Collagen, type VI, alpha 5

COL6A5
Identifiers
Aliases	COL6A5, collagen, type VI, alpha 5, COL29A1, VWA4, collagen type VI alpha 5, collagen type VI alpha 5 chain
External IDs	OMIM: 611916; MGI: 3648134; HomoloGene: 122792; GeneCards: COL6A5; OMA:COL6A5 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	130,484,844 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	105,837,842 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; testicle; ; upper lobe of left lung; ; skin of hip; ; right lung; ; lower lobe of lung; ; duodenum; ; skin of abdomen; ; visceral pleura; ; left testis;
	Top expressed in
	primary oocyte; ; secondary oocyte; ; white adipose tissue; ; ovary; ; urinary bladder; ; zygote; ; colon; ; esophagus; ; Hypothalamus; ; adrenal gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; extracellular matrix structural constituent conferring tensile strength;
Cellular component	collagen; extracellular matrix; extracellular region; collagen-containing extracellular matrix;
Biological process	cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	256076
	665033
	ENSG00000172752
	ENSMUSG00000091345
	A8TX70; H0Y935
	A6H584
	NM_001278298; NM_153264
	NM_001167923
	NP_001265227; NP_694996
	NP_001161395
	Wikidata
View/Edit Human	View/Edit Mouse

Collagen alpha-5(VI) chain also known as von Willebrand factor A domain-containing protein 4 is a protein that in humans is encoded by the COL6A5 gene.

COL6A5 is a part of the Collagen VI gene family which produce collagen components for the Extracellular matrix of most connective tissues.^[5] In the human genome, part of the collagen VI family is located on chromosome 3q in order of COL6A4, COL6A5, COL6A6.^[5] Transcription of COL6A5 only occurs in skin, lung, testis, colon, and small intestine cells.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172752 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000091345 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Fitzgerald J, Holden P, Hansen U (2013). "The expanded collagen VI family: new chains and new questions". Connective Tissue Research. 54 (6): 345–50. doi:10.3109/03008207.2013.822865. PMC 5248970. PMID 23869615.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172752 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000091345 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Fitzgerald-5] Fitzgerald J, Holden P, Hansen U (2013). "The expanded collagen VI family: new chains and new questions". Connective Tissue Research. 54 (6): 345–50. doi:10.3109/03008207.2013.822865. PMC 5248970. PMID 23869615.

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References

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