THE BREAST 1

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THE BREAST

Clifford Owobu
• Relevant Anatomy
• Clinical Presentation of breast lesions
• Inflammatory breast diseases
• Benign breast lesions
• Breast cancer
• Breast cancer screening
MICROANATOMY
• 6 – 10 major ducts
• Lining:
 Keratinizing Strat
sq. epithelium
 Double-layered
epithelium
 Stages of breast
development
MICROANAT
OMY
• Lobes
• Lobules
• Glands/Acini
• Cells
• Stromal
MICROANATOMY
Two major structures:
Ducts
Lobules

Two types of epithelial


cells
Luminal cells
Myoepithelial cells
NB: Strat. Sq Epith – tip of nipple

Two types of stroma


Interlobular
intralobular
MICROANATOM
Y
DEVELOPMENTAL DISORDER
• Supernumerary nipples or breasts

• Accessory Breast Tissue


subcutaneous tissue of the chest wall
subcutaneous tissue of the axillary fossa

NB: Prophylactic mastectomies, therefore markedly reduce, but do not


completely eliminate, the risk of breast cancer.

• Congenital Nipple Inversion


FUNCTION OF
THE FEMALE
BREAST
FUNCTION OF
THE FEMALE
BREAST

Nutritional support
and survival of infants
FUNCTION OF
THE FEMALE
BREAST

Sociocultural
importance
=> Femininity
FUNCTION OF THE
FEMALE BREAST

Symbol of beauty
FUNCTION OF THE
FEMALE BREAST

Erogenous organ
CLINICAL PRESENTATION OF BREAST
DISSEASE
SYMPTOMS OF PATIENTS PRESENTATIONS OF BREAST CANCERS
CLINICAL PRESENTATION OF BREAST
DISSEASE
NIPPLE DISCHARGE • Bloody
• Normal o Large duct papillomas, cysts (+/-
serous discharge)
• Milky o Pregnancy
o Endocrine causes e.g., pit o Cancers
adenoma, hypothyroidism
NB: Discharge in older women that
o Drugs: OCP, tricyclic is spontaneous, unilateral, and
antidepressant, methydopa bloody is likely to have a malignant
o Repeated nipple stimulation origin
CLINICAL PRESENTATION OF BREAST
DISSEASE
PALPABLE MASSES INFLAMMATORY CHANGES
• Benign/malignant lesions LUMPINESS
• Xtics
• Relationship to age and
quadrants NB: Symptoms/signs =>
• Usefulness in screening Anxiety; Existential crisis
PAIN
• Cyclical/non-cyclical
DISEASES OF THE
BREAST

Developmental disorder
Inflammatory
Benign epithelial
Carcinoma
Stromal tumours
DISEASES OF THE
BREAST
Summary

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