Papers by Athanasios Galanopoulos
Case Reports in Medicine, 2011
Aggressive lymphomas can present with symptoms mimicking life-threatening infection. Flow cytomet... more Aggressive lymphomas can present with symptoms mimicking life-threatening infection. Flow cytometry (FC) is usually recommended for the classification and staging of lymphomas in patients with organomegaly and atypical cells in effusions and blood, after the exclusion of other possible diagnoses. FC may also have a place in the initial diagnostic investigation of aggressive lymphoma. Three cases are presented here of highly aggressive lymphomas in young adults, which presented with the clinical picture of fever of unknown origen (FUO) in patients severely ill. All followed a life-threatening clinical course, and two developed the hemophagocytic syndrome (HPS), but microbiological, immunological, and morphological evaluation and immunohistochemistry (IHC) failed to substantiate an early diagnosis. FC was the technique that provided conclusive diagnostic evidence of lymphoma, subsequently verified by IHC. Our experience with these three cases highlights the potential role of FC as an ...
Supplemental material, sj-pdf-2-tah-10.1177_2040620720966121 for Serum ferritin and ECOG performa... more Supplemental material, sj-pdf-2-tah-10.1177_2040620720966121 for Serum ferritin and ECOG performance status predict the response and improve the prognostic value of IPSS or IPSS-R in patients with high-risk myelodysplastic syndromes and oligoblastic acute myeloid leukemia treated with 5-azacytidine: a retrospective analysis of the Hellenic national registry of myelodysplastic and hypoplastic syndromes by Sotirios G. Papageorgiou, Ioannis Kotsianidis, Anthi Bouchla, Argyris Symeonidis, Athanasios Galanopoulos, Nora-Athina Viniou, Eleftheria Hatzimichael, Theodoros P. Vassilakopoulos, Dimitrios Gogos, Aikaterini Megalakaki, Panagiotis Zikos, Panagiotis Diamantopoulos, Alexandra Kourakli, Panagiota Giannoulia, Menelaos Papoutselis, Elias Poulakidas, Maria Arapaki, Anna Vardi, Achilles Anagnostopoulos, Despoina Mparmparousi, Maria Papaioannou, Eleni Bouronikou, Maria Dimou, Helen Papadaki, Panayiotis Panayiotidis and Vasiliki Pappa in Therapeutic Advances in Hematology
Biomedical Journal of Scientific & Technical Research, 2021
Case Reports in Medicine, 2011
Aggressive lymphomas can present with symptoms mimicking life-threatening infection. Flow cytomet... more Aggressive lymphomas can present with symptoms mimicking life-threatening infection. Flow cytometry (FC) is usually recommended for the classification and staging of lymphomas in patients with organomegaly and atypical cells in effusions and blood, after the exclusion of other possible diagnoses. FC may also have a place in the initial diagnostic investigation of aggressive lymphoma. Three cases are presented here of highly aggressive lymphomas in young adults, which presented with the clinical picture of fever of unknown origen (FUO) in patients severely ill. All followed a life-threatening clinical course, and two developed the hemophagocytic syndrome (HPS), but microbiological, immunological, and morphological evaluation and immunohistochemistry (IHC) failed to substantiate an early diagnosis. FC was the technique that provided conclusive diagnostic evidence of lymphoma, subsequently verified by IHC. Our experience with these three cases highlights the potential role of FC as an adjunct methodology in the initial assessment of possible highly aggressive lymphoma presenting with the signs and symptoms of life-threatening infection, although the definitive diagnosis should be established by biopsy. In such cases, FC can contribute to the diagnosis of lymphoma, independently of the presence of HPS.
Leukemia …, Jan 1, 2002
The multidrug resistance (MDR) transporter-proteins P-glycoprotein (Pgp), multidrug resistance pr... more The multidrug resistance (MDR) transporter-proteins P-glycoprotein (Pgp), multidrug resistance protein (MRP) and lung resistance protein (LRP) have been associated with treatment failure. The aim of this study was to investigate prospectively the clinical significance of expression and function of the MDR proteins, considering other prognostic factors, such as age, immunophenotype, and cytogenetics. Mononuclear cells of peripheral blood or bone marrow from 61 patients with de novo acute myelogenous leukemia (AML) were analyzed. The monoclonal antibodies JSB1, MRPm6 and LRP56 were used for expression studies. Accumulation and retention studies were performed using the substrates Daunorubicin, Calcein-AM, Rhodamine-123 and DiOC 2 in the presence or absence of the modifiers Verapamil, Genistein, Probenecid, BIBW22S and PSC833. Induction treatment consisted of a 3 + 7 combination of Ida/Ara-C for patients 5 60 years of age and a 3 + 5 Ida/VP-16 combination per OS for patients \ 60. MDR function was expressed as the ratio of mean fluorescence intensity substrate in the presence of modifier over the substrate alone (resistance index, RI). Patients with advanced age, low CD15 expression and high RI for accumulation of DiOC 2 in the presence of BIBW22S had significantly lower complete remission (CR) rates. No factor was prognostic for event-free survival analysis, which was limited to remitters only. Overall survival was shorter in patients with advanced age, poor prognosis cytogenetics, high CD7 expression, and high RI for Daunorubicin efflux modulated by Verapamil. These results suggest that MDR transporter-proteins have a limited role in the treatment failure of patients treated with Idarubicin-based regimens.
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Papers by Athanasios Galanopoulos