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{{shortShort description|Protrusion of the upper or lower human jaw}}
{{moreMore citations needed|date=September 2018}}
{{Infobox medical condition (new)
| name = Prognathism
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| pronounce =
| field =
| synonyms = Habsburg jaw (in the case of mandibular prognathism)
| symptoms =
| complications =
| onset =
| duration =
| types = {{plainlistplain list|
* Alveolar
* Maxillary
* Mandibular, or progenism }}
| causes = Multifactorial
| risks =
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| medication =
| prognosis =
| frequency = {{plainlistplain list|
* Children: 0.5 to 2.0%
* Adult: 2.0 to 4.0%{{sfnSfn|Wolff|Wienker|Sander|1993|p=112}}}}
| deaths =
}}
 
'''Prognathism''', also called '''Habsburg jaw''' or '''Habsburgs' jaw'''{{https://onlinelibrary.wiley.com/doi/10.1002/ajmg.a.36639}}{{https://pubmed.ncbi.nlm.nih.gov/32083497/}} primarily in the context of its prevalence amongst members of the [[House of Habsburg]]{{ https://pubmed.ncbi.nlm.nih.gov/24942320/}}, is a positional relationship of the [[Human mandible|mandible]] or [[maxilla]] to the skeletal base where either of the jaws protrudes beyond a predetermined imaginary line in the [[coronal plane]] of the skull. In [[Dentistry{{clarify|generalreason=Should dentistry]],it [[oralbe andsagittal maxillofacialplane? surgery]],Do andboth orthodontics,jaws thisnormally isextend assessedventrally clinicallybeyond orany radiographically ([[Cephalometry|cephalometrics]]). The word ''prognathism'' derives from Greek πρό (''pro'', meaning 'forward') and γνάθος (''gnáthos'', 'jaw'). One or more types of prognathism can resultline in the commoncoronal condition of [[malocclusion]], in which an individual's top [[tooth|teeth]] and lower teeth do not align properly.{{citation neededplane?|date=SeptemberDecember 20182022}}
 
In the case of ''mandibular'' prognathism (never maxillary prognathism) this is often also referred to as '''Habsburg chin''', '''Habsburg's chin''', '''Habsburg jaw''' or '''Habsburg's jaw'''<ref name="Peacock Klein Mulliken Kaban 2014">{{cite journal |last1=Peacock |first1=Zachary S. |last2=Klein |first2=Katherine P. |last3=Mulliken |first3=John B. |last4=Kaban |first4=Leonard B. |title=The Habsburg Jaw-re-examined |journal=American Journal of Medical Genetics. Part A |date=September 2014 |volume=164A |issue=9 |pages=2263–2269 |doi=10.1002/ajmg.a.36639 |pmid=24942320 |s2cid=35651759 }}</ref><ref>{{cite journal |last1=Zamudio Martínez |first1=Gabriela |last2=Zamudio Martínez |first2=Adriana |title=A Royal Family Heritage: The Habsburg Jaw |journal=Facial Plastic Surgery & Aesthetic Medicine |date=2020 |volume=22 |issue=2 |pages=120–121 |doi=10.1089/fpsam.2019.29017.mar |pmid=32083497 |s2cid=211232475 }}</ref> especially when referenced with context of its prevalence amongst historical members of the [[House of Habsburg]].<ref name="Peacock Klein Mulliken Kaban 2014"/>
 
Mandibular prognathism is typically pathological, whereas maxillary prognathism is often found as a result of normal human population variation.
 
In [[Dentistry|general dentistry]], [[oral and maxillofacial surgery]], and orthodontics, this is assessed clinically or radiographically ([[Cephalometry|cephalometrics]]). The word ''prognathism'' derives from Greek πρό (''pro'', meaning 'forward') and γνάθος (''gnáthos'', 'jaw'). One or more types of prognathism can result in the common condition of [[malocclusion]], in which an individual's top [[tooth|teeth]] and lower teeth do not align properly.{{citation needed|date=September 2018}}
 
==Presentation==
[[Image:Mandibular prognathism pre-surgery.png|thumb|left|Mandibular prognathism, where teeth have almost reached their final, straight position by [[dental braces]]. This makes the prognathism more obvious, and it will take an operation, moving the jaw backwards, to give the ultimate result.]]
 
