Foundation Module I-Final
Foundation Module I-Final
FOUNDATION MODULE I
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S.No CONTENTS
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1 Overview 1
2 Introduction to Study Guide 2
3 Learning Methodologies 3-4
4 Module 1: FOUNDATION 5
4.1 Introduction 5
4.2 Objectives and strategies 6-17
5 Learning Resources 17
6 Assessment Methods 18
7 LNMC Examination Rules And Regulations 19
8 Schedule 20
LIAQUAT NATIONAL MEDICAL COLLEGE 1ST YEAR MBBS FOUNDATION MODULE
Module name: Foundation Year: One Duration: 7 weeks (February– March 2024)
BIOCHEMISTRY
PSYCHIATRY
Professor Faiza Waseem Dr. Iqtidar Toufiq
⚫ Dr. Sana Farooq Shah ⚫ Dr. Muhammad Ahsan ⚫ Dr. Yusra Nasir
LNH&MC MANAGEMENT
Professor KU Makki, Principal LNH&MC
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LIAQUAT NATIONAL MEDICAL COLLEGE 1ST YEAR MBBS FOUNDATION MODULE
INTRODUCTION
It is an aid to:
Guide students
on assessment
Help students methods, rules and
organize and regulations
Inform students manage their
how student studies throughout
learning program the module
module has been
organized
CURRICULUM FRAMEWORK
INTEGRATED CURRICULUM comprises system-based modules such as foundation and blood which links
basic science knowledge to clinical problems. Integrated teaching means that subjects are presented as
a meaningful whole. Students will be able to have better understanding of basic sciences when they
repeatedly learn in relation to clinical examples.
Case-based discussions, computer-based assignments, early exposure to clinics, wards, and skills
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LIAQUAT NATIONAL MEDICAL COLLEGE 1ST YEAR MBBS FOUNDATION MODULE
RSDC
Anatomy
Psychiatry
Gyneacology Physiology
Molecular Biochemistry
Pathology
Community
Medicine
LEARNING METHODOLOGIES
The following teaching/ learning methods are used to promote better understanding:
Interactive Lectures
Team- Based Learning
Small Group Discussion
Case- Based Learning
Practicals
Skills session
Self-Directed Study
INTERACTIVE LECTURES: In large group, the lecturer introduces a topic or common clinical conditions and
explains the underlying phenomena through questions, pictures, videos of patients’ interviews, exercises,
etc. Students are actively involved in the learning process.
TEAM- BASED LEARNING: Team-Based Learning is an evidence based collaborative learning teaching
strategy designed around units of instruction, known as “modules,” that are taught in a three-step cycle:
preparation, (b) in-class readiness assurance testing, and (c) application-focused exercise.
Preparation before class: Students must complete preparatory materials before a class or the start of
the module. Materials may be text, visual or other, and set at a level that is appropriate to the students
and the course.
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LIAQUAT NATIONAL MEDICAL COLLEGE 1ST YEAR MBBS FOUNDATION MODULE
In-class Readiness Assurance Testing: Students complete an individual readiness assurance test (IRAT),
consisting of 5 to 20 multiple choice questions. After submitting their individual answers, and they take
the same test, the team RAT (TRAT), with their team. All members of each team share the same TRAT
score, and both IRAT and TRAT scores count toward the students’ grades.
Instructor Feedback: The instructor reviews material from the RAT that seems to be difficult for students.
In-class application focused exercise: The remainder of the session is taken up with exercises that help
students learn how to apply and extend the knowledge that they have pre-learned and tested. Teams
are given an appropriate problem or challenge, and must arrive at a consensus to choose a “best”
solution out of options provided. Teams then display their answer choice, and the educator facilitates a
classroom discussion between teams to explore the topic and the possible answers to the problem.
SMALL GROUP DISCUSSION (SGD): This format helps students to clarify concepts acquire skills or
attitudes. Sessions are structured with the help of specific exercises such as patient case, interviews or
discussion topics. Students exchange opinions and apply knowledge gained from lectures, tutorials and
self study. The facilitator role is to ask probing questions, summarize, or rephrase to help clarify
concepts.
CASE- BASED LEARNING: A small group discussion format where learning is focused around a series of
questions based on a clinical scenario. Students’ discuss and answer the questions applying relevant
knowledge gained in clinical and basic health sciences during the module.
PRACTICAL: Basic science practicals related to anatomy, biochemistry and physiology are scheduled for
student learning.
SKILLS SESSION: Skills relevant to respective module are observed and practiced where applicable in
skills laboratory.
