Antialergi dan anafilaksis

Dexamethasone is a highly potent and long-acting Dexa 0,5 mg tab

Diprosone –OV 0,055 CREAM 10 G : beta dipropionate 0,05%
glucocorticoid which acts as an anti-inflammatory agent by Novadex 0,75 mg kap
CENDO TROBSONE EYE DROPS 5 ML : tobramycin 3 mg, dexa 1
suppressing neutrophil migration, decreasing production of Dexaharsen 0,5 mg kap
mg
inflammatory mediators, reversing increased capillary Faridexon 0,5 mg kap
DIPROSONE –ov 0,05% CREAM 5 G : betam dipro 0,05%
permeability, and suppressing immune response. Cendo xitrol minidose 0,6 ml : dexa 1 mg, neomycin
Oviskin 0,05% cream 10 g : idem
sulphate 3,5 mg, polymixin B sulphate 1000 Si
Contraindications Kalmethasone 0,5% mg tab
Faridexon forte 0,75 mg kap
Systemic fungal infections; systemic infection unless being Bufacaryl kap : dmp maleate, dexa
Nufadex 0,5 mg kap
treated with specific anti-infectives. Perforation of drum Zensoderm cream 10 g : genta 0,1%, bet valerate 0,1%
Dextamine tab : dexa micronized 500 mcg,
membrane (otic). Administration of live virus vaccine. gentasonN cream 5 g : bv 1 mg, neomycin 5 mg
Dexchlorpheni maleate (alergi) 2 mg
Orsaderm cream 5 gr : beta
Pregnancy Category (US FDA) Dexa M 0,75 mg tab
Protocort 0,05% cream 10 g : bd
IM/Intraarticular/Intralesional/Intravitreal/IV/Ophth/Otic/Parenteral/PO: C Scandexon 500 mcg tab
Diprosone Ov 0,05% salep 10 g
Dextaco 0,5 mg kap
Megasonum 0,75 mg kap
Licodexon 0,5 mg tab
Intraarticular Ocuson tab : dxclm maleate 2 mg, beta 0,25 mg
Molacort 0,75 mg tab
Inflammatory joint disease : Benoson 0,1% cream 5 g : bv
Danasone 0,5 mg tab
Adl : 333 mcg to 5 mg (depending on degree,size&location of inflammation Corsona 500 mcg tab
 Soft tissue : 2-6 mg  repeated once every 3-5 days to once every 2-3 Domesone kap : dcl maleate 2 mg, dexa 0,5 mg
weeks Ermethasone 0,5 mg tab
Child : 167-333 mcg/kg daily Etason 0,5 mg tab
Intravenous : shock Omedeson tab
Adult : 1,67-5mg/kg  repeated up 72 h in 2-6 h / 2,5mg/kg per 24 h Prodexon 0,5 mg tab
Ch : 167-333 mcg/kg daily Dexteem plus tab : dcl maleate, dexa
Antiinflammatory/immunosuppressive Baycuten-N cream 5 g : dexa 0,4 mg, clotrimazole 10
Adl : 0,4-20 mg daily mg
Ophthalmic Indexon 0,5 mg tab
Inflammation eye disorder : 0,1% sol 1 drop 4-6x daily / 1 drop hourly  Ermethasone 0,75 mg tab
reduced to 1 drop 4 hourly Etadex 0,5 mg kap
Otic/aural Megasonum 0,5 mg kap
0,1% sol : 3-4drops bid or tid Molacort 0,5 mg tab
Oral Nufadex M 0,75 mg kap
Adl : 0,5-9 mg daily in DD, max 1,5 mg daily Bethamethasone 0,1% cream 5 g
Ch : initially : 0,02-0,3 mg/kg daily in 3-4 DD Betason cream 5 gr : bethamethasone 17-valerate 1
mg/gram
Diphenhydramine, a monoethanolamine
Oral Otede 50 mg
derivative, is an antihistamine with sedative Alergi, motion sickness :
and antimuscarinic properties. Adl : 25-50 mg 3-4x/d, max 300 mg daily (prevention motion
sickness : 30 m before), motion sickness : 50 mg 30 before
Pregnancy Category (US FDA) Ch : 2-6 y 6,25 mg 4-6hourly; 6-12 y : 12,5 – 25 mg 4-6 hourly,
IM/IV/Parenteral/PO: B >12 y : same as adult dose
Intravenous
Adl : 10-50 mg up to 100 mg
Ch : 5 mg/kg
Topical/cutaneous
Adl : 2% ream, apply to pruritic area,max bid, no kore than 3
days
 Epinephrine, an active principle of the adrenal medulla, is a direct-acting
sympathomimetic. It stimulates α- and β-adrenergic receptors resulting in
relaxation of smooth muscle of the bronchial tree, cardiac stimulation and
dilation of skeletal muscle vasculature.

