LECTURE 3 Trematodes

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MCB 4324: MEDICAL

PARASITOLOGY

Prof. A. S. Kumurya
.

THE TREMATODES
The Trematodes
• Trematodes are flattened oval or worm-like animals.

• Usually no more than a few centimeters in length,


although species as small as 1 millimeter and as
large as 7 meters are known.

• Their most distinctive external feature is the


presence of two suckers, one close to the mouth, and
the other on the underside of the animal.
The Trematodes
• Schistosoma haematobium
• Schistosoma mansoni
• Fasciola hepatica
.

THE LIFE CYCLE OF


SCHISTOSOMA SPECIES
Eggs of Schistosoma mansoni
Eggs of Schistosoma mansoni
in the liver
Cellular reaction around eggs of
Schistosoma mansoni
Egg of S. haematobium

Schistosomaiasis
granuloma
Schistosomaiasis granuloma
Pathology of Schistosomiasis
• Schistosoma haematobium • Schistosoma mansoni
• Causes urinary schistosomiasis Causes intestinal schistosomiasis

1. PREPATENT PERIOD 10-12 1. PREPATENT PERIOD 5-7 wks


wks 2. EGG DEPOSITION AND
2. EGG DEPOSITION AND EXTRUSION:
EXTRUSION: 1. dysentery (blood and mucus in
1. painless haematuria stools),
2. Inflammation of bladder and 2. hepatomegaly splenomegaly
burning micturition 3. TISSUE PROLIFERATION
3. TISSUE PROLIFERATION AND REPAIR:Fibrosis ,
AND REPAIR: • Papillomata in intestine,
• Fibrosis , papillomata in the • Pperiportal fibrosis,hematemesis
bladder and lower ureter leading • Lung and CNS involvement.
to obstructive uropathy.
• Periportal fibrosis
• Lung and CNS involvement
Schistosome dermatitis, or "swimmers itch” occurs when skin is
penetrated by a free-swimming, fork-tailed infective cercaria.
Source: WikiMedia.
Bladder lesions in urinary schistosomiasis
Hepatosplenomegaly in
chronic schistosomiasis
Diagnosis of Schistosomiasis
Schistosoma haematobium Schistosoma mansoni
• Parasitological: • Parasitological
– Examination of urine – Examination of stools
• Immunological • Immunological
– Serological tests – Serological tests
• Indirect: • Indirect:
– Radiological – Radiological
– Cystoscopy – endoscopy
Egg of S. haematobium

Egg of
S. japonicum

Egg of S. haematobium
Egg of S. mansoni
Drug of choice for schistosomiasis is
Praziquantel
Fasciola hepatica

Fasciola hepatica
Sheep liver infected with Fasciola
hepatica
Life-cycle of Fasciola hepatica
Fasciola hepatica
• Pathology and clinical picture :
– True infection causes mainly biliary obstruction and
liver damage .
– False infection is when eggs are eaten in infected
animal liver and passed in stools.
• Diagnosis: eggs in stools or duodenal
aspirate.
• Treatment: Praziquantel.
Snail intermediate host of:
Fasciola hepatica
Watercress , one means of
transmission of fascioliasis
Fasciola hepatica adult
Fasciola hepatica in bile duct
Egg of Fasciola hepatica
Fasciola hepatica: spurious infection
.

QUESTIONS!!!

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