The results of a search for W boson pair production in pp collisions at √ s = 1.8 TeV with subseq... more The results of a search for W boson pair production in pp collisions at √ s = 1.8 TeV with subsequent decay to dilepton (eµ, ee, and µµ) channels are presented. One event is observed with an expected background of 0.56 ± 0.13 events with an integrated luminosity of approximately 14 pb −1. Assuming equal strengths for the W W Z and W W γ gauge boson coupling parameters κ and λ, limits on the CP-conserving anomalous coupling constants are −2.6 < ∆κ < 2.8 and −2.2 < λ < 2.2 at the 95% confidence level.
We report a measurement of the W boson mass based on an integrated luminosity of 82 pb −1 from pp... more We report a measurement of the W boson mass based on an integrated luminosity of 82 pb −1 from pp collisions at √ s = 1.8 TeV recorded in 1994-1995
Background: Reducing the incidence of Low birth weight (LBW) neonates by at least one third betwe... more Background: Reducing the incidence of Low birth weight (LBW) neonates by at least one third between 2000 and 2010 is one of the major goals of the United Nations resolution "A World Fit for Children". This was a case-control study conducted between August-October 2009 in Medani Hospital, Sudan to investigate the risk factors for LBW. Cases were mothers who delivered singleton baby < 2500 gm. Controls were mothers delivered singleton baby of ≥ 2500 gm. Findings: Out of 1224 deliveries, 97 (12.6%) of the neonates were LBW deliveries. While maternal socio-demographic characteristics (age, parity and mother education) and anthropometrics measurements were not associated with LBW, lack of antenatal care (OR = 5.9, 95% CI = 1.4-24.4; P = 0.01) and maternal anaemia (OR = 9.0, 95% CI = 3.4-23.8; P < 0.001) were the main risk factor for LBW. Conclusion: Thus, more care on antenatal care and nutrition may prevent LBW.
Background: The association between multimorbidity and breast cancer is not yet fully understood.... more Background: The association between multimorbidity and breast cancer is not yet fully understood. Few studies have published data on the association between multimorbidity and breast cancer in Africa, and none of them were conducted in Sudan. This study was conducted to estimate the prevalence and associated factors for multimorbidity (obesity, hypertension, diabetes, cardiovascular disease, asthma and tuberculosis, and HIV) and their association with breast cancer stage in women newly diagnosed with breast cancer in eastern Sudan. Methods: A retrospective cross -sectional study was conducted at East Oncology Center in Gadarif, eastern Sudan, from January to October 2021. Medical files were reviewed and sociodemographic, clinical data (comorbidities of hypertension, diabetes, cardiovascular disease, asthma, tuberculosis, and HIV) were retrieved. Logistics regression analysis was performed. Results: Medical files of 384 women who had newly diagnosed breast cancer were reviewed and in...
Background Body mass index (BMI) remains the most used indicator of nutritional status despite th... more Background Body mass index (BMI) remains the most used indicator of nutritional status despite the presence of a potentially credible alternative. Mid-upper arm circumference (MUAC) is an anthropometric measure that requires simple equipment and minimal training. The aim of this study was to compare MUAC with BMI and propose a MUAC cut-off point corresponding to a BMI of < 18.5 kg/m2 (underweight) and ≥ 30.0 kg/m2 (obesity) among Sudanese adults. Methods A cross-sectional study using multistage cluster sampling was conducted in New-Halfa, eastern Sudan. Participants’ age and sex were recorded and their MUAC, weight and height were measured using the standard procedures. The MUAC (cm) cut-offs corresponding to < 18.5 kg/m2 and ≥ 30.0 kg/m2 were calculated and determined using receiver operating characteristic (ROC) curve analysis Results Five hundreds and fifty-two adults were enrolled in the study. The median (interquartile range, IQR) of the participants age was 31.0 (24.0 ̶ ...