Inhalation/respiration
Acute asthma : 1-2 inhalations, mayrepeat after 3 h
Intramuscular
Anaphylactic shock
Adl : as 1:1,000 solutions : 500 mcg (0,5 ml) repeat every 5 min as needed
Ch : 10 mcg/kg
Intravenous
ACLS
Adl : 1 mg (10 ml of a 1:10.000 sol) may repeat as often as every 3-5 min
Ch : 10 mcg/kg, max SD 1 mg, may repeat as often as every 3-5 min
Anaphylactic shock
Adl : 0,5 mg (5 ml of a 1:10.000 sol)
Ch : 10 mcg/kg
Ophthalmic
Ocular hypertension, open anle glaucoma
Adl : instill 0,5%, 1% or 2% eye drops once/twice daily
Parenteral
Acute asthma
Adl : as 1:1.000 aqueous sol : 0,3-0,5 ml (300-500 mcg)  IM/SC
Ch : as 1:1000 aqueous sol : 0,01 ml/kg (10mcg/kg) max 0,5 ml (500 mcg)  IM/SC

Pregnancy Category (US FDA)

IM/Intraocular/IV/Parenteral/SC: C

Overdosage
Overdosage intravascular inj of epinephrine may cause cerebral
haemorrhage due to a sharp rise in BP. Fatalities may also result
from pulmonary oedema because of peripheral vascular
constriction together with cardiac stimulation.
Hydrocortisone is a glucocorticoid that reduces inflammation by Buccal Nestacort 2,5% cream 5 gr : hidrokortison asetat 28 mg
suppressing the migration of polymorphonuclear leukocytes and Aphthous ulcer Hydrocortisone cream 2,5% 5 gr : Hydrocortisone acetate 2.5 %
reversing the increased capillary permeability. Topically, it has Adl : 1 tab (2,5 mg)  4x daily for 5 days , do not suck Hydrocortisone cream 1% 5 gr : Hydrocortisone acetate 1 %
anti-inflammatory, anti-pruritic, and vasoconstrictive effects. Ch : >= 12 y sae as adult Cendo mycos eye drops 5 ml : Hydrocortisone acetate 5 mg dan
intraarticular, periarticular Chloramphenicol 2 mg
Potentially Fatal: May diminish the serum antibody response to inflammatory joint disease Cendo mycos minidose 0,6 ml
live or live attenuated vaccines. Adl : as hydrocortisone acetate : 5-50 mg depend on size of affected joint maybe Lexacorton 25mg/g 5 g : Hydrocortisone acetate 25 mg
repeated at intervals 3 weeks, max 3 joint treated per day Dermacoid scalp lotion 20 ml : Tiap ml lotion mengandung
Pregnancy Category (US FDA) Intravenous Hydrocortisone-17-Butyrate 1 mg
IM/IV/Parenteral/PO/Rectal/Topical: C Ophthalmic Dermacoid cream 10 g : Hydrocortisone 17-butyrate
Inflammatory eye disorders Hydrocortison cream 2,5% 5 g : Hydrocortisone acetate 2.5 %
Adl : as 1% hydrocortisone acetate ointment : 2-4x daily, seere inflame : 1 or 2
drops every 30-60 min
Oral
Adl : 20-40 mg daily
Parenteral
Shock ?
Anti inflammatory
Adl : as hydrocortisone Na succinate : 100-500 mg via IV
Ch : < 1 y : 25 mg; 1-5 y : 50 mg; 6-12 y : 100 mg  may repeated 3 or 4 times in
24 h
Soft tissue inflammation
Adl : 100-200 mg as local inj into soft tissue lesion may repeated 2 or 3x
Rectal
Hemorroid
Hydrocortisone acetate supp : inert 1 supp (25 mg) bid
Topical/cutaneous
Adl : as 0,1% hydrocortisone base cream, 0,1% hysrocortisone butyrate
cream/ointment/scalp lotion, 0,1% hydrocortisone probutate cream, 1%
hydrocortisone acetate cream  apply 1 or 2 times daily except hydrocortisone
valerate 3x
Ch : >10 y same as adl dose , infant max 7 days
 Ctm 4 mg tab
Zecamex 4 mg tab
Trifachlor 4 mg tab

