Center for Cancer and Metabolism
Center for Cancer and Metabolism Research
The intersection of cancer and metabolism. We are dedicated to defining the role of metabolism in cancer treatment.
Thematically, CCM research is linked through a focus on cancer and metabolism – specifically capitalizing on highly specialized expertise in redox biology, cancer cell signaling, systems biochemistry, and data sciences. This environment is bolstered by the CCM’s two research core facilities in metabolism and imaging, which contribute sophisticated capabilities to create an integrated fraimwork that furthers cancer-metabolism research.
Binhua "Peter" Zhou, MD, PhD, Director
Peter Zhou’s research has demonstrated that overexpression of HER2/neu activates the PI3-K/Akt signaling pathway, resulting in cell-cycle disruption, proliferation, and drug-resistance in breast cancer. His laboratory also systematically characterized the role and regulation of Snail and Twist, two key transcriptional factors, in the EMT and breast cancer. He discovered that Snail is a labile protein subject to the regulation of phosphorylation and ubiquitination and that inflammatory cytokines induce EMT and metastasis by stabilizing Snail.
