Long-term outcomes from the PEARLS randomized trial for the treatment of depression in patients with epilepsy

Naomi Chaytor; Paul Ciechanowski; John W Miller; Robert Fraser; Joan Russo; Jurgen Unutzer; Frank Gilliam

doi:10.1016/j.yebeh.2011.01.017

Long-term outcomes from the PEARLS randomized trial for the treatment of depression in patients with epilepsy

Epilepsy Behav. 2011 Mar;20(3):545-9. doi: 10.1016/j.yebeh.2011.01.017. Epub 2011 Feb 18.

Authors

Naomi Chaytor¹, Paul Ciechanowski, John W Miller, Robert Fraser, Joan Russo, Jurgen Unutzer, Frank Gilliam

Affiliation

¹ Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA. chaytor@u.washington.edu

PMID: 21333607
DOI: 10.1016/j.yebeh.2011.01.017

Abstract

Depression is associated with higher rates of suicide and lower quality of life in individuals with epilepsy. We previously published the 12-month outcome from our randomized clinical trial of PEARLS (Ciechanowski P, Chaytor N, Miller J, et al. Epilepsy Behav. Epub 5 July 2010). The purpose of this study was to determine the long-term effectiveness of PEARLS, a home-based collaborative care intervention consisting of problem-solving treatment, behavioral activation, and psychiatric consultation, in individuals with epilepsy. Patients were randomly assigned to PEARLS (N=40) or usual care (N=40), and assessed at baseline and 6, 12, and 18 months. Patients assigned to PEARLS achieved lower depression severity (P<0.05) (Hopkins Symptoms Checklist-20), lower suicidal ideation (P<0.02), and better emotional well being (QOLIE-31) (P<0.02) over 18 months, compared with patients given the usual care. The PEARLS program significantly reduces depressive symptoms in adults with epilepsy, and this effect is maintained for 18 months after baseline and for more than 1 year after completion of home visits.

Trial registration: ClinicalTrials.gov NCT00459329.

Publication types

Clinical Trial
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Adult
Depression* / etiology
Depression* / psychology
Depression* / therapy
Emotions / physiology
Epilepsy / complications*
Female
Home Care Services*
Humans
Longitudinal Studies
Male
Middle Aged
Psychiatric Status Rating Scales
Quality of Life
Suicide / psychology
Time Factors
Treatment Outcome*

Associated data

ClinicalTrials.gov/NCT00459329

Long-term outcomes from the PEARLS randomized trial for the treatment of depression in patients with epilepsy

Authors

Affiliation

Abstract

Publication types

MeSH terms

Associated data

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