Ch : 0,1mg/kgbb 3-4x
Adl : 1x4 mg
Loratadine, a piperidine derivative, is a long-acting, non- Claritin 10 mg tab
sedating tricyclic antihistamine with no significant Claritin 5 mg tab
antimuscarinic properties Loratadine 10 mg tab
Onset: 1-3 hours. Alerhis 10 mg kap
Duration: >24 hours. Inersyn 10 mg tab
allohex 10 mg tab
Claritin sirup 60 ml : Setiap 5 ml sirup mengandung 5 mg micronized Loratadine.
Oral
Clarhis 10 mg tab
Adl : 10 mg OD/ 5 mg bid
Imunex sirup 60 ml
Ch : 2-12 y <= 30 kg : 5 mg OD
Prohistin 10 mg tab
Lorhis sirup 60 ml
Alloris sirup 60 ml
Miratadin sirup 60 ml : Tiap 5 ml mengandung : Loratadine 5 mg
Alloris 10 mg tab
Alernitis 10 mg tab
Cronitin 10 mg tab
Inclarin 10 mg tab
Lesidas 10 mg tab
Loracor 10 mg tab
Loran 10 mg tab
Lorihis 10 mg tab
Desloratadine 5 mg tab : Desloratadine 5 mg
Aerius 5 mg tab : Tiap ml mengandung : Desloratadin 0.5 mg
Aerius sirup 60 ml
Destavell 2,5 mg ODT tab : Desloratadin 2.5 mg
Destavell sirup 60 ml : Tiap 5 ml megandung: Desloratiadine 2,5 mg
Destavell 5 mg tab : desloratadin 5 mg
Winatin 10 mg tab
 Ritez sirup 60 ml : Tiap 5 ml Xybat 5 mg tab
Cetirizine, a piperazine derivative and metabolite of hydroxyzine, is an Cetirizine 10 mg tab mengandung:Cetirizine Hydrochloride 5 mg Incidal CTN tab
antihistamine which competitively and selectively inhibits H1 receptors in Cerini drop 20 l Hufarizine 5mg/5ml sirup 60 ml Histrine drop 10 ml : Tiap ml : Cetrizine Hcl 10 mg
the gastrointestinal tract, blood vessels, and respiratory tract. Cetinal sir 60 ml : Tiap 5 ml mengandung: Incidal-OD kap Histrine FT 10 mg tab
Cetirizine HCl 5 mg Ryvel drops 10 ml Histrine levo tab
Histrine 10 mg tab Alergine 10 mg tab Histrine sirup 60 ml
Intravena Zine 5 mg/5 ml sirup 60 ml Estin sirup 60 ml
Acute urticarial Lerzin drops 15 ml : Per ml : Cetirizine 10 mg Ritez drops 10 ml : Tiap ml
Adl : 10 mg/24h over 1-2 min Rydian 10 mg tab mengandung:Cetirizine Hydrochloride 10 mg
Ch : 6 m to 5 y : 2,5mg/24 h;6-11 y : 5-10 mg/24 h;>=12 y same as adult dose Cetinal 10 mg tablet kunyah Ritez FT 10 mg tab
Ophthalmic Lerzin 5 mg/5ml sirup 60 ml Cerini sirup 60 ml
Ocular itching associated w/allergic cjt Intrizin drops 15 ml : Per mL : Cetirizine Tiriz 10 mg/ml drops
Adl : 1 drop/8h diHCL 10 mg Capritazin 5mg/ml sirup 60 ml
Ch : >= 2 y same as adult dose Ryvel 10 mg tab Estin drop 10 ml : Cetirizine 10 mg/ml
oral Corizine 10 mg tab Alergia sirup 60 ml
Allergic conditions Incidal-OD kap : Cetirizine HCl 10 mg Tiriz 10 mg tab
Adl : 10 mg/d Intrizin sirup 60 ml : Per 5 mL : Cetirizine Cerini 10 mg kap
Ch : 6-12 y : 5 mg bid; >12 y same as adult dose diHCL 5 mg Lerzin 10 mg kap
Intrizin 10 mg tab Licidal 5mg/5ml sirup 60 ml
Ozen drops 12 ml : Per ml : Cetirizine 10 mg Zenriz 10 mg tab
Cetymin 10 mg tab Ryzicor 10 mg tab
Falergi 10 mg tab Yarizine 10 mg tab
Ozen 10 mg tab Levocetirizine 5 mg tab
Ozen sirup 60 ml Alcet sirup 60 ml
Avocel 5 mg tab
Xyzal 5 mg tab
Description: Cyproheptadine is a potent 1st generation
antihistamine with serotonin antagonist, sedative,
anticholinergic, and Ca channel blocking properties. It
- Cydifar 4 mg kap
competes with histamine for H1 receptor sites on effector
cells in the blood vessels, gastrointestinal and respiratory
- Pronam 4 mg kaplet
tracts. - Pronicy 4 mg kap
Pregnancy Category (US FDA)
PO: B
- Graperide 4 mg tab
Indications an dosage - Heptasan 4 mg tab
Oral
- Migraine, Vascular headache
- Lexahist 4 mg tab
Adult: Prophylaxis and treatment: Initially, 4 mg, may be
repeated after 30 minutes if necessary. Max 4 mg per 4-6 h
- Allergic conditions, Pruritus
Adult: 4 mg tid, max: 4-20 mg/d in DD;. Max: 0.5 mg/kg daily
or 32 mg daily.
Child: 2-6 years Initially, 2 mg bid or tid. Max: 12 mg daily; 7-
14 years Initially, 4 mg bid or tid. Max: 16 mg daily. All doses
may be adjusted as necessary according to patient weight and
response. ≥2 years Approx 0.25 mg/kg daily or 8 mg/m2 daily
in 2-3 divided doses.
 Fexofenadine

