Papers by Parimal M Chatrabhuji
Various 5-oxo-imidazolines derivatives of Cinnamic acid were prepared and evaluated for their in ... more Various 5-oxo-imidazolines derivatives of Cinnamic acid were prepared and evaluated for their in vitro antimicrobial activity against various strains of bacteria.Structures of the compounds synthesized were elucidated by spectral studies. 2015 Trade Science Inc.-INDIA
![Research paper thumbnail of Synthesis of Some New Amino] – 5 – Methyl -4 Their Antimicrobial Activity Synthesis of Some New 2 – Aryl -3 -[(4 -Methyl Cinnamoyl) 4 -Oxothiazolidines and Evaluation for Their Antimicrobial Activity](https://images.weserv.nl/?url=https%3A%2F%2Fattachments.academia-assets.com%2F42760720%2Fthumbnails%2F1.jpg&q=12&output=webp&max-age=110)
4-Oxothiazolidines(1a-o) have been synthesized by cyclisation of various Schiff bases with thiola... more 4-Oxothiazolidines(1a-o) have been synthesized by cyclisation of various Schiff bases with thiolactic acid. The schiff bases are obtained by the condensation reaction of 4 cinnamoyl hydrazine with different benzaldehydes. The synthesized compounds are identified on the basis of spectral and elemental analysis. All the products have been evaluated for their in vitro antimicrobial activity against various strains of bacteria. The chemistry of 4-thiazolidinone ring system was reviewed in depth[1]. 4 thiazolidinone derivatives play a vital role owing to their wide range of biological activities[2]. Compounds containing thiazolidinone ring exhibit variety of biological activities such as anti-HIV[3], antitubercular[4], antioxidant[5] and antimicrobial[6,7] etc. 4 -Oxothiazolidines are synthesized either by cyclisation of thiolactic acid and schiff bases or by interconversion among appropriately substituted thiazolidinone derivatives by . Department of Chemistry, Bahauddin Science College...
ChemInform, 2005
Thiadiazole clubbed thiol derivatives were synthesized using rational approach of synthesis. The ... more Thiadiazole clubbed thiol derivatives were synthesized using rational approach of synthesis. The formations of compounds were confirmed by spectral data analysis viz. FT-IR, 1 H NMR, 13 C NMR, Mass spectra. The derivatives synthesized possessed both electron donating as well as electron-withdrawing groups as substituent.
Bacteriocins are antibacterial proteins produced by bacteria that kill or inhibit the growth of o... more Bacteriocins are antibacterial proteins produced by bacteria that kill or inhibit the growth of other bacteria. The term bacteriocin like inhibitory substances (BLIS) is applied to antagonistic substances which are not completely defined or do not fit the typical criteria of bacteriocin. They have been reported to inhibit a wide range of both Gram-positive and Gram-negative bacteria. In recent years, interest has been shown on the microbiology, biochemistry & molecular biology of bacteriocin like inhibitory substances (BLIS) because they are medically, industrially & agriculturally very important. In this present we provide details of the methods and results from the screening of a large collection of Lactic Acid Bacteria (LAB) isolates for bacteriocin-like activity. The bacteriocin from one strain was isolated and partially characterized. However, studies relating to the antibacterial properties of these organisms have been limited and not fully exploited for use. Three of the most important aspects in the study of bacteriocin are their production, characterization and purification. This represents the first confirmation of the production of a bacteriocin by a soil.
A new family of compounds made of 5-oxo-imidazolines containing styryl moiety has been designed a... more A new family of compounds made of 5-oxo-imidazolines containing styryl moiety has been designed and synthesized from various oxazolones. All the products have been evaluated for their in vitro antimicrobial activity against various strains of bacteria.
In this study, new derivatives of 5-oxo-imidazolines were synthesized and their antimicrobialacti... more In this study, new derivatives of 5-oxo-imidazolines were synthesized and their antimicrobialactivitieswere obtained.The structure elucidation of the compounds was performed by spectroscopic data and elemental analysis results.