SELF DIRECTED STUDY: Students’ assume responsibilities of their own learning through individual study,
sharing and discussing with peers, seeking information from Learning Resource Center, teachers and
resource persons within and outside the college. Students can utilize the time within the college
scheduled hours of self-study.
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LIAQUAT NATIONAL MEDICAL COLLEGE 1ST YEAR MBBS FOUNDATION MODULE
MODULE 1: FOUNDATION
INTRODUCTION
This module has been designed to introduce you to the basics of health sciences. The course coversthe
molecular level of cell biology including genetics and its role in embryology, microbiology and
pathology.
You will also experience clinical skills such as learning to communicate effectively so that you can
relate to patients and their loved ones with compassion and understanding in coming years.
Through working within teams, your co-operative and approachable working style will be
enhanced. Through group and individual work, you will develop problem solving skills to applyyour
medical knowledge to practical situations. This, supplemented by lectures, and practical classes, is
a significant component of the course.
This study guide has been developed to help guide you and keep you focused on the
objectives for this module.
Welcome to the field of medicine and hope that the journey ahead will be exciting and fulfilling for you
all!!
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LIAQUAT NATIONAL MEDICAL COLLEGE 1ST YEAR MBBS FOUNDATION MODULE
ANATOMY
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LIAQUAT NATIONAL MEDICAL COLLEGE 1ST YEAR MBBS FOUNDATION MODULE
• List the features of synovial joint
• Classify Synovial joints on the basis of shape of articulating surfaces and
degree of mobility
• Explain the principles of innervation and blood supply of synovial joints
9. Nervous system- I: Somatic nervous system and typical spinal nerve
• List the basic divisions of Nervous system
• Define the various components of Central and Peripheral nervous systems
(CNS and PNS)
• Describe the structure of Neuron
• Classify neurons on the basis of number of processes and length of fibers
• Define a nerve and its coverings
• Differentiate between myelinated and unmyelinated fibers
• List various types of Neuroglia
• State their functions
• Define a spinal nerve
• List the spinal nerves in different regions
• Identify their location and site of emergence
• Identify various components of a typical spinal nerve
• Describe the fate of rami
• Describe the distribution of gray rami
10. Nervous system-II: Autonomic Nervous System (ANS)
• Describe the anatomical components of ANS
• Differentiate between sympathetic and parasympathetic systems based on
gross structure and distribution
11. Introduction to lymphatic system
• Define lymphatic system, lymphatics and lymph nodes
• Describe the structure of lymph nodes and their general distribution
• List various lymphoid tissues and organs
• Identify large lymphatic channels
• Discuss the role of lymphatics in the spread of cancer
12. Integumentary system -I Interactive
• Define the term integumentary system Lecture/Practical
• Discuss the functions of the skin
• Differentiate between epidermis and dermis
• Discuss the significance of tension lines
13. Integumentary system - II
• Discuss the main determinant of skin color
• Identify the appendages of the skin
• Differentiate between superficial and deep fascia
II. GENERAL EMBRYOLOGY
14. Terms of Embryology Interactive Lecture/
• Explain terms related to embryology Small Group Discussion
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LIAQUAT NATIONAL MEDICAL COLLEGE 1ST YEAR MBBS FOUNDATION MODULE
• List steps of cell division during mitosis
• Explain the significance of mitosis
• Define Meiosis
• List the steps of meiosis
• Differentiate first and second meiotic divisions
• State the phases of meiotic divisions
• Justify the importance meiosis in both sexes
• Differentiate between mitosis and meiosis
15. Introduction to Reproductive Organs
• Identify the male and female reproductive organs
• Describe Ovarian cycle
• Relate ovarian cycle with uterine cycle Interactive Lecture
• Describe the cyclical changes occurring in uterus, preparation of uterus for
implantation, and their endocrine control
16. Oogenesis & Spermiogenesis
• Define gametogenesis (oogenesis and Spermatogenesis)
• Describe the process of oogenesis
• Differentiate between primary and secondary oocytes
• Compare the male and female gametes
• Define gametogenesis
• Describe the sequence events of spermatogenesis
• Discuss the importance of mitosis and meiosis in spermatogenesis
• List the steps in spermiogenesis
• Differentiate between spermatogenesis and spermiogenesis
17. Transportation of Ovum and fertilization
• Explain transportation of sperm and ovum
• Define fertilization
• Discuss phases and results of fertilization
• Discuss the clinical aspects of fertilization
18. 1st week of development after fertilization
• Discuss the formation of zygote Interactive Lecture/
Small Group Discussion
• Explain the transport of zygote from ampulla of fallopian tube to the uterine /Tutorial
cavity
• Discuss initial stages of development by the process of cleavage.
