Unit 3 Gastrointestinal System

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GASTROINTESTINAL SYSTEM

Responsible for consuming and digesting food, absorb


nutrients, expelling waste
DEFINITION

• Peptic ulcer are open sores that develop in the


inside lining of esophagus, stomach, and upper
portion of small intestine as a result from erosion
from stomach acid
Peptic ulcer occur in
• stomach
• First part of duodenum
• Lower end of esophagus
ETIOLOGY

•A bacterium. Helicobacter pylori bacteria commonly live in the mucous


Regular use of certain pain relievers. Taking aspirin, as well as certain
over-the-counter and prescription pain medications called nonsteroidal anti-
inflammatory drugs (NSAIDs) can irritate or inflame the lining of your
stomach and small intestine
•Smoke. 
•Drink alcohol. .
•Have untreated stress.
•Eat spicy foods.
TYPES

• Acute peptic ulcers:


• Chronic ulcers: 1. duodenal ulcer
2. gastric ulcer
Pathogenesis Helicobacter pylori is a gram- negative rod,
curved in shape and motile 
SYMPTOMS •Burning stomach pain
•Feeling of fullness, bloating or belching
•Fatty food intolerance
•Heartburn
•Nausea
•Vomiting or vomiting blood — which may appear
red or black
•Dark blood in stools, or stools that are black or
tarry
•Trouble breathing
•Feeling faint
•Nausea or vomiting
•Unexplained weight loss
•Appetite changes
DIAGNOSIS

• Physical examination: patient history


• Blood, urea , stomach tissue test
• Radiology
• Endoscopy: inserting a small tube through throat and
see stomach abnormality
TREATMENT

NON- PHARMACOLOGICAL:
1. Regulation of salt, diet control
2. Exercise, weight reduction , limited alcohol intake

PHARMACOLOGICAL :

3. Antibiotic to kill H. Pyroli: metronidazole


4. Medications that block acid production and promote healing:
eg omeprazole, rabeprazole
3. Medications reduce the acid production: ranitidine
4. Antacid that neutralize stomach acid
Eg mg hydroxide
surgery

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