Learning Overview

LEARNING OVERVIEW
Prepared By
Ms.Madhuri B.Dagade
Sojar College Of Pharmacy,khandvi
IMPORTANCE OF SUBJECT
1. Pharmaceutical Chemistry is the Chemistry of

substances used as medicines
2. Pharmaceutical Chemistry II is the chemistry of

drugs of organic origin
3. Organic pharmaceutical chemistry is concerned with

medicinal organic compounds,determination of their
structure ,synthesis ,isolation ,and their chemistry
PHARMACEUTICAL CHEMISTRY
 Pharmaceutical chemistry is the discipline at the

intersection of chemistry, especially synthetic organic
chemistry, and pharmacology and various other
biological specialties, where they are involved with
design, chemical synthesis and development for
market of pharmaceutical agents, or bio-active
molecules (drugs).
 Practically speaking, it involves chemical aspects of
identification, and then systematic, thorough synthetic
alteration of new chemical entities to make them
suitable for therapeutic use.
 Pharmaceutical chemistry is focused on quality aspects of
medicines and aims to assure fitness for purpose of medicinal
products by analyzing & evaluating them as per the quality
control standards
VISION
 To create competent chemists & analysts through innovative
ideas, recent concepts & trends in the field of pharmaceutical
chemistry.
MISSION
 To inculcate training & research attitude in students & faculty
by providing academic ambience in area of synthetic &
analytical chemistry.
OBJECTIVES OF THE SUBJECTS
1. To improve the knowledge base required for synthesis,
isolation, purification and characterization of various
pharmaceuticals.
2. To improve skills for effective handling of chemicals,
glasswares and analytical instruments.
3. To equip students with the appropriate qualities & skills
required to fulfill job responsibilities as chemists in
pharmaceutical, chemical and biomedical industries.
4. To provide enduring atmosphere and encourage students &
faculty for research activity.
5. To train faculty & students in safe handling of chemicals &
creating awareness about hazardous effects of chemicals
COURSE OBJECTIVES
 This subject is designed to impart fundamental

knowledge on the structure, chemistry and therapeutic
value of drugs.
 Emphasizes on chemical synthesis of important drugs
under each class
LEARNING OUTCOMES
 Write the structure, IUPAC name of drugs

 Chemical synthesis of some drugs
 Understand the chemistry of drugs with respect to their

pharmacological activity
 Understand the adverse effect and therapeutic value of
drugs
SYLLABUS
MODULE-I
 Introduction to the nomenclature of organic chemical
systems with particular reference to hetero-cyclic system
containing up to 3 rings.
Module II
The chemistry of following pharmaceutical organic compounds

covering their nomenclature, chemical structure, uses and the
important physical and chemical properties(chemical structure of
only those compounds marked with asterisk (*).
The stability and storage conditions and the different type of
pharmaceutical formulations of these drugs and their popular
brand names
1.Antiseptics and Disinfectants-
Proflavine*, Benzalkonium chloride, Cetrimide, Phenol,
chloroxylenol, Formaldehyde solution, Hexachlophene,
Nitrofurantoin
2.Sulphonamides-
Sulphadiazine, Sulphaguanidine, Phthalylsulphathaizole,
Succinylsulphathiazole, Sulphadimethoxine,
Sulphamethoxypyridazine, Co-trimoxazole, sulfacetamide*
3.Antileprotic Drugs-
Clofazimine , Thiambutosine, Dapsone*, solapsone,
4.Anti-tubercular Drugs-
Isoniazid*, PAS*, Streptomycin, Rifampicin, Ethambutol*,
Thiacetazone, Ethionamide, cycloserine, pyrazinamide*.
5.Antimoebic and Anthelmintic Drugs-
Emetine, Metronidazole, Halogenated hydroxyquinolines,
Diloxanide furoate, Paromomycin , Piperazine*, Mebendazole,
D.E.C.*
6.Antibiotics-
Benzyl penicillin*, Phenoxy methyl penicillin*, Benzathine
penicillin, Ampicillin*, Cloxacillin, Carbencicillin, Gentamicin,
Neomycin, Erythromycin, Tetracycline, Cephalexin,
Cephaloridine, Cephalothin, Griseofulvin, Chloramphenicol.
7.Antifungal agents- Udecylenic acid, Tolnaftate, Nystatin,

Amphotericin, Hamycin
8.Antimalarial Drugs-Chloroquine*,Amodiaquine, Primaquine,
Proguanil, Pyrimethamine*, Quinine, Trimethoprim.
9.Drugs acting on CNS

A)Tranquilizers-Chlorpromazine*, Prochlorperazine,
Trifluoperazine, Thiothixene, Haloperiodol*, Triperiodol,
Oxypertine, Chlordizepoxide, Diazepam*, Lorazepam, Meprobamate
B)Hypnotics- Phenobarbitone*, Butobarbitone, Cylobarbitone,
Nitrazepam, Glutethimide*, Methyprylon, Paraldehyde,
Triclofosodium.
C)General Anaesthetics- Halothane*, Cyclopropane*, Diethyl

ether*, Methohexital sodium, Thiopecal sodium, Trichloroethylene.
D)Antidepressant Drugs- Amitriptyline, Nortryptyline, Imperamine*,
Phepelzine, Tranylcypromine.
E)Analeptics- Theophylline, Caffeine*, Coramine*, Dextro-amphetamine.
10)Drugs acting on ANS