• Explain the formation of blastocyst
19. 2nd Week of development
• Define implantation
• Explain the formation of outer and inner cell masses
• Discuss the further development of outer cell mass (trophoblast)
• Differentiate syncytiotrophoblast and cytotrophoblast with its microscopic
appearance
• Describe the process of implantation (day by day changes)
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LIAQUAT NATIONAL MEDICAL COLLEGE 1ST YEAR MBBS FOUNDATION MODULE
• State the differentiation of embryonic pole and development of bilaminar
germ disc with formation of Epiblast, hypoblast, and their cavities (amniotic
cavity and primary yolk sac)
• Discuss the development of the chorionic sac and Primary chorionic villi
• Enumerate the abnormal sites for implantation (ectopic pregnancy) and the
different diagnostic
tools
20. 3rd week of Development: Gastrulation, primitive streak and notochord
• Define gastrulation (formation of three germ layers)
• Discuss the development of primitive streak and related congenital anomalies
(Sacrococcygeal Teratoma)
• Describe the development of notochordal process, notochord canal,
prechordal plate and cloacal membrane
• Describe the location of allantois and its importance
• Discuss the formation of secondary and tertiary chorionic villi
• Describe the development of intra-embryonic coelom
21. 3rd week of Development: Neurulation and somite formation
• Define neurulation
• Describe briefly the events occurring in neurulation
• Describe briefly the formation of somites
22. Embryonic Period
• Define embryonic period
• Describe folding of embryo in median and horizontal planes
• List the derivatives of germ layers
• List events with the corresponding weeks, occurring during the period
23. Fetal Period
Interactive Lecture
• Define fetal period
• Discus the factors affecting fetal period/growth.
• Explain the week by week development of tissues and organs
• Describe the different milestone in development of fetus
• List the causes of fetal loss
24. Amnion, Chorion, umbilical cord and Yolk-Sac, Disorders of amniotic fluid
• List the fetal membranes
• Describe the structure of amnion and chorion
• Describe the formation, circulation and function of amniotic fluid
• Discuss the development of chorion and its complications
• Discuss the disorder related to amniotic fluid volume
• Describe the relationship of twinning (multiple pregnancies) with fetal
membranes
• Describe the umbilical cord (morphology, composite structures, positioning
and fate)
• Discuss the fate of umbilical vesicle (yolk sac)
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LIAQUAT NATIONAL MEDICAL COLLEGE 1ST YEAR MBBS FOUNDATION MODULE
25. Placenta
• Describe the changes in the maternal endometrium with formation of decidua
and decidual reaction Interactive
Lecture /Practical/
• Describe the different types of chorionic villi
Tutorial
• Explain the development of placenta, both the fetal and maternal part
• Describe the placental circulation and barrier
• Describe the functions of placenta
26. Prenatal diagnosis
• Discuss prenatal diagnosis Interactive
• List the types of prenatal diagnosis Lecture
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LIAQUAT NATIONAL MEDICAL COLLEGE 1ST YEAR MBBS FOUNDATION MODULE
• Enumerate the types, distribution and functions of cytoskeleton
• Describe the details of cytoplasmic filaments and microtubules
35. Cell Cycle
• Define cell cycle
• Explain various stages of cell cycle
• Explain the events of somatic cell division (mitosis)
• Discuss the significance of S phase of cell cycle
• Relate phases of cell cycle with the basis of development of cancer
36. Epithelium
• Describe the types, locations and functions of epithelium
• Describe the structural details of organization of cells in epithelium and other
basic tissues of body
• Explain their origin of germinal layer and their derivatives Interactive Lecture/
37. Cell Junctions Practical
• Define cell junction
• Name the junctions along the lateral and basal surfaces of cells
• Discuss the structure and functions of the five main types of cell junction
• List the sites of distribution and components of junctional complex
38. Glands
• Define glands
• Discuss the general feature and structure of exocrine glands
• Classify exocrine glands on the basis of number of cells, their structure and
types of secretions
39. Connective Tissues (Components)
• Define connective tissue
• Differentiate connective from epithelial tissue
• Describe the components of connective tissue
40. Connective Tissues (Classification)
• Classify different types of connective tissue
• Identify different types of connective tissue under the microscope
• State the distribution of each type
41. Histology of muscles
• Describe the histological features of different types of muscular tissue and
their location
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LIAQUAT NATIONAL MEDICAL COLLEGE 1ST YEAR MBBS FOUNDATION MODULE
BIOCHEMISTRY
OBJECTIVES LEARNING STRATEGY
TOPIC 1: WATER
1. Chemical nature of water
• Describe the structure and properties of water.