More than 90% of children who are HIV positive were infected via mother-to-child transmission (MT... more More than 90% of children who are HIV positive were infected via mother-to-child transmission (MTCT). In Sudan, HIV testing rates during pregnancy remain low. This study aimed to understand the key determinants of HIV testing and their association with pregnant women’s intention to undergo HIV test during pregnancy. A cross-sectional survey was conducted among 770 Sudanese pregnant women attending Antenatal care (ANC) visits at maternity hospitals. Based on the flow of antenatal care attendants, the calculated sample size was proportionally allocated to the hospitals. Doctors were most influential regarding pregnant women’s decision to undergo an HIV test during pregnancy (78.8%). Younger women were more likely to be tested. Most participants (68.9%) had high susceptibility with respect to HIV. Nearly half (48.3%) had a positive attitude towards HIV testing. Self-efficacy with regard to HIV testing was high (59.1%). Women with high self-efficacy and perceived susceptibility were mor...
Background and Objectives: COVID-19 is a pandemic disease, and its unpredictable outcome makes it... more Background and Objectives: COVID-19 is a pandemic disease, and its unpredictable outcome makes it particularly dangerous, especially for pregnant women. One of the decisions they have to make is where they will give birth. This study aimed to determine the factors influencing the choice of place of delivery and the impact of the COVID 19 pandemic on these factors. Materials and Methods: The study was conducted on 517 respondents from Poland. The research methods comprised the authors’ own survey questionnaire distributed via the Internet from 8 to 23 June 2021. The survey was fully anonymous, voluntary, and addressed to women who gave birth during the pandemic or will give birth shortly. Results: A total of 440 (85.1%) respondents were afraid of SARS-CoV-2 infection. The most frequently indicated factors were fear of complications in the newborn, fear of intrauterine fetal death, and congenital disabilities in a newborn. A total of 74 (14.3%) women considered home delivery. The main...
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Transactions of The Royal Society of Tropical Medicine and Hygiene
Background Lactating mothers are susceptible to anaemia. Little published data are available on l... more Background Lactating mothers are susceptible to anaemia. Little published data are available on lactational anaemia in Africa, including Sudan. This study was conducted to assess the prevalence of and associated factors for anaemia among lactating mothers in eastern Sudan. Methods A cross-sectional study was conducted and sociodemographic and clinical characteristics were gathered through a questionnaire. Results A total of 650 lactating mothers were included in the analysis. Their median age and parity were 28.0 y (interquartile range [IQR] 23.7‒32.0) and 3.0 (IQR 2.0‒4.0), respectively. Haemoglobin (Hb) levels ranged from 7.0 to 15.0 g/dL (median 11.2 [IQR 10.4‒12.0]). Of the 650 lactating mothers, 442 (68.0%) had anaemia (Hb <12.0 g/dL). In multivariate analysis, lactating mothers with education less than the secondary level (adjusted odds ratio [AOR] 1.58 [95% confidence interval {CI} 1.05 to 2.37]) and lactating mothers who underwent caesarean delivery (AOR 1.74 [95% CI 1.17...
Background : Diabetic nephropathy is one of the major causes of chronic renal failure. Microalbum... more Background : Diabetic nephropathy is one of the major causes of chronic renal failure. Microalbuminuria (MAU) has been recognized as an independent and reliable predictor for future development of overt proteinuria in diabetic patients. Objectives : This descriptive cross-sectional study was carried during the period of January-April 2012, in Omdurman Teaching Hospital, to determine Microalbuminuria creatinine ratio, in long term Diabetic patients. Materials and Methods: Immunoturbidmetric method was used to asses’ microalbuminuria in 50 cases (50%) and 50 controls (50%). Ordinary chemical method (Jaffe reaction) was used for the determination of creatinine for both the groups. Results : Microalbuminuria in Diabetic patients showed an increase when compared with the control group with P value 0.000. Similarly creatinine also showed an increase in diabetic patients. Conclusion: It was concluded and is in further affirmation of the previous studies that microalbuminuria should be used...
Background : It is well known that the Rhesus system remains the second most clinically important... more Background : It is well known that the Rhesus system remains the second most clinically important blood group system after the ABO. There is no published work regarding the frequency of various Rhesus antigens among Sudanese population. Objectives : In order to minimize Rhesus allo-immunization among blood recipients a cross sectional study was conducted to determine the frequency of various Rhesus antigens among the blood donors attending the Central Blood Bank in Khartoum. Methods : Two hundred male blood donors were enrolled in the study. ABO and Rhesus typing were performed using the classical slide method and gel micro typing system. Results : The frequency percentage of ABO blood phenotypes in the total samples were as follows: O(51.5%), A (29.5%), B (16%), and AB (6%); whereas the frequency percentage of Rh antigens were D (93%), e (79.5%), c (68.5%), C, (27%), E (18.5%). Conclusion : We concluded that the frequency of the Rh antigens can be shown in this order D > e > ...
