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Aim and Objectives

The document summarizes 14 studies related to amlodipine besylate, nebivolol hydrochloride, and their combination in pharmaceutical formulations. Several studies developed and validated methods for analyzing the drugs individually or together using techniques like HPLC. Other studies formulated the drugs into single or bilayer tablet designs and evaluated their properties. Interactions between the drugs and common excipients were also reviewed. The combination therapy of amlodipine and nebivolol was found to effectively treat hypertension while reducing side effects.

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Devvrat Dubey
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405 views

Aim and Objectives

The document summarizes 14 studies related to amlodipine besylate, nebivolol hydrochloride, and their combination in pharmaceutical formulations. Several studies developed and validated methods for analyzing the drugs individually or together using techniques like HPLC. Other studies formulated the drugs into single or bilayer tablet designs and evaluated their properties. Interactions between the drugs and common excipients were also reviewed. The combination therapy of amlodipine and nebivolol was found to effectively treat hypertension while reducing side effects.

Uploaded by

Devvrat Dubey
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOC, PDF, TXT or read online on Scribd
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CHAPTER 2 LITERATURE REVIEW

1. Sharma et al., (2011) developed and validated the simultaneous estimation of Amlodipine

Besylate & Nebivolol Hydrochloride in tablet dosage forms by reverse phase High Performance Liquid Chromatography.
2. Kale et al., (2011) reviewed and emphasized that bilayer tablet is improved beneficial technology

to overcome the shortcomings of the single layered tablet.


3. Rao et al., (2011) developed a simple gradient Reverse Phase High Performance Liquid

Chromatography method for quantification of hydrochlorthiazide,Amlodipine Besylate & Nebivolol Hydrochloride in Pharmaceutical Dosage Forms and reported that the recovery results were satisfactory and the developed method is simple, reproducible and accurate.
4. Shaikh et al., (2010) formulated and evaluated S-(-) Amlodipine Besylate and Nebivolol

Hydrochloride tablets and reported that present method was safe and highly effective for treating severe hypertension while reducing undesirable adverse effects associated with anti hypertensive drugs, including the racemic mixture of Amlodipine.
5. Manimaran et al., (2010) studied interactions and incompatabilities of commonly used

pharmaceutical excipients with different Active Pharmaceutical Ingredients in solid dosage forms.
6. Bharate et a., (2010) reviewed interaction and incompatabilities of pharmaceutical excipients

with Active Pharmaceutical Ingredients and reported that such information is very useful for analyzing any instability issues with commercial formulations or during the development of new formulations.

7. Gradman et al., (2010) reviewed the combination therapy in hypertension and reported that the

use of combination therapy routinely is more useful in achieving BP targets.


8. Sharma et a.,l (2010) developed Simultaneous Estimation method of Nebivolol Hydrochloride

and S-(-) Amlodipine Besylate by High Performance Thin Layer Chromatography.


9. Sandozi et al., (2010) evaluated the survey of Prescription pattern of Antihypertensive drugs in

hypertension & hypertension associated Diabetics and found that usage of Calcium Channel Blockers and beta blockers is increased .
10. Mehul et al., (2010) reviewed the challenges in the formulation of bilayer tablets and reported

that the development and production of quality bi-layer tablets needs to be carried out on purpose-built tablet presses to overcome common bi-layer problems, such as layer-separation, insufficient hardness, inaccurate individual layer weight control, cross-contamination between the layers, reduced yield etc.
11. Kumar et al., (2010) formulated and characterized bilayer floating tablets of Ranitidine and

showed a significant increase in bioavailability of drug as compared with conventional dosage form.
12. Munzel et al., (2009) reviewed Nebivolol Adrenergic Receptor Blocker and revealed that this

compound has been proven to have antihypertensive and anti-ischemic effects as well as beneficial effects on hemodynamics and prognosis in patients with chronic congestive heart failure.
13. Joshi et al., (2009) developed and validated a simple and rapid Liquid Chromatography method

for simultaneous estimation of Nebivolol and Amlodipine in a bilayer tablet formulation and reported that the method had requisite accuracy, selectivity, sensitivity, robustness and precision to assay nebivolol and amlodipine in pharmaceutical dosage form.

14. Abdoh A. et al., (2008) reported Amlodipine Besylate- Excipients Interaction in Solid Dosage

Form and that mixture of lactose, magnesium stearate, and water induce some instability on Amlodipine Besylate.

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