• Discuss the physicochemical properties of water (e.g. surface tension,
viscosity, adsorption)
• Explain the role of water as a Solvent
• Describe the role of water in forming molecular bonds.
2. Distribution of water
• Discuss the water distribution and homeostasis
• Explain the clinical aspects of water disturbances
3. pH and Buffers
• Describe the mechanism of dissociation of water and maintenance of normal
pH
• Discuss the change in pH due to the addition of a given quantity of acid or
base Interactive
• Describe the role of buffers in maintaining pH Lecture/Tutorial
• Explain the Henderson–Hassel Balch equation
TOPIC 2: CELL
4. Cell membrane
• Describe the biochemical composition
• Describe the functions of the cell membrane
5. Cell organelles
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LIAQUAT NATIONAL MEDICAL COLLEGE 1ST YEAR MBBS FOUNDATION MODULE
9. Polysaccharides
• Classify Polysaccharides with examples
• Explain the properties and functions of Polysaccharides
• Describe the clinical importance of Polysaccharides
TOPIC 4: LIPID CHEMISTRY
10. Lipid Classification
• Define Lipids with examples
• Classify Lipids with examples
• Describe the biochemical functions of lipids
11. Fatty acids
• Explain the chemical structure of fatty acids.
• Classify fatty acids with examples
• Describe the properties and functions of fatty acids
12. Simple and Compound Lipids
• Classify simple and compound lipids with examples.
• Explain the chemical structure of simple and compound lipids
• Describe the properties and biological functions of simple and compound
lipids
• Discuss the clinical importance of Lipid storage diseases
• Discuss the clinical significance of plasma lipoproteins
13. Steroids and Sterols
• Explain the structure and biochemical importance of steroids and sterols.
• List the sources and functions of Cholesterol
• Discuss the clinical importance of Cholesterol
14. Eicosanoids
• Define Eicosanoids with examples
• Classify Eicosanoids with examples
• Explain the functions of Eicosanoids
• Explain the synthesis of Eicosanoids.
• Discuss the clinical significance of Eicosanoids
TOPIC 5: PROTEIN CHEMISTRY
15. Amino acids
• Describe the structure and classification of amino acids with example
• Describe the properties of amino acids
• Describe the functions of amino acids
16. Peptides and Polypeptides Interactive
• Describe the structure and classification of Peptides and Polypeptides with Lecture
examples
• Describe the characteristics of the Peptide bond
• Describe the functions and biomedical importance of Peptides and
Polypeptides
17. Chemistry of Proteins
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LIAQUAT NATIONAL MEDICAL COLLEGE 1ST YEAR MBBS FOUNDATION MODULE
• Define proteins with examples
• Classify proteins with examples
• List the sources and properties of proteins
• Describe the functions and biomedical importance of individual proteins
18. Protein Structure
• Explain the structure of proteins
TOPIC 6: NUCLEIC ACID CHEMISTRY
19. Nucleotides
• Describe the structure and classification of nitrogenous bases with examples
• Compare the structures of nucleotides and nucleosides
• Discuss the biomedical functions of nucleotides
• Explain the biomedical significance of nucleotide derivatives and synthetic
analogues.
20. Chemistry of Nucleic acids
• Classify DNA and RNA with examples
• Explain the properties of nucleic acids
• Describe the structure and functions of DNA and RNA
TOPIC 7: ENZYME CHEMISTRY
21. Classification of Enzymes
• Define enzymes with examples
• Classify enzymes with examples
• Describe the structure and properties of Enzymes
• Explain Co-enzymes, Co factors, zymogens, prosthetic group and Isoenzymes
22. Enzyme Kinetics
• Explain the energy of activation Interactive
• Explain the two hypothesis enzyme substrate binding. Lecture/Practical
• Explain mechanism of action of enzymes
• Explain the MichaelisMenten Model of enzyme kinetics
23. Factors affecting enzyme activity
• Discuss factors inhibiting and promoting enzyme activity
• Define enzyme inhibitors with examples
• Classify enzyme inhibitors with examples
24. Clinical Enzymology
• Explain the diagnostic importance of enzymes and isoenzymes
• Outline different ways of measuring plasma enzymes
• List enzymes and isoenzymes commonly assayed for diagnostic purposes
• Discuss the clinical importance of isoenzymes of LDH, CPK, Troponin, Alkaline
phosphatase and Aldolase
25. TOPIC 8: VITAMINS
• Define vitamins with examples Interactive Lecture
• Classify vitamins with examples
• Discuss the overall role of vitamins and their importance in normal body
functions
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LIAQUAT NATIONAL MEDICAL COLLEGE 1ST YEAR MBBS FOUNDATION MODULE
• Describe the chemical structure and functions of individual vitamins
• List the sources, daily requirement, digestion absorption of individual vitamins
• Describe the clinical significance of deficiency and toxicity of vitamins
PHYSIOLOGY
OBJECTIVES LEARNING STRATEGY
1. Body Fluid Compartments Interactive
• Describe functional organization of human body. Lecture/Tutorial/
Practical
• Compare the normal ranges, physical characteristics of extracellular and
intracellular fluid compartments
2. Homeostasis and control system of body Interactive
• Define homeostasis and maintenance of internal environment by positive and Lecture/Tutorial
negative feedback mechanism.
