A cohort study of over 15,000 US adults found that the lifetime risk of developing dementia from ages 55 to 95 is 42%, with the highest risk in APOE ε4 carriers, women and Black adults, and projected that approximately 1 million US adults will develop dementia annually by 2060.

With the Declaration of Helsinki now mandating community engagement, Nature Medicine asks three winners of the Nature Awards for Inclusive Health Research to share their tips.

Studies from wearables show that even small doses of physical activity provide health benefits; guidelines should be updated to reflect this.

In a game-changing development for malaria vaccines, single-dose immunization with a genetically weakened whole malaria parasite vaccine achieved an unprecedented 90% protection.

An in vivo base editing approach targeting the PRNP gene led to a 52% increase in the lifespan of mouse models inoculated with the most common sporadic and genetic types of human pathogenic prion isolate.

The oral drug obeldesivir confers 80% survival when given after lethal Marburg virus exposure in cynomolgus macaques and also delays viral replication and disease onset, suggesting a potential treatment option for an infection with no approved therapies.

A cohort study of over 15,000 US adults found that the lifetime risk of developing dementia from ages 55 to 95 is 42%, with the highest risk in APOE ε4 carriers, women and Black adults, and projected that approximately 1 million US adults will develop dementia annually by 2060.

In the TRACERx cohort of 171 patients with lung cancer, the ultrasensitive detection of ctDNA improves preoperative patient stratification, also in early-stage disease.

Results from the phase 2 MATCH01 clinical trial of autologous monocyte-derived macrophage therapy for liver cirrhosis revealed no liver-related severe adverse events or deaths in the treatment group.

In a crossover trial evaluating semaglutide versus placebo as an add-on to automated insulin delivery therapy in adults with type 1 diabetes, the use of semaglutide was associated with an increased percentage of time spent within the target glucose range, along with reduced insulin requirements.

With the Declaration of Helsinki now mandating community engagement, Nature Medicine asks three winners of the Nature Awards for Inclusive Health Research to share their tips.

Base editing, antisense oligonucleotides and siRNA therapies that target low-density lipoprotein and the genes encoding molecules that regulate it are being tested in several clinical trials.

Satellite data assessing residential greenness across Italy indicate that thousands of deaths could be prevented by greening residential areas.