CST9L
Cistatin-9-oliki je protein koji je kod ljudi kodiran genom CST9L.[5]
Supeporodica cistatina obuhvata proteine koji sadrže višestruke sekvence slične cistatinu. Neki od članova su aktivni inhibitori cistein-proteaza, dok su drugi izgubili ili možda nikada nisu stekli ovu inhibitornu aktivnost. U natporodici postoje tri porodice inhibitora, uključujući cistatine tipa 1 (stefini), cistatine tipa 2 i kininogeni. Proteini cistatina tipa 2 su klasa inhibitora cistein-proteinaze, koji se nalaze u raznim ljudskim tečnostima i sekretu. Lokus cistatina na hromosomu 20 sadrži većinu gena i pseudogena cistatina tipa 2. Ovaj gen nalazi se u lokusu cistatina i kodira protein sličan mišjem cistatinu 9. Na osnovu njegovog testis-specifične ekspresije, vjerovatno ima ulogu u reorganizaciji tkiva tokom ranog razvoja testisa.[5]
Reference
[uredi | uredi izvor]- ^ a b c GRCh38: Ensembl release 89: ENSG00000101435 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027445 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: CST9L cystatin 9-like (mouse)".
Dopunska literatura
[uredi | uredi izvor]- Brown WM, Dziegielewska KM (1997). "Friends and relations of the cystatin superfamily--new members and their evolution". Protein Sci. 6 (1): 5–12. doi:10.1002/pro.5560060102. PMC 2143511. PMID 9007972.
- Saitoh E, Isemura S, Sanada K, et al. (1989). "Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes". Biol. Chem. Hoppe-Seyler. 369 Suppl: 191–7. PMID 3202964.
- Dickinson DP, Thiesse M, Dempsey LD, Millar SJ (1993). "Genomic cloning, physical mapping, and expression of human type 2 cystatin genes". Crit. Rev. Oral Biol. Med. 4 (3–4): 573–80. doi:10.1177/10454411930040034401. PMID 7690606.
- Dickinson DP, Zhao Y, Thiesse M, Siciliano MJ (1995). "Direct mapping of seven genes encoding human type 2 cystatins to a single site located at 20p11.2". Genomics. 24 (1): 172–5. doi:10.1006/geno.1994.1595. PMID 7896273.
- Thiesse M, Millar SJ, Dickinson DP (1994). "The human type 2 cystatin gene family consists of eight to nine members, with at least seven genes clustered at a single locus on human chromosome 20". DNA Cell Biol. 13 (2): 97–116. doi:10.1089/dna.1994.13.97. PMID 8179826.
- Eriksson A, Töhönen V, Wedell A, Nordqvist K (2002). "Isolation of the human testatin gene and analysis in patients with abnormal gonadal development". Mol. Hum. Reprod. 8 (1): 8–15. doi:10.1093/molehr/8.1.8. PMID 11756564.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Vanjski linkovi
[uredi | uredi izvor]- Lokacija ljudskog genoma CST9L i stranica sa detaljima o genu CST9L u UCSC Genome Browseru.