A)Adrenergic drugs- Adrenaline*, Noradrenaline, Isoprenaline*, Phenylephrine,
Salbutamol, Terbutaline, Ephedrne*, Pseudoephedrine.
B)Adrenergic antagonist- Tolazoline, Propranolol*, Practolol.
C)Cholinergic Drugs- Neostigmine*, Pyridostigmine, Pralidoxime, Pilocarpine,

Physostigmine*
D)Cholinergic Antagonists- Atropine*, Hyoscine, Homatropine, Propantheline*,

Benztropine, Tropicamide, Biperiden*
11.Diuretic Drugs- Furosemide*, Chlorothiazide, Hydrochlorothiazidc*, Benzthiazide, Urea*,
Mannitol*, Ethacrynic Acid.
12.Cardiovascular Drugs- Ethylnitrite*, Glyceryl trinitrate, Alpha methyldopa, Guanethidine,

Clofibrate, Quinidine.
13.Hypoglycemie Agents- Insulin, Chlorpropamide*, Tolbutamide, Glibenclamide,

Phenformin*, Metformin.
14.Coagulants and Anti coagulants- Heparin, Thrombin, Menadione*,

Bisphydroxycoumarin, Warfarin sodium.
15.Local Anaesthetics- Lignocaine*, Procaine*, Benzocaine,
16.Histamine and anti Histaminic Agents- Histamine, Diphenhydramine*, Promethazine,

Cyproheptadine, Mepyramine*, Pheniramine, Chlorpheniramine*,
17.Analgesics and Anti-pyretics-Morphine, Pethidine, Codeine, Mathadone, Aspirin*,

Paracetamol, Analgin, Dextropropoxphene, Pentazocine.
18.Non-steriodal anti-inflammatory agents- Indomethacin*, Phenylbutazone*,
Oxyphenbutazone, Ibuprofen.
19.Thyroxine and Antithyroids- Thyroxine*, Methimazole, Methyl thiouracil,

Propylthiouracil.
20.Diagnostic Agents- Lopanoic Acid, Propyliodone, Sulfobromopthalein-sodium,

Indigotindisulfonate, Indigo Carmine, Evans blue, Congo Red, Fluorescein sodium.
21.Anticonvulsants, cardiac glycosides, Antiarrhythmic, Antihypertensives &

Vitamins. Steroidal Drugs- Betamethasone, Cortisone, Hydrocortisone,
Prednisolone, Progesterone, Testosterone, Oestradiol, Nandrolone.
22.Anti-Neoplastic Drugs- Actinomycin, Azathioprie, Busulphan, Chloramubucil,

Cisplatin, Cyclophosphamide, Daunorubicin Hydrochoride, Fluorouracil,
Mercaptopurine, Methotrexate, Mytomycin.
REFERENCE BOOKS
1.Pharmacopoeia of India
2. British Pharmaceutical codex
3. Martindale's Extra pharmacopoeia
4. Pharmaceutical chemistry- II, Thakur publication
5.Concise organic Pharmaceutical chemistry II By
Dr.K.R.Mahadik,Dr.B.S.Kuchekar,K.R.deshmukh

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LEARNING OVERVIEW

1. Pharmaceutical Chemistry is the Chemistry of

2. Pharmaceutical Chemistry II is the chemistry of

3. Organic pharmaceutical chemistry is concerned with

 Pharmaceutical chemistry is the discipline at the

 This subject is designed to impart fundamental

 Write the structure, IUPAC name of drugs

 Understand the chemistry of drugs with respect to their

The chemistry of following pharmaceutical organic compounds

7.Antifungal agents- Udecylenic acid, Tolnaftate, Nystatin,

9.Drugs acting on CNS

C)General Anaesthetics- Halothane*, Cyclopropane*, Diethyl

E)Analeptics- Theophylline, Caffeine*, Coramine*, Dextro-amphetamine.

10)Drugs acting on ANS

B)Adrenergic antagonist- Tolazoline, Propranolol*, Practolol.

C)Cholinergic Drugs- Neostigmine*, Pyridostigmine, Pralidoxime, Pilocarpine,

D)Cholinergic Antagonists- Atropine*, Hyoscine, Homatropine, Propantheline*,

12.Cardiovascular Drugs- Ethylnitrite*, Glyceryl trinitrate, Alpha methyldopa, Guanethidine,

13.Hypoglycemie Agents- Insulin, Chlorpropamide*, Tolbutamide, Glibenclamide,

14.Coagulants and Anti coagulants- Heparin, Thrombin, Menadione*,

15.Local Anaesthetics- Lignocaine*, Procaine*, Benzocaine,

16.Histamine and anti Histaminic Agents- Histamine, Diphenhydramine*, Promethazine,

17.Analgesics and Anti-pyretics-Morphine, Pethidine, Codeine, Mathadone, Aspirin*,

19.Thyroxine and Antithyroids- Thyroxine*, Methimazole, Methyl thiouracil,

20.Diagnostic Agents- Lopanoic Acid, Propyliodone, Sulfobromopthalein-sodium,

21.Anticonvulsants, cardiac glycosides, Antiarrhythmic, Antihypertensives &

22.Anti-Neoplastic Drugs- Actinomycin, Azathioprie, Busulphan, Chloramubucil,

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C)General Anaesthetics- Halothane, Cyclopropane, Diethyl

E)Analeptics- Theophylline, Caffeine, Coramine, Dextro-amphetamine.

D)Cholinergic Antagonists- Atropine, Hyoscine, Homatropine, Propantheline,

15.Local Anaesthetics- Lignocaine, Procaine, Benzocaine,