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    syedabismaahmad8

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    3 or more Factor

    Factorial design
    under CRD
    HAMZA RASHEED
    CLINICAL MEDICINE
    2023-PHD-1015
    3 or more Factor
    Factorial design
    under CRD

     Factorial design is a type of research methodology that


    allows for the investigation of the main and interaction
    effects between different number of independent variables
     Total number of effects = 2k Where K is number of factors
     For main effects or interaction effects = n!/r!(n-r)!
    3 Factor
    Factorial design
    under CRD
     yijkl= µ + ɑi+ βj +γk +(ɑβ)ij+ (ɑγ)ik +(βγ)jk +(ɑβγ)ijk + Ԑijkl
     Where
     µ = Overall mean effect

     ɑi= Main Effect of the factor A

     βj= Main Effect of the factor B

     γk = Main Effect of the factor C


     (ɑβ)ij= Interaction Effect of Factor A and Factor B
     (ɑγ)ik = Interaction Effect of Factor A and Factor C
     (βγ)jk= Interaction Effect of Factor B and Factor C
     (ɑβγ)ijk = (Higher Interaction Effect) Interaction effect between all three factors Factor A, B and C
     Ԑijk= random error term (Increase due to extraneous sources)
    More than 3 Factor
    Factorial design

    Penicillin (A)
    1 2
    Acetylcstein (B) Acetylcystein (B)
    1 2 1 2 y..kl.
    Vitamin 1 10 12 12 21 16 23 18 23 135
    Ketoprufen 1 C (D) 2
    14 15 22 25 25 21 21 16 159
    (C)
    Vitamin 1 17 18 18 19 19 17 21 25 154
    2 C (D) 2 19 22 23 15 15 16 15 18 143

    Yij… 127 155 152 157 591


    STATISTICAL SOLUTION

     HYPOTHESIS
     Ho: Effect of all means is equal on recovery
     H1: Effect of any one mean is variable
     Ho: There is no interaction between different drugs
     H1: There is interaction
     LEVEL OF SIGNIFICANCE (α)
     α=5%
    Fixed Effect Model
    Effects
    Calculations
    Calculations
    Calculations
    Calculations
    Calculations
    ANOVA-Table
    S.O.V d.f S.S M.S F-ratio F tabulated
    A (a-1)=1 22.78 22.78 2.314 4.49

    B (b-1)=1 34.03 34.03 3.45 4.49

    C (c-1)=1 0.28 0.28 0.029 4.49


    D (d-1)=1 5.28 5.28 0.537 4.49
    AB (a-1) (b-1)= 1 16.53 16.53 1.67 4.49

    AC (a-1) (c-1)= 1 42.78 42.78 4.36 4.49

    AD (a-1) (d-1)= 1 57.78 57.78 5.87 4.49

    BC (b-1) (c-1)= 1 3.78 3.78 0.38 4.49


    BD (b-1) (d-1)= 1 9.03 9.03 0.91 4.49
    CD (c-1) (d-1)= 1 38.28 38.28 3.88 4.49

    ABC (a-1) (b-1) (c-1)= 1 75.03 75.03 7.62 4.49

    ABD (a-1) (b-1) (d-1)= 1 13.78 13.78 1.40 4.49

    ACD (a-1) (c-1) (d-1)= 1 1.53 1.53 0.15 4.49


    BCD (b-1) (c-1) (d-1)= 1 2.53 2.53 0.25 4.49
    ABCD (a-1) (b-1) (c-1) (d-1)= 1 7.03 7.03 0.71 4.49
    Error abcd (n-1)= 16 157.5 9.84

    Total abcdn-1= 31 487.97


    SPSS
    Data View
    Analysis
    Analysis
    Model
    Plots
    Descriptive Statistics
    ANOVA-Table
    Interaction Effect
    Interaction Effect
    Reference
    Thank you!

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