Classification of Drugs Acting On CNS

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Classification of drugs acting on Central

Nervous System

Dr. Kumari Anjana


Assistant Professor
Deptt. of Veterinary Pharmacology & Toxicology
Bihar Veterinary College, Bihar Animal Sciences University, Patna
Classification of drugs acting on
Central Nervous System
 The CNS is an extremely Complex and heterogeneous
system. It is the major coordinating system of the body
& source of adjustment of an organism to its
environment.
 Function-rapid communication system and is responsible
for moment to moment control of various body activities.
 It regulates-rapidly changing visceral events, muscle
contractions, secretions of some endocrine glands and
functioning of the body system.
Classification of drugs acting contd…

on CNS
 The CNS is more sensitive to effects of drugs than
any other system of the body.

 A large number of drugs influence the CNS as a major


part of their therapeutic effect (e. g,. anaesthesia),
side effect & toxic effect, divided into two major
groups:
CNS stimulants drugs
CNS depressant drugs
CNS stimulants drugs
Classification
1. On the basis of part of CNS where drug act:
 Spinal Stimulants or convulsants: Strychnine,
picrotoxin
 Medullary Stimulants: Doxapram, Bemegride,
Picrotoxin, Nikethamide, Leptazol
 Cortical Stimulants: Cocaine, amphetamine,
methylxanthines.
CNS stimulants drugs contd…

Classification
2. On the basis of action (Direct or Indirect):
 Direct acting stimulants : Strychnine, picrotoxin
and xanthenes derivatives.
 Indirect (Reflexly) acting stimulants: lobeline,
ammonia, Veratrum, nicotine.
CNS stimulants drugs contd…

Classification
3. On the basis of clinical uses:
 Analeptics: Nikethamide, bemegride, doxapram.
 Psychostimulents: Amphetamines,
methylphenidate, cocaine, methylxanthines,
caffeine, theophylline.
 Cerebroactive drugs: Piracetam, dihydroergotoxine,
Pyritinol.
CNS depressant drugs

Classification
 Tranquillizer sedatives : Chlorpromazine, Azaperone,
Droperidol, Haloperidol.
(Neuroleptics, Ataractics, Tranquillizers)

 Hypnotic sedatives : Chloralhydrate, Xylazine,


Detomidine, Medetomidine, Phenobarbitone,
Diazepam, Zolazepam.
CNS depressant drugs contd…

Classification
 General Anaesthetics: Ether, Halothane,
Enflurane, Isoflurane, Chloroform,
Methoxyflurane
 Analgesics : Acetylsalicylate, Salicylate,
Phenylbutazone, Isopyrin, Ibuprofen
CNS depressant drugs contd…

Classification
 Central muscle relaxants: Guaiphenesin,
Mephenesin.

 Anticonvulsants : Phenobarbitone, Phenytoin,


Diazepam, Carbamazepine, (Antiepileptics)
Ethosuximide

 Neuroleptanalgesics: Fentanyl + Droperidol


Thank You

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