Prognathism in humans can occur due to normal variation among [[phenotypes]]. In human populations where prognathism is not the norm, it may be a malformation, the result of injury, a disease state or a hereditary condition.<ref>{{MedlinePlusEncyclopedia|003026|Prognathism}}</ref>
In humans, non-pathological maxillary and alveolar prognathism can occur due to normal variation among [[phenotypes]].
 
Prognathism in humans can occur due to normal variation among [[phenotypes]]. In human populationsHowever, wheremandibular prognathism is notusually the normanomalous, and it may be a malformation, the result of injury, a disease state, or a hereditary condition.<ref>{{MedlinePlusEncyclopedia|003026|Prognathism}}</ref>
 
Prognathism is considered a disorder only if it affects [[chewing]], [[Manner of articulation|speech]] or social function as a byproduct of severely affected aesthetics of the face.{{citation needed|date=September 2018}}
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Cephalometric analysis is the most accurate way of determining all types of prognathism, as it includes assessments of skeletal base, occlusal plane angulation, facial height, soft tissue assessment and anterior dental angulation. Various calculations and assessments of the information in a cephalometric radiograph allow the clinician to objectively determine dental and skeletal relationships and determine a treatment plan.{{citation needed|date=September 2018}}
 
Prognathism should not be confused with [[micrognathism]], although combinations of both are found.
Prognathism should not be confused with [[micrognathism]], although combinations of both are found. It affects the middle third of the face, causing it to jut out, thereby increasing the facial area, similar to the phenotype of archaic hominids and other apes. Mandibular prognathism is a protrusion of the mandible, affecting the lower third of the face. Alveolar prognathism is a protrusion of that portion of the maxilla where the teeth are located, in the dental lining of the upper jaw.{{citation needed|date=September 2018}}
 
Alveolar prognathism is a protrusion of that portion of the maxilla where the teeth are located, in the dental lining of the upper jaw.{{citation needed|date=September 2018}}
 
Maxillary prognathism affects the middle third of the face, causing the maxilla to jut out, thereby increasing the facial area.
 
Mandibular prognathism is a protrusion of the mandible, affecting the lower third of the face.
 
Prognathism can also be used to describe ways that the maxillary and mandibular dental arches relate to one another, including malocclusion (where the upper and lower teeth do not align). When there is maxillary or alveolar prognathism which causes an alignment of the maxillary incisors significantly anterior to the lower teeth, the condition is called an [[malocclusion|overjet]]. When the reverse is the case, and the lower jaw extends forward beyond the upper, the condition is referred to as [[retrognathia|retrognathia (reverse overjet)]].{{citation needed|date=September 2018}}
 
==Classification==
 
===Alveolar prognathism===
[[Image:Alveolprog.jpg|thumb|175px|Alveolar prognathism, caused by thumb sucking and tongue thrusting in a seven-year-old girl.]]
Not all alveolar prognathism is anomalous, and significant differences can be observed among different ethnicities.{{sfn|Vioarsdóttir|O'Higgins|Stringer|2002|pp=211–229}}
 
Not all alveolar prognathism is anomalous, and significant differences can be observed among different ethnicities.{{sfnSfn|Vioarsdóttir|O'Higgins|Stringer|2002|pp=211–229}}
Harmful habits such as [[thumb sucking]] or [[tongue thrust]]ing can result in or exaggerate an alveolar prognathism, causing teeth to misalign. Functional appliances can be used in growing children to help modify bad habits and neuro-muscular function, with the aim of correcting this condition.{{citation needed|date=September 2018}}
 
Harmful habits such as [[thumb sucking]] or [[tongue thrust]]ing can result in or exaggerate an alveolar prognathism, causing teeth to misalign.<ref name=SinghEtAl2020>{{Cite journal |last=Singh |first=Tenali Sushmitha |last2=Sridevi |first2=Enuganti |last3=Sankar |first3=Avula Jogendra Sai |last4=Kakarla |first4=Pranitha |last5=Vallabaneni |first5=Siva Sai Krishna |last6=Sridhar |first6=Mukthineni |date=2020 |title=Cephalometric Assessment of Dentoskeletal Characteristics in Children with Digit-sucking Habit |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450188/ |journal=International Journal of Clinical Pediatric Dentistry |volume=13 |issue=3 |pages=221–224 |doi=10.5005/jp-journals-10005-1761 |issn=0974-7052 |pmc=7450188 |pmid=32904107}}</ref> Functional appliances can be used in growing children to help modify bad habits and neuro-muscular function, with the aim of correcting this condition.<ref name=SinghEtAl2020/>
Alveolar prognathism can also easily be corrected with fixed orthodontic therapy. However, relapse is quite common, unless the cause is removed or a long-term retention is used.{{citation needed|date=September 2018}}
 
