0.937 0.003 Dopamine release stimulant 0.934 0.002 Ligase inhibitor 0.922 0.003 Glucan endo-1,6-beta-glucosidase inhibitor 0.

908 0.004 Pullulanase inhibitor 0.899 0.004 Creatininase inhibitor 0.895 0.004 All-trans-retinyl-palmitate hydrolase inhibitor 0.893 0.003 Glucan 1,4-alpha-maltotriohydrolase inhibitor 0.893 0.008 Thrombocytopoiesis inhibitor 0.903 0.018 Methylenetetrahydrofolate reductase (NADPH) inhibitor 0.884 0.004 L-glutamate oxidase inhibitor 0.885 0.007 Superoxide dismutase inhibitor 0.881 0.004 Poly(alpha-L-guluronate) lyase inhibitor 0.879 0.006 Cardiovascular analeptic 0.870 0.005 Cl--transporting ATPase inhibitor 0.880 0.015 Mucomembranous protector 0.867 0.003 Glucan 1,4-alpha-maltotetraohydrolase inhibitor 0.875 0.014 Phosphatase inhibitor 0.868 0.007 2-Hydroxymuconate-semialdehyde hydrolase inhibitor 0.865 0.004 Xylan endo-1,3-beta-xylosidase inhibitor 0.864 0.005 (-)-(4S)-limonene synthase inhibitor 0.864 0.005 IgA-specific serine endopeptidase inhibitor 0.872 0.013 Feruloyl esterase inhibitor 0.866 0.007 Cutinase inhibitor 0.873 0.016 Acylglycerol lipase inhibitor 0.861 0.004 Poly(beta-D-mannuronate) lyase inhibitor 0.864 0.007 CC chemokine 2 receptor antagonist 0.862 0.008 Bisphosphoglycerate phosphatase inhibitor 0.859 0.005 3-Phytase inhibitor 0.857 0.004 Arylalkyl acylamidase inhibitor 0.860 0.009 Diamine oxidase inhibitor 0.855 0.005 Gluconate 5-dehydrogenase inhibitor 0.856 0.005 Antineurotoxic 0.863 0.013 Prolyl aminopeptidase inhibitor 0.861 0.011 Taurine dehydrogenase inhibitor 0.857 0.008 Dopamine D4 agonist 0.851 0.004 Hydroperoxide dehydratase inhibitor 0.865 0.018 Pro-opiomelanocortin converting enzyme inhibitor 0.854 0.008 Cathepsin G inhibitor 0.856 0.011 Exoribonuclease II inhibitor

0.850 0.007 0.850 0.008 0.845 0.003 0.859 0.018 0.844 0.004 0.862 0.022 0.848 0.009 0.843 0.004 0.843 0.005 0.844 0.005 0.839 0.004 0.837 0.005 0.837 0.005 0.854 0.023 0.836 0.005 0.849 0.019 0.839 0.010 0.861 0.032 0.831 0.004 0.830 0.004 0.829 0.004 0.833 0.010 0.839 0.015 0.826 0.003 0.829 0.007 0.825 0.003 0.827 0.006 0.829 0.011 0.822 0.004 0.825 0.009 0.820 0.005 0.828 0.013 0.821 0.006 0.816 0.004 0.816 0.005 0.815 0.005 0.816 0.005 0.813 0.005

Methylamine-glutamate N-methyltransferase inhibitor Xaa-Pro dipeptidyl-peptidase inhibitor Endo-1,3(4)-beta-glucanase inhibitor Arylacetonitrilase inhibitor N-acetylneuraminate synthase inhibitor Antiseborrheic Glutamine-phenylpyruvate transaminase inhibitor Peptide alpha-N-acetyltransferase inhibitor Sulfite oxidase inhibitor Fatty-acyl-CoA synthase inhibitor 2-Haloacid dehalogenase (configuration-inverting) inhibitor Chenodeoxycholoyltaurine hydrolase inhibitor Amine dehydrogenase inhibitor Beta-adrenergic-receptor kinase inhibitor Lysostaphin inhibitor Glucose oxidase inhibitor Glutathione thiolesterase inhibitor Hematotoxic Crotonoyl-[acyl-carrier-protein] hydratase inhibitor CYP2A8 substrate 2-Haloacid dehalogenase inhibitor N-benzyloxycarbonylglycine hydrolase inhibitor Gaucher disease treatment Trans-pentaprenyltranstransferase inhibitor Shikimate O-hydroxycinnamoyltransferase inhibitor Albendazole monooxygenase inhibitor NADH kinase inhibitor Beta-mannosidase inhibitor (S)-6-hydroxynicotine oxidase inhibitor Sarcosine oxidase inhibitor N-formylmethionyl-peptidase inhibitor Dextranase inhibitor CYP2B5 substrate Polyneuridine-aldehyde esterase inhibitor Tryptophanamidase inhibitor N-Acyl-D-aspartate deacylase inhibitor tRNA-pseudouridine synthase I inhibitor Glyoxylate reductase inhibitor

0.815 0.008 S-alkylcysteine lyase inhibitor 0.827 0.020 Fucosterol-epoxide lyase inhibitor 0.815 0.009 Aspartate-ammonia ligase inhibitor 0.810 0.005 Cyclohexyl-isocyanide hydratase inhibitor 0.811 0.006 Neurotransmitter uptake inhibitor 0.809 0.005 Inulinase inhibitor 0.808 0.004 Ornithine cyclodeaminase inhibitor 0.813 0.009 Gamma-guanidinobutyraldehyde dehydrogenase inhibitor 0.816 0.012 Alkane 1-monooxygenase inhibitor 0.806 0.003 Deoxyribonuclease II inhibitor 0.806 0.005 Long-chain-aldehyde dehydrogenase inhibitor 0.804 0.003 Cyclamate sulfohydrolase inhibitor 0.809 0.008 IgA-specific metalloendopeptidase inhibitor 0.805 0.005 Ferredoxin-NAD+ reductase inhibitor 0.805 0.005 Naphthalene 1,2-dioxygenase inhibitor 0.807 0.009 Limulus clotting factor C inhibitor 0.804 0.007 Phenol O-methyltransferase inhibitor 0.806 0.009 Allyl-alcohol dehydrogenase inhibitor 0.816 0.019 Arylsulfate sulfotransferase inhibitor 0.802 0.006 Glutarate-semialdehyde dehydrogenase inhibitor 0.809 0.014 5 Hydroxytryptamine release stimulant 0.798 0.004 Alopecia treatment 0.799 0.005 Cyclomaltodextrinase inhibitor 0.797 0.004 Carminative 0.810 0.018 ADP-thymidine kinase inhibitor 0.807 0.016 Manganese peroxidase inhibitor 0.796 0.005 Neurotransmitter antagonist 0.795 0.005 Horrilysin inhibitor 0.793 0.004 Glyoxylate oxidase inhibitor 0.802 0.012 Glucan endo-1,3-beta-D-glucosidase inhibitor 0.796 0.007 N-acylmannosamine kinase inhibitor 0.792 0.005 Snapalysin inhibitor 0.799 0.012 Formaldehyde transketolase inhibitor 0.791 0.005 Arylmalonate decarboxylase inhibitor 0.786 0.004 (R)-6-hydroxynicotine oxidase inhibitor Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine 0.792 0.011 amidase inhibitor Aldehyde dehydrogenase (pyrroloquinoline-quinone) 0.789 0.009 inhibitor

0.785 0.006 Opheline kinase inhibitor 0.785 0.006 Taurocyamine kinase inhibitor 0.786 0.008 Glycopeptide alpha-N-acetylgalactosaminidase inhibitor 0.782 0.004 2-Hydroxy-3-oxoadipate synthase inhibitor 0.798 0.023 Peptidyl-dipeptidase Dcp inhibitor 0.787 0.011 Sulfite reductase inhibitor 0.782 0.007 Cholestanetriol 26-monooxygenase inhibitor 0.782 0.008 4-Hydroxyproline epimerase inhibitor 0.786 0.013 Psychosexual dysfunction treatment 0.776 0.005 Nitrite reductase (NO-forming) inhibitor 0.782 0.012 Carnitinamidase inhibitor 0.782 0.012 Hypercholesterolemic 0.777 0.007 Yeast ribonuclease inhibitor 0.773 0.005 Methanol dehydrogenase inhibitor 0.772 0.004 GABA C receptor agonist 0.776 0.009 Cyclohexanone monooxygenase inhibitor 0.774 0.009 Fructan beta-fructosidase inhibitor 0.776 0.012 Corticosteroid side-chain-isomerase inhibitor 0.767 0.005 CYP2D16 substrate 0.769 0.008 Alcohol dehydrogenase (acceptor) inhibitor 0.774 0.013 Nitrate reductase (cytochrome) inhibitor 0.765 0.005 Gluconolactonase inhibitor 0.767 0.009 Alkylglycerone-phosphate synthase inhibitor 0.775 0.018 Nucleoside oxidase (H2O2-forming) inhibitor 0.763 0.006 Mannitol-1-phosphatase inhibitor 0.767 0.011 NADPH oxidase inhibitor 0.758 0.005 Styrene-oxide isomerase inhibitor 0.758 0.004 Phosphoenolpyruvate mutase inhibitor 0.760 0.007 Bothrolysin inhibitor 0.758 0.006 6-Pyruvoyltetrahydropterin synthase inhibitor 0.760 0.009 Aryldialkylphosphatase inhibitor 0.762 0.011 Urethanase inhibitor 0.756 0.005 Acidifying agent non gastric 0.765 0.015 Insulinotropin agonist 0.754 0.004 Peptidoglycan glycosyltransferase inhibitor 0.765 0.016 Mitochondrial processing peptidase inhibitor 0.753 0.006 Sorbitol-6-phosphate 2-dehydrogenase inhibitor Aminocarboxymuconate-semialdehyde decarboxylase 0.755 0.007 inhibitor

0.754 0.007 0.752 0.005 0.758 0.011 0.751 0.005 0.752 0.006 0.805 0.059 0.755 0.009 0.751 0.006 0.747 0.003 0.754 0.010 0.756 0.011 0.760 0.016 0.763 0.020 0.753 0.010 0.752 0.010 0.748 0.007 0.756 0.016 0.743 0.005 0.741 0.004 0.750 0.014 0.744 0.008 0.746 0.010 0.755 0.019 0.741 0.006 0.741 0.006 0.741 0.006 0.741 0.006 0.739 0.004 0.743 0.008 0.741 0.007 0.743 0.010 0.737 0.004 0.739 0.007 0.736 0.004 0.737 0.005 0.764 0.033

4-Chlorophenylacetate 3,4-dioxygenase inhibitor 2-Oxoaldehyde dehydrogenase (NADP+) inhibitor Antiviral (Arbovirus) H+-exporting ATPase inhibitor Carbon-monoxide dehydrogenase inhibitor Membrane integrity agonist Histidinol dehydrogenase inhibitor 4-Hydroxyglutamate transaminase inhibitor GABA C receptor antagonist NMDA receptor glycine site agonist D-xylulose reductase inhibitor Methylumbelliferyl-acetate deacetylase inhibitor Aldehyde oxidase inhibitor Cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase inhibitor Prostaglandin-A1 DELTA-isomerase inhibitor D-alanine 2-hydroxymethyltransferase inhibitor Phosphatidylserine decarboxylase inhibitor Mannan endo-1,6-alpha-mannosidase inhibitor Benzaldehyde dehydrogenase (NADP+) inhibitor Neurotoxin Opine dehydrogenase inhibitor Spermicide DNA-(apurinic or apyrimidinic site) lyase inhibitor 6-Carboxyhexanoate-CoA ligase inhibitor Biotin-CoA ligase inhibitor Homoaconitate hydratase inhibitor Triacetate-lactonase inhibitor Taurine-2-oxoglutarate transaminase inhibitor Endopeptidase So inhibitor 3-Carboxyethylcatechol 2,3-dioxygenase inhibitor Leukopoiesis stimulant N-hydroxy-2-acetamidofluorene reductase inhibitor Phosphoenolpyruvate-protein phosphotransferase inhibitor 2,3,4,5-Tetrahydropyridine-2,6-dicarboxylate Nsuccinyltransferase inhibitor Camphor 1,2-monooxygenase inhibitor Protein-glutamate methylesterase inhibitor

0.737 0.007 0.732 0.004 0.745 0.017 0.736 0.008 0.732 0.006 0.765 0.039 0.730 0.004 0.729 0.004 0.730 0.005 0.733 0.010 0.729 0.006 0.732 0.010 0.727 0.005 0.728 0.007 0.727 0.006 0.728 0.007 0.732 0.012 0.756 0.036 0.739 0.021 0.730 0.013 0.720 0.004 0.727 0.011 0.724 0.009 0.723 0.009 0.725 0.010 0.724 0.009 0.723 0.009 0.722 0.008 0.720 0.007 0.720 0.008 0.720 0.007 0.723 0.011 0.717 0.007 0.715 0.005 0.736 0.028 0.714 0.006 0.714 0.005

Spasmolytic, urinary Glycolate dehydrogenase inhibitor Histidine N-acetyltransferase inhibitor Di-trans,poly-cis-decaprenylcistransferase inhibitor CDP-diacylglycerol-glycerol-3-phosphate 3phosphatidyltransferase inhibitor Urologic disorders treatment Clavaminate synthase inhibitor Imidazoline receptor agonist Peptide-tryptophan 2,3-dioxygenase inhibitor Phenylalanine(histidine) transaminase inhibitor Dolichyl-phosphatase inhibitor Acetylornithine deacetylase inhibitor (+)-borneol dehydrogenase inhibitor Carboxypeptidase U inhibitor Tetrahydroxynaphthalene reductase inhibitor Meprin B inhibitor Leucolysin inhibitor Cardioprotectant Levanase inhibitor Alkenylglycerophosphoethanolamine hydrolase inhibitor Gallate decarboxylase inhibitor Licheninase inhibitor Isopenicillin-N epimerase inhibitor Glycine dehydrogenase (decarboxylating) inhibitor Antidyskinetic Pectate lyase inhibitor CDP-4-dehydro-6-deoxyglucose reductase inhibitor P-benzoquinone reductase (NADPH) inhibitor Quinoprotein glucose dehydrogenase inhibitor Lactaldehyde reductase inhibitor Gamma-D-Glutamyl-meso-diaminopimelate peptidase inhibitor (R)-Pantolactone dehydrogenase (flavin) inhibitor Hydroxylamine oxidase inhibitor Oryzin inhibitor Laccase inhibitor Beta-amylase inhibitor Dimethylmaleate hydratase inhibitor

0.717 0.009 N-methylhydantoinase (ATP-hydrolysing) inhibitor 0.714 0.007 Aspergillopepsin I inhibitor 0.712 0.005 Myeloblastin inhibitor 0.716 0.011 Lysosomal Pro-X carboxypeptidase inhibitor 0.711 0.006 Creatinine deaminase inhibitor 0.721 0.018 GABA A receptor antagonist 0.710 0.007 2,3-Dihydroxyindole 2,3-dioxygenase inhibitor 0.710 0.008 Sigma receptor agonist 0.735 0.034 Sickle-cell anemia treatment 0.727 0.028 Monodehydroascorbate reductase (NADH) inhibitor 0.724 0.025 Linoleate diol synthase inhibitor 0.706 0.007 Alpha-N-acetylglucosaminidase inhibitor 0.702 0.004 Pediculicide 0.702 0.005 N-acetyl-gamma-glutamyl-phosphate reductase inhibitor 0.712 0.015 Biotinidase inhibitor 0.706 0.009 N-Acyl-D-amino-acid deacylase inhibitor 0.704 0.009 Na+-transporting two-sector ATPase inhibitor 0.723 0.028 Protoporphyrinogen oxidase inhibitor 0.705 0.010 Hyponitrite reductase inhibitor 0.700 0.006 3-Oxoadipate enol-lactonase inhibitor 0.701 0.007 Galacturan 1,4-alpha-galacturonidase inhibitor 0.702 0.010 Uroporphyrinogen-III synthase inhibitor 0.697 0.005 Platelet adhesion inhibitor 0.698 0.008 Insulin promoter 0.704 0.014 Alanine-tRNA ligase inhibitor 0.702 0.011 Carcinogenic, group 1 0.695 0.005 Creatinase inhibitor 0.694 0.005 Penicillin amidase inhibitor 0.699 0.010 Poly(3-hydroxybutyrate) depolymerase inhibitor 0.708 0.019 D-lactaldehyde dehydrogenase inhibitor 0.697 0.009 Acetylcholine release stimulant 0.695 0.008 Miotic Undecaprenyldiphospho-muramoylpentapeptide beta-N0.698 0.012 acetylglucosaminyltransferase inhibitor 0.690 0.005 tRNA nucleotidyltransferase inhibitor 0.695 0.014 Nerve growth factor agonist 0.696 0.015 Rhamnulose-1-phosphate aldolase inhibitor 0.697 0.017 Thiol oxidase inhibitor 0.689 0.009 Salicylate 1-monooxygenase inhibitor

