Computational Analysis of MDR1 Variants Predicts Effect on Cancer Cells via their Effect on mRNA Folding
Fig 4
Impact of the three variants on tAI.
a) Changes in tAI caused by the three variants in tissues where MDR1 is highly expressed. Variants are shown in green for kidney renal clear cells (KIRC), yellow for liver hepatocytes (LIHC), purple for astrocytes (GBM), and red for epithelial colon cells (COAD). b) Change in tAI caused by T2677G in epithelial colon cells. The vertical blue line indicates the position of the variant. The tAI scores of the original and mutated codon are shown with dark grey and red x marks, respectively, while light grey x marks indicate the tAI scores of the surrounding codons. c) tAI scores of all codons in human epithelial colon cells, with bar colors representing the amino acid encoded by each codon. Codons with or without each variant are marked as "REF" and "MUT" respectively, colored in red (T1236C), orange (T2677G), or fuchsia (T3435C).