Alveolar prognathism can also easily be corrected with fixed orthodontic therapy. However, relapse is quite common, unless the cause is removed or a long-term retention is used.<ref name=SahilEtAl2021>{{Cite journal |last=Sahil |first=Sahil |last2=Soni |first2=Sanjeev |last3=Kaur |first3=Gurpreet |date=2021-12-31 |title=Challenging Malocclusion in Orthodontics: the Open Bite |url=https://www.neliti.com/publications/426601/challenging-malocclusion-in-orthodontics-the-open-bite |journal=International Journal of Health Sciences |language=en |pages=125–134 |doi=10.53730/ijhs.v5nS2.5581 |issn=2550-6978}}</ref>
 
===Maxillary prognathism===
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Prognathism, if not extremely severe, can be treated in growing patients with orthodontic functional or orthopaedic appliances. In adult patients this condition can be corrected by means of a combined surgical/orthodontic treatment, where most of the time a mandibular advancement is performed. The same can be said for mandibular prognathism.{{citation needed|date=September 2018}}
 
On average, Neanderthals were far more prognathic than modern humans regarding the maxilla. This maxillary prognathism, along with their wide noses, suggests that their faces were not adapted to cold climate.<ref>{{Cite web |last1=Rae |first1=Todd C. |last2=Koppe |first2=Thomas |last3=Stringer |first3=Chris B. |date=27 October 2010 |title=The Neanderthal face is not cold adapted |url=https://edisciplinas.usp.br/pluginfile.php/6200375/mod_resource/content/1/The%20neanderthal%20face%20is%20not%20cold%20adapted%20%28Rae%20et%20al%202011%29.pdf |access-date=5 May 2024 |website=Moodle USP: e-Disciplinas}}</ref>
=== {{anchor|Mandibular prognathism}} Mandibular prognathism (progenism) ===
 
{{Anchor|Mandibular prognathism}}
{{multiple image
| align = right
| image1 = Charles II.jpg
| width1 = 180
| caption1 = [[Charles II of Spain]] showing '''Habsburg jaw''', a severe type of mandibular prognathism.
| image2 = Emperor Komei Portrait by Koyama Shotaro 1902.png
| width2 = 180
| caption2 = [[Emperor Kōmei]] of Japan, showing progenism.
| image3 = Vlad Tepes 002.jpg
| width3 = 180
| caption3 = [[Vlad III]] of Wallachia, showing progenism.
| footer =
}}
 
=== {{anchor|Mandibular prognathism}} Mandibular prognathism (progenism) ===
Pathologic [[Mandible|mandibular]] prognathism is a potentially disfiguring genetic disorder where the lower [[jaw]] outgrows the upper, resulting in an extended [[chin]] and a [[crossbite]]. In both humans and animals, it can be the result of [[inbreeding]].{{sfn|Vilas|Ceballos|Al-Soufi|González-García|2019|pp=563-571}} In brachycephalic or flat-faced dogs, like [[shih tzu]]s and [[Boxer (dog)|boxers]], it can lead to problems such as underbite.{{sfn|Beuchat|2015}}
[[File:Berlín DHM Leopoldo I 02.JPG|thumb|upright|left|[[Leopold I, Holy Roman Emperor|Leopold I]], showing progenism]]
 
Pathologic [[Mandible|mandibularMandibular]] prognathism is a potentially disfiguring genetic disorder where the lower [[jaw]] outgrows the upper, resulting in an extended [[chin]] and a [[crossbite]]. In both humans and animals, it can be the result of [[inbreeding]].{{sfnSfn|Vilas|Ceballos|Al-Soufi|González-García|2019|pp=563-571}} In brachycephalic or flat-faced dogs, like [[shih tzu]]s and [[Boxer (dog)|boxers]], it can lead to problems such as underbite.{{sfn|Beuchat|2015}}
In humans, it results in a condition sometimes called ''lantern jaw'', reportedly derived from 15th century [[Lantern|horn lanterns]], which had convex sides.<ref>{{OMIM|176700|PROGNATHISM, MANDIBULAR}}</ref>{{efn|The [[Oxford English Dictionary|OED]] uses a slightly different definition, "long thin jaws, giving a hollow appearance to the cheek".<ref>{{OED|lantern jaw|id=105665}}</ref>}} Traits such as these were often exaggerated by inbreeding, and can be traced within specific families.{{sfn|Vilas|Ceballos|Al-Soufi|González-García|2019|pp=563-571}}
 