0.692 0.012 Polygalacturonase inhibitor 0.689 0.009 CYP2A3 substrate 0.684 0.005 2,4-Diaminopentanoate dehydrogenase inhibitor 0.684 0.005 3-Hydroxybutyryl-CoA dehydrogenase inhibitor 0.684 0.005 Lysine 6-dehydrogenase inhibitor 0.689 0.011 Transketolase inhibitor 0.683 0.005 Scytalone dehydratase inhibitor 0.723 0.046 Amyotrophic lateral sclerosis treatment 0.690 0.012 Steroid N-acetylglucosaminyltransferase inhibitor 0.695 0.017 Phosphatidylglycerophosphatase inhibitor 0.687 0.011 Nicotinate dehydrogenase inhibitor 0.696 0.021 Cytoprotectant 0.685 0.010 Erythropoietin 0.719 0.045 Convulsant 0.684 0.010 Phosphopantothenoylcysteine decarboxylase inhibitor 0.678 0.005 Polarisation stimulant 0.690 0.016 Procollagen N-endopeptidase inhibitor 0.687 0.014 Histidinol-phosphatase inhibitor 0.686 0.013 Antibacterial activity enhancer 0.681 0.008 Skin diseases treatment 0.693 0.023 Peroxidase inhibitor 0.680 0.011 Antiviral (Picornavirus) 0.674 0.005 Pyruvate dehydrogenase (cytochrome) inhibitor 0.674 0.005 Trans-2-enoyl-CoA reductase (NAD+) inhibitor 0.686 0.019 1-Alkyl-2-acetylglycerophosphocholine esterase inhibitor 0.677 0.009 Serine-pyruvate transaminase inhibitor 0.670 0.005 Glycerol-1-phosphatase inhibitor 0.677 0.013 CYP2A2 substrate 0.679 0.017 Galactolipase inhibitor 0.668 0.006 Allantoate deiminase inhibitor 0.675 0.012 Urease inhibitor 0.690 0.028 Antihypoxic 0.667 0.005 Bisphosphoglycerate mutase inhibitor 0.678 0.017 Glyceryl-ether monooxygenase inhibitor 0.693 0.032 Lipoprotein lipase inhibitor 0.677 0.017 Sulfur reductase inhibitor 0.695 0.036 Fibrinolytic 0.676 0.016 Cathepsin T inhibitor 0.663 0.005 Trimethylamine dehydrogenase inhibitor

0.662 0.005 0.663 0.007 0.697 0.040 0.661 0.005 0.663 0.007 0.674 0.019 0.663 0.008 0.665 0.011 0.668 0.015 0.664 0.012 0.679 0.029 0.675 0.025 0.673 0.023 0.661 0.011 0.662 0.014 0.665 0.017 0.654 0.007 0.658 0.013 0.650 0.004 0.653 0.009 0.665 0.022 0.643 0.004 0.660 0.021 0.646 0.007 0.643 0.004 0.649 0.010 0.647 0.009 0.651 0.013 0.647 0.009 0.647 0.010 0.647 0.011 0.642 0.007 0.654 0.019 0.650 0.016 0.640 0.007 0.641 0.009 0.653 0.021 0.660 0.029 0.644 0.013

Pectin lyase inhibitor Anticarcinogenic Follicle-stimulating hormone agonist DNA-3-methyladenine glycosylase I inhibitor Gly-X carboxypeptidase inhibitor Coccolysin inhibitor 3-Hydroxy-4-oxoquinoline 2,4-dioxygenase inhibitor 2-Oxoglutarate decarboxylase inhibitor Antialcoholic Chitosanase inhibitor NAD(P)+-arginine ADP-ribosyltransferase inhibitor 4-Hydroxyphenylacetate 3-monooxygenase inhibitor Ecdysone 20-monooxygenase inhibitor Galactose oxidase inhibitor N-(long-chain-acyl)ethanolamine deacylase inhibitor Hydroxylamine reductase (NADH) inhibitor Phenylpyruvate decarboxylase inhibitor Catechol oxidase inhibitor Cytochrome-c3 hydrogenase inhibitor Aryl-alcohol dehydrogenase (NADP+) inhibitor X-methyl-His dipeptidase inhibitor Alpha-glucuronidase inhibitor Tocolytic Glucan 1,6-alpha-glucosidase inhibitor Pseudouridylate synthase inhibitor Ferredoxin hydrogenase inhibitor Signal peptidase I inhibitor Arylesterase inhibitor Chaperonin ATPase inhibitor Leukopoiesis inhibitor X-Pro dipeptidase inhibitor GABA receptor antagonist S-formylglutathione hydrolase inhibitor Insulin secretagoues 2-Dehydropantoate aldolase inhibitor 2,6-Dihydroxypyridine 3-monooxygenase inhibitor Leukotriene-B4 20-monooxygenase inhibitor Pitrilysin inhibitor 3-Hydroxybenzoate 4-monooxygenase inhibitor

0.665 0.034 0.648 0.018 0.639 0.009 0.646 0.017 0.640 0.013 0.649 0.021 0.642 0.014 0.637 0.010 0.631 0.004 0.641 0.015 0.641 0.015 0.638 0.014 0.634 0.010 0.638 0.014 0.628 0.005 0.628 0.005 0.639 0.017 0.627 0.005 0.655 0.034 0.639 0.017 0.645 0.024 0.644 0.023 0.634 0.015 0.632 0.012 0.630 0.013 0.641 0.025 0.652 0.036 0.629 0.013 0.627 0.012 0.620 0.006 0.661 0.049 0.618 0.008 0.617 0.008 0.622 0.014 0.630 0.022 0.616 0.008

CYP3A1 substrate Ethanolamine-phosphate cytidylyltransferase inhibitor L-iduronidase inhibitor Phosphatidylcholine-sterol O-acyltransferase inhibitor N-carbamoyl-L-amino-acid hydrolase inhibitor Pyruvate decarboxylase inhibitor Glucuronate isomerase inhibitor Inositol-trisphosphate 3-kinase inhibitor Undecaprenyl-diphosphatase inhibitor Histamine release stimulant Phenylacetate-CoA ligase inhibitor Mannose isomerase inhibitor Sclerosant Protein-Npi-phosphohistidine-sugar phosphotransferase inhibitor Trehalose-phosphatase inhibitor (R,R)-butanediol dehydrogenase inhibitor Apyrase inhibitor Acyl-lysine deacylase inhibitor Torsades de pointes Insulysin inhibitor Membrane permeability inhibitor Vasodilator, cerebral Aspartyl aminopeptidase inhibitor Trans-octaprenyltranstransferase inhibitor Magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase inhibitor L-glucuronate reductase inhibitor Lysase inhibitor Plasmanylethanolamine desaturase inhibitor Ovulation inhibitor 2,2-Dialkylglycine decarboxylase (pyruvate) inhibitor Opioid dependency treatment Pantoate 4-dehydrogenase inhibitor Aminomuconate-semialdehyde dehydrogenase inhibitor Succinate-semialdehyde dehydrogenase [NAD(P)+] inhibitor Aldehyde dehydrogenase (NADP+) inhibitor Glutathione dehydrogenase (ascorbate) inhibitor

0.612 0.005 0.630 0.024 0.618 0.012 0.613 0.008 0.616 0.011 0.639 0.035 0.614 0.010 0.646 0.043 0.608 0.006 0.617 0.015 0.609 0.007 0.630 0.029 0.606 0.005 0.605 0.005 0.609 0.009 0.625 0.025 0.609 0.009 0.606 0.007 0.610 0.013 0.610 0.013 0.627 0.032 0.622 0.027 0.609 0.014 0.622 0.027 0.686 0.092 0.603 0.009 0.608 0.015 0.609 0.016 0.619 0.028 0.595 0.005 0.595 0.005 0.594 0.005 0.611 0.023 0.601 0.013 0.598 0.012 0.593 0.007 0.593 0.008

Glucan endo-1,3-alpha-glucosidase inhibitor Enteropeptidase inhibitor Glycerol 2-dehydrogenase (NADP+) inhibitor Antimutagenic Vitamin-K-epoxide reductase (warfarin-insensitive) inhibitor Membrane integrity antagonist Hematopoietic inhibitor Oxidoreductase inhibitor Oxidizing agent Sphinganine-1-phosphate aldolase inhibitor 3-Chloro-D-alanine dehydrochlorinase inhibitor Aryl-acylamidase inhibitor Dimethylallyltranstransferase inhibitor 3-Aminobutyryl-CoA ammonia-lyase inhibitor Thiosulfate dehydrogenase inhibitor Emetic Cyclopentanone monooxygenase inhibitor Antinociceptive DELTA14-sterol reductase inhibitor Guanidinoacetase inhibitor Cyclooxygenase 1 inhibitor Malate dehydrogenase (acceptor) inhibitor Antiviral (Influenza) Adenylate cyclase stimulant Myocardial ischemia treatment Dimethylaniline monooxygenase (N-oxide-forming) inhibitor Gonadotropin antagonist CYP2A1 substrate NADPH-ferrihemoprotein reductase inhibitor Proline dehydrogenase inhibitor Carboxylate reductase inhibitor Allantoinase inhibitor Candidapepsin inhibitor 4-Chlorobenzoyl-CoA dehalogenase inhibitor Serine 3-dehydrogenase inhibitor Alcohol oxidase inhibitor Maltose-transporting ATPase inhibitor

0.592 0.007 0.601 0.016 0.604 0.019 0.594 0.010 0.589 0.005 0.607 0.024 0.608 0.025 0.587 0.005 0.630 0.049 0.592 0.011 0.589 0.010 0.587 0.008 0.582 0.005 0.580 0.004 0.584 0.008 0.605 0.030 0.602 0.028 0.596 0.022 0.606 0.033 0.596 0.024 0.589 0.017 0.576 0.004 0.599 0.028 0.582 0.011 0.584 0.013 0.575 0.005 0.580 0.010 0.577 0.007 0.578 0.008 0.580 0.011 0.574 0.006 0.577 0.009 0.589 0.021 0.573 0.006 0.577 0.010 0.571 0.005 0.573 0.009 0.578 0.013 0.578 0.014

Pyroglutamyl-peptidase II inhibitor Alpha-Methylacyl-CoA racemase inhibitor Acaricide Alcohol dehydrogenase [NAD(P)+] inhibitor Prunasin beta-glucosidase inhibitor Cytokine modulator Protein-tyrosine sulfotransferase inhibitor Aconitate decarboxylase inhibitor Apoptosis agonist Chitinase inhibitor CYP2F1 substrate Ubiquitin thiolesterase inhibitor Acetoacetate decarboxylase inhibitor Allantoin racemase inhibitor Picornain 3C inhibitor Antianemic Aspergillus nuclease S1 inhibitor Carboxypeptidase D inhibitor Choline-phosphate cytidylyltransferase inhibitor N-hydroxyarylamine O-acetyltransferase inhibitor Antihelmintic (Nematodes) Retinal dehydrogenase inhibitor Acylaminoacyl-peptidase inhibitor 2,5-Dihydroxypyridine 5,6-dioxygenase inhibitor 2,4-Dichlorophenol 6-monooxygenase inhibitor Aureolysin inhibitor Glucan 1,4-beta-glucosidase inhibitor Chloramphenicol O-acetyltransferase inhibitor Butyrylcholinesterase inhibitor Nitrile hydratase inhibitor Diisopropyl-fluorophosphatase inhibitor NAD+ synthase (glutamine-hydrolysing) inhibitor Alzheimer's disease treatment Pappalysin-1 inhibitor ATPase inhibitor Valine dehydrogenase (NADP+) inhibitor Proline racemase inhibitor Glycine amidinotransferase inhibitor Vomilenine glucosyltransferase inhibitor

0.584 0.020 Membrane dipeptidase inhibitor 0.589 0.025 Cognition disorders treatment 0.584 0.021 Cytochrome P450 inhibitor 0.573 0.010 3-Demethylubiquinone-9 3-O-methyltransferase inhibitor 0.580 0.017 3-Isopropylmalate dehydratase inhibitor 0.581 0.018 Dipeptidase E inhibitor 0.591 0.029 Cytochrome-b5 reductase inhibitor 0.566 0.005 Carboxymethylenebutenolidase inhibitor 0.567 0.006 Deoxyribose-phosphate aldolase inhibitor 0.586 0.025 Cytochrome P450 CYP2C9 inhibitor 0.565 0.004 Aldehyde ferredoxin oxidoreductase inhibitor 4-Methoxybenzoate monooxygenase (O-demethylating) 0.584 0.023 inhibitor 0.575 0.015 Subtilisin inhibitor 0.577 0.017 Sulfur dioxygenase inhibitor 0.571 0.011 Indoleacetaldoxime dehydratase inhibitor 0.567 0.008 3-Hydroxyphenylacetate 6-hydroxylase inhibitor 0.562 0.004 Acetylenecarboxylate hydratase inhibitor 0.587 0.030 Dipeptidyl-peptidase II inhibitor 0.576 0.019 Septic shock treatment 0.567 0.010 Methionyl aminopeptidase inhibitor 0.572 0.015 Legumain inhibitor 0.575 0.019 Prostaglandin H2 antagonist 0.565 0.009 Lombricine kinase inhibitor 0.560 0.005 Linoleoyl-CoA desaturase inhibitor 0.572 0.017 Myosin ATPase inhibitor 0.607 0.053 Nootropic 0.586 0.033 Carbonyl reductase (NADPH) inhibitor 0.588 0.035 CYP3A2 substrate 0.562 0.009 Farnesyltranstransferase inhibitor 0.574 0.021 CYP4A11 substrate 0.568 0.016 Guanidinoacetate kinase inhibitor 0.588 0.036 Dependence treatment 0.574 0.022 Valine-tRNA ligase inhibitor 0.556 0.006 Orotate reductase (NADH) inhibitor 0.558 0.009 (S)-3-hydroxyacid ester dehydrogenase inhibitor 0.554 0.006 Alpha-N-acetylgalactosaminidase inhibitor 0.567 0.019 Peptide deformylase inhibitor 0.556 0.009 Hyaluronic acid agonist

0.551 0.005 0.565 0.019 0.575 0.029 0.560 0.015 0.606 0.061 0.562 0.016 0.553 0.009 0.571 0.026 0.558 0.013 0.569 0.025 0.570 0.027 0.549 0.006 0.559 0.017 0.547 0.005 0.553 0.012 0.582 0.041 0.555 0.015 0.552 0.012 0.557 0.019 0.561 0.023 0.559 0.022 0.541 0.004 0.542 0.005 0.565 0.028 0.543 0.008 0.550 0.017 0.541 0.009 0.536 0.004 0.536 0.004 0.610 0.080 0.535 0.004 0.535 0.004 0.549 0.020 0.548 0.019 0.550 0.023 0.533 0.006 0.535 0.008 0.536 0.009

Iduronate-2-sulfatase inhibitor Dynein ATPase inhibitor CYP3A3 substrate CYP2G1 substrate Cardiotoxic 1,4-Alpha-glucan branching enzyme inhibitor Aspartate-tRNA ligase inhibitor Alpha-1,6-mannosyl-glycoprotein 4-beta-Nacetylglucosaminyltransferase inhibitor Aspartoacylase inhibitor Venom exonuclease inhibitor Ionotropic Indolepyruvate C-methyltransferase inhibitor Acetate kinase inhibitor Ferrochelatase inhibitor Glycine C-acetyltransferase inhibitor Antitoxic Tryptophan transaminase inhibitor Interferon agonist Carnosine synthase inhibitor 4-Hydroxymandelate oxidase inhibitor Gingipain K inhibitor 5-Oxoprolinase (ATP-hydrolysing) inhibitor 3-Isopropylmalate dehydrogenase inhibitor Glyoxylate reductase (NADP+) inhibitor Peptidylamidoglycolate lyase inhibitor Respiratory analeptic Neurotrophic factor Alpha-pinene-oxide decyclase inhibitor Orotate reductase (NADPH) inhibitor Antinephritic Haloacetate dehalogenase inhibitor Prepilin peptidase inhibitor L-threonine 3-dehydrogenase inhibitor Glutamate-tRNA ligase inhibitor Beta-carotene 15,15'-monooxygenase inhibitor Antismoking Bile-salt sulfotransferase inhibitor D-lactate dehydrogenase (cytochrome) inhibitor

