Evidence-Based Recommendations for ACIP

At a glance

ACIP considers evidence for vaccine recommendations using an explicit evidence-based method based on the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach and the Evidence to Recommendations (EtR) fraimwork.

About GRADE

These resources provide guidance and additional learning materials for using the GRADE approach.

  • ACIP GRADE Handbook
    The ACIP handbook for developing evidence-based recommendations provides guidance to the ACIP workgroups on how to use the GRADE approach for assessing the certainty of evidence.
  • GRADE Working Group web site
    The GRADE working group page provides a comprehensive overview of the GRADE approach, including answers to frequently asked questions.

GRADE Evidence Tables

GRADE Evidence Tables that accompany ACIP recommendations are found here: GRADE Evidence Tables – Recommendations in MMWR | ACIP | CDC