This paper presents a comparative evaluation of two activated carbons produced from different lignocellulosic residues (spent coffee grounds and Raphanus Sativus press cake), as adsorbents for removal of phenol from aqueous solutions in fixed-bed column studies. Both the prepared adsorbents presented outstanding adsorption capacities when compared to other low-cost adsorbents presented in the literature. Breakthrough curves were produced and several breakthrough models were evaluated for adequate description of the adsorption process in the column, with the Dose-Response model presenting the best fit to the experimental data.