Plant Bitters and Sweeteners

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Some of the key takeaways from the document are that bitters are used to stimulate appetite and the secretion of gastric juice, while sweeteners impart sweet taste and mask other tastes. Various natural sweeteners like stevioside, glycyrrhizin, and thaumatin are discussed.

Some examples of natural sweeteners discussed are stevioside, glycyrrhizin, neohesperidine, thaumatin, monellins, and sucralose.

The sweetness potency of a sweetener can be determined by finding the concentration of the sweetener solution in grams per liter that is equivalent in sweetness to a 100g/l sucrose solution.

PLANT BITTERS AND

NATURAL SWEETNERS
Dr. Md. Rageeb Md. Usman
(M. Pharm., Ph.D., FAPP, FICPHS, FSRHCP, FRSH, FSPER)

Associate Professor
Department of Pharmacognosy

Smt. Sharadchandrika Suresh Patil


College of Pharmacy,
Chopda, Maharashtra, India
Content:-
Introduction

Classification

Determination of sweetness potency

Examples of natural sweeteners


Introduction:-
BITTERS:
Extensively used in liquid medicaments to stimulate
appetite.
Bitter constituents stimulate the nerves in the mouth and
give rise to an increase in psychic secretion of gastric juice.
Extract of the following drugs have been so employed;
Quassia, Cinchona Quinine, Nux vomica Strychnine.
Bitters are used as Anti-tumour and Anti-malarial agents.
Sweetners:
Sweeteners are compound that interact with
the taste buds that evoke a characteristic
response.
They have ability to impart sweet taste by
masking taste of material in which they are
added.
Natural sweetners:-
Sugar or sucrose is the most widely used natural sweetening
agent throughout the world. Sugar imparts a sweet taste that
is quick, clean and short-lived. These are the most desirable
qualities, which render sucrose, the gold standard for sweet
taste.
Nutritive sweetners:-
An ideal alternative to sweetners does not exists. However,
there are many sweet compounds in utility, which generate
less calories.
These can be divided into 2 main groups:
Nutritive Non- Nutritive
Alternative nutritive sweetners are the sugar alcohol such as sorbitol,
mannitol or a mixture of glucosylsorbitol and glucosylmannitol.
Another alternative nutritive sweetner is fructose. It is 1.5 times sweeter
than sugar and cost – effective for food industry.
Non- Nutritive sweetners:
Major Non-nutritive sweetners in use throughout the world were mostly
synthetic sweetner such as saccharin. These are far more sweeter than
sucrose and a very small quantity is required for sweetening food
preparation.
Classification:-
SWEETNERS

NATURAL SYNTHETIC

ORGANIC INORGANIC
SACCHARIDES NON
SALT SUBTITUTED
Eg. sucrose SACCHARIDES
Eg: SALT
Eg
Eg:
Advantages
 Impart sweet taste that is quick clean & short
lived.
 Abundantly available in nature.

Disadvantages
 Obesity
 Dental carries
NEED OF NATURAL SWEETNERS

 Attitude of society divert towards slimness

and health awareness.


 Problems related to high calorific sugar.

 Use of low calorific sugar is restricted due

it’s harmful side effects.


IDEAL PROPERTIES OF NATURAL
SWEETNERS
 Low calorific value.
 Able to mask the taste at low concentration.
 Free from harmful side effects.
 Suitable for long term use.
 Stability.
 Quick onset of action.
 High dissolution rate.
 Synergism with other sweetners.
 Cost effective.
Determination of sweetness potency

sweetness of 100g/l
sucrose solution
sweetness potency=
g/l of sweetner
solution equivalent to
sweetness
Examples of natural sweetners:

 Stevioside
 Glycyrrhizin
 Neohesperidine
 Thaumatin
 Monellins
 Sucralose
Various sweetners of natural origin:-

Stevioside & rebauidoside :


 It is extracted form a south American plant Stevia
rebaudiana Berrtoni, Family: Compositae.
 Extraction:- Stevioside can be isolated from leaves
of stevia.
It is extracted with water or water
methyl alcohol mixture

The ratio of rebaudioside A to stevioside


increased extracting with methanol
Glycyrrhiizin

 It is obtained from liquorice root of Glycyrrhiza


glabra Linn, Family:Leguminoseae

Extraction:-
Dried ,cut liquorice root
Counter current extraction
with water.

A crude liquorice extract


Sulphuric acid

Glycyrrhizinic acid
Disadvantages
 Delayed sweetness onset

 Causes oedema and hypertension

 Neohesperidine dihydrochalcone.

 It is a flavonoids compound present in the

bitter orange Citrus aurantium

Family:- Rutacea.
Semisynthesis of Neohesperidine
dihydrone.

Neohespiridine

NaOH

Neohespiridine dihydrochalcone

DISADVANTAGES:-

1) Prone to hydrolysis.
2) It gives methanol like after taste.
THAUMATIN:-

 Talin is a sweet taste protein found in the arial part of tropical plant

Thaumatococcus danielli

Family:-Marantaceae.

Extraction:-
It is extracted from arils of the plant with water and further
purified with ion-exchange chromatography.
Botanical source Plant part used Sweet Application
principle(s)

1) Illicium verum Dried fruits Trans-Anethole Flavouring and


Illiciacea & estragole sweetening
2) Piper liquors and
marginatum medicines
Dried leaves Trans-Anethole
Piperaceae & estragole
3)Agave juice Fresh leaves Carbohydrate In food stuffs.

4) Cappais Fruits Protein Free radical


masaikai scavenging
Capparidaceae activity

5) Polypodium Rhizomes Proanthrocyani- Analgesic &


feii din anti-
Polypodaceae inflammatory

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