Cystitis

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NOV.

15, 2022

Cystitis

BONIFACIO &
RAYCO - N31
DEFINITION
Cystitis is an infection of the lower urinary system, more
especially the urinary bladder. It may be broadly categorized
as either uncomplicated or complicated.

a lower urinary tract


infection (UTI) in
either men or non-
pregnant women who
are otherwise healthy. connected with risk
factors that worsen
the severity of the
infection or the
possibility of
antibiotic therapy
PATHOPHYSIOLOGY
PATHOPHYSIOLOGY
Cystitis is often caused by bacteria from the fecal or vaginal
flora colonizing the periurethral mucosa and ascending to the
urinary bladder. Uropathogens may have microbial virulence
factors that allow them to bypass host defenses and enter
urinary tract tissues.
Escherichia coli is the most commonly identified bacterium
causing cystitis (75% to 95% of cases). Klebsiella pneumoniae
and Proteus mirabilis are two more pathogens that cause
cystitis. (After E. coli, Klebsiella is the most prevalent cause
of UTIs.)
PATHOPHYSIOLOGY
INFLAMMATION
ENTRY.
After the bacterium
Bacteria must obtain
has avoided the
access to the bladder
body's defense
in order for infection
mechanisms,
to develop.
ATTACHMENT inflammation begins.
The bacteria then
must attach to and
colonize the EVASION
epithelium of the The bacteria avoid
urinary tract to avoid detection by the host's
being washed out defensive
with voiding. mechanisms.
PATHOPHYSIOLOGY
SIGNS and SYMPTOMS

SUPRAPUBIC
PAIN

BURNING

FREQUENCY

NOCTURIA

DYSURIA

URETHRAL
DIAGNOSTIC STUDIES

DIPSTICK ULTRASONOGR
URINALYSIS APHY

URINE
CT SCAN
CULTURE

CELLULAR LEUKOCYTE
STUDIES ESTERASE TEST.
SURGICAL MANAGEMENT
Doctors rarely use surgery to treat cystitis. However, in terms of having interstitial cystitis, when other
treatments have failed to provide adequate relief, doctors may recommend surgery.

• Fulguration - This minimally invasive method involves insertion of instruments through the urethra
to burn off ulcers that may be present with interstitial cystitis.

• Resection - This is another minimally invasive method that involves insertion of instruments
through the urethra to cut around any ulcers.

• Bladder Augmentation - In this procedure, a surgeon increases the capacity of your bladder by
putting a patch of intestine on the bladder.
PHARMACOLOGICAL
MANAGEMENT
Patients who are at low risk for resistant etiologic organisms are treated with one of
the first-line or preferred antimicrobial agents, which include:

• Nitrofurantoin

• Sulfamethoxazole-trimethoprim (SMX-TMP)

• Fosfomycin

• Pivemecillenam
NURSING INTERVENTIONS
• Explain the nature and purpose of the antibiotic therapy and emphasize the importance of
completing the prescribed course of therapy or, with long-term prophylaxis adhering strictly
to the ordered dosage.
• Urge the patient to drink plenty of water (at least eight glasses a day) and stress the need to
maintain a consistent fluid intake of 2L/day.
• Watch for GI disturbances from antimicrobial therapy, and administer nitrofurantoin crystals
with milk or a meal to prevent such distress.
• Encourage client to void frequently.
• Suggest a warm sitz bath for relief of perineal discomfort, or apply heat sparingly to the
perineum but be careful not to burn the patient.
• Teach the client to clean the perineum properly.
CASE STUDY
Patient Presentation
A 27-year-old woman presents to her primary care physician with a report of urinating more frequently and pain
with urination. She denies blood in her urine, fevers, chills, flank pain, and vaginal discharge. She reports having
experienced similar symptoms a few years ago and that they went away after a course of antibiotics. The patient has
no other past medical problems. Pertinent history reveals she has been sexually active with her boyfriend for the
past 4 months and uses condoms for contraception. She reports 2 lifetime partners and no past pregnancies or
sexually transmitted diseases. Her last menstrual period was 1 week ago. A dipstick urinalysis has been ordered to
the patient and laboratory results were as follows: Macroscopic: urine midstream, clean catch. Yellow, cloudy, large
leukocytes, positive nitrites, urine pH= 8, urine hemoglobin, protein, glucose, ketones, and bilirubin negative,
specific gravity = 1.012
Microscopic: WBCs >100, RBCs ), squamous epithelial cells 0, few WBC clumps
On physical exam, the patient is afebrile, normotensive, and non-tachycardic. She appears well on observation. She
has a soft, nondistended abdomen with normoactive bowel sounds. On palpation, she has moderate discomfort in
her suprapubic region but no costovertebral angle (CVA) tenderness. A pelvic exam is normal with no evidence of
abnormal vaginal or cervical discharge or inflammation.
REFERENCES
• Li R, Leslie SW. Cystitis. [Updated 2022 Jun 15]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls
Publishing; 2022 Jan-. Retrieved from: https://www.ncbi.nlm.nih.gov/books/NBK482435/
• Pruthi, S., et al. (2021). Interstitial Cystitis. Mayo Clinic. Retrieved from
https://www.mayoclinic.org/diseases-conditions/interstitial-cystitis/diagnosis-treatment/drc-20354362
• Belleza, M. (2021). Cystitis. Nurselabs. Retrieved from
https://nurseslabs.com/cystitis/#nursing_interventions

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