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    QA - QC - Precision and Accuracy

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    Claire Pras
    The document discusses accuracy and precision in quality control testing. It explains that accuracy can be assessed using proficiency testing, analyzing certified reference materials, and calculating percent recovery from spiking samples. Precision is typically measured using relative standard deviation (RSD) or relative percent difference (RPD), but these may not be suitable for pH. The document proposes that precision for pH can be determined by calculating the standard deviation of replicate measurements. It provides an example of how to establish acceptance criteria for pH precision using historical quality control data and standard deviation calculations.

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    QA - QC - Precision and Accuracy

    Uploaded by

    Claire Pras
    88 views24 pages
    The document discusses accuracy and precision in quality control testing. It explains that accuracy can be assessed using proficiency testing, analyzing certified reference materials, and calculating percent recovery from spiking samples. Precision is typically measured using relative standard deviation (RSD) or relative percent difference (RPD), but these may not be suitable for pH. The document proposes that precision for pH can be determined by calculating the standard deviation of replicate measurements. It provides an example of how to establish acceptance criteria for pH precision using historical quality control data and standard deviation calculations.

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    QA/QC

    Original Title

    QA_QC_Precision and Accuracy

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    The document discusses accuracy and precision in quality control testing. It explains that accuracy can be assessed using proficiency testing, analyzing certified reference materials, and calculating percent recovery from spiking samples. Precision is typically measured using relative standard deviation (RSD) or relative percent difference (RPD), but these may not be suitable for pH. The document proposes that precision for pH can be determined by calculating the standard deviation of replicate measurements. It provides an example of how to establish acceptance criteria for pH precision using historical quality control data and standard deviation calculations.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    88 views24 pages

    QA - QC - Precision and Accuracy

    Uploaded by

    Claire Pras
    The document discusses accuracy and precision in quality control testing. It explains that accuracy can be assessed using proficiency testing, analyzing certified reference materials, and calculating percent recovery from spiking samples. Precision is typically measured using relative standard deviation (RSD) or relative percent difference (RPD), but these may not be suitable for pH. The document proposes that precision for pH can be determined by calculating the standard deviation of replicate measurements. It provides an example of how to establish acceptance criteria for pH precision using historical quality control data and standard deviation calculations.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 24

    QA/QC ACCURACY AND PRECISION

    MARY CLAIRE ALYSSA E. PRAS


    Science Research Analyst
    Accuracy & Precision

    ✅ Precision ✖ Precision ✖ Precision ✅ Precision


    ✖ Accuracy ✅ Accuracy ✖ Accuracy ✅ Accuracy
    Accuracy
    How can we say that we are accurate in terms of analysis in our laboratory??

    • Regularly participating in Proficiency Test Program


     The z-scores of the PT result should be less than 2
    • Analyze a Certified or Quality Reference Material
    quarterly How?
     The results must be within the acceptance criteria
    • Certificate of Analysis
    1. Consensus Value – serves as the true value
    2. Confidence Interval Depends on Level of Confidence
    3. Tolerance Interval of Population
    • Using %Recovery
     Spike Recovery
     Results must be within the acceptance criteria
    (Refer to AOAC Table A5. Expected Recovery as a
    function of analyte concentration
    How to assess accuracy in our laboratory??

    7.5.1 Trueness (accuracy), bias, FAO Soils Bulletin – 74,


    Precision
    RSD vs RPD
      𝑹𝑺𝑫= 𝑺𝑫 × 𝟏𝟎𝟎
    %   𝑹𝑷𝑫=
    %
    | 𝑨 − 𝑩|
    × 𝟏𝟎𝟎
    x̄ x̄
    Comparison of RPD vs RSD

    Types of Precision Pros Cons


    RPD • Good for high concentration • Not good for low
    • < 20% is large (rule of thumb for concentrations esp. for ppb
    aqueous samples) • For field duplicates
    • Good for pH and EC

    RSD • Wide range of conc. From % to • Replicate > 2


    ppb • Not applicable for pH and EC
    • Has a good reference (AOAC unless converted to mass
    table appendix F) fraction
    • Has a higher acceptance criteria
    for low concentrations
    Can WE use %RSD & %RPD as a precision test for pH?

    pH - POTENTIAL OF HYDROGEN ION


    Can WE use %RSD as a precision test for pH?
    Can WE use %RPD as a precision test for pH?

