Papers by Anil Giri
S-1 is a novel oral fluoropyrimidine derivative, widely used for treating gastric, pancreatic, lu... more S-1 is a novel oral fluoropyrimidine derivative, widely used for treating gastric, pancreatic, lung, head, neck and breast carcinomas. It is
designed to enhance the clinical utility of an oral fluoropyrimidine and is associated with low gastrointestinal toxicity. S-1 consists of three
pharmacological agents (at a molar ratio of 1:0.4:1)-Tegafur (FT), a prodrug of 5-Fluorouracil (5-FU), 5-Chloro-2-4-Dihydroxypyridine
(CDHP), which inhibits the activity of Dihydropyrimidine Dehydrogenase (DPD) and Oxonic Acid (Oxo), which reduces Gastrointestinal
(GI) toxicity of 5-FU. The present article reviews the current development of clinical study of S-1.
• Implementation of medicine take-back concept at by Anil Giri
The aim of the present study was to evaluate how clinically two important drugs, Amlodipine Besyl... more The aim of the present study was to evaluate how clinically two important drugs, Amlodipine Besylate (AB) and Olmesartan Medoxomil (OM), bind with serum albumin protein and the effect of drug-protein binding when they administrated concomitantly. In this study the binding chemistry of Amlodipine and Olmesartan to Bovine Serum Albumin (BSA) was evaluated by equilibrium dialysis method utilizing Warfarin Sodium (Site-I specific probe) and Diazepam (Site-II specific probe). Association constant and number of binding sites of the experimental drugs were carried out at PH value 7.4 and the temperature at 370C. The non-linear curve of the plot suggests the presence of at least two classes of binding site (low affinity binding site and high affinity binding site) of experimental drugs to BSA. In both cases the value of association constants of experimental drugs were found high at PH 7.4. One of the experimental drug (AB) found to bind Site-I and the other drug (OM) found to bind Site-II preferentially. During concurrent administration of AB and OM in presence or absence of Diazepam, no significant amount of drug is displaced either Amlodipine or Olmesartan from the binding site on BSA. Also the ability of experimental drugs to displace each other is found less significant in presence of Diazepam. As both drugs do not compete for the same binding site, concurrent administration of these drugs can be the effective in the management of cardiovascular problems.
Factors Associated With Health Complaints Among Leather Tannery Workers in Bangladesh, 2020
Background: Few studies have reported associations between occupational exposure to tannery chemi... more Background: Few studies have reported associations between occupational exposure to tannery chemicals with breathing difficulty and skin diseases and none have been conducted in Bangladesh. The aim of this study was to investigate the associations of health complaints with types of work and length of employment among tannery workers in Bangladesh, where occupational health and safety regulations are less restricted compared with the developed world. Methods: One hundred sixty-seven (n = 167) workers from 10 tanneries were interviewed using a questionnaire adapted from the European Community Respiratory Health Survey (ECRHS) and the Tasmanian Longitudinal Health Study (TAHS) to collect information on occupational exposures and health outcomes. Workers' length of employment was examined, as well as their areas of work including beamhouse, wet finishing, dry finishing, and miscellaneous. Univariate and multivariate logistic regressions were performed to investigate potential associations while controlling for confounders. Results: Length of employment was positively associated with breathing difficulty (odds ratio [OR]: 1.32, 95% confidence interval [CI]:1.07-1.64). Workers involved in the wet finishing (OR: 11.75, 95% CI: 2.12-65.10) and dry finishing (OR: 13.38, 95% CI: 1.00-181.70) had higher odds of breathing difficulty; while, working in the beamhouse was associated with an increased risk of developing skin diseases (OR: 4.36, 95% CI: 1.10-17.32). Conclusion/Application to Practice: Length of employment and types of work were associated with increased risk of health complaints, including breathing difficulty and skin disease among tannery workers. Stronger regulations with regular enforcement, regular health surveillance, and worker and employer education are necessary for reducing these exposures and improving the health outcomes of the tannery workers.
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Papers by Anil Giri
designed to enhance the clinical utility of an oral fluoropyrimidine and is associated with low gastrointestinal toxicity. S-1 consists of three
pharmacological agents (at a molar ratio of 1:0.4:1)-Tegafur (FT), a prodrug of 5-Fluorouracil (5-FU), 5-Chloro-2-4-Dihydroxypyridine
(CDHP), which inhibits the activity of Dihydropyrimidine Dehydrogenase (DPD) and Oxonic Acid (Oxo), which reduces Gastrointestinal
(GI) toxicity of 5-FU. The present article reviews the current development of clinical study of S-1.
• Implementation of medicine take-back concept at by Anil Giri
designed to enhance the clinical utility of an oral fluoropyrimidine and is associated with low gastrointestinal toxicity. S-1 consists of three
pharmacological agents (at a molar ratio of 1:0.4:1)-Tegafur (FT), a prodrug of 5-Fluorouracil (5-FU), 5-Chloro-2-4-Dihydroxypyridine
(CDHP), which inhibits the activity of Dihydropyrimidine Dehydrogenase (DPD) and Oxonic Acid (Oxo), which reduces Gastrointestinal
(GI) toxicity of 5-FU. The present article reviews the current development of clinical study of S-1.