Dna Replication
Dna Replication
Dna Replication
DNA Replication
Copying of DNA.
Starts with one double-stranded DNA
molecule producing two identical copies
it is the basis for
• Transfer of genetic information from
parents to the progeny
• Cell division
General Features of Replication
1. Semi-Conservative
2. Starts at Origin
3. Bidirectional
4. Semi-Discontinuous
Proposed Models of DNA Replication
Parental strand
remains intact
DNA Replication
Semiconservative:
During a round of replication,
each of the two strands of
DNA is used as a template for
synthesis of a new,
complementary strand.
Structure of DNA
4. Elongation
Origin of Replication
• DNA replication begins at a single, unique
nucleotide sequence, the origin of replication
• include a short sequence composed almost
exclusively of AT base pairs
• Binding of DnaA protein causing local
denaturation
Separation of the two complementary
DNA strands
• binding of DnaA protein at oriC leading to
local denaturation and unwinding of AT rich
region
• dsDNA separated (melted), as polymerase use
only ssDNA as a template.
Formation of the replication fork
1. DnaA protein
3. DNA helicases
DnaA protein
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