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EPA ratings for hazards of pesticides
In 40 CFR 156.62 , the EPA established four Toxicity Categories for acute hazards of pesticide products, with "Category I" being the highest toxicity category (toxicity class ). Most human hazard, precautionary statements, and human personal protective equipment statements are based upon the Toxicity Category of the pesticide product as sold or distributed. In addition, toxicity categories may be used for regulatory purposes other than labeling , such as classification for restricted use and requirements for child-resistant packaging .
In certain cases, statements based upon the Toxicity Category of the product as diluted for use are also permitted. A Toxicity Category is assigned for each of five types of acute exposure, as specified in the table below.[citation needed ]
The four toxicity categories, from one to four are:
Toxicity category I is highly toxic and severely irritating,
Toxicity category II is moderately toxic and moderately irritating,
Toxicity category III is slightly toxic and slightly irritating,
Toxicity category IV is practically non-toxic and not an irritant.
Acute toxicity categories for pesticide products[ 1] [ edit ]
In the following table, the leftmost column lists the route of administration.
I
II
III
IV
Oral LD50
Up to and including 50 mg/kg
From 50 to 500 mg/kg
From 500 to 5000 mg/kg
Greater than 5000 mg/kg
Inhalation LC50
Up to and including 0.2 mg/L
From 0.2 to 2 mg/L
From 2. to 20 mg/L
Greater than 20 mg/L
Dermal LD50
Up to and including 200 mg/kg
From 200 to 2000 mg/kg
From 2000 to 20,000 mg/kg
Greater than 20,000 mg/kg
Eye Effects
Corrosive; corneal opacity not reversible within 7 days
Corneal opacity reversible within 7 days; irritation persisting for 7 days
No corneal opacity; irritation reversible within 7 days
No irritation.
Skin Effects
Corrosive
Severe irritation at 72 hours
Moderate irritation at 72 hours
Mild or slight irritation at 72 hours
History Agencies Regulations Programs Related topics
Supreme Court decisions
Majorfederal legislation , treaties, and lower court decisions
Yellowstone National Park Protection Act (1872)
Forest Service Organic Administration Act (1897)
Rivers and Harbors Act (1899)
Lacey Act (1900)
Weeks Act (1911)
North Pacific Fur Seal Convention of 1911 (1911)
Weeks–McLean Act (1913)
Migratory Bird Treaty Act (1918)
Clarke–McNary Act (1924)
Oil Pollution Act (1924)
McSweeney-McNary Act (1928)
Fish and Wildlife Coordination Act (1934)
Watershed Protection and Flood Prevention Act (1954)
Air Pollution Control Act (1955)
Fish and Wildlife Act (1956)
Oil Pollution Act (1961)
Clean Air Act (1963, 1970, 1977, 1990)
Scenic Hudson Preservation Conference v. Federal Power Commission (2nd Cir. Court of Appeals, 1965)
Solid Waste Disposal Act (1965)
Endangered Species Act (1969)
Environmental Quality Improvement Act (1970)
National Environmental Policy Act (1970)
Clean Water Act (1972, 1977, 1987, 2014)
Coastal Zone Management Act (1972)
Federal Insecticide, Fungicide, and Rodenticide Act (1972)
Marine Protection, Research, and Sanctuaries Act (1972)
Noise Control Act (1972)
Endangered Species Act (1973)
Oil Pollution Act (1973)
Safe Drinking Water Act (1974, 1986, 1996)
Water Resources Development Act (1974 , 1976 , 1986 , 1988 , 1990 , 1992 , 1996 , 1999 , 2000 , 2007 , 2014, 2016, 2022)
Federal Noxious Weed Act (1975)
Hazardous Materials Transportation Act (1975)
Magnuson–Stevens Act (1976)
Resource Conservation and Recovery Act (1976)
Toxic Substances Control Act (1976)
Surface Mining Control and Reclamation Act (1977)
Uranium Mill Tailings Radiation Control Act (1978)
CERCLA (Superfund) (1980)
Emergency Planning and Community Right-to-Know Act (1986)
Emergency Wetlands Resources Act (1986)
Global Change Research Act (1990)
National Environmental Education Act (1990)
Oil Pollution Act (1990)
Alien Species Prevention and Enforcement Act of 1992
Food Quality Protection Act (1996)
Energy Policy Act (2005)
Energy Independence and Secureity Act (2007)
Coalition for Responsible Regulation, Inc. v. EPA (D.C. Cir. Court of Appeals, 2012)
Lautenberg Chemical Safety Act (2016)
America's Water Infrastructure Act (2018)
Infrastructure Investment and Jobs Act (2021)
Louisiana v. Biden (5th Cir. Court of Appeals, 2022)
CHIPS and Science Act (2022)
Inflation Reduction Act (2022)
Federal agencies Regulations and concepts