0.545 0.018 Guanidinoacetate N-methyltransferase inhibitor 0.549 0.022 Glucose 1-dehydrogenase inhibitor 0.563 0.037 Calmodulin antagonist 0.556 0.032 Lipotropic 0.554 0.030 Menopausal disorders treatment 0.562 0.038 Metabolic disease treatment 0.529 0.007 Alternansucrase inhibitor 0.528 0.006 (S)-3-amino-2-methylpropionate transaminase inhibitor 0.563 0.043 Phosphatidate phosphatase inhibitor 0.525 0.004 2-Dehydropantolactone reductase (A-specific) inhibitor 0.533 0.012 N-Carbamoyl-D-amino acid hydrolase inhibitor 0.525 0.005 Stromelysin 2 inhibitor 0.534 0.014 Alpha-N-arabinofuranosidase inhibitor 0.538 0.019 N-acetyllactosamine synthase inhibitor 0.537 0.019 Ferredoxin-NADP+ reductase inhibitor 0.544 0.025 Glycerol-3-phosphate dehydrogenase inhibitor 0.530 0.012 CYP2B11 substrate 0.553 0.035 Proteasome endopeptidase complex inhibitor 0.528 0.011 GABA aminotransferase inhibitor 0.525 0.008 CYP4A2 substrate 0.554 0.037 Renal tissue kallikrein inhibitor 0.583 0.067 Lipid metabolism regulator 0.538 0.022 Diamine N-acetyltransferase inhibitor 0.524 0.009 Creatine kinase inhibitor 0.525 0.010 Dihydroorotate dehydrogenase inhibitor 0.536 0.021 Catalase inhibitor 0.541 0.027 Rubredoxin-NAD+ reductase inhibitor 0.565 0.050 Chemoprotective 0.527 0.013 Chemokine receptor antagonist 0.520 0.008 Antiviral (Adenovirus) 0.539 0.028 4-Coumarate-CoA ligase inhibitor 0.522 0.011 Acetylcholine nicotinic agonist 0.533 0.023 Analeptic 0.515 0.005 Carnitine dehydratase inhibitor 0.533 0.023 Mitochondrial intermediate peptidase inhibitor 0.517 0.008 Choline dehydrogenase inhibitor 0.525 0.016 Mandelate 4-monooxygenase inhibitor 0.517 0.009 Cysteine transaminase inhibitor 0.513 0.005 Phosphonoacetate hydrolase inhibitor

0.516 0.008 0.588 0.080 0.603 0.096 0.529 0.021 0.514 0.007 0.518 0.011 0.531 0.025 0.531 0.025 0.528 0.023 0.515 0.010 0.518 0.014 0.518 0.015 0.513 0.010 0.516 0.013 0.517 0.014 0.509 0.007 0.524 0.022 0.512 0.011 0.511 0.010 0.509 0.008 0.512 0.012 0.508 0.009 0.516 0.017 0.509 0.011 0.507 0.010 0.521 0.023 0.509 0.012 0.522 0.025 0.505 0.009 0.508 0.012 0.504 0.008 0.522 0.027 0.523 0.030 0.506 0.013 0.509 0.017 0.508 0.016 0.515 0.024 0.509 0.019

Alkylglycerophosphoethanolamine phosphodiesterase inhibitor Arrhythmogenic Hepatotoxic Thiopurine S-methyltransferase inhibitor CYP2C3 substrate Antiprotozoal (Leishmania) Glucosamine-6-phosphate deaminase inhibitor Phosphatidylinositol diacylglycerol-lyase inhibitor Antiinflammatory, ophthalmic Pyrimidine-deoxynucleoside 2'-dioxygenase inhibitor Thioredoxin-disulfide reductase inhibitor Gamma-butyrobetaine dioxygenase inhibitor Glutamate release inhibitor 4-Alpha-glucanotransferase inhibitor Endo-1,4-beta-xylanase inhibitor Aspergillopepsin II inhibitor Leukotriene-C4 synthase inhibitor Ferredoxin-nitrite reductase inhibitor Fumarate reductase (NADH) inhibitor Carnitine 3-dehydrogenase inhibitor Leucine dehydrogenase inhibitor D-2-hydroxy-acid dehydrogenase inhibitor Thiamine-triphosphatase inhibitor Toxic, respiratory center Alpha 1 adrenoreceptor agonist Sedoheptulose-bisphosphatase inhibitor Metallocarboxypeptidase D inhibitor Thromboxane B2 antagonist Asparagine-tRNA ligase inhibitor Glutamate 5-kinase inhibitor Methionine decarboxylase inhibitor Cyclic AMP agonist Nitrite reductase [NAD(P)H] inhibitor Glycerol dehydratase inhibitor Trypanothione-disulfide reductase inhibitor Hydroxymethylbilane synthase inhibitor D-threo-aldose 1-dehydrogenase inhibitor N-acetyllactosaminide beta-1,3-N-

0.519 0.029 0.493 0.004 0.539 0.051 0.503 0.014 0.498 0.010 0.501 0.014 0.503 0.016 0.523 0.037 0.508 0.022 0.498 0.013 0.502 0.017 0.494 0.011 0.493 0.010 0.524 0.041 0.490 0.007 0.496 0.015 0.488 0.007 0.503 0.023 0.524 0.045 0.510 0.031 0.489 0.010 0.499 0.021 0.485 0.006 0.502 0.024 0.487 0.009 0.509 0.031 0.552 0.074 0.499 0.022 0.493 0.017 0.487 0.012 0.496 0.022 0.482 0.008 0.484 0.010 0.489 0.015 0.490 0.016 0.497 0.024

acetylglucosaminyltransferase inhibitor Glutathione peroxidase inhibitor Glucuronolactone reductase inhibitor 1-Alkylglycerophosphocholine O-acetyltransferase inhibitor Omega-amidase inhibitor Chemopreventive Hydroxylamine reductase inhibitor Dihydroxy-acid dehydratase inhibitor Sodium channel blocker Aminoacylase inhibitor Antiparkinsonian, rigidity relieving D-amino-acid dehydrogenase inhibitor 3-Deoxy-8-phosphooctulonate synthase inhibitor Protein-S-isoprenylcysteine O-methyltransferase inhibitor Psychostimulant Ribitol 2-dehydrogenase inhibitor Choline-sulfatase inhibitor Protein-glucosylgalactosylhydroxylysine glucosidase inhibitor 3'-Nucleotidase inhibitor Eye irritation, inactive Membrane permeability enhancer Hippurate hydrolase inhibitor Glycine-tRNA ligase inhibitor Gingipain R inhibitor Acylglycerone-phosphate reductase inhibitor Riboflavin phosphotransferase inhibitor Antisecretoric Nephrotoxic Bontoxilysin inhibitor Alpha-amylase inhibitor N-methyl-2-oxoglutaramate hydrolase inhibitor Nardilysin inhibitor N-acetylneuraminate lyase inhibitor Cellulose 1,4-beta-cellobiosidase inhibitor 2-Enoate reductase inhibitor Morphine 6-dehydrogenase inhibitor Arylformamidase inhibitor

0.511 0.038 0.491 0.018 0.496 0.024 0.477 0.005 0.489 0.017 0.486 0.015 0.477 0.006 0.475 0.004 0.483 0.013 0.496 0.026 0.509 0.040 0.490 0.020 0.484 0.014 0.480 0.011 0.479 0.010 0.474 0.006 0.523 0.055 0.475 0.007 0.484 0.016 0.502 0.034 0.486 0.018 0.480 0.013 0.479 0.012 0.481 0.014 0.488 0.022 0.476 0.010 0.469 0.004 0.480 0.015 0.570 0.105 0.482 0.017 0.473 0.008 0.523 0.058 0.481 0.017 0.482 0.018 0.478 0.014 0.488 0.024 0.479 0.016 0.473 0.010

Antiviral (Poxvirus) Sweetener Acylphosphatase inhibitor Pancreatic endopeptidase E inhibitor N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase inhibitor Acetylspermidine deacetylase inhibitor Propanediol dehydratase inhibitor Malonate-semialdehyde dehydrogenase inhibitor Quercetin 2,3-dioxygenase inhibitor Indanol dehydrogenase inhibitor Potassium channel antagonist Phenol 2-monooxygenase inhibitor N4-(beta-N-acetylglucosaminyl)-L-asparaginase inhibitor L-galactonolactone oxidase inhibitor Epoxide hydrolase inhibitor Glucarate dehydratase inhibitor Cholesterol antagonist 2-Oxoisovalerate dehydrogenase (acylating) inhibitor CYP2C10 substrate Monophenol monooxygenase inhibitor 8-Amino-7-oxononanoate synthase inhibitor L-lysine 6-transaminase inhibitor Lactaldehyde reductase (NADPH) inhibitor Rhodotorulapepsin inhibitor Furin inhibitor Glutamin-(asparagin-)ase inhibitor Chitin deacetylase inhibitor Methylaspartate ammonia-lyase inhibitor Neuroprotector Alpha-L-fucosidase inhibitor Selenocysteine lyase inhibitor HERG channel antagonist Gentisate 1,2-dioxygenase inhibitor [acyl-carrier-protein] S-acetyltransferase inhibitor Cellulase inhibitor Nucleoside-diphosphatase inhibitor CYP2A5 substrate Formaldehyde dehydrogenase inhibitor

0.490 0.028 0.593 0.131 0.512 0.050 0.483 0.022 0.466 0.005 0.478 0.016 0.486 0.025 0.522 0.061 0.466 0.006 0.491 0.031 0.481 0.022 0.491 0.032 0.476 0.017 0.486 0.027 0.464 0.005 0.475 0.017 0.477 0.022 0.468 0.013 0.531 0.076 0.468 0.014 0.461 0.007 0.466 0.012 0.477 0.024 0.485 0.032 0.477 0.024 0.459 0.007 0.510 0.057 0.466 0.014 0.467 0.016 0.462 0.011 0.493 0.042 0.456 0.006 0.467 0.017 0.455 0.005 0.460 0.010 0.482 0.032 0.474 0.025 0.461 0.012 0.479 0.029

Choline kinase inhibitor Vascular (periferal) disease treatment Hypothermic Monoamine uptake inhibitor Alkene monooxygenase inhibitor Acetylcholine M1 receptor antagonist Methane monooxygenase inhibitor Antiepileptic 3-Ketovalidoxylamine C-N-lyase inhibitor Gynecological disorders treatment Lactate 2-monooxygenase inhibitor Phospholipase C inhibitor Beta-glucosidase inhibitor Aminopeptidase Y inhibitor Dichloromuconate cycloisomerase inhibitor Nitrilase inhibitor Lactose synthase inhibitor Iron-cytochrome-c reductase inhibitor General pump inhibitor Excitatory amino acid agonist CYP2C18 substrate CYP2D1 substrate Glutaminase inhibitor Reductant Carboxypeptidase B inhibitor Glucan 1,3-beta-glucosidase inhibitor H+-transporting two-sector ATPase inhibitor Phosphoglycerate mutase inhibitor Gametolysin inhibitor Glutamate-1-semialdehyde 2,1-aminomutase inhibitor Prostaglandin antagonist 3-Hydroxyacyl-CoA dehydrogenase inhibitor Retinol dehydrogenase inhibitor Deoxyribonuclease (pyrimidine dimer) inhibitor Osteoarthritis treatment Phosphodiesterase I inhibitor Pyruvate dehydrogenase (lipoamide) inhibitor Aryl-alcohol dehydrogenase inhibitor Antidote

0.460 0.011 0.453 0.005 0.466 0.018 0.453 0.005 0.464 0.016 0.456 0.008 0.461 0.013 0.461 0.013 0.456 0.009 0.459 0.012 0.455 0.008 0.518 0.072 0.462 0.015 0.453 0.007 0.473 0.027 0.455 0.009 0.451 0.005 0.464 0.019 0.450 0.005 0.465 0.020 0.508 0.063 0.467 0.022 0.455 0.011 0.461 0.017 0.453 0.009 0.447 0.003 0.464 0.021 0.463 0.020 0.459 0.017 0.458 0.015 0.486 0.043 0.466 0.024 0.510 0.069 0.476 0.035 0.454 0.013 0.474 0.033

D-cysteine desulfhydrase inhibitor Beta glucosidase inhibitor Thiosulfate sulfurtransferase inhibitor Leucine transaminase inhibitor Phosphoinositide phospholipase C inhibitor Gluconate dehydratase inhibitor Beta-alanine-pyruvate transaminase inhibitor Galactose 1-dehydrogenase (NADP+) inhibitor Xylan 1,4-beta-xylosidase inhibitor CYP4B substrate Estradiol 17alpha-dehydrogenase inhibitor Squalene-hopene cyclase inhibitor Carcinogenic, group 2A Arabinose-5-phosphate isomerase inhibitor Inorganic diphosphatase inhibitor Inositol-1(or 4)-monophosphatase inhibitor Aldehyde dehydrogenase [NAD(P)+] inhibitor N-acetylneuraminate 4-O-acetyltransferase inhibitor Lathosterol oxidase inhibitor 15-Hydroxyprostaglandin-D dehydrogenase (NADP+) inhibitor Antipruritic Gestagen antagonist Phosphoenolpyruvate carboxykinase (diphosphate) inhibitor Antiamyloidogenic Glycerophosphocholine cholinephosphodiesterase inhibitor 4-Carboxymethyl-4-methylbutenolide mutase inhibitor Isopenicillin-N synthase inhibitor Deoxyribonuclease X inhibitor Carboxylesterase inhibitor CC chemokine receptor antagonist Antineurogenic pain 4-Phytase inhibitor Nucleotide metabolism regulator L-iditol 2-dehydrogenase inhibitor Porphobilinogen synthase inhibitor Acid phosphatase inhibitor

0.475 0.035 Cystic fibrosis treatment 0.463 0.022 N6-methyl-lysine oxidase inhibitor 0.446 0.006 Pyridoxine 4-oxidase inhibitor 0.445 0.006 Matrilysin inhibitor 0.452 0.014 Deacetoxycephalosporin-C synthase inhibitor 0.448 0.010 Valine decarboxylase inhibitor 0.442 0.004 Guanidinodeoxy-scyllo-inositol-4-phosphatase inhibitor 0.471 0.034 Nitrate reductase inhibitor 0.460 0.024 Protein-tyrosine kinase (PTK, not ETK, WZC) inhibitor 0.475 0.039 4-Hydroxybenzoate nonaprenyltransferase inhibitor 0.445 0.009 Isoamylase inhibitor 0.462 0.027 Gamma-glutamyltransferase inhibitor 0.445 0.010 Osteoclast antagonist 0.460 0.025 Arylsulfatase inhibitor 0.444 0.010 Glycerol dehydrogenase (NADP+) inhibitor 0.455 0.021 Phospholipase D inhibitor 0.464 0.030 Envelysin inhibitor 0.478 0.044 CYP2B6 substrate 0.456 0.024 Galactokinase inhibitor 0.439 0.008 Antidote, heavy metal 0.435 0.004 Thermomycolin inhibitor 0.448 0.018 Phenylalanine racemase (ATP-hydrolysing) inhibitor 0.573 0.143 Apoptosis antagonist 0.434 0.005 Allophanate hydrolase inhibitor 0.466 0.038 CYP2C11 substrate 0.450 0.022 Aminopeptidase I inhibitor 0.443 0.016 Cholesterol oxidase inhibitor 0.469 0.042 CYP2C8 substrate 0.439 0.012 Plasmin inhibitor 0.437 0.011 Diaminopimelate dehydrogenase inhibitor 0.440 0.014 Diaminopropionate ammonia-lyase inhibitor 0.460 0.034 Uric acid excretion stimulant 0.430 0.005 Tryptophanyl aminopeptidase inhibitor 0.449 0.024 Laminaribiose phosphorylase inhibitor 0.441 0.017 Cerebroside-sulfatase inhibitor 0.440 0.017 Enoyl-[acyl-carrier-protein] reductase (NADH) inhibitor 0.449 0.026 Excitatory amino acid antagonist 0.442 0.019 Benzoylformate decarboxylase inhibitor 0.442 0.018 Sulfate adenylyltransferase (ADP) inhibitor

0.434 0.011 0.443 0.021 0.430 0.009 0.461 0.040 0.433 0.012 0.426 0.005 0.510 0.090 0.435 0.015 0.466 0.049 0.421 0.003 0.455 0.038 0.441 0.024 0.422 0.005 0.440 0.023 0.435 0.018 0.421 0.005 0.474 0.059 0.456 0.041 0.418 0.004 0.427 0.014 0.501 0.087 0.441 0.028 0.417 0.004 0.427 0.014 0.429 0.017 0.478 0.066 0.439 0.027 0.436 0.026 0.418 0.008 0.424 0.014 0.423 0.015 0.420 0.012 0.417 0.010 0.442 0.035 0.416 0.011 0.427 0.022