Fexofenadine is a non-sedating antihistamine and an - Telfast 60 mg, 120 mg, 180 mg

active metabolite of terfenadine. It competes with
histamine for H1-receptor on effector cells in the blood
vessels, gastrointestinal tract and respiratory tract.
Onset: 2 hours.
Duration: 24 hours.

Oral
- Seasonal allergic rhinitis
Adult: 120 mg once daily. Alternatively, 60 mg bid or 180 mg once daily
Child: 2-11 years 30 mg bid; ≥12 years Same as adult dose
- Chronic idiopathic urticaria
Adult: 180 mg once daily.
Child: 6 months-<2 years 15 mg bid; 2-11 years 30 mg bid; ≥12 years 60 mg bid or 180 mg once daily.

Special Precautions
Patient with current or history of CV disease. Renal and hepatic
impairment. Children. Pregnancy and lactation.
Drug Interactions
Increased plasma concentrations with erythromycin and ketoconazole. Reduced
bioavailability and absorption with antacids containing Al and Mg.
Food Interaction
Decreased bioavailability with high-fat meals, fruit juice (e.g. apple, grapefruit, orange)
Homochlorcyclizine is a piperazine derivative. It is a sedating
antihistamine with antimuscarinic activity.
Contraindications
Glaucoma, obstructive diseases of the lower urinary tract.
Oral
Allergic conditions
Adult: 10-20 mg tid.

Homoclomin 10 mg tab
kombinasi
• Celestamin : betametason, dexchlorpheniramine maleate
• Dexteamin : Dexamethasone (micronized) 500 mcg,
Dexchlorpheniramine Maleate 2 mg
• Dexteem : Dexchlorpheniramine Maleate 2 mg
• Dexteem plus : Dexamethasone 0.5 mg, Dexchlorpheniramine
maleate 2 mg
• Histapan : Mebhidrolin Napadisilat 50 Mg
• Rupafin : Rupatadine fumarate 10 mg
Rupatadine (obat mahal)

• Rupatadine is NON SEDATIVE - a long-acting, 2nd generation antihistamine that possesses

selective peripheral H1 receptor and platelet activating factor (PAF) antagonistic activities.
At high concentrations, it was noted to prevent the degranulation of mast cells and release
of cytokines, specifically TNFα in human mast cells and monocytes.
• Onset: 1-2 hours.
• Duration: Antihistaminic activity: 24 hours.
• Oral
• Allergic rhinitis, Urticaria
• Dosage
Adult: 10 mg once daily.
Child: 2-11 years ≥10-<25 kg: 2.5 mg once daily; ≥25 kg: 5 mg once daily. ≥12 years Same as
adult dose.
Montelukast is a selective leukotriene receptor antagonist. It inhibits cysteinyl leukotriene
type-1 (CysLT1) receptor found in the human airway and on other pro-inflammatory cells.
The binding of CysLTs in leukotriene receptors is involved in the pathophysiology of
asthma, including bronchoconstriction, mucous secretion, vascular permeability, and
eosinophil recruitment. Additionally, CysLTs are released from the nasal mucosa after
allergen exposure which is associated with symptoms of allergic rhinitis.
Duration: >24 hours.

Pregnancy Category (US FDA)

PO: B

Adult: As conventional tab: 10 mg once daily.

Child: 6-23 months : 4 mg once daily in the evening; 2-5 years As 4 mg chewable tab or
granules: 1 tab or sachet once daily in the evening; 6-14 years As 5 mg chewable tab: 1
tab once daily in the evening; ≥15 years As conventional tab: Same as adult dose

Prophylaxis of exercise-induced asthma

Adult: As conventional tab: 10 mg given at least 2 hours
before exercise; limit to 1 dose every 24 hours.