• Explain the feedback mechanisms with the help of examples.
• Discuss the role of feedforward mechanism in homeostasis
MOLECULAR PATHOLOGY
OBJECTIVES LEARNING STRATEGY
Describe the basic principal of genetics Practical/Small group
List the Data bases and online resources for genetics session
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LIAQUAT NATIONAL MEDICAL COLLEGE 1ST YEAR MBBS FOUNDATION MODULE
balance
Identify potential stress factors
Describe a range of stress management strategies
Identify the support services and online apps available to help with stress
management
Identify your priorities and effectively manage your time
LEARNING RESOURCES
SUBJECT RESOURCES
A. GROSSANATOMY
1. K.L. Moore, Clinically Oriented Anatomy
2. Neuro Anatomy by Richard Snell
ANATOMY B. HISTOLOGY
1. B. Young J. W. Health Wheather’s Functional Histology
C. EMBRYOLOGY
1. Keith L. Moore. The Developing Human
2. Langman’s Medical Embryology
A. TEXTBOOKS
1. Harper’s Illustrated Biochemistry
BIOCHEMISTRY 2. Lehninger Principle of Biochemistry
3. Biochemistry by Devlin
4. Lippincott’s Illustrated reviews of Biochemistry
A. TEXTBOOKS
1. Textbook Of Medical Physiology by Guyton And Hall
2. Ganong ‘ S Review of Medical Physiology
3. Human Physiology by Laura lee Sherwood
4. Berne & Levy Physiology
5. Best & Taylor Physiological Basis of Medical Practice
PHYSIOLOGY B. REFERENCE BOOKS
1. Guyton & Hall Physiological Review
2. Essentials Of Medical Physiology by Jaypee
3. Textbook Of Medical Physiology by Indu Khurana
4. Short Textbook Of Physiology by Mrthur
5. NMS Physiology
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LIAQUAT NATIONAL MEDICAL COLLEGE 1ST YEAR MBBS FOUNDATION MODULE
ASSESSMENT METHODS:
MCQs (Multiple Choice Questions)
Objective Structured Practical/Clinical Examination (OSPE or OSCE)
MCQs and unobserved OSPE will be conducted on the LNH&MC Moodle platform
Observed OSPE will constitute multiple examiner-based stations
Internal Evaluation
Students will be assessed comprehensively through multiple methods.
20% marks of internal evaluation will be added to JSMU final exam. That 20% includes mid-module &
end of module examinations, mid-term & pre-professional examinations.
Formative Assessment
Individual departments may hold quizzes or short answer questions to help students assess their
learning. The marks obtained are not included in the internal evaluation
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LIAQUAT NATIONAL MEDICAL COLLEGE 1ST YEAR MBBS FOUNDATION MODULE
Students must report to the examination hall/venue, 30 minutes before the exam.
No student will be allowed to enter the examination hall after 15 minutes of the scheduled
examination time.
Students must sit according to their roll numbers mentioned on the seats.
If any student is found with a cell phone in any mode (silent, switched off, or on) he/she will not be
allowed to continue their exam.
No students will be allowed to sit in exams without University Admit Card, LNMC College ID Card,
and Lab Coat.
Students must bring the following stationary items for the exam: Pen, Pencil, Eraser, and
sharpener.
Indiscipline in the exam hall/venue is not acceptable. Students must not possess any written
material or communicate with their fellow students.
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LIAQUAT NATIONAL MEDICAL COLLEGE 1ST YEAR MBBS FOUNDATION MODULE
SCHEDULE:
WEEK 2 Foundation 16
WEEK 3 Module
WEEK 4
WEEK 5
WEEK 6
WEEK 7 30th March 2024
WEEK 1
WEEK 2 BLOOD
WEEK 3 MODULE
WEEK 4
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