Saccharopine dehydrogenase (NADP+, L-glutamateforming) inhibitor Acetoin dehydrogenase inhibitor Cysteine desulfurase inhibitor Antiviral (Herpes) Anticholelithogenic (R)-limonene 6-monooxygenase inhibitor Multiple sclerosis treatment Anthranilate 3-monooxygenase (deaminating) inhibitor Skin irritation, inactive Cholesterol ester transfer protein antagonist CYP2A6 substrate Serratia marcescens nuclease inhibitor 1-Aminocyclopropane-1-carboxylate deaminase inhibitor Dethiobiotin synthase inhibitor Phosphoenolpyruvate carboxykinase (ATP) inhibitor Benzodiazepine omega receptor agonist Antipsoriatic Octopamine antagonist Deoxyribonuclease I inhibitor 3-Methylbutanal reductase inhibitor Antineurotic Anesthetic general Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase inhibitor D-glutamate oxidase inhibitor Betaine-aldehyde dehydrogenase inhibitor Immunosuppressant Acetylcholine nicotinic antagonist Antiosteoporotic Hypertensive, ophthalmic 1,5-Anhydro-D-fructose reductase inhibitor Tumour necrosis factor antagonist 3,4-Dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17dione 4,5-dioxygenase inhibitor Aspartate-ammonia ligase (ADP-forming) inhibitor Sleep disorders treatment Peptidyl-dipeptidase B inhibitor Hallucinogen

0.444 0.040 0.425 0.021 0.410 0.007 0.430 0.026 0.459 0.056 0.435 0.033 0.412 0.010 0.434 0.033 0.449 0.048 0.418 0.018 0.404 0.004 0.413 0.014 0.408 0.011 0.446 0.049 0.410 0.012 0.419 0.022 0.407 0.011 0.402 0.008 0.419 0.025 0.412 0.019 0.406 0.013 0.428 0.034 0.442 0.049 0.474 0.082 0.400 0.008 0.443 0.051 0.420 0.028 0.410 0.018 0.403 0.012 0.396 0.005 0.396 0.005 0.452 0.061 0.426 0.036 0.408 0.018 0.414 0.024 0.396 0.006 0.403 0.013 0.456 0.066 0.404 0.015

Skeletal muscle relaxant Glycerone-phosphate O-acyltransferase inhibitor (S)-carnitine 3-dehydrogenase inhibitor Acyloxyacyl hydrolase inhibitor Radioprotector 2-Acylglycerol O-acyltransferase inhibitor Tryptophan dimethylallyltransferase inhibitor Phosphatidate cytidylyltransferase inhibitor CYP2A substrate Shikimate 5-dehydrogenase inhibitor Mycodextranase inhibitor Alpha-L-rhamnosidase inhibitor Bradycardic Cytostatic Cysteine-S-conjugate beta-lyase inhibitor tRNA adenylyltransferase inhibitor Glutamine-pyruvate transaminase inhibitor Pantothenase inhibitor Sterol 3beta-glucosyltransferase inhibitor Thiamine-phosphate kinase inhibitor Beta-D-fucosidase inhibitor Adenylate cyclase inhibitor 4-Nitrophenylphosphatase inhibitor Antipruritic, allergic Granzyme A inhibitor Microtubule formation stimulant ATP phosphoribosyltransferase inhibitor Phosphoserine phosphatase inhibitor Rhizopuspepsin inhibitor Sorbose dehydrogenase inhibitor Aerobactin synthase inhibitor Analgesic Arylamine N-acetyltransferase inhibitor Malate-CoA ligase inhibitor O-aminophenol oxidase inhibitor Opioid kappa receptor antagonist Glutamine-tRNA ligase inhibitor CYP2C9 substrate Brachyurin inhibitor

0.412 0.024 Trimethylamine-N-oxide reductase inhibitor 0.407 0.021 Colony stimulating factor agonist 0.407 0.021 Oxalate oxidase inhibitor 0.404 0.018 Aldehyde dehydrogenase (NAD+) inhibitor 0.408 0.022 Peptidylglycine monooxygenase inhibitor 0.409 0.023 Serine-phosphoethanolamine synthase inhibitor 0.428 0.044 Acrosin inhibitor 0.398 0.015 Antitussive, narcotic 0.388 0.005 DNA-3-methyladenine glycosylase II inhibitor 0.435 0.052 Anaphylatoxin receptor antagonist 0.397 0.014 Guanidinobutyrase inhibitor 0.398 0.016 Galactosylgalactosylglucosylceramidase inhibitor 0.395 0.013 Glutamate (mGluR1) antagonist 0.413 0.031 Formaldehyde dehydrogenase (glutathione) inhibitor 0.394 0.013 Glycine transaminase inhibitor 0.403 0.022 CYP2C6 substrate 0.386 0.005 Aromatic-hydroxylamine O-acetyltransferase inhibitor 0.481 0.100 Antidiarrheal 0.398 0.018 3-Oxoacyl-[acyl-carrier-protein] synthase inhibitor 0.485 0.106 Cholesterol synthesis inhibitor 0.403 0.024 Narcotic 0.385 0.006 3-Dehydroquinate dehydratase inhibitor 0.401 0.024 Tentoxilysin inhibitor 0.399 0.021 Lysozyme inhibitor 0.384 0.007 3-Phosphoshikimate 1-carboxyvinyltransferase inhibitor 0.385 0.009 Homoserine O-succinyltransferase inhibitor 0.396 0.019 Alkanal monooxygenase (FMN-linked) inhibitor 0.391 0.015 D-lactate dehydrogenase inhibitor 0.392 0.016 Amidase inhibitor 0.432 0.056 Carcinogenic, male rats 0.381 0.005 Glucosamine-1-phosphate N-acetyltransferase inhibitor 0.399 0.023 Contraceptive female 0.434 0.059 Spasmogenic 0.385 0.009 Trimethyllysine dioxygenase inhibitor 0.412 0.038 Procollagen C-endopeptidase inhibitor 0.402 0.028 Aldehyde dehydrogenase inhibitor High-mannose-oligosaccharide beta-1,4-N0.378 0.005 acetylglucosaminyltransferase inhibitor 0.391 0.018 Dolichol kinase inhibitor

0.386 0.014 0.395 0.022 0.379 0.007 0.381 0.010 0.387 0.015 0.381 0.010 0.410 0.040 0.378 0.007 0.375 0.004 0.400 0.030 0.389 0.018 0.424 0.054 0.390 0.020 0.423 0.054 0.403 0.034 0.405 0.036 0.394 0.026 0.403 0.035 0.400 0.033 0.396 0.029 0.373 0.006 0.402 0.036 0.380 0.013 0.422 0.056 0.391 0.025 0.394 0.028 0.369 0.005 0.399 0.035 0.371 0.007 0.386 0.021 0.383 0.019 0.369 0.005 0.373 0.010 0.374 0.011 0.372 0.009 0.372 0.009 0.403 0.041 0.377 0.015 0.375 0.014

Glutamate N-acetyltransferase inhibitor Insecticide Phenylacetaldehyde dehydrogenase inhibitor Isoquinoline 1-oxidoreductase inhibitor Platelet aggregation stimulant Pyridoxine 5-dehydrogenase inhibitor Phosphatidylinositol kinase inhibitor Choloylglycine hydrolase inhibitor Fatty-acyl-ethyl-ester synthase inhibitor Bone diseases treatment Oxoglutarate dehydrogenase (lipoamide) inhibitor Hemostatic Aspartate transaminase inhibitor Antiinfective Glycerol dehydrogenase inhibitor Interferon antagonist Prephenate dehydrogenase inhibitor Stearoyl-CoA 9-desaturase inhibitor Adenylyl-sulfate kinase inhibitor Bronchodilator Isomaltulose synthase inhibitor Glycogen (starch) synthase inhibitor 2-Aminoadipate transaminase inhibitor Muscle relaxant Diuretic inhibitor Cathepsin H inhibitor 2-Hydroxy-3-oxopropionate reductase inhibitor Acetate-CoA ligase inhibitor D-proline reductase (dithiol) inhibitor ATP adenylyltransferase inhibitor CYP2B2 substrate Aspartate racemase inhibitor Arabinose isomerase inhibitor Maleate isomerase inhibitor Dihydroorotate oxidase inhibitor Fumarylacetoacetase inhibitor Male reproductive disfunction treatment Cocain dependency treatment Ribonucleoside triphosphate reductase inhibitor

0.366 0.004 0.391 0.030 0.367 0.007 0.370 0.009 0.379 0.018 0.389 0.029 0.443 0.083 0.371 0.012 0.474 0.114 0.442 0.083 0.398 0.040 0.363 0.005 0.366 0.008 0.445 0.087 0.384 0.026 0.362 0.005 0.382 0.025 0.377 0.020 0.362 0.005 0.373 0.017 0.380 0.024 0.378 0.023 0.371 0.016 0.378 0.022 0.364 0.009 0.382 0.027 0.363 0.009 0.369 0.014 0.357 0.003 0.399 0.046 0.369 0.017 0.391 0.039 0.385 0.033 0.368 0.016 0.372 0.020 0.374 0.023 0.372 0.021 0.366 0.015

2-Methylcitrate dehydratase inhibitor Pyruvate dehydrogenase inhibitor Acetylcholine M2 receptor agonist Homocysteine desulfhydrase inhibitor Aryl-aldehyde dehydrogenase (NADP+) inhibitor Succinate-CoA ligase (ADP-forming) inhibitor Acute neurologic disorders treatment CYP4B1 substrate Tumour necrosis factor alpha antagonist Prostaglandin-E2 9-reductase inhibitor Hematopoietic ATP deaminase inhibitor Succinate dehydrogenase inhibitor QT interval prolongation Sulfate adenylyltransferase inhibitor Haloalkane dehalogenase inhibitor Methylenetetrahydrofolate dehydrogenase (NADP+) inhibitor Isovaleryl-CoA dehydrogenase inhibitor Quisqualate antagonist Cerevisin inhibitor Inositol-polyphosphate 5-phosphatase inhibitor Cystathionine gamma-lyase inhibitor 2-Aminohexano-6-lactam racemase inhibitor Cholate-CoA ligase inhibitor Quinoline-4-carboxylate 2-oxidoreductase inhibitor Antiparkinsonian, tremor relieving Formimidoylglutamase inhibitor Polar-amino-acid-transporting ATPase inhibitor Imidazoleglycerol-phosphate dehydratase inhibitor Carcinogenic, female mice Alanine transaminase inhibitor Endopeptidase La inhibitor NADPH:quinone reductase inhibitor Magnesium protoporphyrin IX methyltransferase inhibitor Cysteine synthase inhibitor Leukotriene A4 hydrolase inhibitor CNS active muscle relaxant Serine-glyoxylate transaminase inhibitor

0.357 0.006 0.356 0.005 0.363 0.013 0.392 0.041 0.362 0.011 0.383 0.034 0.366 0.017 0.364 0.015 0.369 0.021 0.433 0.086 0.388 0.042 0.373 0.027 0.368 0.022 0.368 0.023 0.355 0.009 0.361 0.017 0.353 0.010 0.354 0.011 0.439 0.097 0.450 0.107 0.381 0.038 0.348 0.005 0.359 0.018 0.356 0.014 0.369 0.029 0.373 0.033 0.397 0.057 0.346 0.006 0.372 0.033 0.355 0.015 0.352 0.013 0.375 0.036 0.348 0.009 0.374 0.036 0.346 0.008 0.361 0.023 0.367 0.030 0.348 0.011

D-Arabinono-1,4-lactone oxidase inhibitor AMPA receptor agonist D-Ornithine 4,5-aminomutase inhibitor Dihydrodipicolinate reductase inhibitor Xylose isomerase inhibitor Antipruritic, non-allergic Mevalonate kinase inhibitor Mydriatic Glutamate (mGluR group I) antagonist Vasodilator, peripheral Clostripain inhibitor Nicotinamidase inhibitor Phosphoglycolate phosphatase inhibitor Acetolactate decarboxylase inhibitor L-fuconate dehydratase inhibitor Keratoses actinic (solar) treatment D-stereospecific aminopeptidase inhibitor Protein synthesis stimulant Antiischemic, cerebral Leukotriene C4 antagonist Guanylate cyclase inhibitor 2-Methyleneglutarate mutase inhibitor Lysyl endopeptidase inhibitor Nicotinamide-nucleotide adenylyltransferase inhibitor CYP4A substrate DNA ligase (ATP) inhibitor Anorexiant Osmotic diuretic Chymotrypsin inhibitor 5-Methyltetrahydropteroyltriglutamate-homocysteine Smethyltransferase inhibitor Agaritine gamma-glutamyltransferase inhibitor L-amino-acid oxidase inhibitor Acetylcholine neuromuscular blocking agent Diacylglycerol O-acyltransferase inhibitor Guanidinopropionase inhibitor Acyl-CoA oxidase inhibitor Kallikrein inhibitor Tryptophan alpha,beta-oxidase inhibitor

0.349 0.013 Neuropsin inhibitor 0.366 0.030 Estrone sulfotransferase inhibitor 0.348 0.012 Allantoicase inhibitor 0.355 0.019 Acetylcholine agonist 0.365 0.029 Glycerol-3-phosphate O-acyltransferase inhibitor 0.372 0.037 Acetylserotonin O-methyltransferase inhibitor 0.344 0.009 Acidifying agent gastric 0.359 0.023 NAD(P)+ transhydrogenase (AB-specific) inhibitor 0.378 0.044 Aminopeptidase B inhibitor 0.343 0.009 Astringent 0.361 0.027 Glutathione-disulfide reductase inhibitor 0.368 0.034 Contraceptive male 0.337 0.004 Succinic dehydrogenase inhibitor 0.359 0.026 NAD+ kinase inhibitor 0.336 0.004 Demethylsterigmatocystin 6-O-methyltransferase inhibitor 0.346 0.015 Dihydropyrimidinase inhibitor 0.354 0.023 Sodium channel blocker class Ib 0.365 0.034 D-Octopine dehydrogenase inhibitor 0.366 0.035 Aryl sulfotransferase inhibitor 0.357 0.026 Phloroglucinol reductase inhibitor 0.365 0.035 2-Nitropropane dioxygenase inhibitor 0.355 0.024 Diphosphomevalonate decarboxylase inhibitor 0.349 0.018 Dopamine uptake inhibitor 0.341 0.011 Glycerophosphocholine phosphodiesterase inhibitor 0.383 0.053 Carcinogenic, male mice 0.402 0.072 Hepatoprotectant 0.387 0.057 Endopeptidase inhibitor 0.412 0.083 Non mutagenic, Salmonella 0.346 0.017 Biotin carboxylase inhibitor 0.343 0.013 Retinyl-palmitate esterase inhibitor 0.359 0.030 Formate dehydrogenase inhibitor 0.338 0.010 Amino-acid racemase inhibitor 0.372 0.044 Carcinogenic, female rats 0.353 0.025 Indoleamine-pyrrole 2,3-dioxygenase inhibitor 0.331 0.004 Homospermidine synthase inhibitor 0.360 0.033 Serralysin inhibitor 0.369 0.041 Contraceptive 0.341 0.014 Agmatinase inhibitor 0.383 0.056 Ethanolaminephosphotransferase inhibitor

0.339 0.012 0.357 0.031 0.352 0.026 0.362 0.036 0.443 0.119 0.329 0.004 0.351 0.027 0.353 0.029 0.346 0.022 0.345 0.022 0.345 0.022 0.335 0.012 0.329 0.006 0.420 0.098 0.342 0.020 0.348 0.026 0.327 0.007 0.327 0.007 0.325 0.004 0.331 0.011 0.324 0.005 0.402 0.084 0.338 0.020 0.330 0.012 0.408 0.091 0.338 0.022 0.347 0.031 0.320 0.004 0.353 0.037 0.343 0.028 0.332 0.017 0.348 0.033 0.324 0.009 0.448 0.134 0.328 0.014 0.338 0.024

2-Aminoethylphosphonate-pyruvate transaminase inhibitor Methionine-tRNA ligase inhibitor Tryptophan 2,3-dioxygenase inhibitor Peptidyl-Lys metalloendopeptidase inhibitor Antiischemic Potassium channel activator (ATP-sensitive) Polarisation inhibitor Imidazoline I1 receptor agonist (S)-2-hydroxy-acid oxidase inhibitor Cytosole dipeptidase inhibitor Homoserine dehydrogenase inhibitor Acetylcholinesterase inhibitor 2-Dehydro-3-deoxy-L-arabinonate dehydratase inhibitor Dermatologic Saluretic Xanthine dehydrogenase inhibitor Fructuronate reductase inhibitor Tagaturonate reductase inhibitor D(-)-tartrate dehydratase inhibitor Mannonate dehydratase inhibitor Antimyopathies Embryotoxic Phenylalanine decarboxylase inhibitor Adenine deaminase inhibitor Vasodilator, renal ADP-ribosylarginine hydrolase inhibitor Gelatinase inhibitor 11-Cis-retinyl-palmitate hydrolase inhibitor Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase inhibitor Polynucleotide 5'-hydroxy-kinase inhibitor Triose-phosphate isomerase inhibitor Loop diuretic L-lactate dehydrogenase (cytochrome) inhibitor Toxic Na+ K+ transporting ATPase inhibitor Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) inhibitor

