FOXQ1

FOXQ1
Identifiers
Aliases	FOXQ1, HFH1, forkhead box Q1
External IDs	OMIM: 612788; MGI: 1298228; HomoloGene: 7359; GeneCards: FOXQ1; OMA:FOXQ1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p25.3 Start 1,312,098 bp End 1,314,758 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13 A3.2|13 13.46 cM Start 31,740,117 bp End 31,744,959 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland pylorus pancreatic epithelial cell pancreatic ductal cell endothelial cell skin of arm palpebral conjunctiva skin of hip secondary oocyte skin of thigh Top expressed in transitional epithelium of urinary bladder conjunctival fornix pyloric antrum epithelium of stomach hair follicle mucous cell of stomach medullary collecting duct submandibular gland cornea duodenum More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process hair follicle morphogenesis regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of transcription by RNA polymerase II anatomical structure morphogenesis cell differentiation regulation of transcription by RNA polymerase II negative regulation of neuron apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 94234 15220 Ensembl ENSG00000164379 ENSMUSG00000038415 UniProt Q9C009 O70220 RefSeq (mRNA) NM_033260 NM_008239 RefSeq (protein) NP_150285 NP_032265 Location (UCSC) Chr 6: 1.31 – 1.31 Mb Chr 13: 31.74 – 31.74 Mb PubMed search
Wikidata
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Forkhead box Q1 is a protein that in humans is encoded by the FOXQ1 gene.

Function

FOXQ1 is a member of the FOX gene family, which is characterized by a conserved 110-amino acid DNA-binding motif called the forkhead or winged helix domain. FOX genes are involved in embryonic development, cell cycle regulation, tissue-specific gene expression, cell signaling, and tumorigenesis (Bieller et al., 2001 [PubMed 11747606]).

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.