5006
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary

LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks

1. Explain Kinetics, mechanism, stereochemistry and reactivity of SN2 reaction.

2. What are elimination reactions? Discuss the kinetics, mechanism, orientation and reactivity
of E1 reaction.
3. Explain the Benzoin condensation and Cannizzaro condensation with mechanism.

SHORT ESSAYS (Answer any Seven) 7 x 5 = 35 Marks

4. Write the stability order of free radicals. Give reason.
5. What is Aldol condensation? Discuss the mechanism involved.
6. Write any three methods of preparation of Alkanes.
7. Write the mechanism of Perkin condensation.
8. Explain the mechanism of anti-Markovnikov’s addition reaction with suitable example.
9. Explain Factor affecting E1 reaction.
10. Explain in detail saytzeff’s rule with suitable example.
11. Discuss the rearrangement of carbocation with suitable examples.
12. What is isomerism? Classify them with suitable examples.

SHORT ANSWERS (Answer All) 10 x 2 = 20 Marks

13. Write the structure of a) 2-bromo 3-methyl hexane b) amphetamine.
14. What are Elimination and Substitution reactions?
15. Write the structure and IUPAC name of a) Ethyl methyl ketone b) Diethyl ether.
16. Define amines. Give the reason why amines are basic in nature.
17. Write structure and uses of Ethylenediamine and Formaldehyde.
18. Write qualitative test for Cinnamaldehyde and Acetone.
19. What are Nucleophiles? Give two examples.
20. Write two chemical tests for aldehydes.
21. What is Cross Aldol condensation?
22. Write structure and uses of Acetic acid and Lactic acid.

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Rajiv
RajivGandhi
GandhiUniversity
Universityofof
Health Sciences,
Health Karnataka
Sciences, Karnataka
Second Semester B. Pharm Degree Examination – 14-Dec-2020
Time: Three Hours Max. Marks: 75 Marks
Pharmaceutical Organic Chemistry-I
Q.P. CODE: 5006
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary

LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks

1. Define elimination reaction. Discuss the Kinetics and mechanism of E 1 and E2 reaction with
suitable example.
2. Explain kinetics, mechanism, stereochemistry and reactivity of SN 1 reaction.
3. Explain the reaction and mechanism of Perkin condensation and Aldol condensation.

SHORT ESSAYS (Answer any Seven) 7 x 5 = 35 Marks

4. Write the general rules for IUPAC nomenclature of alkanes.
5. Define hybridization? Explain SP3 hybridization in ethane.
6. Give the mechanism involved in the electrophilic addition reactions of conjugated dienes.
7. Define and classify carbocations. Write a note on stability of them.
8. How do you distinguish primary, secondary and tertiary alcohols by chemical test.
9. Explain the reaction and mechanism of Cannizzaro reaction.
10. What are carbonyl compounds? Give any three general reactions of ketones.
11. Explain ionisation of carboxylic acid and write the structure of carboxylate anion.
12. Discuses any four chemical reactions of aliphatic amines.

SHORT ANSWERS (Answer All) 10 x 2 = 20 Marks

13. Define metamerism with example.
14. Write the structure and IUPAC name of a) Isopropyl alcohol b) Ethyl acetoacetate.
15. Give an example of Diel’s alder reaction.
16. Write the uses of paraffins.
17. Give the structure and use of Tetrachloroethylene and Tetrachloromethane.
18. Write the structure and uses of benzaldehyde and paraldehyde.
19. How do you differentiate aldhydes and ketones by chemical test.
20. Write any two qualitative tests for amides.
21. Write the structure and uses of tartaric acid and citric acid.
22. Write the structure and uses of ethanolamine and amphetamine.

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Rajiv
RajivGandhi
GandhiUniversity
Universityofof
Health Sciences,
Health Karnataka
Sciences, Karnataka
Second Semester B.Pharm Degree Examination – 18-Mar-2021
Time: Three Hours Max. Marks: 75 Marks

Pharmaceutical Organic Chemistry-I

Q.P. CODE: 5006
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
All the questions are compulsory

LONG ESSAYS 2 x 10 = 20 Marks

1. a. Define and classify carbocation. Add a note on stability of carbocation.

b. Differentiate between SN1 and SN2 reactions
OR
Discuss the mechanism, reactivity and factors effecting in Elimination Uni-molecular reaction.

2. a) Explain the stability of conjugated dienes.

b) What is peroxide effect? Write its mechanism

SHORT ESSAYS 7 x 5 = 35 Marks

1
3. Write the mechanism and orientation of SN reaction with suitable example
OR
What are Cycloaddition reactions? Explain Diel’s alder reaction with mechanism

4. Explain the mechanism of Perkin’s condensation

OR
Give the structure and uses of a) Benzyl alcohol b) Benzaldehyde c) Chloroform
d) Propylene glycol e) Ethyl alcohol

5. Explain the basicity of amines with suitable examples.

6. Discuss the acidity of carboxylic acid.
7. Write the statement and reaction mechanism of aldol condensation.
8. Explain in detail Saytzeff’s rule.
9. Write a note on free radical addition reaction.

SHORT ANSWERS 10 x 2 = 20 Marks

10. Write the structure and IUPAC name of a) Acetone b) Diethyl ether.
11. Write the structure of a) 1, 3-butadiene b) 2,4,6-tribromo aniline.
12. What is peroxide effect? Give examples.
13. Write qualitative test for Banzaldehyde and ether.
14. Write the structure and uses of Tartaric acid and Salicylic acid.
15. Write any one qualitative test for Acetone and Paraldehyde.
16. What are leaving groups? Give example.
17. Write the structure and IUPAC name of: a) Methyl formate b) Isopropyl alcohol
18. What is elimination reaction? Give an example.
19. Explain the Chemical reactions of Alcohol.

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Rajiv Gandhi University of Health Sciences, Karnataka