Pandemic influenza severity assessment (PISA): a WHO guide to assess the severity of influenza in seasonal epidemics and pandemics, second edition
Overview
The updated WHO pandemic influenza severity assessment (PISA) framework set out in this document
provides a systematic approach for interpreting data collected through existing surveillance systems
and improving their usefulness for risk communication and decision-making. The approach enables
the severity of current influenza and syndromic respiratory illness activity to be assessed relative
to previous years by using historical data to set thresholds that then allow for the qualitative
categorization of such activity. PISA is designed to be implemented continuously based on stable/
routine reporting systems, enabling activity during epidemic and pandemic periods to be compared.
Information to assess severity especially early and throughout the course of a pandemic will also be
provided through investigations, studies and modelling.