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The assignment focuses on analyzing survival data of cancer patients undergoing two treatments using SPSS and Python. It includes tasks such as descriptive analysis, Kaplan-Meier survival curves, log-rank test, and Cox proportional hazards model to evaluate treatment effectiveness. The final conclusion should summarize findings and provide recommendations on adopting the new therapy based on statistical evidence.

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4 views

Assignment_3_2

The assignment focuses on analyzing survival data of cancer patients undergoing two treatments using SPSS and Python. It includes tasks such as descriptive analysis, Kaplan-Meier survival curves, log-rank test, and Cox proportional hazards model to evaluate treatment effectiveness. The final conclusion should summarize findings and provide recommendations on adopting the new therapy based on statistical evidence.

Uploaded by

rowjatul.jannat.aust
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Assignment#3

Department of Mechatronics Engineering, RUET, Rajshahi.


Course No: Math 3127 Course Title: Numerical Analysis & Statistics
Course Instructor: Md. Manirul Islam (MMI)
Full Mark: 10 N.B.: Each question of this assignment covers both PO1 and PO2.
Instruction: Use both SPSS and Python software platform to perform the following analysis.
1.Q1 Regression Problem for Survival Analysis of Patients Undergoing Cancer Treatment
. This problem provides a real-world case for understanding survival analysis, particularly useful for
analyzing the effectiveness of treatments and predicting patient survival times.

Problem Statement
A hospital collects data on cancer patients undergoing two different treatments: Treatment A (a new
therapy) and Treatment B (a standard therapy). The goal is to analyze the survival times of patients
under both treatments and evaluate which treatment is more effective.
The data includes:
i. Survival times of patients (in months) after starting treatment.
ii. Whether the patient is censored (i.e., they are still alive at the time of data collection) or
uncensored (i.e., they have passed away).
iii. Treatment group (A or B). Age and Sex.

Dataset
The dataset contains 20 observations of patients' survival times, censored status, treatment groups, age,
and sex.
Survival Time Censor Status Treatment Group Age Sex
Patient ID
(Months) (0=Censored, 1=Event) (0=Control, 1=New Therapy) (Years) (0=Female, 1=Male)
1 12 1 0 55 1
2 24 0 1 62 0
3 9 1 0 48 1
4 18 1 1 58 0
5 30 0 0 65 1
6 6 1 1 42 0
7 15 0 0 52 1
8 28 1 1 60 0
9 10 1 0 45 1
10 22 0 1 57 0
11 14 1 0 50 1
12 26 0 1 63 0
13 8 1 0 43 1
14 20 1 1 59 0
15 32 0 0 68 1
16 5 1 1 40 0
17 16 0 0 54 1
18 29 1 1 61 0
19 11 1 0 46 1
20 23 0 1 58 0

 Survival Time: Time in months a patient survived after starting treatment.


 Status: 1 = Event (patient passed away), 0 = Censored (Patient alive at last follow-up).
 Treatment: 1 (new therapy) or 0 (standard therapy). Sex: M-Male, F-Female.

Tasks
(i). Descriptive Analysis:
o Compute the mean survival time for both Treatment A and Treatment B.
o Report the percentage of censored patients in each treatment group.
(ii). Kaplan-Meier Survival Curves:
o Plot Kaplan-Meier survival curves for both treatment groups.
o Compare the survival probabilities over time.
(iii). Log-Rank Test:
o Perform the log-rank test to compare the survival distributions between Treatment A and
Treatment B.
o State the null hypothesis (H0) and alternative hypothesis (H1).
o Report the test statistic, p-value, and draw conclusions at a significance level of α=0.05.
(iv). Cox Proportional Hazards Model:
o Fit a Cox regression model with treatment as a predictor variable to determine the
hazard ratio.
o Interpret the hazard ratio and explain if Treatment A significantly reduces the risk of
death compared to Treatment B.
(v). Conclusion:
o Summarize your findings.
o Recommend whether the hospital should adopt the new therapy (Treatment A) based on
statistical evidence.

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