Abstract
The treatment landscape of metastatic castration-resistant prostate cancer (mCRPC) has dramatically improved over the last decade; however, patients with visceral metastases are still faced with poor outcomes. Phosphatase and tensin homolog (PTEN) loss is observed in 40%–60% of mCRPC patients and is also associated with a poor prognosis. Several PI3K/AKT/mTOR pathway inhibitors have been studied, with disappointing anti-tumor activity. Here, we present a case of a patient with heavily treated mCRPC who had a modest tumor response to concurrent carboplatin, abiraterone acetate/prednisone, and liver-directed radiation therapy. We discuss the potential rationale supporting the use of this combination therapy and its safety in mCRPC. While the underlying basic mechanism of our patient’s anti-tumor response remains uncertain, we suggest that further prospective studies are warranted to evaluate whether this combination therapy is effective in this population of patients with pre-treated mCRPC and PTEN loss.
Document Type
Article
Publication Date
9-23-2021
Digital Object Identifier (DOI)
https://doi.org/10.3389/fonc.2021.731002
Funding Information
This funding is supporting the University of Kentucky Markey Cancer Center’s Research Communications Office. They assisted with preparation of this manuscript.
Repository Citation
Myint, Zin W.; Allison, Derek B.; and Ellis, Carleton S., "A Case Report of Metastatic Castration-Resistant Prostate Cancer Harboring a PTEN Loss" (2021). Internal Medicine Faculty Publications. 261.
https://uknowledge.uky.edu/internalmedicine_facpub/261
Included in
Internal Medicine Commons, Oncology Commons, Pathology Commons, Pharmacy and Pharmaceutical Sciences Commons, Urology Commons
Notes/Citation Information
Published in Frontiers in Oncology, v. 11, article 731002.
© 2021 Myint, Allison and Ellis
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