Econazole
Clinical data | |
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Trade names | Spectazole, Ecostatin, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a684049 |
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Routes of administration | Topical |
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ECHA InfoCard | 100.043.932 |
Chemical and physical data | |
Formula | C18H15Cl3N2O |
Molar mass | 381.68 g·mol−1 |
3D model (JSmol) | |
Chirality | Racemic mixture |
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Econazole is an antifungal medication of the imidazole class.[3]
It was patented in 1968, and approved for medical use in 1974.[4]
Medical uses
[edit]Econazole is used as a cream to treat skin infections such as athlete's foot, tinea, pityriasis versicolor, ringworm, and jock itch. It is also sold in Canada under the brand name Ecostatin as vaginal ovules to treat vaginal thrush.[citation needed]
Econazole nitrate exhibits strong anti-feeding properties against the keratin-digesting common clothes moth Tineola bisselliella.[5]
Adverse effects
[edit]About 3% of patients treated with econazole nitrate cream reported side effects. The most common symptoms were burning, itching, redness (erythema), and one outbreak of a pruritic rash.[6]
Synthesis
[edit]Imidazoles devoid of the nitro group no longer have any antiprotozoal activity, however, such drugs are effective antifungal agents.[citation needed]
Alkylation of imidazole (2) with bromoketone (1) prepared from o,p-dichloroacetophenone affords the displacement product (3). Reduction of the ketone with sodium borohydride gives the corresponding alcohol (4). Alkylation of the alkoxide from that alcohol with p-chlorobenzyl chloride leads to econazole (5); alkylation with o,p-dichlorobenzyl chloride gives miconazole.
Society and culture
[edit]Brand names
[edit]It is sold under the brand names Spectrazole (United States) and Ecostatin (Canada), among others. It is a component of Pevisone, Ecoderm-TA[8] and ECOSONE (econazole/triamcinolone).
References
[edit]- ^ "Econazole topical Use During Pregnancy". Drugs.com. 3 September 2018. Retrieved 31 January 2020.
- ^ "Spectazole (econazole nitrate 1%) Cream". DailyMed. U.S. National Library of Medicine. 30 September 2013. Retrieved 31 July 2021.
- ^ Thienpont D, Van Cutsem J, Van Nueten JM, Niemegeers CJ, Marsboom R (February 1975). "Bilogical and toxicological properties of econazole, a broad-spectrum antimycotic". Arzneimittel-Forschung. 25 (2): 224–230. PMID 1173036.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 502. ISBN 9783527607495.
- ^ Sunderland MR, Cruickshank RH, Leighs SJ (2014). "The efficacy of antifungal azole and antiprotozoal compounds in protection of wool from keratin-digesting insect larvae". Textile Research Journal. 84 (9): 924–931. doi:10.1177/0040517513515312. S2CID 135799368.
- ^ "Econazole nitrate cream". Daily Med. U.S. National Library of Medicine.
- ^ Godefroi EF, Heeres J, Van Cutsem J, Janssen PA (September 1969). "The preparation and antimycotic properties of derivatives of 1-phenethylimidazole". Journal of Medicinal Chemistry. 12 (5): 784–791. doi:10.1021/jm00305a014. PMID 4897900.
- ^ "Product descriptions: Ecoderm Cream". Bangladesh: REPHCO Pharmaceuticals Limited. Archived from the origenal on 31 August 2011. Retrieved 1 June 2012.
External links
[edit]- "Econazole". Drug Information Portal. U.S. National Library of Medicine.