Various 5-oxo-imidazolines derivatives of Cinnamic acid were prepared and evaluated for their in ... more Various 5-oxo-imidazolines derivatives of Cinnamic acid were prepared and evaluated for their in vitro antimicrobial activity against various strains of bacteria.Structures of the compounds synthesized were elucidated by spectral studies.
A series of new 5-oxo-imidazolineswere synthesized by condensation 4– methyl cinnamoyl
hydrazine ... more A series of new 5-oxo-imidazolineswere synthesized by condensation 4– methyl cinnamoyl
hydrazine with oxazolonesfrom benzoyl glycine, acetic anhydride and anhydrous sodium acetate and various aldehydes. All the final compounds synthesized were screened for their antimicrobial activities against various strains of bacteria.
New oxazolones were synthesized in good yield from benzoyl glycine, acetic anhydride and anhydrou... more New oxazolones were synthesized in good yield from benzoyl glycine, acetic anhydride and anhydrous
sodium acetate and various aldehydes. Further these oxazolones were converted 5-oxo-imidazolines by coupling with 4– methyl cinnamoyl hydrazine. All the products have been evaluated for their in vitro antimicrobial activity against various strains of bacteria.
Thiadiazole clubbed thiol derivatives were synthesized using rational approach of synthesis. The ... more Thiadiazole clubbed thiol derivatives were synthesized using rational approach of synthesis. The formations of compounds were confirmed by spectral data analysis viz. FT-IR, 1H NMR, 13C NMR, Mass spectra. The derivatives synthesized possessed both electron donating as well as electron-withdrawing groups as substituent.
Carbonitrile bearing pyran derivatives with electron-ithdrawing
substituent (-R) were synthesized... more Carbonitrile bearing pyran derivatives with electron-ithdrawing
substituent (-R) were synthesized via one pot three component mechanism using ultrasound irradiation process involving cyclization reaction between malononitrile, ethylacetoacetate
(Ia-g) / acetylacetone (Ih-k) and variedly substituted aldehydes. The structural formation of titled derivatives (Ia-k) was confirmed by IR, 1H NMR, 13C NMR, mass spectra and elemental analysis. The synthesized derivatives were screened for their antibacterial and antifungal properties against a broad spectrum of bacteria and fungi. The use of ultrasonic method helped to increase the yield of compounds by several folds as compared to the conventional method. Reaction time for the synthesis of titled derivatives was also found to decrease due to employment of green method.
Asimple, selective, linear, precise, and accurate RP-HPLCmethod was developed and validated for t... more Asimple, selective, linear, precise, and accurate RP-HPLCmethod was developed and validated for the estimation of Aceclofenac from bulk drug. Chromatographic separation was achieved isocratically on a Phenomenex, C8 column (250×4.6 mm, 3 µ particle size) using a mobile phase, (0.01M ammoniumacetate bufferwith 2ml triethylamine, (v/v)-acetonitrile (68:32 v/v) pH was adjusted to 6.5 with glacialAcetic acid. The flowrate was 1.2 ml/min and effluent was detected at 270 nm and 20ìl of sample was injected. The retention time of Aceclofenac was 6.4 min. Linearity was observed in the concentration range of 8-16 µg/ml. Percent recoveries obtained for Aceclofenac was 99.65-99.93%. The percentage RSD for precision and accuracy of the method was found to be less than 1%. The method was validated according to the ICH guidelines with respect to specificity, linearity, accuracy, precision, LOD and LOQ. The method developed was successfully applied for the analysis& estimation ofAceclofenac in bulk drug.
