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Set 3 QP - 2

This document is a question paper for the MBBS First Professional Year Resit examination in Biochemistry, consisting of multiple-choice questions, long essays, short essays, and short answers. It covers various topics including protein structure, enzyme functions, metabolic pathways, and biochemical disorders. The total marks for the examination are 100, with a duration of 180 minutes.

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Subhash Desai
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29 views5 pages

Set 3 QP - 2

This document is a question paper for the MBBS First Professional Year Resit examination in Biochemistry, consisting of multiple-choice questions, long essays, short essays, and short answers. It covers various topics including protein structure, enzyme functions, metabolic pathways, and biochemical disorders. The total marks for the examination are 100, with a duration of 180 minutes.

Uploaded by

Subhash Desai
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOC, PDF, TXT or read online on Scribd
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QUESTION PAPER –I

QUESTION PAPER

COURSE : MBBS
FACULTY : MEDICAL
EXAMINATION : FIRST PROFESSIONAL YEAR RESIT
DURATION : 180 MINUTES
SUBJECT NAME : BIOCHEMISTRY PAPER –II
QP CODE : MU0106
Total Marks : 100 marks

I MULTIPLE CHOICE QUESTIONS


20X1=20 Q1. Which of the following is simple protein?
1. Hemoglobin
2. Casein
3. Tyrosinase
4. Insulin
Q2. Example for anticancer drug
1. Acyclovir
2. 6 Mercapto purine
3. Allopurinol
4. Zidovudine
Q3. The enzyme which protects DNA from aging
1. DNA polymerase
2. Topoisomerase
3. Telomerase
4 DNA ligase
Q4. Which of the vitamins listed has no antioxidant property?
1. Vitamin A
2. Vitamin C
3. Vitamin E
4. Vitamin K
QUESTION PAPER –I

Q5. Denatured protein


1. Are soluble
2. Are difficult to digest
3. Have broken peptide bonds
4. Are biologically inactive
Q6. An increase in serum unconjugated bilirubin occurs in
1. Glomerulonephritis
2. Obstructive jaundice
3. Hemolytic jaundice
4. Defect in intestinal absorption
Q7. Acute intermittent porphyria is
1. Characterised by photodermatitis
2. An autosomal dominant trait
3. More common in men than women
4. Associated with haemolytic anaemia
Q8. The amino acid required for both purine and pyrimidine synthesis is
1. Glycine
2. Alanine
3. Glutamine
4. Aspartate
Q9. Recombinant DNA synthesis requires all the following except
1. Restriction endonucleases
2. Plasmid vector
3. RNA primer
4. DNA ligase
Q10. Heme synthesis requires all the following except
1. Glycine
2. Succinyl CoA
3. PLP
4. Vitamin C
Q11. The most abundant immunoglobulin present in blood is
1. IgA
2. IgG
3. IgM
4. IgD

Q12. The enzyme defect in Albumism is


QUESTION PAPER –I

1. Phenyl alanine hydroxylase


2. Tyrosine hydroxylase
3. Tyrosinase
4. Homogentistic oxidase
Q13. Amino acid glycine is used for the synthesis of all of the following except
1. Guanine
2. Glutathione
3. Glutamine
4. Creatine
Q14. In urea cycle, the two nitrogen atoms of urea are derived from
1. Ammonia and arginine
2. Ammonia and aspartate
3. Ammonia and ornithine
4. Both from ammonia
Q15. The drug of choice for primary gout is
1. Allopurinol
2. Aspirin
3. Colchicine
4. Probenecid
Q16. Steroid hormones are produced from
1. Glycine
2. Cholesterol
3. Purine
4. Glucuronic acid
Q17. Gene amplification can be achieved by
1. Gene cloning
2. Polymerase chain reaction
3. Southern blotting
4. DNA finger printing
Q18. Coenzyme required for transaminase reactions are
1. TPP
2. NAD
3. PLP
4. FAD

Q19. Application of recombinant DNA technology includes all the following


except
QUESTION PAPER –I

1. Detection of oncogenes
2. Syntheis of human proteins
3. Gene therapy
4. Inhibition of replication
Q20. All are Post transcriptional modifications in mRNA Except
1. Splicing of introns
2. Modification of bases
3. Attachment of poly A tail
4. Trimming of 3’ end to CCA sequence

Long Essay: Answer all Marks: 02x10=20


Q21. A 30 year old male, who was on a official tour since 15 days came to medicine
OPD with complaints of nausea, vomiting and loss of appetite since one week.
On doing blood investigations his serum total bilirubin was 10mg/dl and
conjugated bilirubin was 6mg/dl, ALT was 330U/L and AST 176U/L.

(a) Write the probable diagnosis. (1)

(b) Write the normal serum bilirubin level. (1)

(b) Explain the reason for altered biochemical parameters. (2)

(c) Write the steps of heme catabolism and excretion of its catabolites.
(4)

(d) Name two congenital hyperbilirubinemia and its biochemical defect. (2)

Q22. Define replication. Describe the steps of DNA replications in prokaryotes. Add a
note on inhibitors of replication.

Short Essay: Answer all Marks: 08x05=40


Q23. Explain the steps of recombinant DNA technology.
Q24. What is gout? Write the causes and clinical features of gout.
Q25. Describe the structure, classification and functions of immunoglobulin.
Q26. Discuss the Glomerular and tubular function tests.
Q27. Explain the steps of urea cycle. Add a note on hyperammonenias.
Q28. What are Xenobiotics? Describe Phase - 2 detoxification reactions.

Q29. Write the biochemical feature of cancer cell.


QUESTION PAPER –I

Q30. Name aromatic amino acids. What are the compounds formed from Phenyl
alanine? Add a note on phenyl ketonuria.
Short Answers: Answer all Marks: 10x02=20
Q31. What is polymerase chain reaction? Write two application of PCR
Q32. Write the steps of post translational modification in Collagen.
Q33. What tests are done for the assessment thyroid function?
Q34. What are acute phase proteins? Name any one acute phase protein and its clinical
significance.
Q35. What is the molecular defect in sickle cell disease? Add a note on biochemical
basis on sickling.
Q36. Name two pre- analytical errors in a clinical laboratory.
Q37. What is the clinical significance of P53?
Q38. What are the compounds formed from glycine?
Q39. What are conjugated proteins? Give examples.
Q40. What is second messenger? Name the hormones which function with second
messenger.
**End of Paper**

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