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Virology is the scientific discipline concerned with the study of the biology of viruses and viral diseases, including the distribution, biochemistry, physiology, molecular biology, ecology, evolution and clinical aspects of viruses.
H7N9 influenza A virus circulates in poultry but can also infect humans with often fatal outcome. Here, Chen et al. identify a novel nanobody that cross-reacts between H7N9 and human viruses H1N1 and H3N2 and protects mice from lethal challenge.
Here the authors made lipid-based CCR5-receptor targeted nanoparticles to facilitate cell-based delivery of the antiretroviral drug rilpivirine, improving HIV-1 suppression in cell and tissue reservoirs. Focused ultrasound facilitates penetrance of the nanoparticles across the blood-brain barrier where they enter myeloid cells in humanized mice.
Phenazine biosynthesis-like domain-containing protein (PBLD) and cedrelone play roles in tumor suppression. Here, authors suggest that PBLD and Cedrelone inhibit viral replication via activating the NF-κB-mediated IFN-I signaling response in cells and mice.
The African swine fever virus represents a threat to global pig production. Here, the authors determine the cryo-EM structures of ASFV RNA polymerase, and suggest that the M1249L subunit may modulate polymerase activity in cells.
The Oropouche virus has long been overlooked, but following a recent global expansion the virologist Marta Giovanetti argues for a One Health strategy to address this emergent public health threat.
T. Jake Liang describes how meeting a patient with fulminant hepatitis led to a collaboration that resulted in the first infectious clone of hepatitis C virus.
In a recent study, Lin et al. uncovered that a single substitution in the bovine influenza H5N1 haemagglutinin protein switches the specificity to human receptors.
In this journal club, Lucy Thorne discusses a paper that compares pandemic and non-pandemic HIV and shows that the ability of pandemic HIV to effectively evade the host’s innate immune response is a key factor in its pandemic potential.