Asimple, selective, linear, precise, and accurate RP-HPLCmethod was developed and validated for t... more Asimple, selective, linear, precise, and accurate RP-HPLCmethod was developed and validated for the simultaneous estimation of Clopidogrel Bi Sulphate and Aspirin from bulk drug. Chromatographic separation was achieved isocratically ona ShimadzuPhenomenexLuna,C18 column (250×4.6mm, 5 µ particle size) using a mobile phase, (0.3%ortho phosphoric acid (v/v)-acetonitrile (40:60 v/v). The flow rate was 1 ml/min and effluent was detected at 226 nm and 20ìl of sample was injected. The retention time of Clopidogrel bisulphate andAspirin were 6.6 and 8.4 min respectively. Linearity was observed in the concentration range of 0.030-0.120 mg/ml for
aspirin and 0.015-0.060mg/ml for clopidogrel. Percent recoveries obtained for for aspirin was 99.12-99.83%and 98.20-100.35%for clopidogrel. The percentage RSD for precision and accuracy of the method was found to be less than 2%. The method was validated according to the ICH guidelines with respect to specificity, linearity, accuracy, precision, LOD and LOQ. The method developed was successfully applied for the analysis of simultaneous estimation of Clopidogrel Bi Sulphate andAspirin bulk drug.
The experiment was conducted with five different cultivars, the results of these study showed tha... more The experiment was conducted with five different cultivars, the results of these study showed that phenols play important roles in disease resistance in both fungicide treated and untreated plants. The phenol content decreased in diseased plants with the advancement of diseases from S 1 to S 3 stage. Change in lignin content was significantly higher in control plants as compared with the diseased plants in all mustard cultivar. Among the different cultivars, lignin content was higher at pre infectional stage (S 1 ) than the infectional stage (S 2 ) in diseased plants. In control plants it showed increasing pattern except in single cultivars.similar trend also observed for crude protein.
Fungicide treated plant (control) and naturally infected plants (Diseased) with powdery mildew of... more Fungicide treated plant (control) and naturally infected plants (Diseased) with powdery mildew of five brassica cultivars are under study. At harvest, siliquae per plant, the seeds per siliqua, and 1000 seed weight obtained from control plants were significantly higher than the diseased plants. The effect of powdery mildew on yield component of five mustard cultivars viz, V 2 (SKM-9801), V 1 (SKM-9804), GM-1, Varuna and Skm-9818 were observed. Finding showed that significant change in all yield quality characteristics. Yield component like no of siliqua/plant, number of seeds per siliqua and 1000 seed weight were higher in control with fungicide treated plant than the naturally infected diseased plant in all cultivars. Varietals differences were found to be non significant in No of seeds per siliqua and siliqua/plant where as test weight were found to be significant in all five cultivar.
Changes in total chlorophyll, total soluble sugar, reducing sugar and non reducing sugar were obs... more Changes in total chlorophyll, total soluble sugar, reducing sugar and non reducing sugar were observed in five different cultivars of mustard in response to powdery mildew viz, Skm-9801, skm-9804, GM-1, Varuna and Skm-9818 at different stages of disease infection. In fungicide treated plant ie. Control plants significantly higher value for total soluble sugar, chlorophyll and reducing sugar where as reverse trend obsereved in non reducing sugar content in all cultivars. Among the different cultivars no similar trend was observed in diseased infectional stages.
To examine the biochemical changes in leaves of five different cultivar with powdery mildew disea... more To examine the biochemical changes in leaves of five different cultivar with powdery mildew disease infected and treated with fungicides (hexaconezole ) results showed that It also showed greater activitity of enzyme peroxidase and polyphenol oxidase. Incase of leaves obtained from naturally infected plants at S 1 stage (no disease) recorded enzyme activity of peroxidase, polyphenol oxides and cellulase suppressed.At infectional stage of fungicide treated plants (S 2 -no disease), cultivar V 1 and V 2 showed similar results as deserved at pre infectional stage (S 1 ). However in addition to the above parameter wax content and cellulase were also higher at stage S 2 . At post infectional stage (S 3 ) controlled plants (no diseased) had higher activities of enzymes peroxidase and cellulase. Incase of diseased leaves at post infectional stage had greater amount of cellulase activity.Overall it may be concluded that mustard cultivars naturally infected with powdery mildew fungus and treated with fungicide (Hexaconezole) showed differential biochemical response and enzyme activity in mustard plants.