0.430 0.115 0.337 0.023 0.339 0.025 0.318 0.005 0.318 0.005 0.332 0.019 0.337 0.025 0.321 0.009 0.361 0.049 0.361 0.049 0.316 0.004 0.357 0.045 0.318 0.007 0.316 0.005 0.329 0.019 0.362 0.051 0.330 0.020 0.355 0.045 0.329 0.020 0.335 0.026 0.314 0.005 0.348 0.040 0.313 0.005 0.317 0.009 0.339 0.032 0.311 0.005 0.347 0.041 0.318 0.013 0.369 0.064 0.360 0.054 0.333 0.029 0.347 0.043 0.331 0.028 0.307 0.005 0.342 0.040

Antiinflammatory, intestinal Adenosylmethionine-8-amino-7-oxononanoate transaminase inhibitor Heparan-alpha-glucosaminide N-acetyltransferase inhibitor Antiviral, ophthalmic L-lysine oxidase inhibitor Testosterone 17beta-dehydrogenase inhibitor Atrolysin A inhibitor Scyllo-inosamine-4-phosphate amidinotransferase inhibitor Acyl-CoA hydrolase inhibitor Palmitoyl-CoA hydrolase inhibitor Anesthetic inhalation Tripeptidyl-peptidase I inhibitor Phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase inhibitor Erythro-3-hydroxyaspartate ammonia-lyase inhibitor MAO A inhibitor Hypnotic Oxaloacetate decarboxylase inhibitor Dactylysin inhibitor Urate-ribonucleotide phosphorylase inhibitor AMP deaminase inhibitor Gentamicin 2''-nucleotidyltransferase inhibitor Hypocalcaemic Alpha,alpha-trehalose phosphorylase inhibitor Formyltetrahydrofolate dehydrogenase inhibitor Glycine hydroxymethyltransferase inhibitor Lysine decarboxylase inhibitor Alcohol dehydrogenase inhibitor Dolichyl-phosphate beta-glucosyltransferase inhibitor Cathepsin D inhibitor Spasmolytic, Papaverin-like UDP-glucose-hexose-1-phosphate uridylyltransferase inhibitor Eye irritation, moderate Homocitrate synthase inhibitor (S)-2-Methylmalate dehydratase inhibitor Antihelmintic

0.311 0.009 0.334 0.032 0.316 0.014 0.306 0.005 0.307 0.006 0.320 0.019 0.329 0.028 0.317 0.016 0.318 0.018 0.313 0.013 0.511 0.211 0.330 0.029 0.325 0.025 0.323 0.023 0.418 0.118 0.367 0.067 0.352 0.053 0.320 0.021 0.348 0.048 0.338 0.039 0.320 0.021 0.318 0.019 0.321 0.022 0.308 0.009 0.313 0.014 0.323 0.025 0.342 0.045 0.318 0.020 0.342 0.045 0.415 0.118 0.433 0.136 0.328 0.031 0.318 0.021 0.304 0.008 0.323 0.027 0.346 0.052

Polyamine oxidase inhibitor CYP4 substrate Argininosuccinate lyase inhibitor Prostaglandin-I synthase inhibitor 2-Nitrophenol 2-monooxygenase inhibitor Oligo-1,6-glucosidase inhibitor Histidine decarboxylase inhibitor Thiol S-methyltransferase inhibitor Isocitrate dehydrogenase (NAD+) inhibitor Site-specific DNA-methyltransferase (adenine-specific) inhibitor Transcription factor inhibitor NADH dehydrogenase inhibitor Iodide peroxidase inhibitor O-acetylhomoserine aminocarboxypropyltransferase inhibitor Teratogen Rheumatoid arthritis treatment CYP2A11 substrate Oligopeptidase B inhibitor Diuretic Cycloartenol synthase inhibitor Indole-3-acetaldehyde reductase (NADPH) inhibitor Biphenyl-2,3-diol 1,2-dioxygenase inhibitor tRNA cytidylyltransferase inhibitor Saccharopine dehydrogenase (NAD+, L-glutamateforming) inhibitor Alpha-N-acetylgalactosaminide alpha-2,6sialyltransferase inhibitor Beta-ureidopropionase inhibitor Pyroglutamyl-peptidase I inhibitor UDP-glucose 4-epimerase inhibitor Diacylglycerol cholinephosphotransferase inhibitor CDK2/cyclin A inhibitor HDL-cholesterol increasing Adenylate kinase inhibitor Fructose-2,6-bisphosphate 2-phosphatase inhibitor Maleate hydratase inhibitor Antiprotozoal (Coccidial) Carcinogenic, group 3

0.335 0.041 0.311 0.018 0.309 0.017 0.353 0.061 0.355 0.063 0.319 0.027 0.309 0.017 0.322 0.031 0.314 0.023 0.301 0.010 0.323 0.033 0.297 0.007 0.316 0.026 0.312 0.022 0.311 0.022 0.303 0.014 0.313 0.024 0.292 0.003 0.351 0.063 0.328 0.040 0.313 0.025 0.292 0.004 0.298 0.010 0.294 0.007 0.365 0.078 0.309 0.022 0.347 0.060 0.334 0.048 0.294 0.007 0.319 0.032 0.334 0.048 0.291 0.005 0.339 0.053 0.293 0.007 0.306 0.020 0.305 0.020 0.308 0.023

Cholinergic Geranylgeranyl-diphosphate geranylgeranyltransferase inhibitor Saccharopine dehydrogenase (NADP+, L-lysine-forming) inhibitor Antiparasitic Bone formation stimulant 3-Hydroxyanthranilate oxidase inhibitor Oxytocic Keratolytic Gamma-glutamyl hydrolase inhibitor tRNA (cytosine-5-)-methyltransferase inhibitor Benzoate 4-monooxygenase inhibitor Benzaldehyde dehydrogenase (NAD+) inhibitor DNA nucleotidylexotransferase inhibitor 5-Formyltetrahydrofolate cyclo-ligase inhibitor D-malate dehydrogenase (decarboxylating) inhibitor Hair growth stimulant Phosphate acetyltransferase inhibitor HCV NS3-helicase inhibitor Irritable Bowel syndrome treatment MAO inhibitor Threonine ammonia-lyase inhibitor Antimetastatic CYP1A3 substrate Glutamate (mGluR5) agonist CYP2D substrate Aminopeptidase microsomal inhibitor Antiinfertility, female CYP2C19 substrate Putrescine oxidase inhibitor Steroid synthesis inhibitor Choleretic Dihydrouracil oxidase inhibitor Malate dehydrogenase inhibitor Deoxycytidine deaminase inhibitor Hypoglycemic CTP synthase inhibitor Glutamate racemase inhibitor

0.292 0.008 Propionate CoA-transferase inhibitor 0.295 0.011 Aspartate 1-decarboxylase inhibitor 0.309 0.025 Glycine N-acyltransferase inhibitor 0.305 0.021 Homogentisate 1,2-dioxygenase inhibitor 0.290 0.005 Choline acetyltransferase stimulant 0.327 0.042 Thimet oligopeptidase inhibitor 0.316 0.032 Anticataract 0.294 0.010 4-Hydroxy-4-methyl-2-oxoglutarate aldolase inhibitor 0.428 0.145 Leukotriene C antagonist 0.327 0.043 Tripeptide aminopeptidase inhibitor 0.322 0.039 FMN reductase inhibitor 0.309 0.027 2-Oxoaldehyde dehydrogenase (NAD+) inhibitor 0.308 0.025 Adrenaline uptake inhibitor 0.415 0.133 Antiprotozoal (Toxoplasma) 0.296 0.014 Pyridoxal kinase inhibitor 0.307 0.025 Lysine 2-monooxygenase inhibitor 0.288 0.006 Diguanidinobutanase inhibitor 0.305 0.023 Pyrroline-5-carboxylate reductase inhibitor 0.327 0.046 Antitussive 0.322 0.041 Inositol oxygenase inhibitor 0.294 0.014 4-Hydroxy-2-oxoglutarate aldolase inhibitor 0.290 0.010 D-lactate-2-sulfatase inhibitor 0.353 0.073 Antiulcerative 0.285 0.005 Rubefacient 0.318 0.039 Alkaline phosphatase inhibitor 0.292 0.013 Transforming growth factor beta 1 agonist 0.321 0.042 Growth factor agonist 0.465 0.186 Transplant rejection treatment 0.311 0.032 Glycerol-3-phosphate dehydrogenase (NAD+) inhibitor 0.387 0.108 Immunostimulant 0.304 0.025 NAD(P)+ transhydrogenase (B-specific) inhibitor 0.284 0.007 Lactaldehyde dehydrogenase inhibitor 0.370 0.093 Rhinitis treatment 0.305 0.028 Estrogen alpha receptor agonist 0.295 0.019 Uroporphyrinogen decarboxylase inhibitor 0.299 0.022 L-ascorbate peroxidase inhibitor 0.293 0.018 Arginyltransferase inhibitor 0.300 0.025 Poly(ADP-ribose) glycohydrolase inhibitor 0.305 0.029 Penicillopepsin inhibitor

0.299 0.023 0.324 0.049 0.286 0.011 0.294 0.020 0.292 0.017 0.283 0.008 0.285 0.010 0.306 0.032 0.290 0.016 0.351 0.078 0.293 0.021 0.290 0.018 0.299 0.028 0.286 0.014 0.321 0.050 0.305 0.034 0.287 0.017 0.296 0.026 0.357 0.087 0.323 0.054 0.356 0.087 0.297 0.028 0.343 0.074 0.285 0.017 0.277 0.008 0.273 0.005 0.288 0.020 0.294 0.026 0.287 0.021 0.280 0.014 0.279 0.013 0.284 0.018 0.279 0.014 0.294 0.028 0.304 0.039 0.301 0.036 0.296 0.031 0.283 0.018

3-Hydroxybutyrate dehydrogenase inhibitor GABA receptor agonist Tyrosine 2,3-aminomutase inhibitor Interleukin 10 antagonist Bis(5'-adenosyl)-triphosphatase inhibitor Beta-cyclopiazonate dehydrogenase inhibitor Urocanate hydratase inhibitor Coproporphyrinogen oxidase inhibitor D-alanine transaminase inhibitor CYP2D6 substrate Picornain 2A inhibitor Cystathionine beta-lyase inhibitor Antidepressant, Imipramin-like Cellobiose phosphorylase inhibitor Eye irritation, weak Melatonin 1 antagonist Galactosylceramide sulfotransferase inhibitor Isocitrate dehydrogenase (NADP+) inhibitor Sedative T cell inhibitor Factor XIIIa inhibitor Glutamate synthase (ferredoxin) inhibitor Cardiodepressant Malate dehydrogenase (NADP+) inhibitor Arabinogalactan endo-1,4-beta-galactosidase inhibitor Antiperistaltic Sigma receptor antagonist Tyrosine-ester sulfotransferase inhibitor Photosensitizer Antileprosy Venombin A inhibitor Chondroitin 6-sulfotransferase inhibitor Renilla-luciferin 2-monooxygenase inhibitor Alpha,alpha-trehalase inhibitor Carcinogenic, group 2B Glutathione synthase inhibitor Cannabinoid receptor agonist Glutaminyl-tRNA synthase (glutamine-hydrolysing) inhibitor

0.282 0.018 0.297 0.033 0.278 0.015 0.279 0.016 0.359 0.097 0.278 0.016 0.319 0.057 0.277 0.015 0.284 0.022 0.280 0.019 0.266 0.005 0.264 0.004 0.305 0.044 0.291 0.031 0.272 0.012 0.277 0.017 0.331 0.071 0.382 0.123 0.305 0.046 0.274 0.016 0.279 0.021 0.288 0.031 0.289 0.031 0.327 0.070 0.264 0.007 0.275 0.018 0.281 0.024 0.278 0.022 0.341 0.085 0.266 0.010 0.280 0.024 0.271 0.015 0.260 0.004 0.271 0.015 0.290 0.035 0.272 0.017 0.336 0.081

O-Pyrocatechuate decarboxylase inhibitor X-His dipeptidase inhibitor Bacterial leucyl aminopeptidase inhibitor Postmenopausal disorders treatment Psychotropic Succinate-hydroxymethylglutarate CoA-transferase inhibitor Myosin-light-chain-phosphatase inhibitor (R)-aminopropanol dehydrogenase inhibitor Phosphoribulokinase inhibitor Histamine N-methyltransferase inhibitor Beta-N-acetylgalactosaminidase inhibitor Sucrose phosphorylase inhibitor Eye irritation, high Opioid delta receptor antagonist Mannosyl-oligosaccharide 1,2-alpha-mannosidase inhibitor Galactoside O-acetyltransferase inhibitor Prostaglandin E1 antagonist Cell adhesion molecule inhibitor Alcohol dehydrogenase (NADP+) inhibitor Dextransucrase inhibitor Glucosamine 6-phosphate N-acetyltransferase inhibitor Skin irritation, high Oxytocin antagonist Antimycobacterial Lactate-malate transhydrogenase inhibitor Octadecanal decarbonylase inhibitor Thermolysin inhibitor Asparaginase inhibitor Antihypercholesterolemic Pyridoxamine-phosphate oxidase inhibitor Aminopeptidase A inhibitor Dihydrodipicolinate synthase inhibitor 4a-Hydroxytetrahydrobiopterin dehydratase inhibitor L-aminoadipate-semialdehyde dehydrogenase inhibitor Pyruvate carboxylase inhibitor Analgesic, opioid Hypertensive

0.288 0.033 0.285 0.031 0.308 0.054 0.261 0.007 0.261 0.007 0.266 0.012 0.285 0.031 0.280 0.026 0.264 0.011 0.277 0.024 0.261 0.009 0.259 0.007 0.314 0.062 0.285 0.033 0.318 0.066 0.324 0.074 0.289 0.039 0.261 0.010 0.283 0.033 0.255 0.005 0.355 0.105 0.275 0.026 0.281 0.031 0.269 0.019 0.289 0.040 0.257 0.008 0.257 0.008 0.267 0.019 0.260 0.011 0.262 0.014 0.336 0.089 0.258 0.010 0.273 0.025 0.259 0.012 0.266 0.019 0.258 0.012 0.281 0.035 0.272 0.026

Atrolysin C inhibitor Peptidyl-glycinamidase inhibitor Calcium regulator Cyanate hydratase inhibitor Glutamate (mGluR group II) antagonist Oxaloacetate tautomerase inhibitor Phosphodiesterase inhibitor Glutamate dehydrogenase (NADP+) inhibitor D-Serine ammonia-lyase inhibitor CDP-diacylglycerol-inositol 3-phosphatidyltransferase inhibitor Cytochrome P450 CYP3A4 inhibitor 2-Dehydro-3-deoxy-phosphogluconate aldolase inhibitor Antituberculosic Cyclic AMP modulator CYP2B substrate CYP1A2 substrate Antiprotozoal (Plasmodium) 3-Dehydroquinate synthase inhibitor 6 Phosphofructokinase inhibitor CYP3C substrate Antiparkinsonian Chloride channel agonist Xanthine oxidase inhibitor Aromatic-amino-acid transaminase inhibitor CYP2B1 substrate Dopamine beta hydroxylase inhibitor Cyclic GMP antagonist UDP-N-acetylglucosamine diphosphorylase inhibitor Inositol-3-phosphate synthase inhibitor Gluconokinase inhibitor CYP2C substrate Narcotic antagonist Isocitrate lyase inhibitor Mannosidase inhibitor Aspartate-semialdehyde dehydrogenase inhibitor Mannosyl-oligosaccharide glucosidase inhibitor NAD(P)H dehydrogenase (quinone) inhibitor Cytosine deaminase inhibitor

0.296 0.051 0.360 0.116 0.249 0.005 0.298 0.054 0.320 0.076 0.257 0.014 0.312 0.069 0.267 0.025 0.257 0.014 0.264 0.023 0.311 0.070 0.267 0.026 0.282 0.042 0.258 0.017 0.259 0.019 0.247 0.007 0.276 0.036 0.270 0.031 0.252 0.014 0.293 0.055 0.264 0.026 0.243 0.005 0.264 0.027 0.255 0.019 0.289 0.053 0.265 0.029 0.247 0.011 0.301 0.066 0.269 0.034 0.263 0.028 0.271 0.036 0.253 0.018 0.253 0.019 0.263 0.029 0.256 0.023 0.242 0.009 0.282 0.049 0.258 0.025