Unlike alveolar or maxillary prognathism, which are common traits in some populations, mandibular prognathism is typically pathological. However, it is more common among East Asian populations but overall, the condition is polygenic.<ref>{{Cite journal |last1=Kulkarni |first1=Shilpa Devdatt |last2=Bhad |first2=Wasundhara A. |last3=Doshi |first3=Umal H. |date=2020 |title=Association Between Mandibular Prognathism and MATRILIN-1 Gene in Central India Population: A Cross-sectional Study |url=https://journals.sagepub.com/doi/full/10.1177/0301574220956421#:~:text=Genetic%20predisposition%20in%20the%20causation,MP)%20is%20an%20established%20fact.&text=It%20is%20an%20autosomal%2Ddominant%20trait%20with%20incomplete%20penetrance.&text=Prevalence%20of%20MP%20is%20found,particularly%20in%20eastern%20Asian%20races. |journal=Journal of Indian Orthodontic Society |volume=55 |issue=1 |pages=28–32 |doi=10.1177/0301574220956421 |via=Sage Journals|doi-access=free }}</ref>
Although more common than appreciated, the best known historical example is '''Habsburg jaw''', or Habsburg or '''Austrian lip''', due to its prevalence in members of the [[House of Habsburg]], which can be traced in their portraits.{{sfn|Vilas|Ceballos|Al-Soufi|González-García|2019}} The process of portrait-mapping has provided tools for [[geneticist]]s and [[Pedigree chart|pedigree]] analysis; most instances are considered [[polygene|polygenic]],{{sfn|Wolff|Wienker|Sander|1993|pp=112–116}} but a number of researchers believe that this trait is transmitted through an autosomal recessive type of inheritance.<ref name="Безуглый 2020">{{cite journal |last1=Безуглый |first1=Т. А. |title=Влияние На Человека Признаков, Передаваемых По Аутосомно-Рецессивному Типу (на Примере Династии Габсбургов) |trans-title=Influence on the Human Traits Transmitted According to the Autosomal-Recessive Type (on the Example of the Habsburg Dynasty) |date=2020 |url=https://www.elibrary.ru/item.asp?id=44270977 |language=ru }}</ref>{{sfn|Vilas|Ceballos|Al-Soufi|González-García|2019}}
 
In brachycephalic or flat-faced dogs, like [[shih tzu]]s and [[Boxer (dog)|boxers]], it can lead to problems such as underbite.{{Sfn|Beuchat|2015}}
[[File:Berlín DHM Leopoldo I 02.JPG|thumb|upright|left|[[Leopold I, Holy Roman Emperor|Leopold I]], showing progenism]]
 
In humans, it results in a condition sometimes called ''lantern jaw'', reportedly derived from 15th century [[Lantern|horn lanterns]], which had convex sides.<ref>{{OMIM|176700|PROGNATHISM, MANDIBULAR}}</ref>{{efnEfn|The ''[[Oxford English Dictionary|OED]]'' uses a slightly different definition,: "long thin jaws, giving a hollow appearance to the cheek".<ref>{{OED|lantern jaw|id=105665}}</ref>}} Traits such as these were often exaggerated by inbreeding, and can be traced within specific families.{{sfnSfn|Vilas|Ceballos|Al-Soufi|González-García|2019|pp=563-571}}
Allegedly introduced into the family by a [[Cymburgis of Masovia|member]] of the [[Piast dynasty]], it is clearly visible on family tomb sculptures in [[St. John's Archcathedral, Warsaw|St. John's Cathedral, Warsaw]]. A high propensity for politically motivated intermarriage among Habsburgs meant the dynasty was virtually unparalleled in the degree of its inbreeding. [[Charles II of Spain]], who lived 1661 to 1700, is said to have had the most pronounced case of the Habsburg jaw on record,{{sfn|Mitchell|2013|pp=303-308}} due to the high number of [[consanguineous]] marriages in the dynasty preceding his birth.<ref name="Безуглый 2020"/>{{sfn|Vilas|Ceballos|Al-Soufi|González-García|2019}}
 
