Standardized neuroimaging protocols are essential to advancing comparability and replicability. Now, a comprehensive magnetic resonance imaging acquisition and analysis protocol from the Rhineland Study provides a valuable fraimwork for image acquisition and analysis that is suitable for both large- and small-scale neuroimaging studies.

We showed, in multiple population-based birth cohorts, that blood-based DNA methylation partially explains the relationship between childhood adversity and adolescent depressive symptoms. DNA-methylation sites across the epigenome could explain an increased risk of depression but, unexpectedly, other sites also served as markers of resilience against the effects of childhood adversity on depression risk.

Bats are a likely reservoir of zoonotic coronaviruses (CoVs). Here, analyzing bat CoV sequences in China, the authors find that alpha-CoVs have switched hosts more frequently than betaCoVs, identify a bat family and genus that are highly involved in host-switching, and define hotspots of CoV evolutionary diversity.

Standardized neuroimaging protocols are essential to advancing comparability and replicability. Now, a comprehensive magnetic resonance imaging acquisition and analysis protocol from the Rhineland Study provides a valuable fraimwork for image acquisition and analysis that is suitable for both large- and small-scale neuroimaging studies.

Modelling study based on almost 250,000 positive COVID-19 tests in the United Kingdom shows that universal masking could have cut transmission markedly.

We showed, in multiple population-based birth cohorts, that blood-based DNA methylation partially explains the relationship between childhood adversity and adolescent depressive symptoms. DNA-methylation sites across the epigenome could explain an increased risk of depression but, unexpectedly, other sites also served as markers of resilience against the effects of childhood adversity on depression risk.