Scribd Logo
Upload

Welcome to Scribd!

  • 19 views

    Myocardial Infarction Unstable Angina Pericarditis

    Uploaded by

    iron
    This document discusses the pathogenesis of chest pain from three conditions: myocardial infarction, unstable angina, and pericarditis. It explains that chest pain from myocardial infarction and unstable angina is caused by a reduction in oxygen supply to the heart muscle due to blockages in the coronary arteries limiting blood flow, especially during periods of increased demand. It describes the pathophysiologic processes involved like plaque rupture and thrombus formation. For pericarditis, it states that chest pain occurs when the inflamed layers of the pericardium rub together during heart contractions, often with audible friction sounds.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd

    Myocardial Infarction Unstable Angina Pericarditis

    Uploaded by

    iron
    19 views15 pages
    This document discusses the pathogenesis of chest pain from three conditions: myocardial infarction, unstable angina, and pericarditis. It explains that chest pain from myocardial infarction and unstable angina is caused by a reduction in oxygen supply to the heart muscle due to blockages in the coronary arteries limiting blood flow, especially during periods of increased demand. It describes the pathophysiologic processes involved like plaque rupture and thrombus formation. For pericarditis, it states that chest pain occurs when the inflamed layers of the pericardium rub together during heart contractions, often with audible friction sounds.

    Original Description:

    mi

    Original Title

    Path.of MI,UA,P

    Copyright

    © © All Rights Reserved

    Available Formats

    PPTX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    This document discusses the pathogenesis of chest pain from three conditions: myocardial infarction, unstable angina, and pericarditis. It explains that chest pain from myocardial infarction and unstable angina is caused by a reduction in oxygen supply to the heart muscle due to blockages in the coronary arteries limiting blood flow, especially during periods of increased demand. It describes the pathophysiologic processes involved like plaque rupture and thrombus formation. For pericarditis, it states that chest pain occurs when the inflamed layers of the pericardium rub together during heart contractions, often with audible friction sounds.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    19 views15 pages

    Myocardial Infarction Unstable Angina Pericarditis

    Uploaded by

    iron
    This document discusses the pathogenesis of chest pain from three conditions: myocardial infarction, unstable angina, and pericarditis. It explains that chest pain from myocardial infarction and unstable angina is caused by a reduction in oxygen supply to the heart muscle due to blockages in the coronary arteries limiting blood flow, especially during periods of increased demand. It describes the pathophysiologic processes involved like plaque rupture and thrombus formation. For pericarditis, it states that chest pain occurs when the inflamed layers of the pericardium rub together during heart contractions, often with audible friction sounds.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    You are on page 1of 15

    Myocardial Infarction

    Unstable Angina
    Pericarditis
    Pathogenesis of Chest Pain

    Normal coronary arteries mediate changes in


    coronary blood flow in response to changes in
    myocardial oxygen demand (MV0 2 ).
    When the demands of the heart increases (during
    exercise)

    the coronary arteries dilate to allow


    increased blood flow to meet these
    demands
    Pathogenesis of Chest Pain

    When a coronary artery


    becomes narrowed by greater
    than 70%, its blood flow is
    by approximately 90%.
    Pathogenesis of Chest Pain

    In this setting, maximal coronary vasodilation


    occurs and allows for enough blood flow to
    meet the metabolic demands of the resting
    heart

    However, during periods of increased myocardial


    demand (exercise), the artery is unable to dilate further,
    resulting in inadequate coronary blood
    flow and ischemia
    Pathogenesis of Chest Pain
    caused by
    Reduction in oxygen supply
    Increase in myocardial oxygen demand
    superimposed on an atherosclerotic
    coronary plaque, with varying degrees
    of obstruction
    Four pathophysiologic processes
    1. Plaque rupture or erosion with
    superimposed nonocclusive
    thrombus
    the most common cause
    2. Dynamic obstruction
    Coronary spasm
    (Prinzmetal's variant angina)
    3. Progressive mechanical
    obstruction
    Rapidly advancing coronary
    atherosclerosis or restenosis
    following percutaneous coronary
    intervention
    4. Secondary UA related to
    increased myocardial oxygen
    demand and/or decreased supply
    Tachycardia, anemia
    Fissue or
    ruptures Tissue factor
    plaque is released
    Coronary exposure of with the
    atheroscleros Crack or sub- arterial injury
    is an essential fissure in the endothelial ext Occlusive
    part of the diseased matrix coagulation thrombus
    process in arterial wall elements cascade and
    most patients platelet promotes
    activation and formation of
    thrombus fibrin
    formation
    , the 2 layers of the
    pericardium are separated by a pericardial
    space that contains 50 mL of clear fluid
    The fluid lubricates the pericardium and
    prevents friction between the two layers
    during caridiac contraction
    Pericarditis is marked by
    infiltration of the
    pericardium by
    polymorphonuclear
    leukocytes with eventual The inflamed pericardial layers
    deposition of fibrin in the rub against each other during
    pericardial space each cardiac contraction, often
    resulting in pain and an audible
    friction rub

    You might also like

    pFad - Phonifier reborn

    Pfad - The Proxy pFad of © 2024 Garber Painting. All rights reserved.

    Note: This service is not intended for secure transactions such as banking, social media, email, or purchasing. Use at your own risk. We assume no liability whatsoever for broken pages.


    Alternative Proxies:

    Alternative Proxy

    pFad Proxy

    pFad v3 Proxy

    pFad v4 Proxy