Experiment: Acid-Base Titration of Aspirin: Objective
Experiment: Acid-Base Titration of Aspirin: Objective
Experiment: Acid-Base Titration of Aspirin: Objective
Chemicals
Potassium hydrogen phthalate (KHP, 204.23 g/mol)
Deionized water
Sodium hydroxide, ~0.10 M (~150 mL per team)
ASA
Phenolphthalein indicator solution
Aspirin tablet
Apparatus
Top loading balance
Weigh paper
Erlenmeyer flasks, 3 x 250 mL
Scoopulas or spatulas
Magnetic stirrer and stir bar
Buret, 25 mL
Buret stand and clamp
1
CH 113 (M.Hall) Ch4
Data & Observations:
NaOH KHP
Part I. Standardization of the Sodium Hydroxide Solution (wet & sticky) (nice & dry)
Solid sodium hydroxide cannot be massed accurately because it absorbs water and carbon dioxide from the
air. Consequently, it is not possible to make an aqueous solution to a very specific and accurate
concentration. Before you use NaOH(aq) to titrate Aspirin, you need to “standardize“ it, that is determine
its accurate concentration. The solution of NaOH(aq) that you are given is approximately 0.10 M. You will
titrate it against a known amount of an acid to determine the concentration of NaOH.
The acid used to standardize the concentration of NaOH is potassium hydrogen phthalate (KHP). It can be
massed very accurately. KHP is actually the potassium salt of the phthalate ion:
The phthalate ion is the acid that is titrated by NaOH in the standardization:
Calculations:
14. Show your calculations for the concentration of sodium hydroxide, the mean, the standard deviation, and
the RSD.
15. Calculate the mass of ASA in the Aspirin tablet.
16. Assuming 325 mg ASA/tablet is the accepted value, determine your percent error.
Results:
Summarize your results here.
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