Skin irritation, weak Selectin antagonist Cholesterol esterase inhibitor Serine protease unspecified inhibitor CYP1A substrate Kallikrein 13 inhibitor Skin irritative effect Ceramidase inhibitor Acetylcholine M2 receptor antagonist Xanthommatin reductase inhibitor Non-steroidal antiinflammatory agent CMP-N-acetylneuraminate monooxygenase inhibitor Lactosylceramide alpha-2,3-sialyltransferase inhibitor Amylo-alpha-1,6-glucosidase inhibitor Glucagon receptor antagonist Geranyltranstransferase inhibitor Chitin synthase inhibitor Procollagen-lysine 5-dioxygenase inhibitor Opioid antagonist Calcium channel agonist Argininosuccinate synthase inhibitor Deoxyhypusine synthase inhibitor Malate dehydrogenase (oxaloacetate-decarboxylating) inhibitor Glycosylphosphatidylinositol diacylglycerol-lyase inhibitor Cathepsin L inhibitor Choline sulfotransferase inhibitor Alpha-mannosidase inhibitor Carcinogenic Glutamate (mGluR) antagonist Aspartate kinase inhibitor Alpha 1b adrenoreceptor antagonist Aminolevulinate transaminase inhibitor 6-Methylsalicylate decarboxylase inhibitor Carbamoyl-phosphate synthase (ammonia) inhibitor Thermitase inhibitor Glutamate uptake inhibitor Cathepsin B inhibitor Cancer procoagulant inhibitor

0.345 0.113 0.240 0.009 0.345 0.114 0.265 0.035 0.247 0.017 0.255 0.025 0.260 0.030 0.234 0.005 0.243 0.014 0.253 0.024 0.254 0.025 0.240 0.012 0.237 0.009 0.265 0.037 0.277 0.048 0.289 0.060 0.261 0.033 0.246 0.018 0.251 0.024 0.240 0.013 0.247 0.020 0.245 0.018 0.256 0.030 0.265 0.038 0.323 0.096 0.327 0.100 0.253 0.026 0.242 0.015 0.288 0.062 0.286 0.060 0.236 0.011 0.338 0.113 0.247 0.022 0.244 0.019 0.247 0.023 0.245 0.022 0.228 0.005 0.227 0.004 0.241 0.019

CYP3A4 substrate Glutamate (mGluR1) agonist Anticonvulsant Glucokinase inhibitor Ribonuclease U2 inhibitor Beta-fructofuranosidase inhibitor Phenylalanine dehydrogenase inhibitor 5 Hydroxytryptamine 7 antagonist Ribulose-bisphosphate carboxylase inhibitor 4,5-Dihydroxyphthalate decarboxylase inhibitor Galactoside 2-alpha-L-fucosyltransferase inhibitor Peptidylprolyl isomerase inhibitor Altronate dehydratase inhibitor Kexin inhibitor Skin irritation, moderate Acetylcholine antagonist Adenylylsulfatase inhibitor L-3-cyanoalanine synthase inhibitor Beta galactosidase inhibitor Acetylcholine M3 receptor antagonist Coagulant Dopachrome isomerase inhibitor Antirickettsial Trypsin inhibitor CYP2 substrate Antifungal Mucolytic Vanillyl-alcohol oxidase inhibitor CYP2E substrate Channel-conductance-controlling ATPase inhibitor tRNA (guanine-N2-)-methyltransferase inhibitor Tumour necrosis factor alpha release inhibitor Ribose-5-phosphate-ammonia ligase inhibitor Guanylate kinase inhibitor Aspartate ammonia-lyase inhibitor UDP-glucuronate decarboxylase inhibitor GABA uptake inhibitor (-)-endo-fenchol synthase inhibitor Anthranilate synthase inhibitor

0.248 0.026 0.285 0.063 0.243 0.022 0.280 0.059 0.282 0.061 0.362 0.141 0.256 0.035 0.240 0.020 0.236 0.016 0.234 0.014 0.255 0.036 0.245 0.025 0.289 0.069 0.230 0.011 0.251 0.032 0.222 0.004 0.224 0.006 0.238 0.020 0.230 0.013 0.305 0.088 0.239 0.022 0.281 0.064 0.224 0.008 0.236 0.020 0.241 0.025 0.232 0.017 0.235 0.019 0.245 0.030 0.233 0.019 0.236 0.022 0.275 0.061 0.230 0.016 0.242 0.029 0.222 0.010 0.228 0.017 0.231 0.020 0.230 0.019 0.220 0.010

Glutamate decarboxylase inhibitor Antiglaucomic Beta lactamase inhibitor Gastrin inhibitor CYP2E1 substrate Ophthalmic drug Expectorant dUTP diphosphatase inhibitor Aldosterone antagonist Lanosterol 14 alpha demethylase inhibitor Adenosine deaminase inhibitor Malonyl-CoA decarboxylase inhibitor Antipyretic D-Alanine-poly(phosphoribitol) ligase inhibitor ATP-binding cassette A1 stimulant 15 Lipoxygenase inhibitor Phosphodiesterase IV inhibitor Arginine deiminase inhibitor Kainate receptor antagonist 1,2-alpha-L-fucosidase inhibitor Biliverdin reductase inhibitor ATPase stimulant Gonadotropin-releasing hormone Neolactotetraosylceramide alpha-2,3-sialyltransferase inhibitor Glycine N-methyltransferase inhibitor Acetylcholine muscarinic agonist Ornithine decarboxylase inhibitor Tryptophan 2-monooxygenase inhibitor Beta-N-acetylhexosaminidase inhibitor Cystathionine beta-synthase inhibitor Cholinergic antagonist Decylcitrate synthase inhibitor Alpha adrenoreceptor agonist Glucan 1,4-alpha-glucosidase inhibitor Phosphoglucomutase inhibitor [acetyl-CoA carboxylase] kinase inhibitor Glutamate receptor agonist 1-Alkyl-2-acetylglycerol O-acyltransferase inhibitor

0.217 0.007 Glycogen synthase kinase-3 beta inhibitor 0.250 0.040 Glutamate dehydrogenase inhibitor 0.230 0.021 Trimerelysin II inhibitor 0.377 0.168 Respiratory distress syndrome treatment 0.221 0.012 MAO B inhibitor 0.218 0.009 CYP2B4 substrate 0.222 0.014 Deoxycytidylate 5-hydroxymethyltransferase inhibitor 0.226 0.018 Sulfonylureas 0.225 0.017 Cholestenone 5alpha-reductase inhibitor 0.210 0.003 Calcium channel N-type antagonist 0.237 0.030 6,7-Dihydropteridine reductase inhibitor 0.214 0.007 CMP-KDO synthase inhibitor 0.218 0.011 Diiodotyrosine transaminase inhibitor 0.257 0.051 Chymase inhibitor 0.226 0.020 Glycoprotein 3-alpha-L-fucosyltransferase inhibitor 0.227 0.021 CYP4A1 substrate 0.261 0.056 Cytosol alanyl aminopeptidase inhibitor 0.325 0.119 CYP3A substrate 0.225 0.020 L-Serine ammonia-lyase inhibitor 0.212 0.006 Histamine H2 receptor agonist 0.224 0.019 Glycerol kinase inhibitor 0.210 0.005 Tartrate decarboxylase inhibitor 0.226 0.021 Branched-chain-amino-acid transaminase inhibitor 0.426 0.221 Neurotrophic factor enhancer 0.225 0.020 6-Phosphofructo-2-kinase inhibitor 0.355 0.150 Atherosclerosis treatment 0.220 0.016 Sulfinoalanine decarboxylase inhibitor 0.216 0.011 4-Hydroxybenzoate 1-hydroxylase inhibitor 0.227 0.022 Thiamine-phosphate diphosphorylase inhibitor 0.239 0.035 CMP-N-acylneuraminate phosphodiesterase inhibitor 0.271 0.067 Antihistaminic 0.212 0.008 Hydroxyquinol 1,2-dioxygenase inhibitor 0.216 0.013 Dynamin GTPase inhibitor 0.222 0.019 N-acetylglucosamine-6-phosphate deacetylase inhibitor 0.213 0.011 Hydroxylysine kinase inhibitor 0.213 0.011 [citrate-(pro-3S)-lyase] thiolesterase inhibitor 0.221 0.019 Acetolactate synthase inhibitor 0.219 0.018 Hydroxymethylglutaryl-CoA lyase inhibitor 0.216 0.015 2-Methylcitrate synthase inhibitor

0.233 0.032 0.225 0.025 0.226 0.027 0.323 0.123 0.211 0.012 0.223 0.024 0.256 0.058 0.221 0.022 0.214 0.016 0.221 0.023 0.203 0.006 0.212 0.015 0.226 0.029 0.213 0.016 0.216 0.020 0.234 0.038 0.220 0.024 0.222 0.028 0.366 0.173 0.207 0.013 0.197 0.004 0.260 0.067 0.200 0.007 0.203 0.010 0.202 0.009 0.212 0.020 0.205 0.012 0.217 0.024 0.214 0.022 0.225 0.032 0.206 0.015 0.224 0.033 0.244 0.054 0.219 0.028 0.307 0.117 0.217 0.027

Phenylalanine 4-monooxygenase inhibitor Uterine stimulant Ribonuclease inhibitor Cyclic AMP phosphodiesterase inhibitor [myelin basic protein]-arginine N-methyltransferase inhibitor Arginine decarboxylase inhibitor CYP1A1 substrate UDP-N-acetylglucosamine 1-carboxyvinyltransferase inhibitor Mannose-6-phosphate isomerase inhibitor Malate synthase inhibitor Glutamate (mGluR group III) antagonist 3(or 17)alpha-hydroxysteroid dehydrogenase inhibitor Methionine adenosyltransferase inhibitor Antihelmintic (Fasciola) Shikimate kinase inhibitor Meprin A inhibitor 5 Hydroxytryptamine 1A antagonist S-methyl-5-thioadenosine phosphorylase inhibitor Interleukin 1 antagonist Arginine racemase inhibitor Glutamate (iGluR5) receptor agonist Antiseptic Amylosucrase inhibitor Alpha-1,6-mannosyl-glycoprotein 6-beta-Nacetylglucosaminyltransferase inhibitor CYP2C2 substrate Malyl-CoA lyase inhibitor Glucan 1,3-alpha-glucosidase inhibitor Histidine ammonia-lyase inhibitor Streptopain inhibitor Ethanolamine kinase inhibitor 4-Hydroxybenzoate decarboxylase inhibitor Sucrose synthase inhibitor Acetylcholine muscarinic antagonist Long-chain-fatty-acid-CoA ligase inhibitor Spasmolytic Ornithine-oxo-acid transaminase inhibitor

0.251 0.061 0.209 0.019 0.201 0.011 0.194 0.004 0.266 0.077 0.198 0.009 0.215 0.026 0.192 0.003 0.211 0.022 0.218 0.030 0.217 0.028 0.204 0.016 0.297 0.110 0.216 0.029 0.219 0.032 0.204 0.017 0.215 0.029 0.193 0.007 0.214 0.029 0.219 0.034 0.205 0.022 0.188 0.005 0.198 0.015 0.206 0.024 0.193 0.010 0.223 0.041 0.205 0.023 0.191 0.009 0.191 0.009 0.194 0.013 0.193 0.013 0.185 0.005 0.204 0.023 0.189 0.009 0.184 0.005 0.205 0.026 0.184 0.005

Anesthetic Glyceraldehyde-3-phosphate dehydrogenase (NADP+) inhibitor Phosphoserine transaminase inhibitor Hydroxysteroid dehydrogenase inhibitor Bradykinin B1 receptor antagonist Strombine dehydrogenase inhibitor 1-Pyrroline-5-carboxylate dehydrogenase inhibitor Lipase inhibitor S-methyl-5-thioribose kinase inhibitor Arginase inhibitor Melatonin antagonist Thyroid hormone antagonist Chronic obstructive pulmonary disease treatment Ribose-5-phosphate isomerase inhibitor Pantoate-beta-alanine ligase inhibitor Tubulinyl-Tyr carboxypeptidase inhibitor N-acetylglucosamine kinase inhibitor Opioid partial agonist Beta 1 adrenoreceptor agonist Sepiapterin reductase inhibitor Tryptophan synthase inhibitor Nuclease inhibitor Glutamate formimidoyltransferase inhibitor Acetyl-CoA C-acyltransferase inhibitor 2-Ethylmalate synthase inhibitor Astacin inhibitor Leucine-tRNA ligase inhibitor MEK1 inhibitor Thioether S-methyltransferase inhibitor Phenylalanine 2-monooxygenase inhibitor Calpain inhibitor GABA B receptor antagonist Acyl-CoA dehydrogenase (NADP+) inhibitor Dopamine D3 agonist Biotin-[methylmalonyl-CoA-carboxytransferase] ligase inhibitor 5 Hydroxytryptamine 2C agonist Acetylcholine M4 receptor agonist

0.382 0.204 0.199 0.022 0.202 0.025 0.223 0.045 0.202 0.024 0.200 0.023 0.224 0.047 0.290 0.113 0.249 0.072 0.206 0.029 0.191 0.014 0.206 0.030 0.184 0.008 0.203 0.027 0.217 0.042 0.232 0.056 0.228 0.052 0.198 0.023 0.190 0.015 0.252 0.077 0.186 0.012 0.182 0.008 0.219 0.045 0.190 0.017 0.177 0.004 0.302 0.129 0.182 0.010 0.178 0.006 0.205 0.033 0.182 0.010 0.202 0.030 0.181 0.009 0.176 0.005 0.273 0.102 0.178 0.008 0.194 0.024 0.273 0.104

Inflammatory Bowel disease treatment [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase inhibitor Succinate-semialdehyde dehydrogenase inhibitor 5 Hydroxytryptamine uptake inhibitor Glycoprotein-fucosylgalactoside alpha-Nacetylgalactosaminyltransferase inhibitor Protocatechuate 3,4-dioxygenase inhibitor Phosphorylase kinase inhibitor Antiurolithic Histamine antagonist Cannabinoid CB2 receptor agonist Postcoital contraceptive Procollagen glucosyltransferase inhibitor Methylaspartate mutase inhibitor Rho-associated kinase inhibitor 5 Hydroxytryptamine 2B antagonist Sodium/hydrogen exchange inhibitor Leukotriene B4 antagonist HIV-1 integrase (Overall Integration) inhibitor Dihydrolipoamide S-acetyltransferase inhibitor Amyloid beta precursor protein antagonist 3 Hydroxyanthranilate oxygenase inhibitor 4-Pyridoxolactonase inhibitor Alpha 2 adrenoreceptor antagonist Acetylcholine M1 receptor agonist Dichloromethane dehalogenase inhibitor Antithrombotic Sucrose alpha-glucosidase inhibitor Thiazolidinedione Diacylglycerol kinase inhibitor Retinoic acid receptor antagonist 3-Deoxy-7-phosphoheptulonate synthase inhibitor Spermidine synthase inhibitor Glutamate (mGluR6) antagonist Phospholipase A1 inhibitor Kainate receptor agonist 4-Hydroxybenzoate 3-monooxygenase inhibitor Thyroxine 5-deiodinase inhibitor

0.227 0.057 0.226 0.056 0.288 0.119 0.242 0.073 0.200 0.032 0.190 0.022 0.196 0.029 0.184 0.017 0.208 0.042 0.198 0.032 0.170 0.004 0.208 0.043 0.298 0.132 0.185 0.020 0.193 0.028 0.245 0.081 0.173 0.009 0.179 0.015 0.222 0.058 0.187 0.024 0.231 0.068 0.194 0.031 0.170 0.007 0.172 0.010 0.190 0.028 0.167 0.005 0.242 0.080 0.181 0.020 0.170 0.009 0.270 0.109 0.178 0.018 0.174 0.014 0.170 0.011 0.169 0.010 0.190 0.031 0.171 0.012 0.236 0.078

Anesthetic local Corticosteroid antagonist Potassium channel (Voltage-sensitive) antagonist Lipocortins synthesis antagonist FAD diphosphatase inhibitor Abortion inducer Glutamate-cysteine ligase inhibitor 3,4-Dihydroxyphenylacetate 2,3-dioxygenase inhibitor Uterine relaxant Cysteine-tRNA ligase inhibitor Histamine H3 receptor antagonist Carboxypeptidase E inhibitor CYP3A5 substrate Malate dehydrogenase (decarboxylating) inhibitor Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) inhibitor Urinary incontinence treatment Opioid mu receptor antagonist Aldose 1-epimerase inhibitor Interleukin 2 antagonist 3-Oxoacid CoA-transferase inhibitor Endoglycosylceramidase inhibitor Aspartate carbamoyltransferase inhibitor Granulocyte stimulating factor agonist Glucosylceramidase inhibitor Uridine nucleosidase inhibitor Homoisocitrate dehydrogenase inhibitor Prostate cancer treatment Phosphoketolase inhibitor Parathyroid hormone antagonist Lipid peroxidase inhibitor Asparagine-oxo-acid transaminase inhibitor 3'(2'),5'-Bisphosphate nucleotidase inhibitor N-acetylglucosaminyldiphosphoundecaprenol N-acetylbeta-D-mannosaminyltransferase inhibitor Hypercalcaemic Actin depolymerization stimulant Thyroid hormone agonist Neuropeptide Y antagonist

