Scribd Logo
Upload

Welcome to Scribd!

  • 708 views

    Non-Sterile Manufacture PPT M.M.P

    Uploaded by

    rj
    The document discusses methods for manufacturing various solid and liquid dosage forms including tablets, powders, capsules, ointments, emulsions, and suppositories. It describes processes like wet and dry granulation for tablets, mixing equipment for powders and capsules, fusion and incorporation methods for ointments, and types of bases used for emulsions and suppositories. Requirements for facilities and equipment to manufacture these dosage forms are also provided.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd

    Non-Sterile Manufacture PPT M.M.P

    Uploaded by

    rj
    708 views14 pages
    The document discusses methods for manufacturing various solid and liquid dosage forms including tablets, powders, capsules, ointments, emulsions, and suppositories. It describes processes like wet and dry granulation for tablets, mixing equipment for powders and capsules, fusion and incorporation methods for ointments, and types of bases used for emulsions and suppositories. Requirements for facilities and equipment to manufacture these dosage forms are also provided.

    Original Title

    NON-STERILE MANUFACTURE PPT M.M.P - Copy

    Copyright

    © © All Rights Reserved

    Available Formats

    PPTX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    The document discusses methods for manufacturing various solid and liquid dosage forms including tablets, powders, capsules, ointments, emulsions, and suppositories. It describes processes like wet and dry granulation for tablets, mixing equipment for powders and capsules, fusion and incorporation methods for ointments, and types of bases used for emulsions and suppositories. Requirements for facilities and equipment to manufacture these dosage forms are also provided.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    708 views14 pages

    Non-Sterile Manufacture PPT M.M.P

    Uploaded by

    rj
    The document discusses methods for manufacturing various solid and liquid dosage forms including tablets, powders, capsules, ointments, emulsions, and suppositories. It describes processes like wet and dry granulation for tablets, mixing equipment for powders and capsules, fusion and incorporation methods for ointments, and types of bases used for emulsions and suppositories. Requirements for facilities and equipment to manufacture these dosage forms are also provided.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    You are on page 1of 14

    NON-STERILE MANUFACTURE

    Methods of granulation

     Wet granulation

     Dry granulation
     Direct compression
    Requirements of equipments for the mfg
    of pills and compressed tablets
    a. Granulating section-Disintegrator, powder and
    mass mixer
    b. Tableting section-tablet machine and counter
    c. Coating section-coating pan, polishing pan
    heater etc,

    Manufacture of powders-
    Mixing of powders-
    Powders are mixed by the method of Spatulation,
    trituration, shifting, mechanical mixers
    • Capsules
    • Filing of capsules- mixing and blending
    equipment, capsule filling unit, capsule counters.
    • Soft gelatin capsules-
    1) Preparation- prepared from gelatin to
    which glycerin or sorbitol is added to render it
    elastic
    2) Plate method
    3)Rotary die method
    Facilities required for mfg of Tablets,
    Powders, and capsules
    • Granulation- provision of stainless still scoops,
    vacuum cleaner, sinks for washing , facility foe
    weighing product ,etc
    • Dry blending – dust control and personnel
    protection is by suitable clothing is necessary.
    • Compression – facilities for measuring thickness,
    hardness , weight , QC lab, disintegration an
    friability apparatus.
    Manufacture of liquid orals
    • Solutions-
    • Syrup-
    • Elixirs

    Requirements:
    • Mixing and storage tanks
    • Portable mixer
    • Filter press
    • Vacuum or gravity filter
    • Water still or Deionizer
    The area required for the mfg. of these is 30 sq. meters
    Manufacture of externals
    • Preparation of ointment

    Ointment bases-

    a. Absorption bases - 1) Non emulsified 2) Emulsified


    b. Water soluble bases -. Polyethylene glycols etc.

    c. Hydrocarbon bases – Soft paraffin, hard paraffin,


    liquid paraffin etc.

    d. Water miscible bases – emulsifying wax, white soft


    paraffin.
    The ointments are prepared by two methods

    a. Fusion method
    b. Incorporation method

    Other additives in ointment


    c. preservatives- Organic mercurials, quaternary
    ammonium compounds, benzoic acid is generally
    used.
    d. Antioxidants-BHA, BHT, Ethyl or propyl gallates
    Emulsions
    Types of emulgents-
    1.Synthetic emulgents –
    a) Anionic surfactants – e.g. sodium, potassium or
    ammonium salt of oleic acid & stearic acid
    b) Cationic surfactants- cetrimide
    c) Non-ionic surfactants- Glycol and glycerol esters.
    2.Natural products- acacia, tragacanth etc
    3. Finely divided solids – Clays, bentonite, silica gel etc.
    Requirements
    1. Mixing tanks
    2. Kettle, steam, gas
    3. A suitable powder driven mixer
    4. Storage tank or pots
    5. A colloid mil or suitable emulsifier
    6. A triple roller mill or ointment mill
    7. Liquid filling equipment
    8. Jar or tube filling equipment
    Suppositories
    There are two main type of bases
    1.Fatty or oleaginous bases- e.g. Theobroma oil
    (cocoa butter)

    Advantages-
    i. Non-irritating
    ii. Melts at 30-60 degree c.
    iii. Miscible with any ingredients
    Disadvantages-
    1. On cooling it does not contract sufficiently and
    problem of adherence to mould occurs.
    2. It may become rancid on storage.
    3. The water absorbing ability is poor.
    4. It is expensive

    2. Water soluble bases-


    Two main type of bases are:
    a) Glycerogelatin base b) Polyethylene glycol base
    a) Glycerogelatin base:
    It is used in the preparation of vaginal suppositories

    Disadvantages:
    1. Unpredictable solution time.
    2. The dehydrating effect of the base causes irritation
    to the rectal or vaginal mucosa.
    3. Preservatives are required in the formulation to
    prevent microbial contamination, which results in
    incompatibility.
    4. The suppositories have laxative effect.
    b) Polyethylene glycol base : (PEG base)
    These materials have wide range of melting points
    & solubilities. Hence it is possible to prepare
    suppositories of varying heat stability and dissolution
    rates.

    You might also like

    pFad - Phonifier reborn

    Pfad - The Proxy pFad of © 2024 Garber Painting. All rights reserved.

    Note: This service is not intended for secure transactions such as banking, social media, email, or purchasing. Use at your own risk. We assume no liability whatsoever for broken pages.


    Alternative Proxies:

    Alternative Proxy

    pFad Proxy

    pFad v3 Proxy

    pFad v4 Proxy