Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Remodeling after stroke

Nature Medicine volume 12, pages 390–391 (2006)Cite this article

A promising approach to treating ischemic stroke, inhibition of matrix metalloproteinases (MMPs), may need to be rethought. Previous work suggested that inhibitors of MMPs could protect the brain, but now it seems that such inhibitors might contribute to damage (pages 441–445).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Redistribution of MMP-9 within the neurovascular unit after stroke.

Katie Ris

References

  1. Zhao, B-Q. et al. Nat. Med. 12, 441–445 (2006).

    Article  CAS  Google Scholar 

  2. Stemlicht, M. D. & Werb, Z. Annu. Rev. Cell Dev. Biol. 17, 463–516 (2001).

    Article  Google Scholar 

  3. Visse, R. & Nagase, H. Circ. Res. 92, 827–839 (2003).

    Article  CAS  Google Scholar 

  4. Cunningham, L.A., Wetzel, M. & Rosenberg, G.A. Glia 50, 329–339 (2005).

    Article  Google Scholar 

  5. Yong, V.W. Nat. Neurosci. Rev. 6, 931–944 (2005).

    Article  CAS  Google Scholar 

  6. Gu, Z. et al. Science 297, 1186–1190 (2002).

    Article  CAS  Google Scholar 

  7. Gu, Z. et al. J. Neurosci. 25, 6401–6408 (2005)

    Article  CAS  Google Scholar 

  8. Asahi, M. et al. J. Neurosci. 21, 7724–7732 (2001).

    Article  CAS  Google Scholar 

  9. Pfefferkon, T. & Rosenberg, G.A. Stroke 34, 2025–2030 (2003).

    Article  Google Scholar 

  10. Lee, S-R., Tsuji, K., Lee, S-R. & Lo, E.H. J. Neurosci. 24, 671–678 (2004).

    Article  CAS  Google Scholar 

  11. Montaner, J. et al. Circulation 105, 598–603 (2003).

    Article  Google Scholar 

  12. Zhang, Z.G., et al. J. Clin. Invest. 106, 829–838 (2000).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Frank P. Smith Laboratories for Neuroscience and Neurosurgical Research, University of Rochester, Rochester, 14642, New York, USA

    Berislav V Zlokovic

Authors
  1. Berislav V Zlokovic
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zlokovic, B. Remodeling after stroke. Nat Med 12, 390–391 (2006). https://doi.org/10.1038/nm0406-390

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0406-390

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing
pFad - Phonifier reborn

Pfad - The Proxy pFad of © 2024 Garber Painting. All rights reserved.

Note: This service is not intended for secure transactions such as banking, social media, email, or purchasing. Use at your own risk. We assume no liability whatsoever for broken pages.


Alternative Proxies:

Alternative Proxy

pFad Proxy

pFad v3 Proxy

pFad v4 Proxy