Medical Presentation
Medical Presentation
CASE PRESENTATION
VITALS
BP -106/58 mmHg
P- 110 b/min
RR-16 breathes / min
Body Temp - 36.7o C
SPO2- 87% on RA
REVIEW OF SYSTEMS
CVS
Hyperactive precordium
Parasternal heave
S1,S2 S3 gallop
+ve hepatojugular reflex
RESP
In resp distress
Mild bilateral crepitations on the lower lung zones
REVIEW OF SYSTEMS
CNS
GCS 9/15 ( E-3, V-1, M-5)
P/A
Abdomen with normal contour- flat not distended
Right upper quadrant tenderness
No hepatomegaly
Impression
Heart failure r/o valvular heart disease
PLAN
Admit to ward 3
FHG/ LFTS/ UECS
Echo/ ECG
Oxygen therapy at 5l/min
Investigations
Full hemogram done on 22/08/2023
WBC – 6.6
HB- 9.5 ↓
MCV – 70.0 ↓
MCH- 23.6 N
PLT- 393 N
UECs
Urea- 4.7 mmol/L normal
Sodium- 138 mmol/L normal
CHOWDHURY S, KOZIATEK CA, RAJNIK M. ACUTE RHEUMATIC FEVER. [UPDATED 2023 AUG 2]. IN:
STATPEARLS [INTERNET]. TREASURE ISLAND (FL): STATPEARLS PUBLISHING; 2023 JAN-. AVAILABLE
FROM: HTTPS://WWW.NCBI.NLM.NIH.GOV/BOOKS/NBK594238/
pathogenesis
An immune mediated pathogenesis, in which there is Antigenic molecular mimicry between the
mammalian tissues and the GABHS cell wall.
GABHS antigens stimulate the activation of CD4+ T cells which then cross react with similar
peptides in the heart. The M protein moiety and N-acetyl-β-D-glucosamine (NABG) of GAS
species exhibit structural similarity to myosin, leading to cardiac myositis and valvulitis.(1)
Antibody-antigen complexes may also deposit in joints leading to the characteristic migratory
polyarthritis in the skin, brain and subcutaneous tissues resulting in erythema marginatum,
chorea, subcutaneous nodules respectively.
CHOWDHURY S, KOZIATEK CA, RAJNIK M. ACUTE RHEUMATIC FEVER. [UPDATED 2023 AUG 2]. IN:
STATPEARLS [INTERNET]. TREASURE ISLAND (FL): STATPEARLS PUBLISHING; 2023 JAN-. AVAILABLE
FROM: HTTPS://WWW.NCBI.NLM.NIH.GOV/BOOKS/NBK594238
Diagnosis
Supporting evidence of a preceding strep
infection within last 45 days
Elevated or rising antistreptolysin-O or other streptococcal antibody
Positive throat culture
Rapid antigen test for Group A streptococci
Recent scarlet fever
CHOWDHURY S, KOZIATEK CA, RAJNIK M. ACUTE RHEUMATIC FEVER. [UPDATED 2023 AUG 2]. IN:
STATPEARLS [INTERNET]. TREASURE ISLAND (FL): STATPEARLS PUBLISHING; 2023 JAN-. AVAILABLE
FROM: HTTPS://WWW.NCBI.NLM.NIH.GOV/BOOKS/NBK594238/
Migratory Polyarthritis
Occurs in about 75% of patients with ARF and typically involves larger joints; knees, ankles,
wrists and elbows.
Joints are generally hot, red, swollen and tender with no obvious deformity.
Involvement of the spine, small joints of the hand and feet is uncommon.
Rapidly improves on NSAIDS.
Usually runs a self-limited course lasting about 4 weeks
Monoarthritis may be presenting feature in high-risk population