0.236 0.078 0.184 0.027

Neuropeptide antagonist Pyruvate, phosphate dikinase inhibitor Alpha-1,6-mannosyl-glycoprotein 2-beta-N0.171 0.014 acetylglucosaminyltransferase inhibitor 0.166 0.008 Sucrose-phosphatase inhibitor 0.177 0.019 Phenylalanine-tRNA ligase inhibitor 0.188 0.031 Glucuronosyltransferase inhibitor 0.304 0.147 Glycine receptor antagonist 0.267 0.110 Antidepressant 0.162 0.005 Granulocyte macrophage colony stimulating factor agonist 0.177 0.020 Dihydrofolate reductase inhibitor 0.164 0.007 Carboxy-cis,cis-muconate cyclase inhibitor 0.175 0.018 Maleylacetoacetate isomerase inhibitor 0.170 0.015 Linoleate isomerase inhibitor 0.173 0.018 Long-chain-acyl-CoA dehydrogenase inhibitor 0.188 0.033 Tryptase inhibitor 0.180 0.025 Glycine N-benzoyltransferase inhibitor 0.172 0.017 Serine-tRNA ligase inhibitor UDP-N-acetylglucosamine-dolichyl-phosphate N0.178 0.023 acetylglucosaminephosphotransferase inhibitor 0.217 0.063 Adrenergic 0.198 0.045 Glutamate dehydrogenase [NAD(P)+] inhibitor 0.171 0.018 Progesterone antagonist 0.164 0.012 5-Aminovalerate transaminase inhibitor 0.179 0.027 Adenine phosphoribosyltransferase inhibitor 0.204 0.052 Antineoplastic alkaloid 0.198 0.047 Nitric oxide synthase inhibitor 0.191 0.040 Nucleotide diphosphatase inhibitor 0.226 0.076 5 Hydroxytryptamine 2C antagonist 0.163 0.013 Nucleoside deoxyribosyltransferase inhibitor 0.168 0.019 Methylthioadenosine nucleosidase inhibitor 0.179 0.030 Citrate (Si)-synthase inhibitor 0.178 0.029 Estrogen antagonist 0.192 0.044 5 Hydroxytryptamine 2 agonist 0.159 0.010 Phosphoglycerate phosphatase inhibitor 0.209 0.061 Lactoylglutathione lyase inhibitor 0.206 0.058 Thrombolytic 0.178 0.030 Polynucleotide adenylyltransferase inhibitor 0.174 0.026 X-Trp aminopeptidase inhibitor

0.184 0.036 0.160 0.014 0.159 0.013 0.230 0.085 0.358 0.212 0.177 0.031 0.179 0.034 0.158 0.013 0.148 0.004 0.161 0.018 0.161 0.018 0.163 0.020 0.147 0.005 0.160 0.018 0.152 0.010 0.157 0.016 0.223 0.081 0.231 0.091 0.198 0.058 0.190 0.050 0.200 0.060 0.168 0.029 0.155 0.017 0.166 0.028 0.153 0.016 0.165 0.028 0.148 0.011 0.199 0.062 0.195 0.058 0.339 0.202 0.194 0.058 0.193 0.056 0.147 0.011 0.168 0.034 0.156 0.022 0.151 0.017

Thromboxane synthase inhibitor Mycolysin inhibitor Glutamate (mGluR group I) agonist Platelet antagonist Immunomodulator NAD+ nucleosidase inhibitor Phosphoglycerate kinase inhibitor Alpha glucosidase inhibitor Cytokine production inhibitor Betaine-homocysteine S-methyltransferase inhibitor 3-Hydroxydecanoyl-[acyl-carrier-protein] dehydratase inhibitor 3-Methyl-2-oxobutanoate dehydrogenase (lipoamide) inhibitor Calcitonin stimulant ATP diphosphatase inhibitor 4-Hydroxyphenylacetate 1-monooxygenase inhibitor Arginine kinase inhibitor Antibacterial Atrial natriuretic peptide agonist Gastrointestinal motility stimulant Prolactin inhibitor Antianorexic Globoside alpha-N-acetylgalactosaminyltransferase inhibitor [hydroxymethylglutaryl-CoA reductase (NADPH)]phosphatase inhibitor Cytidine deaminase inhibitor Putrescine carbamoyltransferase inhibitor Adenosine A1 receptor antagonist Carnitine palmitoyltransferase inhibitor Arachidonic acid antagonist Prokinetic Alcohol O-acetyltransferase inhibitor Endothelin converting enzyme inhibitor Mutagenic Stipitatonate decarboxylase inhibitor N-formylglutamate deformylase inhibitor Pyruvate, water dikinase inhibitor Cathepsin S inhibitor

0.157 0.024 Rhodopsin kinase inhibitor 0.165 0.031 Mannitol-1-phosphate 5-dehydrogenase inhibitor 0.149 0.016 Uridine phosphorylase inhibitor 0.187 0.054 Retinoic acid alpha receptor agonist 0.155 0.023 Ketohexokinase inhibitor 0.151 0.019 Enoyl-CoA hydratase inhibitor 0.143 0.011 Thymidine-triphosphatase inhibitor 0.272 0.141 Cell adhesion inhibitor 0.163 0.032 Glutamate carboxypeptidase inhibitor 0.158 0.026 Nicotinate phosphoribosyltransferase inhibitor 0.144 0.013 Deoxyhypusine monooxygenase inhibitor 0.210 0.079 Inotropic 0.182 0.051 Mutagenic, Salmonella 0.150 0.020 D-Lysine 5,6-aminomutase inhibitor 0.140 0.010 Isopentenyl-diphosphate DELTA-isomerase inhibitor 0.142 0.012 Prostaglandin D2 agonist 0.158 0.028 Dolichyl-phosphate beta-D-mannosyltransferase inhibitor 0.150 0.020 Mandelate racemase inhibitor 0.146 0.016 Cysteine dioxygenase inhibitor 0.155 0.026 Alanine carboxypeptidase inhibitor 0.218 0.088 GABA A receptor agonist 0.140 0.011 D-aspartate oxidase inhibitor 0.188 0.059 Phosphodiesterase III inhibitor 0.201 0.072 CYP2A10 substrate 0.145 0.017 Butyryl-CoA dehydrogenase inhibitor 0.155 0.027 Adenosine kinase inhibitor 0.268 0.139 Antihypertensive Biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] 0.141 0.013 ligase inhibitor 0.204 0.076 Corticotropin releasing factor 1 receptor antagonist 0.159 0.032 Thromboxane antagonist 0.137 0.010 Sepiapterin deaminase inhibitor 0.199 0.073 Nitric oxide agonist 0.156 0.029 Glucose-1-phosphate adenylyltransferase inhibitor 0.159 0.033 Histidine-tRNA ligase inhibitor 0.156 0.029 Hypoxanthine phosphoribosyltransferase inhibitor (R)-3-amino-2-methylpropionate-pyruvate transaminase 0.148 0.022 inhibitor 0.150 0.025 Fumarate hydratase inhibitor

0.178 0.053 0.157 0.032 0.130 0.005 0.167 0.043 0.177 0.053 0.212 0.088 0.248 0.124 0.144 0.020 0.148 0.024 0.128 0.005 0.134 0.011 0.135 0.014 0.139 0.017 0.126 0.004 0.176 0.054 0.192 0.070 0.139 0.018 0.140 0.019

Adrenaline agonist Amino-acid N-acetyltransferase inhibitor Alpha 1d adrenoreceptor antagonist Neurolysin inhibitor Phosphorylase inhibitor Cyclooxygenase inhibitor Anxiolytic Anabolic Antihemorrhagic CYP3A11 substrate Neuraminidase inhibitor Plus-end-directed kinesin ATPase inhibitor Uracil phosphoribosyltransferase inhibitor Tartrate dehydrogenase inhibitor Hydroxyacylglutathione hydrolase inhibitor Antiacne dCTP deaminase inhibitor Steroid sulfotransferase inhibitor Phosphogluconate dehydrogenase (decarboxylating) 0.159 0.038 inhibitor 0.136 0.016 NMDA receptor glycine site antagonist 0.139 0.019 [Isocitrate dehydrogenase (NADP+)] kinase inhibitor 0.149 0.028 Catechol 2,3-dioxygenase inhibitor 0.204 0.084 Interleukin 4 antagonist 0.137 0.017 Pyridoxamine-oxaloacetate transaminase inhibitor 0.138 0.018 [acyl-carrier-protein] S-malonyltransferase inhibitor 0.155 0.037 Cathepsin E inhibitor 0.133 0.014 Diphosphate-serine phosphotransferase inhibitor 0.165 0.047 Glutamine synthetase inhibitor 0.130 0.013 Glycerate kinase inhibitor Alpha,alpha-trehalose-phosphate synthase (UDP-forming) 0.145 0.029 inhibitor 0.120 0.005 Transaldolase inhibitor 0.167 0.052 Leukotriene E4 antagonist 0.119 0.004 Retinoid X receptor agonist 0.118 0.004 Histamine H3 receptor agonist UDP-N-acetylmuramoylalanine-D-glutamate ligase 0.138 0.023 inhibitor 0.119 0.005 Riboflavin synthase inhibitor

0.169 0.055 ADP ribose polymerase inhibitor 0.135 0.021 Carnitine O-octanoyltransferase inhibitor 0.151 0.037 Kynureninase inhibitor 0.319 0.205 Muramoyltetrapeptide carboxypeptidase inhibitor 0.199 0.086 Antipsychotic 0.211 0.098 Saccharolysin inhibitor 0.156 0.044 Thymidylate synthase inhibitor 0.124 0.012 Protein-glutamate O-methyltransferase inhibitor 0.177 0.065 Cytotoxic 0.284 0.172 Undecaprenyl-phosphate mannosyltransferase inhibitor 0.161 0.049 Androgen antagonist 0.135 0.024 Prephenate dehydratase inhibitor 0.125 0.014 Tannase inhibitor 0.270 0.159 Antiallergic 0.151 0.041 Cytokine release inhibitor 0.213 0.103 Beta glucuronidase inhibitor 0.160 0.050 Antimetabolite 0.119 0.010 D-Alanine-alanyl-poly(glycerolphosphate) ligase inhibitor 0.121 0.011 Opioid kappa receptor agonist 0.125 0.016 Vitamin 0.124 0.015 Protein C (activated) inhibitor 0.270 0.162 Antiasthmatic 0.121 0.012 Queuine tRNA-ribosyltransferase inhibitor 0.115 0.006 Glycolaldehyde dehydrogenase inhibitor 0.113 0.004 Dolichyldiphosphatase inhibitor 0.153 0.045 Hydroxymethylglutaryl-CoA reductase inhibitor 0.154 0.047 Glutamate synthase (NADPH) inhibitor 0.132 0.024 Hydroxypyruvate reductase inhibitor 0.115 0.007 Glucose-6-phosphate translocase inhibitor 0.127 0.021 Antineoplastic, alkylator 0.229 0.123 Antineoplastic (breast cancer) 0.136 0.030 Orotate phosphoribosyltransferase inhibitor 0.128 0.021 Phosphoenolpyruvate carboxykinase (GTP) inhibitor 0.134 0.028 N-acylneuraminate cytidylyltransferase inhibitor 0.158 0.053 NMDA receptor antagonist 0.163 0.057 Dopamine D1 antagonist 0.124 0.019 UDP-glucose 6-dehydrogenase inhibitor 0.126 0.021 Formate C-acetyltransferase inhibitor 0.115 0.010 Glutamate (mGluR group III) agonist

0.246 0.141 0.131 0.026 0.114 0.010 0.221 0.116 0.169 0.065 0.130 0.026 0.108 0.004 0.111 0.007 0.238 0.135 0.162 0.059 0.119 0.018 0.157 0.055 0.110 0.009 0.265 0.165 0.133 0.033 0.109 0.010 0.140 0.041 0.118 0.018 0.125 0.026 0.132 0.034 0.304 0.206 0.127 0.029 0.109 0.012 0.144 0.047 0.111 0.015 0.123 0.027 0.154 0.059 0.124 0.028 0.141 0.046 0.103 0.008 0.106 0.011 0.186 0.091 0.108 0.013 0.108 0.013 0.199 0.105 0.108 0.014

Myelodysplastic syndrome treatment Prolyl endopeptidase inhibitor Glycine N-choloyltransferase inhibitor Antioxidant Glutamate receptor antagonist NMN nucleosidase inhibitor Anhydrotetracycline monooxygenase inhibitor Plasminogen activator stimulant Antihyperlipoproteinemic Matrix metalloproteinase 1 (membrane-type) inhibitor Orcinol 2-monooxygenase inhibitor Gastrin-releasing peptide antagonist Valine-pyruvate transaminase inhibitor 1-Acylglycerol-3-phosphate O-acyltransferase inhibitor Tryptophan-tRNA ligase inhibitor Androst-4-ene-3,17-dione monooxygenase inhibitor Pyruvate kinase inhibitor Assemblin inhibitor Beta-1,4-mannosyl-glycoprotein 4-beta-Nacetylglucosaminyltransferase inhibitor Nicotinate-nucleotide diphosphorylase (carboxylating) inhibitor Phosphoinositide 5-phosphatase inhibitor Beta 2 adrenoreceptor agonist Spermine synthase inhibitor Ornithine carbamoyltransferase inhibitor Theanine hydrolase inhibitor 5'-Nucleotidase inhibitor Nucleotidase inhibitor GTP cyclohydrolase I inhibitor 5 Hydroxytryptamine 1 antagonist Macrophage scavenger receptor antagonist RNA agonist Thromboxane A2 antagonist Dipeptidyl peptidase IV inhibitor Dipeptidyl peptidase inhibitor Vasopressor 3-Galactosyl-N-acetylglucosaminide 4-alpha-Lfucosyltransferase inhibitor

0.107 0.013 Glucose-6-phosphate isomerase inhibitor 0.111 0.017 Protein N-acetylglucosaminyltransferase inhibitor 0.224 0.130 Cyclic GMP phosphodiesterase inhibitor 0.107 0.014 Tubulin GTPase inhibitor 0.316 0.222 Ceramide glucosyltransferase inhibitor 0.116 0.023 Prostacyclin agonist 0.116 0.024 Histamine H2 receptor antagonist 0.157 0.065 Antiemetic 0.114 0.021 Deoxyguanosine kinase inhibitor 0.109 0.017 2-Methyl-branched-chain-enoyl-CoA reductase inhibitor Membrane-oligosaccharide glycerophosphotransferase 0.100 0.008 inhibitor 0.096 0.004 Cannabinoid receptor antagonist 0.274 0.182 Antineoplastic (multiple myeloma) 0.104 0.012 Glutamate (mGluR6) agonist 0.274 0.183 Antileukemic 0.112 0.021 1-Phosphofructokinase inhibitor 0.122 0.031 Tubulin-tyrosine ligase inhibitor 0.189 0.099 Antispirochetal 0.110 0.020 Chalcone isomerase inhibitor 0.106 0.016 Beta 2 adrenoreceptor antagonist 0.127 0.038 Adenylosuccinate synthase inhibitor 0.116 0.027 Quinate 5-dehydrogenase inhibitor 0.125 0.036 Thrombin inhibitor 0.128 0.039 Phosphoenolpyruvate carboxylase inhibitor 0.096 0.008 Phosphopyruvate hydratase inhibitor 0.098 0.011 2-Aminohexanoate transaminase inhibitor UDP-N-acetylglucosamine-lysosomal-enzyme N0.113 0.026 acetylglucosaminephosphotransferase inhibitor 0.128 0.041 Peristaltic stimulant 0.113 0.026 NAD+ diphosphatase inhibitor 0.141 0.054 Sterol 24-C-methyltransferase inhibitor 0.151 0.064 Neurokinin 1 antagonist 0.113 0.026 AMP nucleosidase inhibitor 0.098 0.011 Farnesoid X receptor agonist 0.236 0.149 Prenyl-diphosphatase inhibitor 0.104 0.017 Cyclohexadienyl dehydrogenase inhibitor 0.115 0.028 Estrogen agonist 0.094 0.008 Dopamine transporter antagonist