Although more common than appreciated, the best known historical example is '''Habsburg jaw''', or Habsburg or '''Austrian lip''', due to its prevalence in members of the [[House of Habsburg]], which can be traced in their portraits.{{sfnSfn|Vilas|Ceballos|Al-Soufi|González-García|2019}} The process of portrait-mapping has provided tools for [[geneticist]]s and [[Pedigree chart|pedigree]] analysis; most instances are considered [[polygene|polygenic]],{{sfnSfn|Wolff|Wienker|Sander|1993|pp=112–116}} but a number of researchers believe that this trait is transmitted through an autosomal recessive type of inheritance.<ref name="Безуглый 2020">{{cite journalweb |last1=Безуглый |first1=Т. А. |title=Влияние На Человека Признаков, Передаваемых По Аутосомно-Рецессивному Типу (на Примере Династии Габсбургов) |trans-title=Influence on the Human Traits Transmitted According to the Autosomal-Recessive Type (on the Example of the Habsburg Dynasty) |date=2020 |url=https://www.elibrary.ru/item.asp?id=44270977 |language=ru }}</ref>{{sfnSfn|Vilas|Ceballos|Al-Soufi|González-García|2019}}
==Treatment==
Prior to the development of modern dentistry, there was no treatment for this condition; those who had it simply endured it. Today, the most common treatment for mandibular prognathism is a combination of [[orthodontics]] and [[orthognathic surgery]]. The orthodontics can involve [[Dental braces|braces]], removal of teeth, or a [[mouthguard]].<ref>{{cite web |url=https://www.colgate.com/en-us/oral-health/developmental-disabilities/treating-prognathism-ways-to-correct-abnormal-jaw-alignment |title = Treating Prognathism: Ways To Correct Abnormal Jaw Alignment}}</ref>
 
Allegedly introduced into the family by a [[Cymburgis of Masovia|member]] of the [[Piast dynasty]], it is clearly visible on family tomb sculptures in [[St. John's Archcathedral, Warsaw|St. John's Cathedral, Warsaw]]. A high propensity for politically motivated intermarriage among Habsburgs meant the dynasty was virtually unparalleled in the degree of its inbreeding. [[Charles II of Spain]], who lived 1661 to 1700, is said to have had the most pronounced case of the Habsburg jaw on record,{{sfnSfn|Mitchell|2013|pp=303-308}} due to the high number of [[consanguineous]] marriages in the dynasty preceding his birth.<ref name="Безуглый 2020"/>{{sfnSfn|Vilas|Ceballos|Al-Soufi|González-García|2019}}
==In insects==
 
{{multiple image
| align = rightcenter
| image1 = Charles II.jpg
| width1 = 180150
| caption1 = [[Charles II of Spain]] showing '''Habsburg jaw''', a severe type of mandibular prognathism.
| image3image2 = Vlad Tepes 002.jpg
| width2 = 180150
| caption2 = [[EmperorVlad KōmeiIII]] of JapanWallachia, showing progenism.
| image3 = Arveprins Frederik (Juel).JPG
| width3 = 180150
| caption3 = [[Frederick, Hereditary Prince of Denmark|Frederick, regent of Denmark-Norway]], showing progenism.
| image4 = Pedro II of Brazil 1851 edit.png
| width4 = 150
| caption4 = [[Pedro II of Brazil]], showing progenism. His mother was Archduchess [[Maria Leopoldina of Austria]], a member of the [[House of Habsburg-Lorraine]] by birth.
| footer =
}}
 
==Treatment of mandibular prognathism==
Prior to the development of modern dentistry, there was no treatment for this condition; those who had it simply endured it. Today, the most common treatment for mandibular prognathism is a combination of [[orthodontics]] and [[orthognathic surgery]]. The orthodontics can involve [[Dental braces|braces]], removal of teeth, or a [[mouthguard]].<ref>{{cite web |url=https://www.colgate.com/en-us/oral-health/developmental-disabilities/treating-prognathism-ways-to-correct-abnormal-jaw-alignment |title = Treating Prognathism: Ways Toto Correct Abnormal Jaw Alignment}}</ref>
 
==In insects==
In [[entomology]], prognathous means that the mouthparts face forwards, being at the front of the head, rather than facing downwards as in some insects.<ref>{{cite web |title=Prognathous |url=https://www.earthlife.net/insects/glossary.html#16 |website=A Glossary of Entomological Terms |access-date=11 September 2019}}</ref>
 
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* [[Dental pathology]]
 