New anils were synthesized in good yield from 4-Methoxy cinnamoyl hydrazine and various benzaldeh... more New anils were synthesized in good yield from 4-Methoxy cinnamoyl hydrazine and various benzaldehydes. Further these anils were converted into 4-thiazolidines by the action of mercapto acetic acid. All the products have been evaluated for their in vitro antimicrobial activity against various strains of bacteria.
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Papers by Parimal M Chatrabhuji
hydrazine with oxazolonesfrom benzoyl glycine, acetic anhydride and anhydrous sodium acetate and various aldehydes. All the final compounds synthesized were screened for their antimicrobial activities against various strains of bacteria.
sodium acetate and various aldehydes. Further these oxazolones were converted 5-oxo-imidazolines by coupling with 4– methyl cinnamoyl hydrazine. All the products have been evaluated for their in vitro antimicrobial activity against various strains of bacteria.
substituent (-R) were synthesized via one pot three component mechanism using ultrasound irradiation process involving cyclization reaction between malononitrile, ethylacetoacetate
(Ia-g) / acetylacetone (Ih-k) and variedly substituted aldehydes. The structural formation of titled derivatives (Ia-k) was confirmed by IR, 1H NMR, 13C NMR, mass spectra and elemental analysis. The synthesized derivatives were screened for their antibacterial and antifungal properties against a broad spectrum of bacteria and fungi. The use of ultrasonic method helped to increase the yield of compounds by several folds as compared to the conventional method. Reaction time for the synthesis of titled derivatives was also found to decrease due to employment of green method.
aspirin and 0.015-0.060mg/ml for clopidogrel. Percent recoveries obtained for for aspirin was 99.12-99.83%and 98.20-100.35%for clopidogrel. The percentage RSD for precision and accuracy of the method was found to be less than 2%. The method was validated according to the ICH guidelines with respect to specificity, linearity, accuracy, precision, LOD and LOQ. The method developed was successfully applied for the analysis of simultaneous estimation of Clopidogrel Bi Sulphate andAspirin bulk drug.
hydrazine with oxazolonesfrom benzoyl glycine, acetic anhydride and anhydrous sodium acetate and various aldehydes. All the final compounds synthesized were screened for their antimicrobial activities against various strains of bacteria.
sodium acetate and various aldehydes. Further these oxazolones were converted 5-oxo-imidazolines by coupling with 4– methyl cinnamoyl hydrazine. All the products have been evaluated for their in vitro antimicrobial activity against various strains of bacteria.
substituent (-R) were synthesized via one pot three component mechanism using ultrasound irradiation process involving cyclization reaction between malononitrile, ethylacetoacetate
(Ia-g) / acetylacetone (Ih-k) and variedly substituted aldehydes. The structural formation of titled derivatives (Ia-k) was confirmed by IR, 1H NMR, 13C NMR, mass spectra and elemental analysis. The synthesized derivatives were screened for their antibacterial and antifungal properties against a broad spectrum of bacteria and fungi. The use of ultrasonic method helped to increase the yield of compounds by several folds as compared to the conventional method. Reaction time for the synthesis of titled derivatives was also found to decrease due to employment of green method.
aspirin and 0.015-0.060mg/ml for clopidogrel. Percent recoveries obtained for for aspirin was 99.12-99.83%and 98.20-100.35%for clopidogrel. The percentage RSD for precision and accuracy of the method was found to be less than 2%. The method was validated according to the ICH guidelines with respect to specificity, linearity, accuracy, precision, LOD and LOQ. The method developed was successfully applied for the analysis of simultaneous estimation of Clopidogrel Bi Sulphate andAspirin bulk drug.
understanding and to create interest in the subject of chemical kinetics in comprehensive
way.