The current pandemic of coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory... more The current pandemic of coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory coronavirus syndrome 2 (SARS-CoV-2). It is a global public health concern that has resulted in the rapid growth in the number of infected patients with significant mortality rates. Hence, we conducted a retrospective study in Gadarif Hospital to evaluate the presenting manifestations, mortality rate, and the risk factors associated with mortality in hospitalized patients. Methods: A retrospective study was conducted at Gadarif Hospital in Eastern Sudan. Medical files of the patients admitted during the period between April and July 2020 were reviewed. All the files of the adult patients (aged 18 or above), of both sexes, who had a confirmed COVID-19-positive status via laboratory testing using PCR and who were admitted during this period were reviewed. The data extracted included patients' demographics and initial clinical presentation, symptoms, signs, and the laboratory and radiographic findings. The data were analyzed using SPSS v22. Results: Eighty-eight patients were admitted with COVID-19. The median (interquartile) age was 62 (55.00-70.00) years old, and 72 (81.8%) of them were males. Most patients (75%) experienced a one-week duration of symptoms. A fever (87.5%), cough (80.68%), and shortness of breath (77.27%) were the most common presenting symptoms. Following a clinical assessment, both the systolic and diastolic blood pressure were found to be normal in most patients, at 92.05% and 89.77%, respectively. An oxygen saturation of less than 90% was seen in 71.59% of patients. The general mortality rate was 37.5% and most deaths occurred during the first 24 h of admission (21/33 [63.64%]). There was no significant difference in the death rate between females and males (5/16 [31.3%] vs 28/72 [38.9%], P = 0.776). There was no significant difference in the body mass index, tobacco use, or education level between the patients who died and those who survived. A logistic regression showed that being older (AOR = 1.05, 95% CI = [1.01, 1.10]) and having a lower PO 2 level (AOR = 1.11, 95% CI = [1.04, 1.16]) were associated with mortality. Conclusion: The general mortality rate was 37.5%, and the risk factors that could predict increased mortality in hospitalized COVID-19 positive cases included old age and a lower PO 2 level.
Transactions of The Royal Society of Tropical Medicine and Hygiene, 2018
Background Pre-eclampsia is the main cause of maternal and perinatal adverse effects. Although th... more Background Pre-eclampsia is the main cause of maternal and perinatal adverse effects. Although the exact mechanism and pathophysiology of pre-eclampsia are not yet fully understood, there are recent studies on the association between various infections and pre-eclampsia. This study investigated the association between maternal Toxoplasma gondii infection and pre-eclampsia. Methods A case-control study was conducted at Saad Abualila Hospital, Khartoum, Sudan. The cases were pregnant women with pre-eclampsia and the controls were healthy pregnant women. Their obstetrics history was collected using a questionnaire. T. gondii antibodies (immunoglobulin G [IgG] and IgM) were analysed in the maternal serum of both the cases and the controls using enzyme-linked immunosorbent assay. Results Maternal age and parity were not different between the cases and controls (90 women in each arm). There was a significant difference in the maternal anti-T. gondii IgG seropositivity, which was higher in the cases (pre-eclampsia) compared with the controls (32.3% vs 4.4%; p<0.001). There was no significant difference in the IgM seropositivity for T. gondii between the cases and controls (3.3% vs 1.1%; p=0.621). Binary logistic regression showed that women with toxoplasma IgG seropositivity were at higher risk for pre-eclampsia (odds ratio 9.40 [95% confidence interval 3.01 to 29.32]; p<0.001). Conclusions In the current study, T. gondii infection seems to be associated with pre-eclampsia. Further research is needed.