==Notes Footnotes ==
{{notelist}}
 
== References ==
{{Reflist}}
 
== General and cited sources ==
==Sources==
* {{citeCite web |last1=Beuchat |first1=Carol|date=12 March 2015 |title=Why all the fuss about inbreeding? |url=https://www.instituteofcaninebiology.org/blog/why-all-the-fuss-about-inbreeding-or-why-do-we-have-so-many-genetic-disorders-in-dogs |websitepublisher=Institute of Canine Biology |access-date=16 April 2020}}
* {{citeCite thesis |last1=Mitchell |first1=Sylvia Z |date=May 2013 |title=Mariana of Austria and Imperial Spain: Court, Dynastic, and International Politics in Seventeenth-Century Europe |date=2013 |url=https://scholarship.miami.edu/permalink/01UOML_INST/1grrnr5/alma991031447870202976 |type=Ph.D. |location=Coral Gables, Florida |publisher=University of Miami}}
* {{citeCite journal |last1=Vilas |first1=Román |last2=Ceballos |first2=Francisco C. |last3=Al-Soufi |first3=Laila |last4=González-García |first4=Raúl |last5=Moreno |first5=Carlos |last6=Moreno |first6=Manuel |last7=Villanueva |first7=Laura |last8=Ruiz |first8=Luis |last9=Mateos |first9=Jesús |last10=González |first10=David |last11=Ruiz |first11=Jennifer |last12=Cinza |first12=Aitor |last13=Monje |first13=Florencio |last14=Álvarez |first14=Gonzalo |title=Is the 'Habsburg jaw' related to inbreeding? |journal=Annals of Human Biology |date=17 November 2019 |volume=46 |issue=7–8 |pages=553–561 |doi=10.1080/03014460.2019.1687752 |pmid=31786955 |s2cid=208536371 |url=https://figshare.com/articles/dataset/Is_the_Habsburg_jaw_related_to_inbreeding_/11302394 }}
}}
* {{Cite journal |last1=Vioarsdóttir|first1=US|last2=O'Higgins|first2=O|last3=Stringer|first3=C |title=A geometric morphometric study of regional differences in the ontogeny of the modern human facial skeleton |journal=J. Anat. |volume=201 |issue=3 |year=2002 |pages=211–229|pmid=12363273 |doi=10.1046/j.1469-7580.2002.00092.x |pmc=1570912}}
* {{cite journal |last1=Vilas |first1=Román |last2=Ceballos |first2=Francisco C. |last3=Al-Soufi |first3=Laila |last4=González-García |first4=Raúl |last5=Moreno |first5=Carlos |last6=Moreno |first6=Manuel |last7=Villanueva |first7=Laura |last8=Ruiz |first8=Luis |last9=Mateos |first9=Jesús |last10=González |first10=David |last11=Ruiz |first11=Jennifer |last12=Cinza |first12=Aitor |last13=Monje |first13=Florencio |last14=Álvarez |first14=Gonzalo |title=Is the 'Habsburg jaw' related to inbreeding? |journal=Annals of Human Biology |date=17 November 2019 |volume=46 |issue=7–8 |pages=553–561 |doi=10.1080/03014460.2019.1687752 |pmid=31786955 |s2cid=208536371 |url=https://figshare.com/articles/dataset/Is_the_Habsburg_jaw_related_to_inbreeding_/11302394 }}
* {{citeCite journal |last1=VioarsdóttirWolff |first1=USG |last2=O'HigginsWienker |first2=OT F |last3=StringerSander |first3=CH |title=AOn geometric morphometricthe studygenetics of regionalmandibular differencesprognathism: inanalysis theof ontogenylarge ofEuropean thenoble modernfamilies. human|journal=Journal facialof skeletonMedical Genetics |journaldate=J.1 Anat.February 1993 |volume=20130 |issue=3 |year=20022 |pages=211–229|pmid=12363273112–116 |doi=10.10461136/jjmg.1469-758030.20022.00092.x112 |pmid=8445614 |pmc=15709121016265}}
* {{cite journal |last1=Wolff |first1=G |last2=Wienker |first2=T F |last3=Sander |first3=H |title=On the genetics of mandibular prognathism: analysis of large European noble families. |journal=Journal of Medical Genetics |date=1 February 1993 |volume=30 |issue=2 |pages=112–116 |doi=10.1136/jmg.30.2.112 |pmid=8445614 |pmc=1016265}}
 
== External links ==
* {{Wiktionary-inline}}
 
{{Medical resources
| DiseasesDB = 29354
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| MeshID = D011378
}}
* {{Wiktionary-inline}}
 
{{Dentofacial anomalies and jaw disease}}
 
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