Papers by J. Castro-rodriguez
JOURNAL OF ASTHMA, 2013
Background. Although the measurement of fractional exhaled nitric oxide (FE NO) has been recommen... more Background. Although the measurement of fractional exhaled nitric oxide (FE NO) has been recommended for observational studies and clinical trials of asthma, FE NO has not been examined in studies of childhood asthma in Latin America, Objective. To examine the relationship between FE NO and indicators of disease control or severity [asthma control test/childhood asthma control test (ACT/C-ACT), lung function, and exercise challenge test (ECT)] in Mexican children with persistent asthma, Methods. Children (6-18 years of age) with persistent asthma were consecutively recruited in a tertiary asthma clinic and divided into two groups, e.g. FE NO < 20 parts per billion (ppb) and !20 ppb.Adequate FE NO measurements were obtained in 134 (83.2%) of 161 eligible children, Results. Children with FE NO <20 ppb had significantly higher scores on the ACT/C-ACT than those with FE NO ! 20 ppb (median [interquartile range] :23 [20.8-25] vs. 21 [18-24], p ¼ .002, respectively). Compared to children with FE NO !20 ppb, those with FE NO <20 ppb had a higher baseline predicted forced expiratory volume (FEV 1) [94% (92.5%-99.4%) vs. 83% (81%-89.9%), p ¼ .001] and a lower probability of having a positive ECT (42.7% vs. 71.2%, p ¼ .001). In addition, FE NO was significantly inversely correlated with the participants' ACT/C-ACT score and predicted FEV 1 , and directly correlated with positive ECT, Conclusion. Among Mexican children with persistent asthma, low levels of FE NO (<20 ppb) are associated with better asthma control, and higher lung function.
Durante las últimas décadas hemos presenciado un aumento sostenido de la prevalencia de asma y de... more Durante las últimas décadas hemos presenciado un aumento sostenido de la prevalencia de asma y de obesidad en muchos países 1 . Por ejemplo, en los Estados Unidos entre los años 1980 y 1996 la prevalencia de asma se incrementó en un 73,9% 2 y la de obesidad se elevó de 15,8% a 33,2% en mujeres y de 13,4% a 27,6% en hombres durante el período 1960-2000 3 . Este incremento paralelo de estas dos enfermedades ha dado origen a que se postule que ambas entidades podrían estar de algún modo relacionadas.
Maternal & Child Nutrition, 2008
None of the epidemiological studies indicating that obesity is a risk factor for asthma in school... more None of the epidemiological studies indicating that obesity is a risk factor for asthma in schoolchildren have used the percent body fat (PBF) to define obesity. The present study compares the definition of obesity using body mass index (BMI), PBF and the raw sum of the thickness of four skinfolds (SFT) to evaluate this condition as a risk factor for asthma.All classes of children of the target ages of 6-8 years of all schools in four municipalities of Murcia (Spain) were surveyed. Participation rate was 70.2% and the number of children included in the study was 931. Height, weight and SFT (biceps, triceps, subscapular and suprailiac) were measured according to standard procedures. Current active asthma was defined from several questions of the International Study of Asthma and Allergies in Childhood questionnaire. Obesity was defined using two standard cut-off points for BMI and PBF, and the 85th percentile for BMI, PBF and SFT. The highest quartile of each type of measurement was also compared with the lowest. A multiple logistic regression analysis was made for the various obesity definitions, adjusting for age, asthma in the mother and father and gender. The adjusted odds ratios of having asthma among obese children were different for boys and girls and varied across the different obesity definitions. For the standard cut-off points of BMI they were 1.19 [95% confidence interval (CI) 0.41-3.43] for girls and 2.00 (95% CI 0.97-4.10) for boys; however, for PBF (boys 25%, girls 30%) the corresponding figures were 1.54 (95% CI 0.63-3.73) and 1.20 (95% CI 0.66-2.21). BMI, PBF and SFT showed more consistency between each other when using the other cut-off points. BMI, PBF (except standard cut-off points) and SFT produce relatively comparable results when analysing the interaction between obesity and asthma.
The Journal of Pediatrics, 2008
Objective To test the hypothesis that the Mediterranean diet can be a protective factor for curre... more Objective To test the hypothesis that the Mediterranean diet can be a protective factor for current wheezing in preschoolers. Study design Questionnaires were completed by parents of 1784 preschoolers (mean age, 4.08 ؎ 0.8 years). Children were stratified according to whether they experienced wheezing (20.0%) or not in the previous year. A Mediterranean diet score was built according to the intake frequency of several foods.
Allergologia et Immunopathologia, 2012
European Respiratory Journal, 2008
Archives of Disease in Childhood, 2010
Allergy, 2012
RS. International consensus on (icon) pediatric asthma. Allergy 2012; 67: 976-997.
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Papers by J. Castro-rodriguez