Rare clotting factor (F) deficiency is a deficiency of one or more of coagulation factors other t... more Rare clotting factor (F) deficiency is a deficiency of one or more of coagulation factors other than FVIII, FIX and vonWillebrand (FI, FII, FV, FV R FVIII, FVII, FIX, FX, FXI and FXIII) that cause bleeding disorders and are inherited as autosomal recessive. Descriptive study was conducted in Hemophilia Centre, Khartoum, Sudan. The medical files of pediatric patients presented to the center were reviewed retrospectively. Forty-seven patients (male : female ratio U 1.2 : 1) were included. The majority (93.6%) have parental history of consanguinity and around one third (31.9%) have family history of bleeding disorder. FV deficiency was the most common deficient factor (36.2%) followed by FI deficiency (23.4%) and FX111 deficiency (21.3%). Bruising (46.8%) and epistaxis (25.5%) were the most common presenting complains. FV deficiency mainly presented with cutaneous ecchymosis (47.1%). FI deficiency presented with umbilical bleeding (45.5%) and FXIII presented with cutaneous ecchymosis (50%). Rare clotting factor deficiency is an existing disease in Sudan with the male : female ratio was 1.2 : 1. FV deficiency, FI deficiency, FXIII deficiency were the common deficiency encountered.
Transactions of The Royal Society of Tropical Medicine and Hygiene, 2019
Background Accurate diagnosis of malaria infection is essential for successful control and manage... more Background Accurate diagnosis of malaria infection is essential for successful control and management of the disease. Both microscopy and rapid diagnostic tests (RDTs) are recommended for malaria diagnosis, however, RDTs are more commonly used. The aim of the current study was to assess the performance of microscopy and RDTs in the diagnosis of Plasmodium falciparum infection using a nested polymerase chain reaction (PCR) assay as the gold standard. Methods A cross-sectional study was carried out in Kassala Hospital, eastern Sudan. A total of 341 febrile participants of all ages were recruited. Blood specimens were collected and malaria testing was performed using an RDT (SD Bioline Malaria Ag Pf), microscopy and nested PCR. The sensitivity, specificity, positive and negative predictive values (PPV and NPV, respectively) of microscopy and the RDT were investigated. Results The prevalence of P. falciparum malaria infections in this study was 22.9%, 24.3% and 26.7% by PCR, microscopy ...
Therapeutic Advances in Endocrinology and Metabolism, 2019
Background:Diabetes mellitus (DM) constitutes a global health threat and burden, especially in de... more Background:Diabetes mellitus (DM) constitutes a global health threat and burden, especially in developing countries. We conducted a cross-sectional study in Gadarif in eastern Sudan to evaluate the prevalence and glycaemic control of patients with type 2 diabetes mellitus (T2DM).Methods:We performed a cross-sectional community-based study. Data on blood glucose levels, and anthropometric, demographic and clinical history data were obtained.Results:Six hundred Sudanese adults with a mean (SD) age of 44.9 (16.5) years were enrolled. More than two-thirds (70.3%) of the study participants were women. The prevalence of T2DM, newly diagnosed T2DM and uncontrolled T2DM was 20.8%, 10.0% and 80.0%, respectively. Logistic regression analysis showed no significant association between education, marital status, body mass index, waist circumference and DM. However older age (AOR = 4.88, 95% CI = 3.09–7.70) and a family history of DM (AOR = 2.58, 95% CI = 1.59–4.20) were associated with T2DM.Conc...
This study aimed to establish the reference intervals (RIs) of thyroid function test among the ad... more This study aimed to establish the reference intervals (RIs) of thyroid function test among the adult Sudanese population in Khartoum, Sudan. A multi-stage survey stratified sampling method was used. Total triiodothyronine (TT3), total thyroxine (TT4) level and thyroid stimulating hormone (TSH) levels were measured using radioimmunoassay gamma counter (Riostad, Germany) to determine the reference intervals. A total of 390 adults aged 20-75 years (male: 40.5%, female: 59.5%) were recruited. The median (95% intervals) serum TSH, TT4 and TT3 levels were 1.2 (0.50-3.1) mIU/L, 103.0 (63.0-159.0) nmol/L and 1.4 (0.8-2.7) nmol/L respectively. Compared with males; females had significantly lower TSH level and significantly higher TT4 level, but there was no significant difference when the TT3 level was assessed. While there was no significant difference in the level of TSH and T3 in the age group, T4 levels have shown a progressive increase with age. In summary the RIs for TSH, TT4 and TT3 i...