    Types of Precision Pros Cons

    RPD • Good for high concentration • Not good for low


    • < 20% is large (rule of thumb for concentrations esp. for ppb
    aqueous samples) • For field duplicates
    • Good for pH and EC

    • The lower the concentration


    the higher the %RPD How about
    higher pH
    values or
    Alkaline?
    HOW ARE WE GOING TO ASSESS
    THE PRECISION OF OUR
    REPLICATES IN TERMS OF pH
    VALUES?
    • Research an alternative Precision Test.
    • Gather References that will support the
    idea of using alternative Precision Test
    aside from RSD and RPD
    We are lucky, we
    found an
    alternative
    Precision Test
    STANDARD METHOD FOR EXAMINATION
    OF WASTE AND WASTEWATER, 23rd. Soil Test Methods From the Southeastern United States
    EDITION

    BOTH REFERENCES USED STANDARD DEVIATION IN


    ESTABLISHING ACCEPTANCE CRITERIA FOR pH.
    IS THAT POSSIBLE TO USE
    STANDARD DEVIATION IN
    ASSESSING PRECISION OF
    REPLICATES??
    SOIL SCIENCE SOCIETY OF AMERICA, BOOK SERIES
    METHOD OF SOIL ANALYSIS, PART 3 CHEMICAL METHODS

    THIS SUPPORTS HOW THEY


    MADE THE PRECISIONS USED IN
    SMEWW AND STSUS
    • PRECISION CAN BE DETERMINED BY A STATISTICAL
    METHOD CALLED A STANDARD DEVIATION

    • STANDARD DEVIATION IS HOW MUCH, ON AVERAGE,


    MEASUREMENTS DIFFER FROM EACH OTHER.

    • HIGH STANDARD DEVIATION INDICATES LOW PRECISION


    • LOW STANDARD DEVIATION INDICATES HIGH PRECISION
    HOW ARE WE GOING TO
    ESTABLISH PRECISION
    ACCEPTANCE CRITERIA??
    • We can gather measured replicates
    of from different laboratories.
    • We can gather sufficient number of
    measured replicates within our
    laboratory.
    SAMPLE ON HOW WE CAN ESTABLISH OUR
    ACCEPTANCE CRITERIA IN OUR LABORATORY
    Sample Data for pH from previous
    Control Chart of Quality Control
    Material NOTE:
    DATE Soil pH This is a sample data.
    1/21/2020 5.04 This is not the official
    1/14/2020 5.08 precision acceptance criteria
    12/15/2020 5.09 As soon as ECQ is done we
    can establish this in our
    11/19/2019 5.04
    laboratory
    10/23/2019 5.03
    10/21/2019 5.09
    10/16/2019 5.10
    10/9/2020 5.10
    10/9/2019 5.09
    10/2/2019 5.02
    Ave 5.07
    Stdev 0.03
    Conclusion: Therefore, the precision acceptance
    criteria data is +/- 0.03
    • CAN WE USE OUR OLD CONTROL CHART QCM
    DATA IN ESTABLISHING PRECISION ACCEPTANCE
    CRITERIA??
    • Yes, if the QCM data plotted in the
    control chart is homogenized

    NOTE:
    THE QCM MUST UNDERGO
    HOMOGENIETY TEST AND
    RUN WITH CRM FOR
    ACCURACY (WITHIN
    ACCEPTABLE CRITERIA),
    OTHERWISE THE PRECISION
    ACCEPTANCE CRITERIA WILL
    BE INVALID
    • HOW MANY MEASURED REPLICATES ARE WE
    GOING TO USE. TO SAY THAT THE ESTABLISHED
    PRECISION ACCEPTANCE CRITERIA IS
    ADEQUATE ENOUGH?• The more measured replicates
    the more scattered our data the
    better the Standard deviation
    For Accuracy:
    • We always need ACCEPTANCE CRITERIA to
    assess the accuracy of every parameter in
    our laboratory

    For Precision:
    • We know that there are OTHER PRECISION
    TEST aside from RPD and RSD
    • We can establish acceptance criteria like
    what SMEWW and STSUS did, using
    STANDARD DEVIATION
    REFERENCES

    • STANDARD METHOD FOR EXAMINATION OF WASTE AND WASTEWATER,


    23rd. Edition
    • Soil Test Methods From the Southeastern United States
    • Soil Science Society Of America, Book Series Method Of Soil Analysis,
    Part 3 Chemical Methods
    • American Society for Testing and Materials, International

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