0.099 0.014 0.160 0.075 0.091 0.006 0.104 0.019 0.158 0.073 0.132 0.047 0.109 0.025 0.089 0.004 0.099 0.014 0.140 0.056 0.102 0.020 0.102 0.019 0.099 0.017 0.157 0.075 0.102 0.021 0.097 0.017 0.299 0.219 0.147 0.067 0.098 0.019 0.095 0.016 0.193 0.114 0.143 0.064 0.092 0.014 0.097 0.019 0.094 0.017 0.132 0.055 0.104 0.027 0.082 0.005 0.105 0.028 0.107 0.031 0.102 0.026 0.116 0.041 0.176 0.101 0.104 0.029 0.078 0.005 0.211 0.138 0.177 0.104

Luteinizing hormone-releasing hormone agonist Syk tyrosine kinase inhibitor Nicotinamide-nucleotide amidase inhibitor Polyphosphate kinase inhibitor Neurotensin receptor antagonist Adenosine A2b receptor antagonist Deoxycytidine kinase inhibitor Platelet activating factor agonist Chorismate mutase inhibitor Benzodiazepine agonist partial Acyl-CoA dehydrogenase inhibitor Cytidylate kinase inhibitor N-acetylglucosaminyldiphosphodolichol Nacetylglucosaminyltransferase inhibitor Erectile disfunction treatment Deoxyadenosine kinase inhibitor Histone-arginine N-methyltransferase inhibitor Corticotropin releasing factor antagonist 5 Hydroxytryptamine 2A antagonist Diphosphate-fructose-6-phosphate 1-phosphotransferase inhibitor Histone deacetylase inhibitor Growth stimulant Antibiotic Glucose-1-phosphatase inhibitor Nicotinamide phosphoribosyltransferase inhibitor Fructose 5-dehydrogenase (NADP+) inhibitor Alpha 2 adrenoreceptor agonist Steroid DELTA-isomerase inhibitor Cortisone alpha-reductase inhibitor Dopamine D3 antagonist Adenosine uptake inhibitor Adenylosuccinate lyase inhibitor 5 Hydroxytryptamine 1A agonist Tubulin antagonist Fructokinase inhibitor Alkylphospholipid Myc inhibitor NMDA receptor agonist

0.175 0.102 Leukotriene agonist 0.092 0.019 Tyrosine phenol-lyase inhibitor 0.173 0.100 Methylglutamate dehydrogenase inhibitor 0.092 0.020 Bis(5'-nucleosyl)-tetraphosphatase (symmetrical) inhibitor 0.098 0.027 Arginine-tRNA ligase inhibitor 0.100 0.028 Purine nucleosidase inhibitor 0.101 0.030 Procollagen galactosyltransferase inhibitor 0.107 0.036 Caspase 3 stimulant 0.092 0.022 Androgen agonist 0.139 0.068 Dopamine agonist 0.098 0.028 GMP synthase inhibitor 0.104 0.034 Matrix metalloproteinase 1 inhibitor 0.088 0.019 Thymidine phosphorylase inhibitor 0.089 0.019 Nucleoside-triphosphate-adenylate kinase inhibitor 0.105 0.036 Opioid agonist 0.126 0.057 Retinoic acid beta receptor agonist 0.110 0.041 Threonine-tRNA ligase inhibitor 0.080 0.012 Estrone sulfatase inhibitor 0.102 0.034 Interleukin 1 beta converting enzyme inhibitor 0.101 0.034 Histamine agonist 0.097 0.029 Lysine carboxypeptidase inhibitor 0.188 0.121 Gastric antisecretory 0.071 0.005 Mineralocorticoid antagonist 0.146 0.079 5 Hydroxytryptamine 2 antagonist 0.073 0.006 Cytokine production stimulant 0.069 0.003 MKK4 inhibitor 0.069 0.003 MKK7 inhibitor 0.095 0.029 Vasopressin 1 antagonist 0.071 0.006 Myristoyl transferase inhibitor 0.090 0.025 Glycogenin glucosyltransferase inhibitor 0.248 0.183 Antidiabetic symptomatic 0.115 0.050 Beta adrenoreceptor agonist 0.216 0.151 Platelet aggregation inhibitor 0.081 0.016 Nucleoside phosphoacylhydrolase inhibitor 0.120 0.056 3-Oxosteroid 1-dehydrogenase inhibitor 0.192 0.128 Antiuremic 0.079 0.015 Small monomeric GTPase inhibitor 0.088 0.025 RNA polymerase RNA directed stimulant 0.068 0.005 Secretase beta inhibitor

0.091 0.028 0.086 0.023 0.096 0.034 0.140 0.079 0.076 0.014 0.081 0.019 0.078 0.016 0.144 0.083 0.288 0.227 0.226 0.166 0.086 0.025 0.088 0.028 0.078 0.018 0.073 0.014 0.203 0.144 0.097 0.038 0.170 0.111 0.072 0.013 0.172 0.113 0.186 0.128 0.087 0.030 0.076 0.019 0.081 0.024 0.077 0.020 0.091 0.035 0.221 0.166 0.220 0.165 0.131 0.076 0.130 0.075 0.071 0.017 0.087 0.033 0.077 0.023 0.080 0.026 0.294 0.241 0.099 0.046 0.076 0.023

2-Isopropylmalate synthase inhibitor UDP-sugar diphosphatase inhibitor Calcineurin inhibitor Liver X receptor alpha agonist Ribose-5-phosphate adenylyltransferase inhibitor Methylcrotonoyl-CoA carboxylase inhibitor Glutaryl-CoA dehydrogenase inhibitor Thymidine kinase inhibitor CDP-diacylglycerol-serine O-phosphatidyltransferase inhibitor Capillary fragility treatment Methenyltetrahydrofolate cyclohydrolase inhibitor DNA repair enzyme inhibitor Protocatechuate 4,5-dioxygenase inhibitor Uridine kinase inhibitor Antimigraine Testosterone agonist Tyrosine phosphatase 1B inhibitor Orsellinate decarboxylase inhibitor Protease inhibitor Antiarrhythmic Secretase inhibitor Gentamicin 3'-N-acetyltransferase inhibitor dCMP deaminase inhibitor Bacillus subtilis ribonuclease inhibitor Glutamate (mGluR group II) agonist Tauropine dehydrogenase inhibitor RNA synthesis inhibitor Factor VIIa inhibitor Ribonucleoside diphosphate reductase inhibitor Ribosylpyrimidine nucleosidase inhibitor [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] kinase inhibitor Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) inhibitor Amidophosphoribosyltransferase inhibitor Protein-arginine deiminase inhibitor Antifibrinolytic GMP reductase inhibitor

0.086 0.033 0.067 0.014 0.064 0.012 0.154 0.102 0.067 0.015 0.145 0.094 0.070 0.021 0.074 0.024 0.066 0.017 0.088 0.038 0.185 0.137 0.058 0.009 0.065 0.017 0.052 0.004 0.078 0.030 0.066 0.018 0.063 0.015 0.052 0.004 0.110 0.062 0.056 0.009 0.066 0.019 0.254 0.207 0.087 0.040 0.057 0.011 0.059 0.013 0.071 0.025 0.076 0.030 0.049 0.003 0.058 0.012 0.070 0.025 0.149 0.103 0.072 0.028 0.049 0.005 0.070 0.026 0.067 0.023 0.137 0.094 0.100 0.057

Neurokinin 3 antagonist [Skp1-protein]-hydroxyproline Nacetylglucosaminyltransferase inhibitor Cyclomaltodextrin glucanotransferase inhibitor Guanylate cyclase stimulant Estradiol 17 beta dehydrogenase 2 inhibitor Vitronectin receptor antagonist Glutamate (mGluR3) agonist Vibriolysin inhibitor Alpha-1,3-mannosyl-glycoprotein 2-beta-Nacetylglucosaminyltransferase inhibitor Cholecystokinin B antagonist Ganglioside galactosyltransferase inhibitor Phenylpyruvate tautomerase inhibitor Glutathione S transferase inhibitor Thyrotropin releasing hormone agonist Beta-galactoside alpha-2,3-sialyltransferase inhibitor Adenine nucleotide translocase inhibitor Somatostatin agonist Kanamycin kinase inhibitor Opioid mu receptor agonist Procollagen-proline 3-dioxygenase inhibitor Heparanase inhibitor Analgesic, non-opioid Antidiuretic hormone antagonist Riboflavin kinase inhibitor Histone-lysine N-methyltransferase inhibitor Purinergic P2X antagonist Beta 1 adrenoreceptor antagonist Dopamine D2 agonist inducer tRNA (guanine-N7-)-methyltransferase inhibitor Oligonucleotidase inhibitor Glutamate (mGluR5) antagonist 5 Hydroxytryptamine 3 antagonist Purinergic P2X7 antagonist Fucokinase inhibitor Cortisol sulfotransferase inhibitor Liver X receptor agonist Squalene epoxidase inhibitor

0.046 0.005 Vesicular glutamate transport inhibitor 0.067 0.026 Polypeptide N-acetylgalactosaminyltransferase inhibitor 0.065 0.024 UDP-N-acetylmuramate dehydrogenase inhibitor 0.157 0.117 Platelet activating factor antagonist 0.062 0.022 Cellulose synthase (UDP-forming) inhibitor 0.075 0.036 Aromatase inhibitor 0.044 0.005 Adenosine A2a receptor antagonist 0.049 0.010 CC chemokine 1 receptor antagonist 0.050 0.011 CYP17A substrate 0.136 0.097 DOPA decarboxylase inhibitor 0.048 0.010 Ketosteroid monooxygenase inhibitor 0.091 0.053 Purinergic P2 antagonist 0.091 0.053 Purinergic receptor antagonist 0.067 0.030 Estradiol 17 beta dehydrogenase 3 inhibitor 0.053 0.017 2-Methylacyl-CoA dehydrogenase inhibitor 0.044 0.007 CYP11B1 substrate 0.097 0.061 Matrix metalloproteinase inhibitor 0.210 0.174 Antiobesity 0.149 0.113 5 Hydroxytryptamine antagonist 0.155 0.119 Alkylator 0.065 0.029 Tyrosine transaminase inhibitor Chitobiosyldiphosphodolichol beta-mannosyltransferase 0.052 0.017 inhibitor 0.068 0.033 Adenosine A2a receptor agonist 0.041 0.006 Vitamin D receptor agonist N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl0.059 0.025 transferase inhibitor 0.063 0.029 5 Hydroxytryptamine 4 antagonist 0.169 0.135 Prostate disorders treatment 0.036 0.003 Glutathione reductase (NADPH) stimulant 0.036 0.003 Glutathione reductase stimulant 0.151 0.118 5 Hydroxytryptamine 1B antagonist 0.044 0.011 Formimidoyltetrahydrofolate cyclodeaminase inhibitor 0.061 0.029 Glycolipid 3-alpha-mannosyltransferase inhibitor 0.093 0.061 Angiotensin converting enzyme inhibitor 0.058 0.026 5 Hydroxytryptamine 4 agonist 0.213 0.181 Cardiotonic 0.213 0.183 Pancreatic disorders treatment 0.049 0.020 Phytanoyl-CoA dioxygenase inhibitor

0.062 0.033 0.143 0.114 0.042 0.013 0.176 0.148 0.039 0.011 0.263 0.235 0.050 0.022 0.037 0.009 0.031 0.004 0.051 0.025 0.174 0.147 0.032 0.005 0.032 0.005 0.144 0.118 0.044 0.017 0.175 0.149 0.031 0.004 0.031 0.004 0.073 0.047 0.039 0.013 0.163 0.137 0.038 0.013 0.035 0.010 0.195 0.171 0.027 0.003 0.030 0.007 0.197 0.174 0.045 0.023 0.184 0.162 0.038 0.016 0.030 0.008 0.082 0.061 0.135 0.115 0.064 0.045 0.033 0.014 0.073 0.054 0.045 0.026 0.165 0.147

S-adenosyl-L-methionine decarboxylase inhibitor Electrolyte absorption antagonist 17 Alpha hydroxylase/C17-20 lyase inhibitor Anti-Helicobacter pylori Antibiotic beta Lactam-like Pulmonary hypertension treatment Streptomycin 6-kinase inhibitor 5 Lipoxygenase activating protein inhibitor ADAM inhibitor Pantothenate kinase inhibitor [phosphorylase] phosphatase inhibitor Insulin growth factor antagonist Insulin like growth factor 1 antagonist Ribonucleotide reductase inhibitor Acetoacetyl-CoA reductase inhibitor Melanin inhibitor Bax channel antagonist Cytochrome C release inhibitor Asparagine synthase (glutamine-hydrolysing) inhibitor Retinoic acid receptor agonist Calcium channel antagonist Gestagen-like Transthyretin amyloid fibril formation inhibitor Antithrombocytopenic Antixerophthalmic CYP19 substrate Antineoplastic enhancer Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase inhibitor Lymphocytopoiesis inhibitor Tyrosine 3 hydroxylase stimulant Methionyl-tRNA formyltransferase inhibitor 5 Alpha reductase inhibitor Leukotriene synthesis inhibitor Vasopressin 2 antagonist Octopamine agonist 5 Hydroxytryptamine 6 antagonist Xanthine phosphoribosyltransferase inhibitor Protein synthesis inhibitor

0.022 0.005 Protein glycation inhibitor 0.048 0.033 Renin inhibitor 0.067 0.051 Lipocortins synthesis agonist 0.168 0.153 Lipoprotein lipase stimulant 0.030 0.015 UTP-glucose-1-phosphate uridylyltransferase inhibitor 0.018 0.003 P-glycoprotein 1 inhibitor 0.258 0.243 Radiosensitizer 0.092 0.077 Potassium channel activator 0.022 0.009 Calcium/calmodulin-dependent protein kinase II inhibitor 0.022 0.009 Protein kinase C beta inhibitor 0.018 0.005 Antibiotic Carbapenem-like 0.046 0.034 Glutamate (mGluR) agonist 0.016 0.004 sAPP-alpha secretion enhancer 0.047 0.034 Prostaglandin agonist 0.181 0.168 Anthranilate-CoA ligase inhibitor Protein kinase (Mos, Mil/Raf, MEKK, RIPK, TESK, LIMK, 0.017 0.006 IRAK, ILK, Activin/TGF-beta) inhibitor 0.017 0.006 Raf kinase inhibitor 0.142 0.131 Iron antagonist 0.054 0.043 Thromboxane agonist 0.018 0.007 Antimitotic Podophyllotoxin-like 0.101 0.090 5 Hydroxytryptamine agonist 0.017 0.006 Antibiotic Tribactam-like Cholesterol monooxygenase (side-chain-cleaving) 0.016 0.006 inhibitor 0.028 0.018 Methylmalonyl-CoA mutase inhibitor 0.113 0.102 Prolactin release inhibitor 0.047 0.037 Nitric oxide donor 0.036 0.026 [protein-PII] uridylyltransferase inhibitor 0.105 0.096 Adenosine receptor antagonist 0.013 0.004 Protein kinase C alpha stimulant 0.029 0.019 Glucosamine N-acetyltransferase inhibitor 0.034 0.024 Prostaglandin E1 agonist 0.018 0.009 Galectin-3 antagonist 0.012 0.003 Cannabinoid CB1 receptor antagonist 0.013 0.004 Melanocortin MC-4 antagonist 0.013 0.004 Melanocortin antagonist 0.028 0.020 CDP-diacylglycerol diphosphatase inhibitor 0.074 0.066 Fatty acid synthase inhibitor

0.048 0.040 0.050 0.043 0.012 0.004 0.016 0.009 0.014 0.006 0.080 0.073 0.095 0.088 0.089 0.082 0.015 0.008 0.023 0.017 0.022 0.016 0.288 0.282 0.042 0.037 0.080 0.075 0.034 0.029 0.077 0.072 0.014 0.010 0.008 0.004 0.143 0.139 0.021 0.018 0.021 0.018 0.079 0.076 0.008 0.005 0.025 0.023 0.008 0.006 0.056 0.055 0.111 0.109 0.015 0.014 0.040 0.039 0.093 0.093

CYP17 substrate Estradiol 17 beta dehydrogenase inhibitor CYP24 substrate Growth hormone releasing factor antagonist Opioid ORL1 receptor agonist Acetyl CoA transferase inhibitor Retinol O-fatty-acyltransferase inhibitor 2,3 Oxidosqualene lanosterol cyclase inhibitor Janus tyrosine kinase 3 inhibitor CYP27 substrate M7G(5')pppN diphosphatase inhibitor Kinase inhibitor Dopamine D1 agonist AMPA receptor antagonist Endonuclease (influenza) inhibitor Antibiotic Aminoglycoside-like Microtubule stabilizator Rotamase (FKBP12) inhibitor Sucrose-phosphate synthase inhibitor Macrocin O-methyltransferase inhibitor Demethylmacrocin O-methyltransferase inhibitor Dopamine D2 antagonist Tubulin agonist Ribonuclease T2 inhibitor CYP27A substrate Dopamine D2 agonist Collagenase inhibitor Deoxynucleoside kinase inhibitor Melatonin agonist Phosphodiesterase V inhibitor