The results of a search for W boson pair production in pp collisions at √ s = 1.8 TeV with subseq... more The results of a search for W boson pair production in pp collisions at √ s = 1.8 TeV with subsequent decay to dilepton (eµ, ee, and µµ) channels are presented. One event is observed with an expected background of 0.56 ± 0.13 events with an integrated luminosity of approximately 14 pb −1. Assuming equal strengths for the W W Z and W W γ gauge boson coupling parameters κ and λ, limits on the CP-conserving anomalous coupling constants are −2.6 < ∆κ < 2.8 and −2.2 < λ < 2.2 at the 95% confidence level.
We report a measurement of the W boson mass based on an integrated luminosity of 82 pb −1 from pp... more We report a measurement of the W boson mass based on an integrated luminosity of 82 pb −1 from pp collisions at √ s = 1.8 TeV recorded in 1994-1995
Background: Reducing the incidence of Low birth weight (LBW) neonates by at least one third betwe... more Background: Reducing the incidence of Low birth weight (LBW) neonates by at least one third between 2000 and 2010 is one of the major goals of the United Nations resolution "A World Fit for Children". This was a case-control study conducted between August-October 2009 in Medani Hospital, Sudan to investigate the risk factors for LBW. Cases were mothers who delivered singleton baby < 2500 gm. Controls were mothers delivered singleton baby of ≥ 2500 gm. Findings: Out of 1224 deliveries, 97 (12.6%) of the neonates were LBW deliveries. While maternal socio-demographic characteristics (age, parity and mother education) and anthropometrics measurements were not associated with LBW, lack of antenatal care (OR = 5.9, 95% CI = 1.4-24.4; P = 0.01) and maternal anaemia (OR = 9.0, 95% CI = 3.4-23.8; P < 0.001) were the main risk factor for LBW. Conclusion: Thus, more care on antenatal care and nutrition may prevent LBW.
Background: The association between multimorbidity and breast cancer is not yet fully understood.... more Background: The association between multimorbidity and breast cancer is not yet fully understood. Few studies have published data on the association between multimorbidity and breast cancer in Africa, and none of them were conducted in Sudan. This study was conducted to estimate the prevalence and associated factors for multimorbidity (obesity, hypertension, diabetes, cardiovascular disease, asthma and tuberculosis, and HIV) and their association with breast cancer stage in women newly diagnosed with breast cancer in eastern Sudan. Methods: A retrospective cross -sectional study was conducted at East Oncology Center in Gadarif, eastern Sudan, from January to October 2021. Medical files were reviewed and sociodemographic, clinical data (comorbidities of hypertension, diabetes, cardiovascular disease, asthma, tuberculosis, and HIV) were retrieved. Logistics regression analysis was performed. Results: Medical files of 384 women who had newly diagnosed breast cancer were reviewed and in...
Background Body mass index (BMI) remains the most used indicator of nutritional status despite th... more Background Body mass index (BMI) remains the most used indicator of nutritional status despite the presence of a potentially credible alternative. Mid-upper arm circumference (MUAC) is an anthropometric measure that requires simple equipment and minimal training. The aim of this study was to compare MUAC with BMI and propose a MUAC cut-off point corresponding to a BMI of < 18.5 kg/m2 (underweight) and ≥ 30.0 kg/m2 (obesity) among Sudanese adults. Methods A cross-sectional study using multistage cluster sampling was conducted in New-Halfa, eastern Sudan. Participants’ age and sex were recorded and their MUAC, weight and height were measured using the standard procedures. The MUAC (cm) cut-offs corresponding to < 18.5 kg/m2 and ≥ 30.0 kg/m2 were calculated and determined using receiver operating characteristic (ROC) curve analysis Results Five hundreds and fifty-two adults were enrolled in the study. The median (interquartile range, IQR) of the participants age was 31.0 (24.0 ̶ ...
