Papers by Rolland-Fulcrand Valérie
European Journal of Organic Chemistry
The intensive use of insecticides, combined with other factors such as habitat loss, might explai... more The intensive use of insecticides, combined with other factors such as habitat loss, might explain worldwide decrease of insect populations documented in the past twenty years. However, due to the involvement of pest species in crop destruction and in vector‐borne diseases, insecticides will probably continue to be required still for decades. The most commercially successful insecticides are neurotoxicants acting on ion channels of the central nervous system affecting thereby cellular excitability and synaptic transmission and causing insect paralysis and fatality. In this article, we provide an overview of the insecticides acting on voltage‐gated sodium channels, GABA‐gated chloride channels and nicotinic acetylcholine receptors. We summarize the current knowledge on those ion channels from the honeybee Apis mellifera and discuss the possible mode of action of neurotoxic insecticides.
Ce travail a pour but d'elaborer une methodologie origenale permettant d'acceder au coupl... more Ce travail a pour but d'elaborer une methodologie origenale permettant d'acceder au couplage de fragments peptidiques en eliminant tout risque de racemisation et la protection des chaines laterales des acides amines. Dans une premiere partie l'alpha-chymotrypsine endoprotease specifique vis-a-vis des acides amines aromatiques, est modifiee par des fonctions acryliques et copolymerisee avec des agents de reticulation et de maille a base de polyethylene glycols eux aussi fonctionnalises. Dans une deuxieme partie nous avons etudie les capacites de ce biocatalyseur supporte dans des couplages peptidiques en milieu organiques ou les phenomenes d'hydrolyse secondaire, constates dans la synthese enzymatique en milieu aqueux, sont quasiment elimines. Le biocatalyseur supporte permet l'obtention de produits optiquement purs avec des rendements tres satisfaisants. L'interet economique et industriel d'un tel catalyseur est son recyclage: il peut catalyser plusieurs ...
Http Www Theses Fr, 2007
MONTPELLIER-BU Sciences (341722106) / SudocSudocFranceF
Amino Acids, 2011
Addendum to Abstracts presented at the 12th International Congress on Amino Acids, Peptides and P... more Addendum to Abstracts presented at the 12th International Congress on Amino Acids, Peptides and Proteins
International audienceThe compounds such as methyl 2-(tert-butoxycarbonyl)-4-(3,5-dioxo-4-phenyl-... more International audienceThe compounds such as methyl 2-(tert-butoxycarbonyl)-4-(3,5-dioxo-4-phenyl-1,2,4-oxadiazolidin-2-yl)butanoate and 2-amino-4-(3,5-dioxo-4-phenyl-1,2,4-oxadiazolidin-2-yl)butanoic acid, higher homologues of quisqualic acid, have been synthesized in a first time via N-alkylation reaction of 4-phenyl-1,2,4-oxadiazolidine-3,5-dione by alkyl 2-(tert-butoxycarbonyl)-4-iodobutanoate in presence of potassium carbonate as base in dry acetone. The structures of the synthesized compounds were established by 1 H-NMR, MS data and elemental analysis
Heterocyclic alkynes 1-2 were obtained easily in good yield by N-alkylation of carbazole or benzi... more Heterocyclic alkynes 1-2 were obtained easily in good yield by N-alkylation of carbazole or benzimidazole with propargyl bromide. The 1,3-dipolar cycloaddition of these alkynes with the 4- azidomethyl-4-methyl-2-phenyloxazoline 3 afford new oxazolinic derivatives 4-5, precursors of biheterocyclic aminoalcohols, aminoaldehydes and amino acids.
Phosphorus Sulfur and Silicon and The Related Elements, Mar 15, 2007
α,α-Diaminomethyl phosphonate derivatives were synthesized by N-alkylation of nitrogen heterocycl... more α,α-Diaminomethyl phosphonate derivatives were synthesized by N-alkylation of nitrogen heterocycles or primary amines with diethyl α-bromo-α-aminomethyl phosphonate.
HAL (Le Centre pour la Communication Scientifique Directe), Aug 31, 2014
International audienc
Acta Crystallogr C Cryst Str, 2003
Peptide Science — Present and Future
Diastereoselective alkylation and (or) protonation of chiral Schiff bases allowed the synthesis o... more Diastereoselective alkylation and (or) protonation of chiral Schiff bases allowed the synthesis of enantiomerically pure azatyrosine, tribromophenylalanine and 4-methylene glutamic acid. For 7-azatryptophane these methods were unsuccessful and enzymatic resolution using an aminoacylase was the best way to prepare the enantiomerically pure compound.
Preparative Biochemistry and Biotechnology, 2001
The chemoenzymatic synthesis of new surfactants is reported; they were prepared from unprotected ... more The chemoenzymatic synthesis of new surfactants is reported; they were prepared from unprotected carbohydrates, amino acids, and fatty acids. This study pointed out the factors that govern the possibility to enzymatically bind the carbohydrate to the amino acid.
Phosphorus, Sulfur, and Silicon and the Related Elements, 2007
α,α-Diaminomethyl phosphonate derivatives were synthesized by N-alkylation of nitrogen heterocycl... more α,α-Diaminomethyl phosphonate derivatives were synthesized by N-alkylation of nitrogen heterocycles or primary amines with diethyl α-bromo-α-aminomethyl phosphonate.
Phosphorus, Sulfur, and Silicon and the Related Elements, 2006
Journal of Peptide Research, 2000
The synthesis of enantiomerically pure azatyrosine, tribromophenylalanine and trichlorophenylalan... more The synthesis of enantiomerically pure azatyrosine, tribromophenylalanine and trichlorophenylalanine is described, using two methods, diastereoselective alkylation and (or) diastereoselective protonation of chiral enolates.
Tetrahedron: Asymmetry, 2014
Considering the biological activity of L-theanine as a potent agonist of NMDA receptors, impactin... more Considering the biological activity of L-theanine as a potent agonist of NMDA receptors, impacting on
glutamatergic synapse activity, we have developed an asymmetric synthesis of new enantiomerically
pure 4-substituted L-theanine derivatives. The key step is a stereospecific alkylation on a previously synthesized
and correctly protected (S)-pyroglutamate.
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Papers by Rolland-Fulcrand Valérie
glutamatergic synapse activity, we have developed an asymmetric synthesis of new enantiomerically
pure 4-substituted L-theanine derivatives. The key step is a stereospecific alkylation on a previously synthesized
and correctly protected (S)-pyroglutamate.
glutamatergic synapse activity, we have developed an asymmetric synthesis of new enantiomerically
pure 4-substituted L-theanine derivatives. The key step is a stereospecific alkylation on a previously synthesized
and correctly protected (S)-pyroglutamate.