More than 90% of children who are HIV positive were infected via mother-to-child transmission (MT... more More than 90% of children who are HIV positive were infected via mother-to-child transmission (MTCT). In Sudan, HIV testing rates during pregnancy remain low. This study aimed to understand the key determinants of HIV testing and their association with pregnant women’s intention to undergo HIV test during pregnancy. A cross-sectional survey was conducted among 770 Sudanese pregnant women attending Antenatal care (ANC) visits at maternity hospitals. Based on the flow of antenatal care attendants, the calculated sample size was proportionally allocated to the hospitals. Doctors were most influential regarding pregnant women’s decision to undergo an HIV test during pregnancy (78.8%). Younger women were more likely to be tested. Most participants (68.9%) had high susceptibility with respect to HIV. Nearly half (48.3%) had a positive attitude towards HIV testing. Self-efficacy with regard to HIV testing was high (59.1%). Women with high self-efficacy and perceived susceptibility were mor...
Background and Objectives: COVID-19 is a pandemic disease, and its unpredictable outcome makes it... more Background and Objectives: COVID-19 is a pandemic disease, and its unpredictable outcome makes it particularly dangerous, especially for pregnant women. One of the decisions they have to make is where they will give birth. This study aimed to determine the factors influencing the choice of place of delivery and the impact of the COVID 19 pandemic on these factors. Materials and Methods: The study was conducted on 517 respondents from Poland. The research methods comprised the authors’ own survey questionnaire distributed via the Internet from 8 to 23 June 2021. The survey was fully anonymous, voluntary, and addressed to women who gave birth during the pandemic or will give birth shortly. Results: A total of 440 (85.1%) respondents were afraid of SARS-CoV-2 infection. The most frequently indicated factors were fear of complications in the newborn, fear of intrauterine fetal death, and congenital disabilities in a newborn. A total of 74 (14.3%) women considered home delivery. The main...
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Transactions of The Royal Society of Tropical Medicine and Hygiene
Background Lactating mothers are susceptible to anaemia. Little published data are available on l... more Background Lactating mothers are susceptible to anaemia. Little published data are available on lactational anaemia in Africa, including Sudan. This study was conducted to assess the prevalence of and associated factors for anaemia among lactating mothers in eastern Sudan. Methods A cross-sectional study was conducted and sociodemographic and clinical characteristics were gathered through a questionnaire. Results A total of 650 lactating mothers were included in the analysis. Their median age and parity were 28.0 y (interquartile range [IQR] 23.7‒32.0) and 3.0 (IQR 2.0‒4.0), respectively. Haemoglobin (Hb) levels ranged from 7.0 to 15.0 g/dL (median 11.2 [IQR 10.4‒12.0]). Of the 650 lactating mothers, 442 (68.0%) had anaemia (Hb <12.0 g/dL). In multivariate analysis, lactating mothers with education less than the secondary level (adjusted odds ratio [AOR] 1.58 [95% confidence interval {CI} 1.05 to 2.37]) and lactating mothers who underwent caesarean delivery (AOR 1.74 [95% CI 1.17...
Background : Diabetic nephropathy is one of the major causes of chronic renal failure. Microalbum... more Background : Diabetic nephropathy is one of the major causes of chronic renal failure. Microalbuminuria (MAU) has been recognized as an independent and reliable predictor for future development of overt proteinuria in diabetic patients. Objectives : This descriptive cross-sectional study was carried during the period of January-April 2012, in Omdurman Teaching Hospital, to determine Microalbuminuria creatinine ratio, in long term Diabetic patients. Materials and Methods: Immunoturbidmetric method was used to asses’ microalbuminuria in 50 cases (50%) and 50 controls (50%). Ordinary chemical method (Jaffe reaction) was used for the determination of creatinine for both the groups. Results : Microalbuminuria in Diabetic patients showed an increase when compared with the control group with P value 0.000. Similarly creatinine also showed an increase in diabetic patients. Conclusion: It was concluded and is in further affirmation of the previous studies that microalbuminuria should be used...
Background : It is well known that the Rhesus system remains the second most clinically important... more Background : It is well known that the Rhesus system remains the second most clinically important blood group system after the ABO. There is no published work regarding the frequency of various Rhesus antigens among Sudanese population. Objectives : In order to minimize Rhesus allo-immunization among blood recipients a cross sectional study was conducted to determine the frequency of various Rhesus antigens among the blood donors attending the Central Blood Bank in Khartoum. Methods : Two hundred male blood donors were enrolled in the study. ABO and Rhesus typing were performed using the classical slide method and gel micro typing system. Results : The frequency percentage of ABO blood phenotypes in the total samples were as follows: O(51.5%), A (29.5%), B (16%), and AB (6%); whereas the frequency percentage of Rh antigens were D (93%), e (79.5%), c (68.5%), C, (27%), E (18.5%). Conclusion : We concluded that the frequency of the Rh antigens can be shown in this order D > e > ...
The current pandemic of coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory... more The current pandemic of coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory coronavirus syndrome 2 (SARS-CoV-2). It is a global public health concern that has resulted in the rapid growth in the number of infected patients with significant mortality rates. Hence, we conducted a retrospective study in Gadarif Hospital to evaluate the presenting manifestations, mortality rate, and the risk factors associated with mortality in hospitalized patients. Methods: A retrospective study was conducted at Gadarif Hospital in Eastern Sudan. Medical files of the patients admitted during the period between April and July 2020 were reviewed. All the files of the adult patients (aged 18 or above), of both sexes, who had a confirmed COVID-19-positive status via laboratory testing using PCR and who were admitted during this period were reviewed. The data extracted included patients' demographics and initial clinical presentation, symptoms, signs, and the laboratory and radiographic findings. The data were analyzed using SPSS v22. Results: Eighty-eight patients were admitted with COVID-19. The median (interquartile) age was 62 (55.00-70.00) years old, and 72 (81.8%) of them were males. Most patients (75%) experienced a one-week duration of symptoms. A fever (87.5%), cough (80.68%), and shortness of breath (77.27%) were the most common presenting symptoms. Following a clinical assessment, both the systolic and diastolic blood pressure were found to be normal in most patients, at 92.05% and 89.77%, respectively. An oxygen saturation of less than 90% was seen in 71.59% of patients. The general mortality rate was 37.5% and most deaths occurred during the first 24 h of admission (21/33 [63.64%]). There was no significant difference in the death rate between females and males (5/16 [31.3%] vs 28/72 [38.9%], P = 0.776). There was no significant difference in the body mass index, tobacco use, or education level between the patients who died and those who survived. A logistic regression showed that being older (AOR = 1.05, 95% CI = [1.01, 1.10]) and having a lower PO 2 level (AOR = 1.11, 95% CI = [1.04, 1.16]) were associated with mortality. Conclusion: The general mortality rate was 37.5%, and the risk factors that could predict increased mortality in hospitalized COVID-19 positive cases included old age and a lower PO 2 level.
Transactions of The Royal Society of Tropical Medicine and Hygiene, 2018
Background Pre-eclampsia is the main cause of maternal and perinatal adverse effects. Although th... more Background Pre-eclampsia is the main cause of maternal and perinatal adverse effects. Although the exact mechanism and pathophysiology of pre-eclampsia are not yet fully understood, there are recent studies on the association between various infections and pre-eclampsia. This study investigated the association between maternal Toxoplasma gondii infection and pre-eclampsia. Methods A case-control study was conducted at Saad Abualila Hospital, Khartoum, Sudan. The cases were pregnant women with pre-eclampsia and the controls were healthy pregnant women. Their obstetrics history was collected using a questionnaire. T. gondii antibodies (immunoglobulin G [IgG] and IgM) were analysed in the maternal serum of both the cases and the controls using enzyme-linked immunosorbent assay. Results Maternal age and parity were not different between the cases and controls (90 women in each arm). There was a significant difference in the maternal anti-T. gondii IgG seropositivity, which was higher in the cases (pre-eclampsia) compared with the controls (32.3% vs 4.4%; p<0.001). There was no significant difference in the IgM seropositivity for T. gondii between the cases and controls (3.3% vs 1.1%; p=0.621). Binary logistic regression showed that women with toxoplasma IgG seropositivity were at higher risk for pre-eclampsia (odds ratio 9.40 [95% confidence interval 3.01 to 29.32]; p<0.001). Conclusions In the current study, T. gondii infection seems to be associated with pre-eclampsia. Further research is needed.
Rare clotting factor (F) deficiency is a deficiency of one or more of coagulation factors other t... more Rare clotting factor (F) deficiency is a deficiency of one or more of coagulation factors other than FVIII, FIX and vonWillebrand (FI, FII, FV, FV R FVIII, FVII, FIX, FX, FXI and FXIII) that cause bleeding disorders and are inherited as autosomal recessive. Descriptive study was conducted in Hemophilia Centre, Khartoum, Sudan. The medical files of pediatric patients presented to the center were reviewed retrospectively. Forty-seven patients (male : female ratio U 1.2 : 1) were included. The majority (93.6%) have parental history of consanguinity and around one third (31.9%) have family history of bleeding disorder. FV deficiency was the most common deficient factor (36.2%) followed by FI deficiency (23.4%) and FX111 deficiency (21.3%). Bruising (46.8%) and epistaxis (25.5%) were the most common presenting complains. FV deficiency mainly presented with cutaneous ecchymosis (47.1%). FI deficiency presented with umbilical bleeding (45.5%) and FXIII presented with cutaneous ecchymosis (50%). Rare clotting factor deficiency is an existing disease in Sudan with the male : female ratio was 1.2 : 1. FV deficiency, FI deficiency, FXIII deficiency were the common deficiency encountered.
Transactions of The Royal Society of Tropical Medicine and Hygiene, 2019
Background Accurate diagnosis of malaria infection is essential for successful control and manage... more Background Accurate diagnosis of malaria infection is essential for successful control and management of the disease. Both microscopy and rapid diagnostic tests (RDTs) are recommended for malaria diagnosis, however, RDTs are more commonly used. The aim of the current study was to assess the performance of microscopy and RDTs in the diagnosis of Plasmodium falciparum infection using a nested polymerase chain reaction (PCR) assay as the gold standard. Methods A cross-sectional study was carried out in Kassala Hospital, eastern Sudan. A total of 341 febrile participants of all ages were recruited. Blood specimens were collected and malaria testing was performed using an RDT (SD Bioline Malaria Ag Pf), microscopy and nested PCR. The sensitivity, specificity, positive and negative predictive values (PPV and NPV, respectively) of microscopy and the RDT were investigated. Results The prevalence of P. falciparum malaria infections in this study was 22.9%, 24.3% and 26.7% by PCR, microscopy ...
Therapeutic Advances in Endocrinology and Metabolism, 2019
Background:Diabetes mellitus (DM) constitutes a global health threat and burden, especially in de... more Background:Diabetes mellitus (DM) constitutes a global health threat and burden, especially in developing countries. We conducted a cross-sectional study in Gadarif in eastern Sudan to evaluate the prevalence and glycaemic control of patients with type 2 diabetes mellitus (T2DM).Methods:We performed a cross-sectional community-based study. Data on blood glucose levels, and anthropometric, demographic and clinical history data were obtained.Results:Six hundred Sudanese adults with a mean (SD) age of 44.9 (16.5) years were enrolled. More than two-thirds (70.3%) of the study participants were women. The prevalence of T2DM, newly diagnosed T2DM and uncontrolled T2DM was 20.8%, 10.0% and 80.0%, respectively. Logistic regression analysis showed no significant association between education, marital status, body mass index, waist circumference and DM. However older age (AOR = 4.88, 95% CI = 3.09–7.70) and a family history of DM (AOR = 2.58, 95% CI = 1.59–4.20) were associated with T2DM.Conc...
This study aimed to establish the reference intervals (RIs) of thyroid function test among the ad... more This study aimed to establish the reference intervals (RIs) of thyroid function test among the adult Sudanese population in Khartoum, Sudan. A multi-stage survey stratified sampling method was used. Total triiodothyronine (TT3), total thyroxine (TT4) level and thyroid stimulating hormone (TSH) levels were measured using radioimmunoassay gamma counter (Riostad, Germany) to determine the reference intervals. A total of 390 adults aged 20-75 years (male: 40.5%, female: 59.5%) were recruited. The median (95% intervals) serum TSH, TT4 and TT3 levels were 1.2 (0.50-3.1) mIU/L, 103.0 (63.0-159.0) nmol/L and 1.4 (0.8-2.7) nmol/L respectively. Compared with males; females had significantly lower TSH level and significantly higher TT4 level, but there was no significant difference when the TT3 level was assessed. While there was no significant difference in the level of TSH and T3 in the age group, T4 levels have shown a progressive increase with age. In summary the RIs for TSH, TT4 and TT3 i...
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Papers by Ishag Adam